JP5198290B2 - 免疫反応を誘発する酵母ベースワクチン - Google Patents

免疫反応を誘発する酵母ベースワクチン Download PDF

Info

Publication number
JP5198290B2
JP5198290B2 JP2008553534A JP2008553534A JP5198290B2 JP 5198290 B2 JP5198290 B2 JP 5198290B2 JP 2008553534 A JP2008553534 A JP 2008553534A JP 2008553534 A JP2008553534 A JP 2008553534A JP 5198290 B2 JP5198290 B2 JP 5198290B2
Authority
JP
Japan
Prior art keywords
yeast
protein
antigen
influenza
vaccine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2008553534A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009528987A (ja
JP2009528987A5 (forum.php
Inventor
デューク,リチャード,シー.
フランツソッフ,アレックス
ハラー,オーレリア
キング,トーマス,エイチ.
ル,インニエン
ハドソン,ビクトリア,ケリー
Original Assignee
グローブイミューン,インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by グローブイミューン,インコーポレイテッド filed Critical グローブイミューン,インコーポレイテッド
Publication of JP2009528987A publication Critical patent/JP2009528987A/ja
Publication of JP2009528987A5 publication Critical patent/JP2009528987A5/ja
Application granted granted Critical
Publication of JP5198290B2 publication Critical patent/JP5198290B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/145Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/21Retroviridae, e.g. equine infectious anemia virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541Mucosal route
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541Mucosal route
    • A61K2039/543Mucosal route intranasal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55588Adjuvants of undefined constitution
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16111Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16311Influenzavirus C, i.e. influenza C virus
    • C12N2760/16334Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
JP2008553534A 2006-02-02 2007-02-02 免疫反応を誘発する酵母ベースワクチン Expired - Fee Related JP5198290B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US76502506P 2006-02-02 2006-02-02
US60/765,025 2006-02-02
PCT/US2007/061572 WO2007092792A2 (en) 2006-02-02 2007-02-02 Yeast-based vaccine for inducing an immune response

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012260860A Division JP2013075899A (ja) 2006-02-02 2012-11-29 治療用組成物

Publications (3)

Publication Number Publication Date
JP2009528987A JP2009528987A (ja) 2009-08-13
JP2009528987A5 JP2009528987A5 (forum.php) 2010-04-02
JP5198290B2 true JP5198290B2 (ja) 2013-05-15

Family

ID=38345897

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2008553534A Expired - Fee Related JP5198290B2 (ja) 2006-02-02 2007-02-02 免疫反応を誘発する酵母ベースワクチン
JP2012260860A Pending JP2013075899A (ja) 2006-02-02 2012-11-29 治療用組成物
JP2014230982A Withdrawn JP2015038147A (ja) 2006-02-02 2014-11-13 免疫反応を誘発する酵母ベースワクチン

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2012260860A Pending JP2013075899A (ja) 2006-02-02 2012-11-29 治療用組成物
JP2014230982A Withdrawn JP2015038147A (ja) 2006-02-02 2014-11-13 免疫反応を誘発する酵母ベースワクチン

Country Status (14)

Country Link
US (2) US7736642B2 (forum.php)
EP (2) EP1988919A4 (forum.php)
JP (3) JP5198290B2 (forum.php)
KR (2) KR101492524B1 (forum.php)
CN (2) CN104826102A (forum.php)
AU (1) AU2007212076B2 (forum.php)
BR (1) BRPI0706913A2 (forum.php)
CA (1) CA2638815A1 (forum.php)
IL (2) IL193196A (forum.php)
IN (1) IN2014DN08830A (forum.php)
MX (1) MX2008009929A (forum.php)
SG (2) SG10201402236VA (forum.php)
TW (2) TW201412329A (forum.php)
WO (1) WO2007092792A2 (forum.php)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002039951A2 (en) * 2000-11-15 2002-05-23 Globe Immune, Inc. Yeast-dentritic cell vaccines and uses thereof
DK1581174T3 (en) * 2002-12-16 2018-06-18 Globeimmune Inc Yeast-based vaccines such as immunotherapy
US8343502B2 (en) * 2002-12-16 2013-01-01 Globeimmune, Inc. Yeast-based vaccines as immunotherapy
EP2371381A3 (en) * 2005-07-11 2012-07-18 Globeimmune, Inc. Compositions and methods for eliciting an immune response to escape mutants of targeted therapies
US20070172503A1 (en) 2005-12-13 2007-07-26 Mycologics,Inc. Compositions and Methods to Elicit Immune Responses Against Pathogenic Organisms Using Yeast Based Vaccines
EP1988919A4 (en) * 2006-02-02 2009-06-10 Globeimmune Inc VAKZINE ON YEAST BASE FOR TRIGGERING AN IMMUNE RESPONSE
GB0613977D0 (en) 2006-02-07 2006-08-23 Peptcell Ltd Peptide sequences and compositions
WO2007130330A2 (en) * 2006-05-01 2007-11-15 Technovax, Inc. Polyvalent influenza virus-like particle (vlp) compositions
WO2008054535A2 (en) * 2006-05-11 2008-05-08 Novavax, Inc. Novel influenza m2 vaccines
DK2023952T3 (en) * 2006-05-18 2015-10-19 Epimmune Inc Induction of immune responses to influenza virus using polypeptide and nucleic acid compositions
US9066893B2 (en) 2007-02-02 2015-06-30 GlobelImmune, Inc. Yeast-based vaccines
CN101730542A (zh) * 2007-03-19 2010-06-09 环球免疫公司 用于靶向消除癌症靶向疗法的突变逃逸的组合物和方法
GB0719526D0 (en) * 2007-10-05 2007-11-14 Isis Innovation Compositions and methods
US20100285050A1 (en) 2007-10-05 2010-11-11 Isis Innovation Limited Compositions and Methods
US20110177122A1 (en) * 2008-09-26 2011-07-21 The United States Of America, As Represented By The Secretary, Dept. Of Health & Human Services Dna prime/activated vaccine boost immunization to influenza virus
US10383924B2 (en) 2009-04-17 2019-08-20 Globeimmune, Inc. Combination immunotherapy compositions against cancer and methods
US20120141525A1 (en) * 2009-05-18 2012-06-07 Panacea Biotec Limited Universal influenza vaccine based on recombinant modified vaccine ankara virus (mva)
JP5913103B2 (ja) 2009-09-14 2016-04-27 ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド,ア ボディー コーポレイトTHE REGENTS OF THE UNIVERSITY OF COLORADO,a body corporate 酵母ベースの免疫療法組成物を含む組合せ物及び被験者のスクリーニング方法
US20120015346A1 (en) * 2010-07-08 2012-01-19 New York Medical College Influenza virus detection and diagnosis
CN103328002B (zh) * 2010-10-04 2020-01-14 麻省理工学院 血球凝集素多肽以及与其相关的试剂和方法
AU2011316164B2 (en) * 2010-10-15 2016-01-14 Bavarian Nordic A/S Recombinant modified vaccinia virus Ankara (MVA) influenza vaccine
ES2696551T3 (es) * 2010-12-17 2019-01-16 Globeimmune Inc Composiciones y métodos para el tratamiento o la prevención de la infección por adenovirus-36 humano
WO2012106231A2 (en) * 2011-01-31 2012-08-09 Baxter International Inc. Recombinant viral vectors and methods for inducing a heterosubtypic immune response to influenza a viruses
MA34956B1 (fr) 2011-02-12 2014-03-01 Globeimmune Inc Therapeutique a base de levure pour infection chronique par l'hepatite b
AU2012228937B2 (en) * 2011-03-17 2016-11-03 Globeimmune, Inc. Yeast-Brachyury immunotherapeutic compositions
WO2012162342A2 (en) * 2011-05-23 2012-11-29 The Wistar Institute Of Anatomy And Biology Influenza vaccines containing modified adenovirus vectors
BR112013032381B1 (pt) * 2011-06-14 2021-01-12 Globeimmune, Inc. composições à base de levedura e métodos para o tratamento ou prevenção de infecção pelo vírus da hepatite delta
CN103732749B (zh) * 2011-06-20 2017-03-29 高等教育联邦系统-匹兹堡大学 计算优化的宽反应性的h1n1流感抗原
CA2844500C (en) 2011-08-17 2022-05-10 Globeimmune, Inc. Yeast-muc1 immunotherapeutic compositions and uses thereof
PL2591798T3 (pl) * 2011-11-09 2015-04-30 Werner Lubitz Szczepionka do zastosowania w immunoterapii nowotworów
DE102011121069A1 (de) 2011-12-13 2013-06-13 Martin-Luther-Universität Halle-Wittenberg Vakzinierung mittels rekombinanter Hefe durch Erzeugung einer protektiven humoralen Immunantwort gegen definierte Antigene
CA2878044C (en) 2012-06-26 2021-10-26 Biodesix, Inc. Mass-spectral method for selection, and de-selection, of cancer patients for treatment with immune response generating therapies
US20140065173A1 (en) 2012-09-06 2014-03-06 Orbis Health Solutions Llc Tumor lysate loaded particles
JP5954079B2 (ja) 2012-09-25 2016-07-20 ソニー株式会社 培養観察装置及び培養観察方法
WO2014093357A1 (en) * 2012-12-10 2014-06-19 The University Of Queensland Cell-free biofragment compositions and related systems, devices, and methods
CN105209063A (zh) * 2013-03-15 2015-12-30 宾夕法尼亚大学理事会 具有抗原和作为佐剂的白细胞介素-23的疫苗
BR112015023968A2 (pt) 2013-03-19 2017-08-22 Globeimmune Inc Uso de um veículo de levedura e um antígeno do câncer compreendendo pelo menos um antígeno de brachyury na preparação de uma composição imunoterapêutica para tratar ou prevenir cordoma, bem como composição assim preparada
TWI626948B (zh) 2013-03-26 2018-06-21 環球免疫公司 治療或預防人類免疫缺乏病毒感染之組合物及方法
JP2014210747A (ja) * 2013-04-19 2014-11-13 アンジェスMg株式会社 細胞性免疫誘導能が改善された経口ワクチン
WO2015031778A2 (en) * 2013-08-30 2015-03-05 Globeimmune, Inc. Compositions and methods for the treatment or prevention of tuberculosis
KR20250061774A (ko) * 2014-01-06 2025-05-08 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Pd1 및 pdl1 항체 및 백신 조합 및 면역요법을 위한 이들의 사용
AU2015227226B2 (en) 2014-03-05 2017-10-05 Orbis Health Solutions Llc Vaccine delivery systems using yeast cell wall particles
CA2948803A1 (en) 2014-04-11 2015-10-15 Globeimmune, Inc. Yeast-based immunotherapy and type i interferon sensitivity
CN105233302B (zh) * 2014-07-10 2018-10-19 中国人民解放军军事医学科学院生物工程研究所 一种流感血凝素糖蛋白多聚物纳米颗粒的制备方法
US10695417B2 (en) 2015-01-09 2020-06-30 Etubics Corporation Human adenovirus serotype 5 vectors containing E1 and E2B deletions encoding the ebola virus glycoprotein
WO2016168187A1 (en) * 2015-04-13 2016-10-20 The Regents Of The University Of Michigan Virus-like particles
TWI748957B (zh) 2015-08-03 2021-12-11 美商環球免疫公司 經修飾之酵母-短尾畸型(Brachyury)免疫治療組合物
WO2017027568A1 (en) * 2015-08-11 2017-02-16 Orbis Health Solutions Llc Bacterial and viral vaccine strategy
GB2552441A (en) * 2015-10-22 2018-01-31 Royal Veterinary College Methods
EP3195878A1 (en) 2016-01-22 2017-07-26 Werner Lubitz Bacterial ghosts for the treatment of cancer
MX2018011491A (es) 2016-03-24 2019-08-01 Nantcell Inc Disposiciones de secuencia y secuencias para presentacion de neoepitopos.
IL270132B2 (en) 2017-04-24 2024-12-01 Nantcell Inc Neoepitope vectors and methods for them
WO2019124557A1 (ja) 2017-12-21 2019-06-27 株式会社グリーンバイオメッド 交差免疫抗原ワクチン及びその調製方法
DE102017012109A1 (de) 2017-12-27 2019-06-27 Martin-Luther-Universität Halle-Wittenberg Optimiertes Wirts-/Vektorsystem zur Erzeugung protektiver mono- und multivalenter subunit-Vakzine auf Basis der Hefe Kluyveromyces lactis
US12128078B2 (en) 2018-05-15 2024-10-29 Globeimmune, Inc. Lysates of recombinant yeast for inducing cellular immune responses
US12239699B2 (en) * 2018-09-11 2025-03-04 Shanghai Public Health Clinical Center Immunogen for broad-spectrum influenza vaccine and application thereof
WO2020061203A1 (en) 2018-09-21 2020-03-26 Nantcell, Inc. Methods and compositions for modulating myeloid-derived suppressor cells
BR112021023348A2 (pt) * 2019-05-21 2022-02-01 Esperovax Inc Vacinação oral à base de levedura
AU2021220188A1 (en) * 2020-02-11 2022-09-08 Cytonus Therapeutics, Inc. Rapid vaccine platform
US20210284716A1 (en) 2020-03-11 2021-09-16 Immunitybio, Inc. ACE2-Fc Trap
US12285480B2 (en) 2020-03-11 2025-04-29 Nantcell, Inc. Method of inducing immunity against SARS-CoV-2 using spike and nucleocapsid-ETSD immunogens delivered by RNA and replication-defective adenoviruses
US11857620B2 (en) 2020-03-11 2024-01-02 Immunitybio, Inc. Method of inducing immunity against SARS-CoV-2 using spike (s) and nucleocapsid (N)-ETSD immunogens delivered by a replication-defective adenovirus
CA3170359A1 (en) 2020-04-14 2021-10-21 Nantcell, Inc. Yeast lysate covid-19 vaccine

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5413914A (en) 1993-07-07 1995-05-09 The Regents Of The University Of Colorado Yeast assay to identify inhibitors of dibasic amino acid processing endoproteases
US5830463A (en) * 1993-07-07 1998-11-03 University Technology Corporation Yeast-based delivery vehicles
PT733113E (pt) 1994-01-11 2007-08-10 Vlaams Interuniv Inst Biotech Vacina contra a gripe
US5691189A (en) * 1994-01-19 1997-11-25 Bristol-Myers Squibb Company Saccharomyces cerevisiae expressing M2 protein of influenza A virus
US6696251B1 (en) * 1996-05-31 2004-02-24 Board Of Trustees Of The University Of Illinois Yeast cell surface display of proteins and uses thereof
US20020044948A1 (en) * 2000-03-15 2002-04-18 Samir Khleif Methods and compositions for co-stimulation of immunological responses to peptide antigens
JP5008244B2 (ja) * 2000-06-23 2012-08-22 ワイス・ホールディングズ・コーポレイション 野性型およびキメラのインフルエンザウイルス様粒子(vlp)のアセンブリー
WO2002039951A2 (en) * 2000-11-15 2002-05-23 Globe Immune, Inc. Yeast-dentritic cell vaccines and uses thereof
US20030008000A1 (en) * 2001-03-08 2003-01-09 Wong Jonathan P. DNA vaccine using liposome-encapsulated plasmid DNA encoding for hemagglutinin protein of influenza virus
US20030202982A1 (en) * 2001-08-15 2003-10-30 Birkett Ashley J. Influenza immunogen and vaccine
DK1581174T3 (en) 2002-12-16 2018-06-18 Globeimmune Inc Yeast-based vaccines such as immunotherapy
US7439042B2 (en) 2002-12-16 2008-10-21 Globeimmune, Inc. Yeast-based therapeutic for chronic hepatitis C infection
US8592197B2 (en) * 2003-07-11 2013-11-26 Novavax, Inc. Functional influenza virus-like particles (VLPs)
EP1766094A4 (en) * 2004-05-18 2009-11-25 Vical Inc INFLUENZA VIRUS VACCINE COMPOSITION AND METHODS OF USE
US8007814B2 (en) 2004-06-16 2011-08-30 University Of Massachusetts Therapy for lysosomal enzyme deficiencies
EP1988919A4 (en) * 2006-02-02 2009-06-10 Globeimmune Inc VAKZINE ON YEAST BASE FOR TRIGGERING AN IMMUNE RESPONSE

Also Published As

Publication number Publication date
IL232518A0 (en) 2014-06-30
IL193196A (en) 2015-01-29
IL193196A0 (en) 2011-08-01
US20100196411A1 (en) 2010-08-05
JP2009528987A (ja) 2009-08-13
EP2468296A2 (en) 2012-06-27
EP2468296A3 (en) 2013-12-04
EP1988919A2 (en) 2008-11-12
CN104826102A (zh) 2015-08-12
SG10201402236VA (en) 2014-08-28
EP1988919A4 (en) 2009-06-10
MX2008009929A (es) 2008-10-01
US20080003239A1 (en) 2008-01-03
WO2007092792A3 (en) 2008-02-28
US7736642B2 (en) 2010-06-15
AU2007212076B2 (en) 2012-10-18
CN101405026B (zh) 2015-04-22
JP2015038147A (ja) 2015-02-26
KR101492524B1 (ko) 2015-02-12
CA2638815A1 (en) 2007-08-16
TW200806316A (en) 2008-02-01
BRPI0706913A2 (pt) 2011-04-12
KR20140029551A (ko) 2014-03-10
IN2014DN08830A (forum.php) 2015-07-10
AU2007212076A1 (en) 2007-08-16
CN101405026A (zh) 2009-04-08
WO2007092792A2 (en) 2007-08-16
JP2013075899A (ja) 2013-04-25
SG169375A1 (en) 2011-03-30
TW201412329A (zh) 2014-04-01
KR20080089671A (ko) 2008-10-07

Similar Documents

Publication Publication Date Title
JP5198290B2 (ja) 免疫反応を誘発する酵母ベースワクチン
US10849971B2 (en) Compositions and methods for the treatment or prevention of human immunodeficiency virus infection
CN103476426B (zh) 用于慢性乙型肝炎病毒感染的基于酵母的治疗剂
EP2720716B1 (en) Immunotherapeutic compositions for the treatment or prevention of hepatitis delta virus infection
JP2012034700A (ja) 酵母を用いた慢性c型肝炎感染の治療用ワクチンおよびその使用方法
JP2012503011A (ja) 慢性c型肝炎ウイルス感染の免疫療法
CA3170359A1 (en) Yeast lysate covid-19 vaccine
HK1172556A (en) Yeast-based vaccine for inducing an immune response
AU2013200249A1 (en) Yeast-based vaccine for inducing an immune response
US20250009825A1 (en) Lysates of recombinant yeast for inducing cellular immune responses

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100201

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20100201

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20110114

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20110225

RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20110613

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20110628

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20120106

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120529

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120822

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120829

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20121129

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20130108

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20130206

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20160215

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees