JP5189977B2 - Ｌｉｆおよびｂｍｐによる腫瘍性幹細胞の潜在的腫瘍形成能力の抑制 - Google Patents

Ｌｉｆおよびｂｍｐによる腫瘍性幹細胞の潜在的腫瘍形成能力の抑制 Download PDF

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JP5189977B2
JP5189977B2 JP2008522091A JP2008522091A JP5189977B2 JP 5189977 B2 JP5189977 B2 JP 5189977B2 JP 2008522091 A JP2008522091 A JP 2008522091A JP 2008522091 A JP2008522091 A JP 2008522091A JP 5189977 B2 JP5189977 B2 JP 5189977B2
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bmp
cells
preparation
tumor
cell
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JP2009502771A (ja
JP2009502771A5 (enExample
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ルイージ ベスコビ、アンジェロ
アラン レイノルズ、ブレント
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STEMGEN SpA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2093—Leukaemia inhibitory factor [LIF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2008522091A 2005-07-19 2006-07-19 Ｌｉｆおよびｂｍｐによる腫瘍性幹細胞の潜在的腫瘍形成能力の抑制 Expired - Lifetime JP5189977B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70085905P 2005-07-19 2005-07-19
US60/700,859 2005-07-19
PCT/IB2006/002296 WO2007010394A2 (en) 2005-07-19 2006-07-19 Inhibition of the tumorigenic potential of tumor stem cells by lif and bmps

Related Child Applications (1)

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JP2012044260A Division JP5891068B2 (ja) 2005-07-19 2012-02-29 Ｌｉｆおよびｂｍｐによる腫瘍性幹細胞の潜在的腫瘍形成能力の抑制

Publications (3)

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JP2009502771A JP2009502771A (ja) 2009-01-29
JP2009502771A5 JP2009502771A5 (enExample) 2012-04-19
JP5189977B2 true JP5189977B2 (ja) 2013-04-24

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JP2008522091A Expired - Lifetime JP5189977B2 (ja) 2005-07-19 2006-07-19 Ｌｉｆおよびｂｍｐによる腫瘍性幹細胞の潜在的腫瘍形成能力の抑制
JP2012044260A Expired - Lifetime JP5891068B2 (ja) 2005-07-19 2012-02-29 Ｌｉｆおよびｂｍｐによる腫瘍性幹細胞の潜在的腫瘍形成能力の抑制
JP2014262190A Withdrawn JP2015057452A (ja) 2005-07-19 2014-12-25 Ｌｉｆおよびｂｍｐによる腫瘍性幹細胞の潜在的腫瘍形成能力の抑制

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JP2012044260A Expired - Lifetime JP5891068B2 (ja) 2005-07-19 2012-02-29 Ｌｉｆおよびｂｍｐによる腫瘍性幹細胞の潜在的腫瘍形成能力の抑制
JP2014262190A Withdrawn JP2015057452A (ja) 2005-07-19 2014-12-25 Ｌｉｆおよびｂｍｐによる腫瘍性幹細胞の潜在的腫瘍形成能力の抑制

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US (2) US9220756B2 (enExample)
EP (2) EP3117833B1 (enExample)
JP (3) JP5189977B2 (enExample)
KR (2) KR101311061B1 (enExample)
AU (1) AU2006271308B2 (enExample)
CA (2) CA2615491C (enExample)
DK (2) DK3117833T3 (enExample)
ES (2) ES2686093T3 (enExample)
HR (1) HRP20181379T1 (enExample)
HU (2) HUE042197T2 (enExample)
NZ (2) NZ565172A (enExample)
PL (2) PL3117833T3 (enExample)
WO (1) WO2007010394A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012107063A (ja) * 2005-07-19 2012-06-07 Stemgen Spa Ｌｉｆおよびｂｍｐによる腫瘍性幹細胞の潜在的腫瘍形成能力の抑制

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US8361955B2 (en) 2008-02-13 2013-01-29 Dkfz Deutsches Krebsforschungszentrum, Stiftung Des Offentlichen Rechts Methods for treating and preventing brain tumors based on bone morphogenetic proteins
CA2995310A1 (en) 2015-08-25 2017-03-02 Histide Ag Compounds for inducing tissue formation and uses thereof
EP3349778B1 (en) * 2015-09-17 2021-09-01 Histide AG Pharmaceutical association of growth factor receptor agonist and adhesion protein inhibitor for converting a neoplastic cell into a non-neoplastic cell and uses thereof
KR20180050744A (ko) * 2015-09-17 2018-05-23 히스티드 아게 신생물성 세포를 비-신생물성 세포로 전환시키기 위한 약제학적 회합물 및 이것의 용도
KR20180052705A (ko) * 2015-09-17 2018-05-18 히스티드 아게 신생물성 세포를 비-신생물성 세포로 전환시키기 위한 약제학적 회합물 및 이것의 용도
WO2017046226A2 (en) * 2015-09-17 2017-03-23 Histide Ag Pharmaceutical association for converting a neoplastic cell into a non-neoplastic cell and uses thereof.
CA2998677A1 (en) * 2015-09-17 2017-03-23 Histide Ag Pharmaceutical association for converting a neoplastic cell into a non-neoplastic cell and uses thereof
WO2020138503A1 (ja) * 2018-12-28 2020-07-02 国立大学法人 東京大学 神経膠腫の治療および予防剤、脳腫瘍の悪性度のマーカーおよび脳腫瘍の予後マーカー、脳腫瘍の悪性度および予後の判定方法並びに腫瘍増殖を抑制する抗体
WO2026022122A1 (en) * 2024-07-23 2026-01-29 Eos Research Sa Checkpoint inhibitors in the treatment of glioblastoma multiforme

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012107063A (ja) * 2005-07-19 2012-06-07 Stemgen Spa Ｌｉｆおよびｂｍｐによる腫瘍性幹細胞の潜在的腫瘍形成能力の抑制

Also Published As

Publication number Publication date
EP1904093B1 (en) 2018-06-13
US9737589B2 (en) 2017-08-22
KR101311061B1 (ko) 2013-09-25
CA2615491A1 (en) 2007-01-25
HRP20181379T1 (hr) 2018-11-16
EP3117833B1 (en) 2019-01-23
CA2615491C (en) 2016-11-29
EP3117833A1 (en) 2017-01-18
KR20120125990A (ko) 2012-11-19
JP2012107063A (ja) 2012-06-07
ES2686093T3 (es) 2018-10-16
US20100167999A1 (en) 2010-07-01
KR101338533B1 (ko) 2013-12-12
JP2015057452A (ja) 2015-03-26
JP2009502771A (ja) 2009-01-29
NZ565172A (en) 2012-12-21
WO2007010394A3 (en) 2007-08-30
PL1904093T3 (pl) 2018-12-31
AU2006271308B2 (en) 2012-12-20
EP1904093A2 (en) 2008-04-02
KR20080082595A (ko) 2008-09-11
AU2006271308A1 (en) 2007-01-25
ES2710601T3 (es) 2019-04-26
WO2007010394A2 (en) 2007-01-25
HUE040063T2 (hu) 2019-02-28
CA2790675A1 (en) 2007-01-25
DK1904093T3 (en) 2018-09-03
DK3117833T3 (en) 2019-03-18
JP5891068B2 (ja) 2016-03-22
CA2790675C (en) 2016-12-20
US9220756B2 (en) 2015-12-29
NZ598031A (en) 2013-11-29
US20160228511A1 (en) 2016-08-11
PL3117833T3 (pl) 2019-06-28
HUE042197T2 (hu) 2019-06-28

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