JP5216957B2 - 変異原性抑制剤 - Google Patents
変異原性抑制剤 Download PDFInfo
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- JP5216957B2 JP5216957B2 JP2006184916A JP2006184916A JP5216957B2 JP 5216957 B2 JP5216957 B2 JP 5216957B2 JP 2006184916 A JP2006184916 A JP 2006184916A JP 2006184916 A JP2006184916 A JP 2006184916A JP 5216957 B2 JP5216957 B2 JP 5216957B2
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- Prior art keywords
- mutagenicity
- extract
- inhibitor
- agaricus
- present
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Landscapes
- Fodder In General (AREA)
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Description
アガリクス ブラゼイ ムリルの乾燥子実体を約0.7cm角サイズに粗砕したもの300gをステンレス製耐圧釜に仕込み、水(pH8)3Lを添加し、常圧下、90℃で3時間抽出処理した後、減圧濾過して残渣を分離し第1抽出液を採取した。次いで、前記残渣に水(pH8)2.5Lを加えて同様に処理して第2抽出液を採取した。両抽出液を合わせて減圧濃縮及び凍結乾燥処理し、本発明に係るアガリクス茸抽出物(試料1)40.5gを得た。試料1は遊離脂肪酸、グリセリド、レシチン等の脂質類を全く含まないものであった。
製造例1において、常圧下を1.3気圧の加圧下に置き換えて同様に処理して本発明に係るアガリクス茸抽出物(試料2)88.0gを得た。試料2も脂質類を全く含まない。
製造例2で得た試料2の一部50gにエタノール濃度が70%の含水エタノール400mLを加え、常圧下で一旦溶解後30℃にて1時間静置し、生じた沈殿物を遠心分離して除き、含水エタノール可溶分を採取し、減圧濃縮及び乾燥処理して本発明に係るアガリクス抽出物(試料3)17.4gを得た。
ケールの葉部の乾燥物を粉砕機で粗砕したもの(約0.5cm以下のサイズ)100gにイオン交換水3Lを加え、常圧下、80〜90℃で2時間抽出処理し、残渣除去、濃縮及び乾燥処理してケール抽出物(試料4)28.5gを得た。
ブロッコリーの発芽体をミキサー処理して搾汁液1Lを調製し、これにエタノール濃度が40%の含水エタノール3Lを加え、60℃で1時間抽出処理し、以後、製造例4と同様に処理してブロッコリー抽出物(試料5)35.0gを得た。
製造例5において、ダイコンの根部分を用い、40%含水エタノールを70%含水エタノールに置き換えること以外は同様に処理してダイコン抽出物(試料6)20.4gを得た。
アガリクス ブラゼイ ムリルの乾燥子実体を約0.7cm角サイズに粗砕したもの300gをステンレス製耐圧釜に仕込み、ヘキサン3Lを添加し、常温常圧下で1時間抽出処理後、減圧濾過して抽出液と残渣に分離した。抽出液を脱溶媒及び乾燥処理してヘキサン抽出物(比較試料1)を得た。この抽出物の成分は遊離脂肪酸、エルゴステロール等の遊離ステロール及びその配糖体、リン脂質、セラミド等の脂質類がほとんどを占め、遊離脂肪酸はリノール酸が主成分であった。
上記の各製造例で調製した試料の変異原性抑制作用を、復帰突然変異試験法(エイムズ法)を利用して試験評価した。すなわち、前記の各試料を0.1モルリン酸緩衝液(pH7.4)に溶解し、その最終濃度が2.5及び10mg/mLとなるように各溶液を調製し、各0.1mLを試験管に分注した。次いで、これに前記緩衝液又はS9mixを0.5mL、変異原物質をジメチルスルホン酸アミドに溶解した溶液を0.05mL、及びサルモネラ ティフィムリウム(Salmonella typhimurium)TA−100株培養液を0.1mLそれぞれ添加して混合溶液を調製した。ここで、変異原物質はNDMA、MNNG、4−NQO及びTrp−P1を用い、その濃度(単位:nmol/plate)を200,000、5、0.4及び20として試験した。前記混合溶液を37℃にて20分間振とう後、軟寒天液2mLを加え、エイムズ・プレート(1LあたりD−グルコース:20g、寒天:15g、Vogel−Bonner培地:100mL、ヒスチジン:0.62mg及びビオチン:0.98mgを含む)にまき、37℃で48時間インキュベートし、該プレート上に出現した復帰突然変異コロニー数を計測した。試験試料による変異原物質の変異原性抑制率(%)は{1−(変異原物質及び試料添加時の変異数−自然発生変異数)/(変異原物質添加時の変異数−自然発生変異数}×100の計算式から求めた。ここで、自然発生変異数とは試料のみ添加時に発生する変異コロニー数である。この結果を表1に示す。
製造例3に記載の方法で調製したアガリクス茸の熱水抽出物の含水エタノール可溶画分(試料3):170部、ミツロウ:30部及びコーン油;50部を約50℃に加熱混合して均質にした後、カプセル充填機に供して、常法により1粒あたり内容量が300mgのゼラチン被覆ソフトカプセル製剤を試作した。このカプセル製剤は経口摂取できる栄養補助食品又は医薬品として利用できる。
試作例1において、試料3:170部を試料3:100部及び製造例5の方法で調製したブロッコリー発芽物の含水エタノール抽出物(試料5):70部の混合物に置きかえて同様に処理して栄養補助食品を試作した。
試作例1において、試料3:170部を製造例2の方法で調製したアガリクス茸の加圧熱水抽出物(試料2):85部及び製造例4の方法で調製したケール葉の熱水抽出物(試料4):85部の混合物に置きかえて同様に処理して栄養補助食品を試作した。
試料3:100部、試料5:30部、製造例6の方法で調製したダイコン根の含水エタノール抽出物(試料6):30部、化工デンプン(松谷化学工業(株)製、商品名:「パインフロー」):70部、リン酸三カルシウム(米山化学工業(株)製):85部、及びセルロース35部を混合機に仕込み、10分間攪拌混合した。この混合物を直打式打錠機に供して直径7mm、高さ4mm、重量150mg/個の素錠を作成し、ついでコーティング機でシェラック被膜を形成させて錠剤形状の経口摂取用組成物を試作した。
市販のグレープジュース1000部に試料3:10部、試料5:5部を加えて十分に混合し均質なグレープ風味飲料を試作した。これは冷蔵庫で1週間保存しても外観及び風味に異状及び違和感は認められなかった。
Claims (5)
- アガリクス茸の子実体を熱水抽出処理して得た熱水抽出物をさらに70重量%エタノール水溶液を用いて抽出処理して得たエタノール抽出物を有効成分として含有してなることを特徴とする変異原性抑制剤(但し、抗癌用途を除く。)。ここで、変異原はN−ニトロソジメチルアミン、3−アミノ−1,4−ジメチル−5H−ピリド〔4,3−b〕インドール、N−メチル−N’−ニトロ−N−ニトロソグアニジン及び4−ニトロキノリン−1−オキシドからなる群から選択される少なくとも1種である。
- アガリクス茸がアガリクス ブラゼイ ムリル(Agaricus blazei Murill)である請求項1に記載の変異原性抑制剤。
- アブラナ属、ダイコン属、セイヨウワサビ属及びワサビ属からなる群から選択される1種又は2種以上の属に属する植物の乾燥粉末及び/又は抽出物を併用するものである請求項1又は2に記載の変異原性抑制剤。
- アブラナ属に属する植物がアブラナ、キャベツ、ケール,ブロッコリー又はナタネであり、ダイコン属に属する植物がダイコン又はハツカダイコンであり、セイヨウワサビ属に属する植物がホースラディッシュであり、ワサビ属に属する植物がワサビである請求項3に記載の変異原性抑制剤。
- 変異原がN−ニトロソジメチルアミン及び/又は3−アミノ−1,4−ジメチル−5H−ピリド〔4,3−b〕インドールである請求項1〜4のいずれか1項に記載の変異原性抑制剤。
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