JP5185826B2 - ウイルス性肝炎の処置 - Google Patents
ウイルス性肝炎の処置 Download PDFInfo
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- JP5185826B2 JP5185826B2 JP2008549616A JP2008549616A JP5185826B2 JP 5185826 B2 JP5185826 B2 JP 5185826B2 JP 2008549616 A JP2008549616 A JP 2008549616A JP 2008549616 A JP2008549616 A JP 2008549616A JP 5185826 B2 JP5185826 B2 JP 5185826B2
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- interferon
- patient
- nitazoxanide
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- treatment
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Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicinal Preparation (AREA)
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| PCT/US2007/000574 WO2007081974A2 (en) | 2006-01-09 | 2007-01-09 | Viral hepatitis treatment |
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| JP (2) | JP5185826B2 (https=) |
| CN (1) | CN101448497B (https=) |
| AP (1) | AP2907A (https=) |
| AU (1) | AU2007204963B2 (https=) |
| BR (1) | BRPI0706379A2 (https=) |
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| AU2006235490A1 (en) * | 2005-04-12 | 2006-10-19 | Romark Laboratories, L.C. | Methods for treating diseases through the function of molecular chaperones such as protein disulfide isomerases, pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents |
| CA2636527C (en) | 2006-01-09 | 2016-05-17 | Romark Laboratories, L.C. | Viral hepatitis treatment |
| WO2009015336A2 (en) * | 2007-07-25 | 2009-01-29 | Biolex Therapeutics, Inc. | Controlled release interferon drug products and treatment of hcv infection using same |
| SI2395840T1 (sl) * | 2009-02-13 | 2020-08-31 | Romark Laboratories, L.C. | Farmacevtske formulacije nitazoksanida z nadzorovanim sproščanjem |
| EP2408770B1 (en) | 2009-03-20 | 2014-11-05 | University Of Virginia Patent Foundation | Broad spectrum benzothiophene-nitrothiazolide and other antimicrobials |
| NZ596538A (en) | 2009-05-12 | 2014-04-30 | Romark Lab Lc | Haloalkyl heteroaryl benzamide compounds |
| CN108042535A (zh) | 2009-06-26 | 2018-05-18 | 罗马克实验室有限公司 | 用于治疗流感的化合物和方法 |
| US9333193B2 (en) | 2010-09-20 | 2016-05-10 | University Of Virginia Patent Foundation | Compositions and methods for treating tuberculosis |
| CN107096032A (zh) | 2011-05-16 | 2017-08-29 | 罗马克实验室有限公司 | 在有需要的对象中刺激免疫应答的方法 |
| CN102805747B (zh) * | 2011-06-01 | 2013-09-18 | 漳州片仔癀药业股份有限公司 | 2-(4-吗啉苯胺)-6-环己基氨基嘌呤及其药学上可接受的盐在制药中的用途 |
| EP2583677A3 (en) | 2011-10-21 | 2013-07-03 | Abbvie Inc. | Methods for treating HCV comprising at least two direct acting antiviral agent, ribavirin but not interferon. |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| DE202012012955U1 (de) | 2011-10-21 | 2014-07-14 | Abbvie Inc. | Eine Kombination aus mindestens zwei direkt wirkenden antiviralen Wirkstoffen (DAAs) für die Verwendung zur Behandlung von HCV |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| WO2013110975A1 (es) | 2012-01-27 | 2013-08-01 | Siegfried Rhein S.A. De C.V. | Composición de nitazoxanida mejorada y proceso para prepararla |
| MX2017006083A (es) | 2014-11-11 | 2017-11-08 | Romark Laboratories Lc | Composicones y metodos de tratamiento con profarmacos de tizoxanida, un analogo o sal de la misma. |
| WO2016123073A1 (en) | 2015-01-26 | 2016-08-04 | Children's Medical Center Corporation | Treatment of infectious diseases |
| PT3436074T (pt) | 2016-03-31 | 2020-08-21 | Romark Laboratories Lc | Compostos tiazolida para tratamento de infeções virais |
| JP2019513762A (ja) * | 2016-04-11 | 2019-05-30 | ジェンフィＧｅｎｆｉｔ | 胆汁うっ滞及び線維症の処置方法 |
| JP6894923B2 (ja) * | 2016-04-11 | 2021-06-30 | ジェンフィＧｅｎｆｉｔ | 胆汁うっ滞性及び線維性の疾患の処置方法 |
| EA201892448A1 (ru) | 2016-04-28 | 2019-06-28 | Эмори Юниверсити | Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения |
| WO2018140504A1 (en) | 2017-01-24 | 2018-08-02 | Patel Manoj K | Compositions and methods for blocking sodium channels |
| US11033534B2 (en) * | 2017-01-27 | 2021-06-15 | Genfit | Pharmaceutical compositions for combination therapy |
| WO2018167103A1 (en) * | 2017-03-13 | 2018-09-20 | Genfit | Pharmaceutical compositions for combination therapy |
| WO2018195035A1 (en) | 2017-04-18 | 2018-10-25 | Romark Laboratories L.C. | Inhibition of protein disulfide-isomerase a3 |
| JP7365054B2 (ja) * | 2017-11-17 | 2023-10-19 | ケスター，ヒューバート | リンパ管平滑筋腫症及びその他の疾患に使用するための［２－［（５－ニトロ－１，３－チアゾール－２－イル）カルバモイル］フェニル］エタノエート |
| CN109364067B (zh) * | 2018-11-17 | 2020-07-28 | 王海玲 | 一种化合物在制备提高血脑屏障通透性药物中的用途 |
| CA3130713A1 (en) | 2019-04-09 | 2020-10-15 | Peggy Parroche | Combination of nitazoxanide and elafibranor for the treatment of immune diseases or inflammation |
| WO2021016543A1 (en) * | 2019-07-25 | 2021-01-28 | Romark Laboratories L.C. | Antiviral combinations of thiazolide compounds |
| CN111012788B (zh) * | 2019-12-12 | 2021-01-15 | 武汉职业技术学院 | 硝唑尼特和替唑尼特在制备抗猪繁殖与呼吸综合征病毒药物中的应用 |
| US20230303504A1 (en) | 2020-07-20 | 2023-09-28 | Romark Laboratories, L.C. | Crystalline salts of tizoxanide and 2-hydroxy-n-(5-chloro-1,3-thiazol-2-yl)benzamide (rm-4848) with ethanolamine, morpholine, propanolamine, piperazine and n-methylpiperazine |
| MX2023002208A (es) | 2020-08-24 | 2023-05-17 | Romark Laboratories Lc | Uso de tiazolidas contra los coronavirus. |
| CN114259492A (zh) * | 2021-12-21 | 2022-04-01 | 中以海德人工智能药物研发股份有限公司 | 硝唑尼特在治疗乙肝中的应用 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1437800A (en) * | 1973-08-08 | 1976-06-03 | Phavic Sprl | Derivatives of 2-benzamido-5-nitro-thiazoles |
| GB1440212A (en) * | 1973-08-29 | 1976-06-23 | Phavic Sprl | Derivatives of 2-phenoxyacetamido-5-nitrothiazoles |
| US4315018A (en) * | 1978-12-07 | 1982-02-09 | Rossignol Jean F | Specific parasiticidal use of 2-benzamido-5-nitro-thiazole derivatives |
| US5387598A (en) * | 1994-04-13 | 1995-02-07 | Rossignol; Jean-Francois | Composition and galenic formulation suitable for combatting affections of the lower abdomen |
| US5578621A (en) * | 1994-09-08 | 1996-11-26 | Romark Lab Lc | Benzamide derivatives |
| PL186504B1 (pl) | 1994-04-13 | 2004-01-30 | Romark Lab | Pochodne benzamidowe i kompozycje farmaceutyczne zawierające te pochodne |
| US5859038A (en) * | 1994-09-08 | 1999-01-12 | Romark Laboratories, L.C. | Method for treatment of helicobacter pylori infections |
| MX9604483A (es) * | 1994-09-08 | 1998-02-28 | Jean-Francois Rossignol | Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas. |
| US5965590A (en) * | 1994-09-08 | 1999-10-12 | Romark Lab Lc | Method for treatment of opportunistic infections with pharmaceutical compositions of tizoxanide and nitazoxanide |
| US5968961A (en) * | 1997-05-07 | 1999-10-19 | Romark Laboratories, L.C. | Pharmaceutical compositions of tizoxanide and nitazoxanide |
| US5856348A (en) * | 1994-09-08 | 1999-01-05 | Romark Laboratories, L.C. | Method for treatment of trematodes with pharmaceutical compositions of tizoxanide and nitazoxanide |
| US6576636B2 (en) * | 1996-05-22 | 2003-06-10 | Protarga, Inc. | Method of treating a liver disorder with fatty acid-antiviral agent conjugates |
| CN100515420C (zh) * | 1997-05-07 | 2009-07-22 | 罗马克实验室有限公司 | 脱乙酰基硝噻醋柳胺和硝噻醋柳胺的药用组合物 |
| US5935591A (en) * | 1998-01-15 | 1999-08-10 | Romark Laboratories, L.C. | Method for treatment of equine protozoal myeloencephalitis with thiazolides |
| AU766597B2 (en) * | 1998-05-15 | 2003-10-16 | Schering Corporation | Combination therapy comprising ribavirin and interferon alpha in antiviral treatment naive patients having chronic hepatitis C infection |
| US5925622A (en) * | 1998-07-13 | 1999-07-20 | Romark Laboratories, L.C. | Synthesis of aryl glucuronide of 2-hydroxy-N- (5-nitro-2-thiazolyl) benzamide, and pharmaceutical compositions comprising same |
| US6180136B1 (en) * | 1998-11-10 | 2001-01-30 | Idexx Laboratories, Inc. | Phospholipid-coated microcrystals for the sustained release of pharmacologically active compounds and methods of their manufacture and use |
| US6340696B1 (en) * | 1999-03-31 | 2002-01-22 | The Procter & Gamble Company | Viral treatment |
| US7125568B2 (en) * | 2001-08-23 | 2006-10-24 | Sung Michael T | Lipophilic drug compositions |
| EP1562617B1 (en) | 2002-10-29 | 2006-12-20 | Council of Scientific and Industrial Research | New use of pipataline |
| US7081260B2 (en) * | 2002-10-29 | 2006-07-25 | Council Of Scientific And Industrial Research | α-Glucosidase inhibitors from a natural source |
| EA200501524A1 (ru) * | 2003-03-28 | 2006-06-30 | Сентокор, Инк. | Антитела против амилоида, композиции, способы и применения |
| WO2005049065A2 (en) * | 2003-11-19 | 2005-06-02 | Rigel Pharmaceuticals, Inc. | Synergistic combinations of dihaloacetamide with interferon or ribavirin for treatment hcv infections |
| UA90864C2 (en) * | 2004-09-09 | 2010-06-10 | Ромарк Лебораториз, Л.К. | Halogenated benzamide derivatives |
| US20060194853A1 (en) * | 2004-10-08 | 2006-08-31 | Rossignol Jean F | Alkyl benzamides |
| AU2006235490A1 (en) | 2005-04-12 | 2006-10-19 | Romark Laboratories, L.C. | Methods for treating diseases through the function of molecular chaperones such as protein disulfide isomerases, pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents |
| CA2636527C (en) | 2006-01-09 | 2016-05-17 | Romark Laboratories, L.C. | Viral hepatitis treatment |
| SI2395840T1 (sl) * | 2009-02-13 | 2020-08-31 | Romark Laboratories, L.C. | Farmacevtske formulacije nitazoksanida z nadzorovanim sproščanjem |
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| CA2636527A1 (en) | 2007-07-19 |
| JP2009522371A (ja) | 2009-06-11 |
| US20070167504A1 (en) | 2007-07-19 |
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| CN101448497A (zh) | 2009-06-03 |
| EP1976516A2 (en) | 2008-10-08 |
| DK1976516T3 (da) | 2013-07-15 |
| EA200870164A1 (ru) | 2008-12-30 |
| US8633230B2 (en) | 2014-01-21 |
| US20140112888A1 (en) | 2014-04-24 |
| UA100840C2 (ru) | 2013-02-11 |
| MX2008008723A (es) | 2008-09-26 |
| EP1976516A4 (en) | 2009-11-11 |
| ES2422556T3 (es) | 2013-09-12 |
| IL192548A0 (en) | 2009-02-11 |
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| USRE47404E1 (en) | 2019-05-28 |
| JP2010070566A (ja) | 2010-04-02 |
| ZA200806310B (en) | 2009-12-30 |
| WO2007081974A2 (en) | 2007-07-19 |
| EP1976516B1 (en) | 2013-04-24 |
| AP2008004550A0 (en) | 2008-08-31 |
| IL192548A (en) | 2015-08-31 |
| HK1123733A1 (en) | 2009-06-26 |
| AU2007204963B2 (en) | 2012-09-27 |
| AP2907A (en) | 2014-05-31 |
| NZ569507A (en) | 2011-11-25 |
| US9107913B2 (en) | 2015-08-18 |
| CA2636527C (en) | 2016-05-17 |
| CN101448497B (zh) | 2013-07-10 |
| AU2007204963A1 (en) | 2007-07-19 |
| BRPI0706379A2 (pt) | 2011-03-22 |
| WO2007081974A3 (en) | 2008-01-17 |
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