JP5222134B2 - Ｈｅｒ−２ペプチド - Google Patents

Ｈｅｒ−２ペプチド Download PDF

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Publication number
JP5222134B2
JP5222134B2 JP2008517193A JP2008517193A JP5222134B2 JP 5222134 B2 JP5222134 B2 JP 5222134B2 JP 2008517193 A JP2008517193 A JP 2008517193A JP 2008517193 A JP2008517193 A JP 2008517193A JP 5222134 B2 JP5222134 B2 JP 5222134B2
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Japan
Prior art keywords
epitope
chimeric peptide
peptide
linker
sequence
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JP2008517193A
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English (en)
Japanese (ja)
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JP2009500298A (ja
JP2009500298A5 (https=
Inventor
プラビン ティー． ピー． カウマヤ，
Original Assignee
ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション
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Publication of JP2009500298A publication Critical patent/JP2009500298A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2008517193A 2005-06-15 2006-06-15 Ｈｅｒ−２ペプチド Expired - Fee Related JP5222134B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69057405P 2005-06-15 2005-06-15
US60/690,574 2005-06-15
PCT/US2006/023672 WO2006138675A2 (en) 2005-06-15 2006-06-15 Her-2 peptides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012093680A Division JP5542865B2 (ja) 2005-06-15 2012-04-17 Ｈｅｒ−２ペプチド

Publications (3)

Publication Number Publication Date
JP2009500298A JP2009500298A (ja) 2009-01-08
JP2009500298A5 JP2009500298A5 (https=) 2009-07-30
JP5222134B2 true JP5222134B2 (ja) 2013-06-26

Family

ID=37571268

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2008517193A Expired - Fee Related JP5222134B2 (ja) 2005-06-15 2006-06-15 Ｈｅｒ−２ペプチド
JP2012093680A Expired - Fee Related JP5542865B2 (ja) 2005-06-15 2012-04-17 Ｈｅｒ−２ペプチド

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012093680A Expired - Fee Related JP5542865B2 (ja) 2005-06-15 2012-04-17 Ｈｅｒ−２ペプチド

Country Status (7)

Country Link
US (3) US7691396B2 (https=)
EP (1) EP1912680B1 (https=)
JP (2) JP5222134B2 (https=)
AU (1) AU2006261342B2 (https=)
CA (1) CA2612394C (https=)
ES (1) ES2531483T3 (https=)
WO (1) WO2006138675A2 (https=)

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EP1246597B1 (en) * 1999-08-03 2015-01-14 The Ohio State University Polypeptides and polynucleotides for enhancing immune reactivity to her-2 protein
AU2006261342B2 (en) 2005-06-15 2012-02-02 The Ohio State University Research Foundation Her-2 peptides
US8945573B2 (en) * 2005-09-08 2015-02-03 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Targeted identification of immunogenic peptides
WO2008097229A1 (en) * 2007-02-09 2008-08-14 The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health And Human Services Method for spectroscopic quantitation of her-2 in biological samples
US20110044882A1 (en) * 2008-04-22 2011-02-24 David Buckley Method of making high purity lithium hydroxide and hydrochloric acid
US20100234283A1 (en) 2009-02-04 2010-09-16 The Ohio State University Research Foundation Immunogenic epitopes, peptidomimetics, and anti-peptide antibodies, and methods of their use
US9125848B2 (en) 2010-06-10 2015-09-08 The Cleveland Clinic Foundation Alpha lactalbumin immunization methods
RU2607033C2 (ru) * 2010-09-28 2017-01-10 Ноно Инк. Пептиды nd2 и способы лечения неврологического заболевания
CA2870537A1 (en) 2012-04-16 2013-10-24 The Cleveland Clinic Foundation Multivalent breast cancer vaccine
US10221230B2 (en) 2013-02-25 2019-03-05 Ohio State Innovation Foundation HER-1, HER-3 and IGF-1R compositions and uses thereof
CN105017425B (zh) * 2014-04-30 2018-02-16 京天成生物技术(北京)有限公司 抗her2中和活性单克隆抗体及其应用
US20180327453A1 (en) * 2015-11-06 2018-11-15 Evorx Technologies, Inc. Her-2-specific cyclized supr peptides
WO2018145020A1 (en) 2017-02-03 2018-08-09 The Medical College Of Wisconsin, Inc. Kras peptide vaccine compositions and method of use
ES2963635T3 (es) * 2017-03-28 2024-04-01 Ohio State Innovation Foundation Vacunas de péptido PD1 humano y usos de las mismas
US20200179500A1 (en) 2018-12-05 2020-06-11 Wayne State University Methods and immunogenic compositions relating to her2 with selective sequence modifications
CN113993902B (zh) * 2019-03-22 2025-03-14 瑟缇斯治疗私人有限公司 抗her2结合分子
BR112022005044A2 (pt) * 2019-09-17 2022-07-05 Ohio State Innovation Foundation Peptídeo quimérico, peptídeo sintético, composição farmacêutica, anticorpo, método de tratamento
EP4486389A1 (en) 2022-02-28 2025-01-08 Tridem Bioscience GmbH & Co KG A conjugate comprising at least a beta-glucan
CN119019569B (zh) * 2024-08-19 2025-10-24 中国人民解放军陆军军医大学 一种可定向增强胸腺新生t细胞杀伤乳腺癌的多肽及其应用

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JP3040121B2 (ja) 1988-01-12 2000-05-08 ジェネンテク，インコーポレイテッド 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法
DE69031120T2 (de) 1989-05-19 1998-01-15 Genentech, Inc., South San Francisco, Calif. Her2 extrazellulare domäne
WO1991011719A1 (en) 1990-01-26 1991-08-08 Washington Research Foundation Immune reactivity to expressed activated oncogenes for diagnosis and treatment of malignancy
IL101943A0 (en) 1991-05-24 1992-12-30 Genentech Inc Structure,production and use of heregulin
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DE69333588T2 (de) 1992-09-28 2005-08-04 Wyeth Holdings Corp. Verfahren zur verstärkung zellularer immunantworten
AU679902B2 (en) 1992-09-30 1997-07-17 Ohio State University Research Foundation, The Vaccines and antigenic conjugates
US5801005A (en) 1993-03-17 1998-09-01 University Of Washington Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated
US5869445A (en) 1993-03-17 1999-02-09 University Of Washington Methods for eliciting or enhancing reactivity to HER-2/neu protein
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EP1246597B1 (en) 1999-08-03 2015-01-14 The Ohio State University Polypeptides and polynucleotides for enhancing immune reactivity to her-2 protein
US6432409B1 (en) 1999-09-14 2002-08-13 Antigen Express, Inc. Hybrid peptides modulate the immune response
US20030235594A1 (en) * 1999-09-14 2003-12-25 Antigen Express, Inc. Ii-Key/antigenic epitope hybrid peptide vaccines
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US20100234283A1 (en) 2009-02-04 2010-09-16 The Ohio State University Research Foundation Immunogenic epitopes, peptidomimetics, and anti-peptide antibodies, and methods of their use
JP5510272B2 (ja) 2010-06-21 2014-06-04 株式会社リコー 画像形成装置

Also Published As

Publication number Publication date
AU2006261342A1 (en) 2006-12-28
WO2006138675A2 (en) 2006-12-28
US20070060516A1 (en) 2007-03-15
JP5542865B2 (ja) 2014-07-09
US7691396B2 (en) 2010-04-06
US20110086055A1 (en) 2011-04-14
WO2006138675A9 (en) 2010-01-28
JP2012136555A (ja) 2012-07-19
CA2612394A1 (en) 2006-12-28
EP1912680A4 (en) 2010-09-22
EP1912680B1 (en) 2014-11-26
JP2009500298A (ja) 2009-01-08
US20140010831A1 (en) 2014-01-09
EP1912680A2 (en) 2008-04-23
US9452204B2 (en) 2016-09-27
CA2612394C (en) 2017-02-21
ES2531483T3 (es) 2015-03-16
US8470333B2 (en) 2013-06-25
AU2006261342B2 (en) 2012-02-02

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