JP5175744B2 - 海松子抽出物を有効成分として含有する化粧料組成物 - Google Patents
海松子抽出物を有効成分として含有する化粧料組成物 Download PDFInfo
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- JP5175744B2 JP5175744B2 JP2008551169A JP2008551169A JP5175744B2 JP 5175744 B2 JP5175744 B2 JP 5175744B2 JP 2008551169 A JP2008551169 A JP 2008551169A JP 2008551169 A JP2008551169 A JP 2008551169A JP 5175744 B2 JP5175744 B2 JP 5175744B2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9755—Gymnosperms [Coniferophyta]
- A61K8/9767—Pinaceae [Pine family], e.g. pine or cedar
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Description
海松子(Pinus koraiensis)は、マツ科に属する朝鮮松の熟した実を乾したもので、漢方では松の実を薬剤として称する言葉で、柏子、松子、実柏とも言う。これは、松かさのような毬果に入っており、種子は、三角卵状形である。昔から海松子は、滋養強壮剤として多く使用し、病後回復期に食べれば良いものと知られている。また、これは、脂肪及びタンパク質が豊かな高熱量食品であり、特にビタミンBが豊かで、皮膚を柔らかくし、血圧を下げる作用をする。
海松子、梅子、赤小豆、カリン、巨勝子(ゴンファ薬品(株))の各薬材を採取し
た後、品質に優れた薬材のみを選別し、水洗して不純物を除去した後、日陰で乾燥した。次に、海松子、梅子、赤小豆、カリン、巨勝子を各々100g取って精製水2Lずつを添加した後、約95〜100℃還流装置下で18時間沸かしながら抽出した。抽出完了後、続いて蒸溜濃縮して、全体重量が約500gになるまで煎じた後、常温に冷却した。次に、濾過布に入れて圧搾し、固形粉を分離し除去した後、濾過し、粘性ある濃縮液を得た。濃縮液を80℃減圧下で濃縮し、水を完全に除去した後、真空乾燥し、て粉末固体状態の抽出物(海松子5.0g、梅子10g、赤小豆5.0g、カリン5.0g、巨勝子5.0g)を収得した。
前記参考例1で得た各生薬材水抽出物を下記表1の組合せで混合して実施例1〜15及び比較例1を製造し、実験に使用した。この時、各抽出物の混合割合は、同量にした。
前記実施例1〜15及び比較例1の抽出物が角質形成細胞の成長能に及ぶ効果をMTT方法で測定した。以下、その方法を簡略に説明する。
前記実施例1〜15及び比較例1の抽出物の紫外線によって生成される活性酸素生成抑制効果、すなわち活性酸素消去効果を調べるために蛍光物質を利用して下記のような実験を行った。
前記実施例1〜15及び比較例1の抽出物の皮膚基質の分解に関連された紫外線によるMMP−1の生合成を減少させて、タイプ1プロコラーゲンの生合成を促進させる効果を調べるために、MMP−1及びプロコラーゲン分析を下記のような方法で行った。
下記表7の組成によって前記実施例1〜15及び比較例1の抽出物を使用して剤型例1〜15及び比較剤型例1の化粧料組成物を製造した。下記表7の組成によって成分1〜7の油相パートと成分8〜15の水相パートをそれぞれ加熱して溶解した後、水相を撹拌しながら油相パートを水相に徐々に添加して乳化した。
前記剤型例1〜15の化粧料組成物は、有効成分として海松子抽出物に梅子抽出物、赤小豆抽出物、カリン抽出物及び巨勝子抽出物よりなる群から選択された1つ以上をさらに含有する組成物であるのに対し、比較剤型例1の化粧料組成物は、ただ海松子抽出物のみを含有するものである。前記組成物は、それぞれ油相と水相を65〜75℃で完全溶解させ、7,000乃至8,000rpmで5分間乳化させてクリーム剤型を製造した。
前記剤型例15及び比較剤型例1のしわ改善効果を調べるために、下記のような方法を行った。
ヒト角質形成細胞を培養用フラスコに入れて培養し、約80%程度に成長させた後、下記表9の試料をそれぞれ5ppm濃度で添加して4日間処理した。次に、尿素やSDS(sodiumdodecyl sulfate)のような変成剤及びβ-メルカプトエタノールのような還元剤を混合し、溶解されるタンパク質を除去した。その後、残った角質層を310nmでの吸光度を測定してペプチド濃度を分析し、陰性対照群である蒸留水を基準(0%)にして各試料による増加量を比較し、その結果を下記表9に示した。
下記表10の組成によって前記実施例1〜15及び比較例1の抽出物を使用して剤型例16〜30及び比較剤型例2の化粧料組成物を製造した。下記表10の組成によって成分1〜5の水相パートと成分6〜9のアルコールパートをそれぞれ室温で溶解した後、水相を撹拌しながらアルコールパートを水相に徐々に添加して可溶化した。次に、アルコールパートの添加が完了した後、3〜5分間撹拌を続いた後、真空脱気し、化粧料の製造を完成した。
前記剤型例16〜30及び比較剤型例2の皮膚障壁機能回復効果を測定するために、無毛マウスの皮膚にアセトンを繰り返し的に塗布し、障壁機能を損傷させた後、Servomed社(スウェーデン)製evaporimeter EP1で測定された表皮水分損失量(TEWL, transdermal water loss)が4.0g/m2/hに到逹したときに、前記剤型例16〜30及び比較剤型例2の試料を5cm2面積に塗布し、その後、表皮水分損失量を1時間、2時間、4時間、8時間経過後に測定し、減少する程度を評価することによって、障壁機能が回復される程度を評価した。この時、公知の脂質混合物(セラミド:コレステロール:脂肪酸の2:1:1混合物)を陽性対照群として使用した。その結果は、初期損傷された障壁状態での表皮水分損失量を基準(100%)にして時間による変化を比較し、下記表11に示した。
以下では、本発明による化粧料組成物の剤型例を説明するが、本発明は、これらを限定するものではなく、ただ具体的に説明するためのものである。
Claims (7)
- 有効成分として海松子抽出物に梅子抽出物、赤小豆抽出物、カリン抽出物及び巨勝子抽出物よりなる群から選択された1つ以上をさらに含有し、且つ、前記各抽出物は、いずれも水を抽出溶媒として抽出したものであることを特徴とする角質形成細胞成長促進用化粧料組成物。
- 有効成分として海松子抽出物に梅子抽出物、赤小豆抽出物、カリン抽出物及び巨勝子抽出物よりなる群から選択された1つ以上をさらに含有し、且つ、前記各抽出物は、いずれも水を抽出溶媒として抽出したものであることを特徴とする活性酸素消去用化粧料組成物。
- 有効成分として海松子抽出物に梅子抽出物、赤小豆抽出物、カリン抽出物及び巨勝子抽出物よりなる群から選択された1つ以上をさらに含有し、且つ、前記各抽出物は、いずれも水を抽出溶媒として抽出したものであることを特徴とするMMP−1の生合成減少によるタイプ1プロコラーゲンの生合成促進用化粧料組成物。
- 有効成分として海松子抽出物に梅子抽出物、赤小豆抽出物、カリン抽出物及び巨勝子抽出物よりなる群から選択された1つ以上をさらに含有し、且つ、前記各抽出物は、いずれも水を抽出溶媒として抽出したものであることを特徴とする皮膚老化防止用化粧料組成物。
- 有効成分として海松子抽出物に梅子抽出物、赤小豆抽出物、カリン抽出物及び巨勝子抽出物よりなる群から選択された1つ以上をさらに含有し、且つ、前記各抽出物は、いずれも水を抽出溶媒として抽出したものであることを特徴とする皮膚保湿用化粧料組成物。
- 前記組成物は、1,3-ブチレングリコールをさらに含むことを特徴とする請求項1乃至5のいずれかに記載の化粧料組成物。
- 前記抽出物は、組成物の全体重量に対して0.0001乃至25重量%含有することを特徴とする請求項1乃至5のいずれかに記載の化粧料組成物。
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