JP5149184B2 - ゲノムｄｎａの検出、分析、および種名を同定のための方法と分子診断装置 - Google Patents

ゲノムｄｎａの検出、分析、および種名を同定のための方法と分子診断装置 Download PDF

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Publication number
JP5149184B2
JP5149184B2 JP2008529337A JP2008529337A JP5149184B2 JP 5149184 B2 JP5149184 B2 JP 5149184B2 JP 2008529337 A JP2008529337 A JP 2008529337A JP 2008529337 A JP2008529337 A JP 2008529337A JP 5149184 B2 JP5149184 B2 JP 5149184B2
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sample
microfluidic
exemplary embodiment
cartridge
dna
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JP2009506775A (ja
JP2009506775A5 (enExample
Inventor
裕司 井上
イボール， ティー． ナイト，
グレゴリー， エー． デイル，
リタ， アール． コルウェル，
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Canon USA Inc
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Canon US Life Sciences Inc
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
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    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
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    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
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    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
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    • B01L2300/18—Means for temperature control
    • B01L2300/1833—Means for temperature control using electrical currents in the sample itself
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L2400/04—Moving fluids with specific forces or mechanical means
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    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
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    • B01L2400/0442—Moving fluids with specific forces or mechanical means specific forces thermal energy, e.g. vaporisation, bubble jet
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L7/54—Heating or cooling apparatus; Heat insulating devices using spatial temperature gradients
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
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    • G01N2035/00099—Characterised by type of test elements
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    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2008529337A 2005-09-01 2006-09-01 ゲノムｄｎａの検出、分析、および種名を同定のための方法と分子診断装置 Active JP5149184B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71281305P 2005-09-01 2005-09-01
US60/712,813 2005-09-01
PCT/US2006/034336 WO2007028084A2 (en) 2005-09-01 2006-09-01 Method and molecular diagnostic device for detection, analysis and identification of genomic dna

Publications (3)

Publication Number Publication Date
JP2009506775A JP2009506775A (ja) 2009-02-19
JP2009506775A5 JP2009506775A5 (enExample) 2012-04-26
JP5149184B2 true JP5149184B2 (ja) 2013-02-20

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Country Status (5)

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US (3) US7915030B2 (enExample)
EP (1) EP1941035B1 (enExample)
JP (1) JP5149184B2 (enExample)
CN (1) CN101300352B (enExample)
WO (1) WO2007028084A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230069081A1 (en) * 2021-08-30 2023-03-02 Taiwan Semiconductor Manufacturing Co., Ltd. Method and system for adjusting the gap between a wafer and a top plate in a thin-film deposition process

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US7915030B2 (en) * 2005-09-01 2011-03-29 Canon U.S. Life Sciences, Inc. Method and molecular diagnostic device for detection, analysis and identification of genomic DNA
WO2007081385A2 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
US7598091B2 (en) * 2006-04-04 2009-10-06 Micropoint Bioscience, Inc. Micromachined diagnostic device with controlled flow of fluid and reaction
WO2007133710A2 (en) 2006-05-11 2007-11-22 Raindance Technologies, Inc. Microfluidic devices and methods of use thereof
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US7745129B1 (en) * 2006-07-12 2010-06-29 Kenneth David Schatz Methods for sequencing of a necleic acid
US8148159B2 (en) * 2006-10-05 2012-04-03 Massachusetts Institute Of Technology System and methods for stretching polynucleotides
US20080167198A1 (en) * 2007-01-04 2008-07-10 Christopher Gerard Cooney Filter based detection system
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
JP5494480B2 (ja) * 2007-06-11 2014-05-14 和光純薬工業株式会社 集積リアルタイムｃｅ検出を用いるマイクロチップ大容量ｐｃｒ
AU2008302367B2 (en) * 2007-09-17 2013-10-03 Red Ivory Llc Self-actuating signal producing detection devices and methods
CL2008003007A1 (es) * 2007-10-12 2009-10-02 Bigtec Private Ltd Un micro chip con capas de ceramicas de coccion conjunta a baja temperatura (ltcc) formando una camara de reaccion, anillos conductores que rodean a la camara de reaccion y un calentador que suministra calor a los anillos, el metodo de fabricacion del micro chip y un micro dispositivo de reaccion en cadena de polimerasa (pcr).
US9114397B2 (en) * 2007-10-25 2015-08-25 Canon U.S. Life Sciences, Inc. Method of reducing cross-contamination in continuous amplification reactions in a channel
EP2212437A4 (en) 2007-11-07 2011-09-28 Univ British Columbia MICROFLUIDIC DEVICE AND METHOD OF USING THE DEVICE
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
EP4047367A1 (en) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Method for detecting target analytes with droplet libraries
RU2380418C1 (ru) * 2008-10-01 2010-01-27 Учреждение Российской академии наук Институт молекулярной биологии им. В.А. Энгельгардта РАН Сменный микрофлюидный модуль для автоматизированного выделения и очистки нуклеиновых кислот из биологических образцов и способ выделения и очистки нуклеиновых кислот с его использованием
WO2010111231A1 (en) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation of microfluidic droplets
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
US10196700B2 (en) 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
AU2010229490B2 (en) 2009-03-24 2015-02-12 University Of Chicago Slip chip device and methods
US8354080B2 (en) 2009-04-10 2013-01-15 Canon U.S. Life Sciences, Inc. Fluid interface cartridge for a microfluidic chip
AU2010257118B2 (en) 2009-06-04 2014-08-28 Lockheed Martin Corporation Multiple-sample microfluidic chip for DNA analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
EP4435111A1 (en) 2010-02-12 2024-09-25 Bio-Rad Laboratories, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
WO2012045012A2 (en) 2010-09-30 2012-04-05 Raindance Technologies, Inc. Sandwich assays in droplets
EP2439512A1 (en) * 2010-10-01 2012-04-11 Aqsens Oy A device for holding a sample
AU2011315951B2 (en) 2010-10-15 2015-03-19 Lockheed Martin Corporation Micro fluidic optic design
JP2013545475A (ja) * 2010-11-30 2013-12-26 クワンタムディーエックス・グループ・リミテッド マイクロ流体多重温度可撓性反応デバイスの設計、製造及び使用
GB2486435A (en) * 2010-12-14 2012-06-20 Morteza Bahrami Liquid sample receiving apparatus
JP2014505594A (ja) * 2011-02-07 2014-03-06 プレジデント アンド フェロウズ オブ ハーバード カレッジ 液滴を分裂させるためのシステムおよび方法
EP3859011A1 (en) 2011-02-11 2021-08-04 Bio-Rad Laboratories, Inc. Methods for forming mixed droplets
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
EP2714970B1 (en) 2011-06-02 2017-04-19 Raindance Technologies, Inc. Enzyme quantification
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
US11198126B2 (en) * 2011-10-31 2021-12-14 Fluid-Screen, Inc. Apparatus for pathogen detection
US9433943B2 (en) 2011-11-15 2016-09-06 The Board Of Trustees Of The University Of Illinois Thermal control of droplets by nanoscale field effect transistors
WO2013119753A1 (en) 2012-02-08 2013-08-15 President And Fellows Of Harvard College Droplet formation using fluid breakup
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
WO2013132645A1 (ja) * 2012-03-09 2013-09-12 独立行政法人産業技術総合研究所 核酸増幅方法
DE102012205171B3 (de) * 2012-03-29 2013-09-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Integriertes Einweg-Chipkartuschensystem für mobile Multiparameteranalysen chemischer und/oder biologischer Substanzen
US9551030B2 (en) * 2012-06-17 2017-01-24 Pacific Biosciences Of California, Inc. Filter architecture for analytical devices
US9366647B2 (en) * 2013-03-14 2016-06-14 Taiwan Semiconductor Manufacturing Company, Ltd. Optical detection for bio-entities
JP2014176302A (ja) * 2013-03-13 2014-09-25 Seiko Epson Corp 核酸増幅反応装置及び核酸増幅方法
US9718056B2 (en) 2013-03-15 2017-08-01 Syracuse University Microfluidics polymerase chain reaction and high resolution melt detection
RU2015150548A (ru) * 2013-05-22 2017-06-23 Имек Взв Компактное устройство для анализа текучей среды и способ его изготовления
WO2015048798A1 (en) * 2013-09-30 2015-04-02 Gnubio, Inc. Microfluidic cartridge device and methods of use and assembly
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US10627358B2 (en) 2014-10-06 2020-04-21 Alveo Technologies, Inc. Method for detection of analytes
US10352899B2 (en) 2014-10-06 2019-07-16 ALVEO Technologies Inc. System and method for detection of silver
US9506908B2 (en) 2014-10-06 2016-11-29 Alveo Technologies, Inc. System for detection of analytes
US9921182B2 (en) 2014-10-06 2018-03-20 ALVEO Technologies Inc. System and method for detection of mercury
US10196678B2 (en) 2014-10-06 2019-02-05 ALVEO Technologies Inc. System and method for detection of nucleic acids
US20160116409A1 (en) * 2014-10-28 2016-04-28 Omnivision Technologies, Inc. Color-Sensitive Image Sensor With Embedded Microfluidics And Associated Methods
US10519493B2 (en) 2015-06-22 2019-12-31 Fluxergy, Llc Apparatus and method for image analysis of a fluid sample undergoing a polymerase chain reaction (PCR)
US10214772B2 (en) 2015-06-22 2019-02-26 Fluxergy, Llc Test card for assay and method of manufacturing same
US11371091B2 (en) 2015-06-22 2022-06-28 Fluxergy, Inc. Device for analyzing a fluid sample and use of test card with same
BR122020004273B1 (pt) * 2015-07-17 2022-11-29 Cue Health Inc Cartucho de análise de amostras
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
WO2017119904A1 (en) * 2016-01-08 2017-07-13 Hewlett-Packard Development Company, L.P. Polymerase chain reaction device including ejection nozzles
US20190032114A1 (en) * 2016-01-20 2019-01-31 Triv Tech, Llc Point-of-care nucleic acid amplification and detection
US11060959B2 (en) * 2016-06-03 2021-07-13 Purdue Research Foundation Systems and methods for analyzing an analyte extracted from a sample using an adsorbent material
AU2017330304A1 (en) 2016-09-23 2019-04-11 Alveo Technologies, Inc. Methods and compositions for detecting analytes
CN107151700B (zh) 2017-06-08 2023-11-07 杭州遂真生物技术有限公司 一种基因检测方法及基因检测试剂盒和基因检测设备
CN107527595B (zh) * 2017-09-27 2019-06-07 京东方科技集团股份有限公司 一种微流控系统及其驱动方法
WO2019078891A1 (en) * 2017-10-20 2019-04-25 Hewlett-Packard Development Company, L.P. AMPLIFICATION OF NUCLEIC ACIDS
US11931738B2 (en) 2018-04-24 2024-03-19 Hewlett-Packard Development Company, L.P. Sequenced droplet ejection to deliver fluids
WO2019209273A1 (en) 2018-04-24 2019-10-31 Hewlett-Packard Development Company, L.P. Microfluidic devices
US11547993B2 (en) 2018-07-17 2023-01-10 Hewlett-Packard Development Company, L.P. Droplet ejectors with target media
US11325380B2 (en) 2018-07-17 2022-05-10 Hewlett-Packard Development Company, L.P. Droplet ejectors to provide fluids to droplet ejectors
GB201812192D0 (en) 2018-07-26 2018-09-12 Ttp Plc Variable temperature reactor, heater and control circuit for the same
AU2019401601B2 (en) 2018-12-20 2026-04-02 Alveo Technologies, Inc. Handheld impedance-based diagnostic test system for detecting analytes
EP3902632A1 (en) * 2018-12-28 2021-11-03 Astraveus Device and method for handling a particle suspension
US11195864B2 (en) 2019-03-01 2021-12-07 Omnivision Technologies, Inc. Flip-chip sample imaging devices with self-aligning lid
WO2020185200A1 (en) * 2019-03-08 2020-09-17 Hewlett-Packard Development Company, L.P. Disposable microfluidic cassettes
EP4028353B1 (en) * 2019-09-09 2025-07-16 Lumacyte, LLC Microfluidic devices and method for sampling and analysis of cells using optical forces and raman spectroscopy
US20210205813A1 (en) * 2019-12-23 2021-07-08 National Technology & Engineering Solutions Of Sandia, Llc Contactless liquid loading to microfluidic devices
WO2022010461A1 (en) * 2020-07-07 2022-01-13 Hewlett-Packard Development Company, L.P. Microfluidic sensing
US12472492B2 (en) 2020-08-14 2025-11-18 Alveo Technologies, Inc. Systems and methods of sample depositing and testing
KR102416335B1 (ko) * 2021-06-29 2022-07-05 에스디바이오센서 주식회사 기체 이동 통로와 추출액 이동 통로를 갖는 증폭 모듈
CN113552379A (zh) * 2021-08-24 2021-10-26 中国科学院上海微系统与信息技术研究所 一种多通道液滴采样装置、包括其的光学分析系统以及方法
DE102023129147A1 (de) 2023-10-24 2025-04-24 Technische Universität Dresden, Körperschaft des öffentlichen Rechts Fluidische Vorrichtung und Verfahren zur Probenvorbereitung mit einer fluidischen Vorrichtung

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1127227A (en) 1977-10-03 1982-07-06 Ichiro Endo Liquid jet recording process and apparatus therefor
US4330787A (en) 1978-10-31 1982-05-18 Canon Kabushiki Kaisha Liquid jet recording device
US4345262A (en) 1979-02-19 1982-08-17 Canon Kabushiki Kaisha Ink jet recording method
US4463359A (en) 1979-04-02 1984-07-31 Canon Kabushiki Kaisha Droplet generating method and apparatus thereof
US4313124A (en) 1979-05-18 1982-01-26 Canon Kabushiki Kaisha Liquid jet recording process and liquid jet recording head
US4558333A (en) 1981-07-09 1985-12-10 Canon Kabushiki Kaisha Liquid jet recording head
JPS59123670A (ja) 1982-12-28 1984-07-17 Canon Inc インクジエツトヘツド
JPS59138461A (ja) 1983-01-28 1984-08-08 Canon Inc 液体噴射記録装置
US5714380A (en) * 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
US6001229A (en) 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
US6168948B1 (en) * 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US5885470A (en) 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
GB9608644D0 (en) * 1996-04-26 1996-07-03 Scient Genarics Ltd Nucleic acid manipulation
CN1173776C (zh) 1996-06-28 2004-11-03 卡钳技术有限公司 在微规模流体性设备里的高通过量的筛选分析系统
US6221654B1 (en) * 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
JP4274561B2 (ja) * 1997-08-01 2009-06-10 キヤノン株式会社 プローブアレイとその製造方法
JP4313861B2 (ja) 1997-08-01 2009-08-12 キヤノン株式会社 プローブアレイの製造方法
US5989402A (en) 1997-08-29 1999-11-23 Caliper Technologies Corp. Controller/detector interfaces for microfluidic systems
US5965410A (en) 1997-09-02 1999-10-12 Caliper Technologies Corp. Electrical current for controlling fluid parameters in microchannels
US6914137B2 (en) 1997-12-06 2005-07-05 Dna Research Innovations Limited Isolation of nucleic acids
ES2177093T3 (es) 1997-12-06 2002-12-01 Dna Res Innovations Ltd Aislamiento de acidos nucleicos.
WO1999058664A1 (en) * 1998-05-14 1999-11-18 Whitehead Institute For Biomedical Research Solid phase technique for selectively isolating nucleic acids
US6958392B2 (en) * 1998-10-09 2005-10-25 Whatman, Inc. Methods for the isolation of nucleic acids and for quantitative DNA extraction and detection for leukocyte evaluation in blood products
US6500323B1 (en) 1999-03-26 2002-12-31 Caliper Technologies Corp. Methods and software for designing microfluidic devices
MXPA02008290A (es) 2000-02-23 2004-09-10 Caliper Technologies Inc Sistema de control de presion de multi-reserva-.
AU2001275995A1 (en) * 2000-07-31 2002-02-13 Applera Corporation Apparatus and method for specific release of captured extension products
CA2417341A1 (en) * 2000-08-08 2002-02-14 Jing Cheng Methods for manipulating moieties in microfluidic systems
ATE448875T1 (de) 2000-09-14 2009-12-15 Caliper Life Sciences Inc Mikrofluidische vorrichtungen und methoden um temperatur-vermittelte reaktionen durchzuführen
WO2002046398A2 (en) * 2000-11-06 2002-06-13 The University Of Houston System Nucleic acid separation using immobilized metal affinity chromatography
EP1355823A4 (en) 2001-01-29 2005-04-20 Caliper Life Sciences Inc NON-MECHANICAL VALVES FOR FLUID SYSTEMS
WO2002061392A2 (en) 2001-01-31 2002-08-08 Board Of Regents, The University Of Texas System Method and apparatus for the confinement of materials in a micromachined chemical sensor array
JP2003014773A (ja) * 2001-03-28 2003-01-15 Canon Inc プローブ担体、その製造装置およびその製造方法
EP2156879A3 (en) * 2001-10-11 2010-07-07 Aviva Biosciences Corporation Methods, compositions and automated systems for separating rare cells from fluid samples
US20030138819A1 (en) * 2001-10-26 2003-07-24 Haiqing Gong Method for detecting disease
JP2003180351A (ja) 2001-12-13 2003-07-02 Adgene Co Ltd 核酸高次構造誘導を用いた核酸変異検出法
JP2003334082A (ja) 2002-05-17 2003-11-25 Adgene Co Ltd 波形生成プライマー、該プライマーを使用した核酸増幅方法及び核酸同定方法
JP2004037112A (ja) * 2002-06-28 2004-02-05 Canon Inc 核酸チップ基板、及び核酸チップの検査方法、並びに製造方法
JP3937954B2 (ja) * 2002-07-18 2007-06-27 キヤノン株式会社 プローブ担体の製造方法および製造装置
US7217542B2 (en) * 2002-10-31 2007-05-15 Hewlett-Packard Development Company, L.P. Microfluidic system for analyzing nucleic acids
US20060210984A1 (en) * 2003-03-03 2006-09-21 Jeremy Lambert Use of nucleic acid mimics for internal reference and calibration in a flow cell microarray binding assay
US20040197780A1 (en) * 2003-04-02 2004-10-07 Agencourt Bioscience Corporation Method for isolating nucleic acids
JP2005024278A (ja) * 2003-06-30 2005-01-27 Canon Inc プローブ担体の製造方法及び製造装置
JP2006198523A (ja) * 2005-01-20 2006-08-03 Fuji Photo Film Co Ltd 加圧エア供給機構、加圧装置、及び抽出機
KR101544351B1 (ko) * 2005-02-18 2015-08-13 캐논 유.에스. 라이프 사이언시즈, 인크. 유기체의 게놈 ｄｎａ를 확인하기 위한 장치 및 방법
US7915030B2 (en) * 2005-09-01 2011-03-29 Canon U.S. Life Sciences, Inc. Method and molecular diagnostic device for detection, analysis and identification of genomic DNA

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230069081A1 (en) * 2021-08-30 2023-03-02 Taiwan Semiconductor Manufacturing Co., Ltd. Method and system for adjusting the gap between a wafer and a top plate in a thin-film deposition process
US12266579B2 (en) * 2021-08-30 2025-04-01 Taiwan Semiconductor Manufacturing Co., Ltd. Method and system for adjusting the gap between a wafer and a top plate in a thin-film deposition process

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