JP5217050B2 - リパーゼ含有組成物およびこれらの使用方法 - Google Patents
リパーゼ含有組成物およびこれらの使用方法 Download PDFInfo
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- JP5217050B2 JP5217050B2 JP2001561344A JP2001561344A JP5217050B2 JP 5217050 B2 JP5217050 B2 JP 5217050B2 JP 2001561344 A JP2001561344 A JP 2001561344A JP 2001561344 A JP2001561344 A JP 2001561344A JP 5217050 B2 JP5217050 B2 JP 5217050B2
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- composition
- lipase
- protease
- activity
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| US18451700P | 2000-02-24 | 2000-02-24 | |
| US60/184,517 | 2000-02-24 | ||
| US09/791,947 US20010046493A1 (en) | 2000-02-24 | 2001-02-22 | Lipase-containing composition and methods of use thereof |
| US09/791,947 | 2001-02-22 | ||
| PCT/US2001/006074 WO2001062280A2 (en) | 2000-02-24 | 2001-02-23 | Lipase-containing composition and methods of use thereof |
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| JP2011260721A Division JP2012040028A (ja) | 2000-02-24 | 2011-11-29 | リパーゼ含有組成物およびこれらの使用方法 |
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| JP2003524421A JP2003524421A (ja) | 2003-08-19 |
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| US (4) | US20010046493A1 (https=) |
| EP (1) | EP1261368B1 (https=) |
| JP (2) | JP5217050B2 (https=) |
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| PT (1) | PT1261368E (https=) |
| WO (1) | WO2001062280A2 (https=) |
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|---|---|---|---|---|
| US20010046493A1 (en) * | 2000-02-24 | 2001-11-29 | Alex Margolin | Lipase-containing composition and methods of use thereof |
| IT1319655B1 (it) | 2000-11-15 | 2003-10-23 | Eurand Int | Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione. |
| AU2002364750A1 (en) * | 2001-12-14 | 2003-06-30 | Solvay Pharmaceuticals Gmbh | Use of digestive enzyme mixtures for treating pathological bacterial overgrowth of the small intestine of mammals and humans |
| ES2355890T3 (es) * | 2002-04-05 | 2011-04-01 | Societe des Produits Nestlé S.A. | Composiciones y métodos para promocionar la asimilación de lípidos en los animales domésticos. |
| KR20040012305A (ko) * | 2002-08-02 | 2004-02-11 | 김영권 | 리파아제를 생산능을 가지는 신규한 불콜데리아멀티보란스 dh4와 이를 이용한 리파아제 생산방법 |
| FR2848847B1 (fr) * | 2002-12-18 | 2005-10-14 | Coletica | Composition cosmetique ou dermopharmaceutique comprenant une enzyme insoluble en milieu aqueux, ainsi que ses utilisations |
| KR20060127857A (ko) * | 2003-10-29 | 2006-12-13 | 알투스 파마슈티컬스 인코포레이티드 | 혈장 콜레시스토키닌(cck) 농도 조절 및 통증 치료를위한 비-췌장 프로테아제 |
| JP2005222035A (ja) * | 2004-01-09 | 2005-08-18 | Canon Inc | 電子写真画像形成装置 |
| CA2554033C (en) * | 2004-01-28 | 2013-04-02 | Csir | Stabilization of enzymes |
| CA2560613C (en) * | 2004-03-22 | 2015-11-24 | Solvay Pharmaceuticals Gmbh | Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants |
| EP2422804A1 (en) * | 2004-06-17 | 2012-02-29 | Amano Enzyme USA., Ltd. | Controlled release formulations of enzymes, microorganisms, and antibodies with mucoadhesive polymers |
| PT1809320E (pt) * | 2004-10-14 | 2010-10-25 | Altus Pharmaceuticals Inc | Composições contendo lipase, protease e amilase para o tratamento de insuficiência pancreática |
| JP5199077B2 (ja) * | 2005-06-10 | 2013-05-15 | アルタス ファーマシューティカルズ インコーポレイテッド | シュウ酸オキシダーゼ結晶の投与による、シュウ酸塩濃度を低下させるための方法 |
| AU2006261444A1 (en) * | 2005-06-24 | 2006-12-28 | Novozymes A/S | Amylases for pharmaceutical use |
| HUE031042T2 (en) | 2005-07-29 | 2017-06-28 | Abbott Laboratories Gmbh | Methods for producing pancreatin powder with low viral content |
| US9198871B2 (en) * | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
| US11266607B2 (en) * | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
| US20100196344A1 (en) * | 2005-10-14 | 2010-08-05 | Cystic Fibrosis Foundation Therapeutics, Inc. | Compositions and methods for treating pancreatic insufficiency |
| WO2007053619A2 (en) * | 2005-11-01 | 2007-05-10 | Bio-Cat, Inc. | A composition with a fungal (yeast) lipase and method for treating lipid malabsorption in cystic fibrous as well as people suffering from pancreatic lipase insufficiency |
| US10072256B2 (en) * | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
| US20080199448A1 (en) * | 2007-02-16 | 2008-08-21 | Ross Mairi R | Enzyme composition for improving food digestion |
| US8246950B2 (en) * | 2007-02-20 | 2012-08-21 | Aptalis Pharma Limited | Stable digestive enzyme compositions |
| CA2702577A1 (en) | 2007-10-15 | 2009-04-23 | Jbs United, Inc. | Method for increasing performance of offspring |
| US20090130063A1 (en) * | 2007-11-15 | 2009-05-21 | Solvay Pharmaceuticals Gmbh | Process for separating and determining the viral load in a pancreatin sample |
| WO2009109856A2 (en) | 2008-03-07 | 2009-09-11 | Axcan Pharma Inc. | Method for detecting infectious parvovirus in pharmaceutical preparations |
| DE102009006594A1 (de) | 2009-01-29 | 2010-08-05 | Nordmark Arzneimittel Gmbh & Co. Kg | Pharmazeutisches Präparat |
| BRPI0922653B8 (pt) | 2009-01-29 | 2021-05-25 | Nordmark Arzneimittel Gmbh & Co Kg | uso de uma lipase bacteriana do tipo pseudomonas em solução aquosa |
| US8784884B2 (en) | 2009-09-17 | 2014-07-22 | Stephen Perrett | Pancreatic enzyme compositions and methods for treating pancreatitis and pancreatic insufficiency |
| SE535296C2 (sv) | 2010-09-08 | 2012-06-19 | Anara Ab | Mognad av mag-tarmkanalen |
| UA111726C2 (uk) | 2010-10-01 | 2016-06-10 | Апталіс Фарма Лімітед | Препарат панкреліпази низької сили з кишковорозчинним покриттям |
| CA2843556A1 (en) | 2011-08-08 | 2013-02-14 | Aptalis Pharma Ltd. | Method for dissolution testing of solid compositions containing digestive enzymes |
| US8268305B1 (en) | 2011-09-23 | 2012-09-18 | Bio-Cat, Inc. | Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase |
| CA2884592C (en) | 2012-09-19 | 2021-08-31 | Grespo Ab | Compositions for improvement of brain function |
| EP2996712B1 (en) | 2013-03-15 | 2018-10-31 | Allergan Pharmaceuticals International Limited | Process for the preparation of a composition containing digestive enzymes and nutrients suitable for enteral administration |
| WO2015019198A2 (en) | 2013-07-22 | 2015-02-12 | Aptalis Pharma S.R.L. | High potency pancreatin pharmaceutical compositions |
| MX2016001593A (es) | 2013-08-09 | 2016-09-29 | Allergan Pharmaceuticals Int Ltd | Composicion de enzima digestiva adecuada para administracion enterica. |
| MX2016000480A (es) | 2013-11-05 | 2016-10-21 | Allergan Pharmaceuticals Int Ltd | Composiciones farmaceuticas de pancreatina de alta potencia. |
| JP2017519490A (ja) | 2014-06-19 | 2017-07-20 | アプタリス ファルマ リミテッド | 膵臓抽出物からのウイルス汚染の除去方法 |
| GB201501081D0 (en) | 2015-01-22 | 2015-03-11 | Cilian Ag | Use of enzymes with a wide pH activity range as medicaments for promoting digestion |
| WO2016126970A1 (en) * | 2015-02-04 | 2016-08-11 | Abbvie Inc. | Pharmaceutical compositions and methods of use thereof to treat pancreatic enzyme insufficiency |
| BR112018003766A2 (pt) | 2015-08-28 | 2018-09-25 | Unilever Nv | composição detergente líquida compreendendo enzima protease e não protease |
| DE102015114857A1 (de) | 2015-09-04 | 2017-03-09 | Nordmark Arzneimittel Gmbh & Co. Kg | Getränk, enthaltend eine pharmazeutische Zusammensetzung |
| US10560349B2 (en) | 2018-01-31 | 2020-02-11 | Salesforce.Com, Inc. | Data consistency of policy enforcement for distributed applications |
| EP4501403A3 (en) * | 2019-08-30 | 2025-05-14 | Société des Produits Nestlé S.A. | Engineered lipase variants |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3944470A (en) * | 1973-06-29 | 1976-03-16 | The Procter & Gamble Company | Stabilization and enhancement of enzymatic activity |
| GB1509866A (en) * | 1975-06-10 | 1978-05-04 | Johnson & Johnson | Enteric coated digestive enzyme compositions |
| US4659667A (en) * | 1985-02-26 | 1987-04-21 | Miles Laboratories, Inc. | Process to recover crystalline enzymes and crystalline enzymes produced thereby |
| DK154572C (da) * | 1985-08-07 | 1989-04-24 | Novo Industri As | Enzymatisk detergentadditiv, detergent og fremgangsmaade til vask af tekstiler |
| JP3079276B2 (ja) * | 1988-02-28 | 2000-08-21 | 天野製薬株式会社 | 組換え体dna、それを含むシュードモナス属菌及びそれを用いたリパーゼの製造法 |
| DE3808695A1 (de) * | 1988-03-16 | 1989-10-05 | Henkel Kgaa | Fluessiges waschmittel |
| DK173590D0 (da) * | 1990-06-06 | 1990-07-19 | Novo Nordisk As | Rekombinante terapeutiske lipaser |
| US5618710A (en) * | 1990-08-03 | 1997-04-08 | Vertex Pharmaceuticals, Inc. | Crosslinked enzyme crystals |
| US5892013A (en) * | 1990-09-13 | 1999-04-06 | Novo Nordisk A/S | Lipase variants |
| CA2110497C (en) * | 1991-07-01 | 2005-04-19 | Reinhard Braatz | Use of bacterial lipases for producing drugs for maldigestion therapy |
| WO1993013200A1 (en) * | 1991-12-20 | 1993-07-08 | Novo Nordisk A/S | A process for the preparation of lipase |
| DK0671943T3 (da) * | 1992-06-30 | 2000-03-27 | Cortecs Uk Ltd | Anvendelse af enzymer, især bromelain, i behandlingen af ikke-infektiøs diarré |
| DK154292D0 (da) * | 1992-12-23 | 1992-12-23 | Novo Nordisk As | Nyt enzym |
| DK39693D0 (da) * | 1993-04-02 | 1993-04-02 | Novo Nordisk As | Enzym |
| US6051020A (en) * | 1994-02-09 | 2000-04-18 | Boston Scientific Technology, Inc. | Bifurcated endoluminal prosthesis |
| GB9403344D0 (en) * | 1994-02-22 | 1994-04-13 | Cortecs Ltd | Medical application of bromelain |
| DE4408152A1 (de) * | 1994-03-11 | 1995-09-14 | Studiengesellschaft Kohle Mbh | Immobilisierte Lipasen in hydrophoben Sol-Gel-Materialien |
| WO1995030744A2 (en) * | 1994-05-04 | 1995-11-16 | Genencor International Inc. | Lipases with improved surfactant resistance |
| JPH08143469A (ja) * | 1994-11-14 | 1996-06-04 | Amano Pharmaceut Co Ltd | 膵外分泌機能不全症治療剤 |
| JPH08264685A (ja) * | 1995-03-27 | 1996-10-11 | Toshiba Corp | 樹脂封止型半導体装置及びその製造方法 |
| US6051220A (en) * | 1995-05-31 | 2000-04-18 | Medzyme N.V. And Simon Lodewijk Scharpe | Composition to improve digestibility and utilization of nutrients |
| US5932212A (en) * | 1996-05-24 | 1999-08-03 | Altus Biologics, Inc. | Crosslinked protein crystal formulations and their use as catalysts in organic solvents |
| US5750104A (en) * | 1996-05-29 | 1998-05-12 | Digestive Care Inc. | High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith |
| US5843296A (en) * | 1996-12-26 | 1998-12-01 | Digital Matrix | Method for electroforming an optical disk stamper |
| US6140475A (en) * | 1997-04-11 | 2000-10-31 | Altus Biologics Inc. | Controlled dissolution crosslinked protein crystals |
| US6013680A (en) * | 1997-10-21 | 2000-01-11 | Amano Pharmaceutical Co., Ltd. | Digestive enzyme-containing medicament |
| WO1999055310A1 (en) * | 1998-04-27 | 1999-11-04 | Altus Biologics Inc. | Stabilized protein crystals, formulations containing them and methods of making them |
| US6541606B2 (en) * | 1997-12-31 | 2003-04-01 | Altus Biologics Inc. | Stabilized protein crystals formulations containing them and methods of making them |
| US6156552A (en) * | 1998-02-18 | 2000-12-05 | Novo Nordisk A/S | Lipase variants |
| US6042823A (en) * | 1998-07-02 | 2000-03-28 | Amano Pharmaceuticals Co., Ltd. | Enzyme composition and use thereof |
| US20010046493A1 (en) * | 2000-02-24 | 2001-11-29 | Alex Margolin | Lipase-containing composition and methods of use thereof |
| AR032392A1 (es) * | 2001-01-19 | 2003-11-05 | Solvay Pharm Gmbh | Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado. |
| PT1809320E (pt) * | 2004-10-14 | 2010-10-25 | Altus Pharmaceuticals Inc | Composições contendo lipase, protease e amilase para o tratamento de insuficiência pancreática |
-
2001
- 2001-02-22 US US09/791,947 patent/US20010046493A1/en not_active Abandoned
- 2001-02-23 PT PT01922251T patent/PT1261368E/pt unknown
- 2001-02-23 WO PCT/US2001/006074 patent/WO2001062280A2/en not_active Ceased
- 2001-02-23 AT AT01922251T patent/ATE465748T1/de active
- 2001-02-23 ES ES01922251T patent/ES2345032T3/es not_active Expired - Lifetime
- 2001-02-23 JP JP2001561344A patent/JP5217050B2/ja not_active Expired - Fee Related
- 2001-02-23 IL IL15131301A patent/IL151313A0/xx not_active IP Right Cessation
- 2001-02-23 DK DK01922251.2T patent/DK1261368T3/da active
- 2001-02-23 DE DE60141950T patent/DE60141950D1/de not_active Expired - Lifetime
- 2001-02-23 EP EP01922251A patent/EP1261368B1/en not_active Expired - Lifetime
- 2001-02-23 AU AU2001249072A patent/AU2001249072B2/en not_active Ceased
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2002
- 2002-08-20 US US10/225,426 patent/US20030017144A1/en not_active Abandoned
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2005
- 2005-12-06 US US11/295,986 patent/US20060128587A1/en not_active Abandoned
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2009
- 2009-10-06 US US12/573,913 patent/US20100040592A1/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
|---|---|
| US20100040592A1 (en) | 2010-02-18 |
| US20030017144A1 (en) | 2003-01-23 |
| JP2012040028A (ja) | 2012-03-01 |
| US20060128587A1 (en) | 2006-06-15 |
| PT1261368E (pt) | 2010-07-27 |
| WO2001062280A3 (en) | 2002-01-31 |
| IL151313A0 (en) | 2003-04-10 |
| WO2001062280A2 (en) | 2001-08-30 |
| ES2345032T3 (es) | 2010-09-14 |
| JP2003524421A (ja) | 2003-08-19 |
| DK1261368T3 (da) | 2010-08-09 |
| ATE465748T1 (de) | 2010-05-15 |
| AU2001249072B2 (en) | 2004-09-30 |
| EP1261368A2 (en) | 2002-12-04 |
| EP1261368B1 (en) | 2010-04-28 |
| US20010046493A1 (en) | 2001-11-29 |
| DE60141950D1 (de) | 2010-06-10 |
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