JP5134974B2 - 血漿中のグルコースレベル、コレステロールレベル及びトリグリセリドレベルを低下させるための５−［４−（４−（２−アミノ−２−メトキシカルボニルエチル）フェノキシ）ベンジリデン］チアゾリジン−２，４−ジオン誘導体及び関連化合物 - Google Patents
血漿中のグルコースレベル、コレステロールレベル及びトリグリセリドレベルを低下させるための５−［４−（４−（２−アミノ−２−メトキシカルボニルエチル）フェノキシ）ベンジリデン］チアゾリジン−２，４−ジオン誘導体及び関連化合物 Download PDFInfo
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- JP5134974B2 JP5134974B2 JP2007556366A JP2007556366A JP5134974B2 JP 5134974 B2 JP5134974 B2 JP 5134974B2 JP 2007556366 A JP2007556366 A JP 2007556366A JP 2007556366 A JP2007556366 A JP 2007556366A JP 5134974 B2 JP5134974 B2 JP 5134974B2
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- phenoxy
- amino
- phenyl
- thiazolidine
- ylmethyl
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- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
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- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
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| PCT/US2006/005846 WO2006089225A1 (en) | 2005-02-17 | 2006-02-17 | 5- [4- (4- (2 -amino- 2 -methoxycarbonylethyl) phenoxy) benzilidene] thiazolidin-2 , 4-dion e derivatives and related compounds for reducing glucose, cholesterol and triglyceride levels in plasma |
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| US9969977B2 (en) * | 2002-09-20 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| US7521465B2 (en) | 2003-01-17 | 2009-04-21 | Bexel Pharmaceuticals, Inc. | Diphenyl ether derivatives |
| US7781464B2 (en) | 2003-01-17 | 2010-08-24 | Bexel Pharmaceuticals, Inc. | Heterocyclic diphenyl ethers |
| US7087576B2 (en) * | 2003-10-07 | 2006-08-08 | Bexel Pharmaceuticals, Inc. | Dipeptide phenyl ethers |
| KR100814109B1 (ko) * | 2006-01-09 | 2008-03-14 | 한국생명공학연구원 | 로다닌 유도체, 이의 제조방법 및 이를 유효성분으로함유하는 약학적 조성물 |
| US7989480B2 (en) * | 2006-08-04 | 2011-08-02 | Decode Genetics Ehf | Aryl amino acid derivatives as inhibitors for treating inflammation |
| US20090069313A1 (en) * | 2007-09-06 | 2009-03-12 | Orchid Research Laboratories Ltd. | Novel MAO-A inhibitors |
| MX2010012626A (es) | 2008-05-20 | 2011-02-22 | Merck Sharp & Dohme | Produccion eficiente de proteinas heterologas utilizando inhibidores de manosil transferasa. |
| WO2012014218A1 (en) * | 2010-07-28 | 2012-02-02 | Orchid Research Laboratories Ltd. | Diphenyl ether compounds for the treatment of liver, lung disorders, diabetic complications and cardiovascular diseases |
| WO2012153775A1 (ja) | 2011-05-10 | 2012-11-15 | 国立大学法人神戸大学 | Ras機能阻害作用を有するチオキソチアゾリジン誘導体 |
| WO2016080853A1 (en) * | 2014-11-21 | 2016-05-26 | Bsim2 – Biomolecular Simulations Lda | 2-thioxothiazolidin-4-one derivatives active as transthyretin ligands and uses thereof |
| TW202019923A (zh) * | 2018-07-16 | 2020-06-01 | 義大利商吉斯藥品公司 | 作為Ｒｈｏ－激酶抑制劑之酪胺酸醯胺衍生物 |
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| US6331633B1 (en) * | 1998-05-08 | 2001-12-18 | Calyx Therapeutics Inc. | Heterocyclic analogs of diphenylethylene compounds |
| US6699896B1 (en) * | 1998-05-12 | 2004-03-02 | Wyeth | Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia |
| TR200003595T2 (tr) * | 1998-06-05 | 2001-07-23 | Astrazeneca Ab | Kimyasal bileşikler |
| AU4713499A (en) * | 1998-06-27 | 2000-01-17 | Photogenesis, Inc. | Ophthalmic uses of ppargamma agonists and ppargamma antagonists |
| KR100613175B1 (ko) * | 1998-08-27 | 2006-08-17 | 오노 야꾸힝 고교 가부시키가이샤 | 카르복실산 유도체 및 그 유도체를 유효 성분으로서함유하는 약제 |
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| HRP20010795A2 (en) | 1999-04-28 | 2003-02-28 | Aventis Pharma Gmbh | Di-aryl acid derivatives as ppar receptor ligands |
| TWI284533B (en) * | 1999-05-24 | 2007-08-01 | Sankyo Co | Pharmaceutical composition for treating hyperglycemia, impaired glucose tolerance, diabetes complications and for improving insulin resistant |
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| DE60020381T2 (de) * | 1999-08-23 | 2006-01-26 | Kyorin Pharmaceutical Co., Ltd. | Substituierte benzylthiazolidin-2,4-dion-derivate |
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| WO2003027081A2 (en) | 2001-09-14 | 2003-04-03 | Novo Nordisk A/S | NOVEL LIGANDS FOR THE HisB10 Zn2+ SITES OF THE R-STATE INSULIN HEXAMER |
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| US6794401B2 (en) | 2003-01-17 | 2004-09-21 | Bexel Pharmaceuticals, Inc. | Amino acid phenoxy ethers |
| BRPI0408229A (pt) | 2003-03-11 | 2006-02-21 | Novo Nordisk As | preparação farmacêutica, métodos para preparar um ligando de ligação de zinco, para prolongar a ação de uma preparação de insulina estabilizada por ácido e para tratar diabete do tipo 1 ou tipo 2, e, uso de uma preparação |
| US7087576B2 (en) * | 2003-10-07 | 2006-08-08 | Bexel Pharmaceuticals, Inc. | Dipeptide phenyl ethers |
-
2005
- 2005-03-31 US US11/096,718 patent/US7521465B2/en not_active Expired - Fee Related
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2006
- 2006-02-17 JP JP2007556366A patent/JP5134974B2/ja not_active Expired - Fee Related
- 2006-02-17 ES ES06735487.8T patent/ES2566337T3/es active Active
- 2006-02-17 CA CA2598087A patent/CA2598087C/en not_active Expired - Fee Related
- 2006-02-17 WO PCT/US2006/005846 patent/WO2006089225A1/en not_active Ceased
- 2006-02-17 EP EP06735487.8A patent/EP1848700B1/en not_active Not-in-force
- 2006-02-17 KR KR1020077021343A patent/KR20070105364A/ko not_active Ceased
- 2006-02-17 HU HUE06735487A patent/HUE028882T2/en unknown
- 2006-02-17 PL PL06735487T patent/PL1848700T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1848700A1 (en) | 2007-10-31 |
| ES2566337T3 (es) | 2016-04-12 |
| US20050288341A1 (en) | 2005-12-29 |
| HUE028882T2 (en) | 2017-01-30 |
| KR20070105364A (ko) | 2007-10-30 |
| WO2006089225A1 (en) | 2006-08-24 |
| US7521465B2 (en) | 2009-04-21 |
| PL1848700T3 (pl) | 2016-08-31 |
| EP1848700B1 (en) | 2015-12-30 |
| JP2008530242A (ja) | 2008-08-07 |
| CA2598087A1 (en) | 2006-08-24 |
| CA2598087C (en) | 2014-05-27 |
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