JP5192392B2 - コレステリルエステル転送タンパク質阻害剤 - Google Patents

コレステリルエステル転送タンパク質阻害剤 Download PDF

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Publication number
JP5192392B2
JP5192392B2 JP2008548751A JP2008548751A JP5192392B2 JP 5192392 B2 JP5192392 B2 JP 5192392B2 JP 2008548751 A JP2008548751 A JP 2008548751A JP 2008548751 A JP2008548751 A JP 2008548751A JP 5192392 B2 JP5192392 B2 JP 5192392B2
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JP
Japan
Prior art keywords
alkyl
optionally
substituted
phenyl
halogens
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Expired - Fee Related
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JP2008548751A
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English (en)
Japanese (ja)
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JP2009522292A (ja
JP2009522292A5 (https=
Inventor
アリ，アムジヤド
シンクレア，ピーター・ジエイ
テイラー，ゲイル・イー
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Merck and Co Inc
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Merck and Co Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • C07D265/08—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D265/10—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2008548751A 2005-12-30 2006-12-29 コレステリルエステル転送タンパク質阻害剤 Expired - Fee Related JP5192392B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75520105P 2005-12-30 2005-12-30
US60/755,201 2005-12-30
PCT/US2006/049504 WO2007081570A2 (en) 2005-12-30 2006-12-29 Cholesteryl ester transfer protein inhibitors

Publications (3)

Publication Number Publication Date
JP2009522292A JP2009522292A (ja) 2009-06-11
JP2009522292A5 JP2009522292A5 (https=) 2010-02-12
JP5192392B2 true JP5192392B2 (ja) 2013-05-08

Family

ID=38256810

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008548751A Expired - Fee Related JP5192392B2 (ja) 2005-12-30 2006-12-29 コレステリルエステル転送タンパク質阻害剤

Country Status (6)

Country Link
US (1) US8865707B2 (https=)
EP (1) EP1973546B1 (https=)
JP (1) JP5192392B2 (https=)
AU (1) AU2006335109B2 (https=)
CA (1) CA2635087A1 (https=)
WO (1) WO2007081570A2 (https=)

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AR069207A1 (es) * 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
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CA2708303A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
TW200934490A (en) * 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
WO2009094169A1 (en) * 2008-01-24 2009-07-30 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5734666B2 (ja) * 2008-02-11 2015-06-17 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の１，３−オキサアゼパン−２−オン及び１，３−ジアゼパン−２−オン阻害剤
EP2257536A4 (en) 2008-02-14 2011-03-23 Amira Pharmaceuticals Inc CYCLIC DIARYL ETHERS AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS
US8598160B2 (en) * 2008-02-15 2013-12-03 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
JP2011513242A (ja) 2008-02-25 2011-04-28 アミラ ファーマシューティカルズ，インク． プロスタグランジンｄ２受容体アンタゴニスト
JP5538356B2 (ja) * 2008-03-18 2014-07-02 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤
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US8765780B2 (en) 2008-05-13 2014-07-01 Boehringer Ingelheim International Gmbh Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
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US8846668B2 (en) 2008-07-25 2014-09-30 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
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UA109255C2 (ru) 2009-04-30 2015-08-10 Берінгер Інгельхайм Інтернешнл Гмбх Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1
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TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
PL2697207T3 (pl) * 2011-04-12 2017-08-31 Chong Kun Dang Pharmaceutical Corp. Pochodne 3-(2-arylocykloalkenylometylo)oksazolidyn-2-onu jako inhibitory białka transportującego estry cholesterolu (cetp)
CN103570499B (zh) * 2011-08-02 2016-04-13 浙江永太科技股份有限公司 一种2-卤代-5-三氟甲基苄醇化合物的制备方法
CN102372605B (zh) * 2011-08-02 2014-03-05 浙江永太科技股份有限公司 一种2-卤代-5-三氟甲基苄醇化合物的制备方法
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Also Published As

Publication number Publication date
EP1973546B1 (en) 2012-06-13
WO2007081570A2 (en) 2007-07-19
CA2635087A1 (en) 2007-07-19
US20090018054A1 (en) 2009-01-15
EP1973546A4 (en) 2010-12-01
US8865707B2 (en) 2014-10-21
WO2007081570A3 (en) 2008-08-28
AU2006335109A1 (en) 2007-07-19
JP2009522292A (ja) 2009-06-11
AU2006335109B2 (en) 2011-04-07
EP1973546A2 (en) 2008-10-01

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