JP5117183B2 - 腎障害のための薬草抽出物 - Google Patents
腎障害のための薬草抽出物 Download PDFInfo
- Publication number
- JP5117183B2 JP5117183B2 JP2007506899A JP2007506899A JP5117183B2 JP 5117183 B2 JP5117183 B2 JP 5117183B2 JP 2007506899 A JP2007506899 A JP 2007506899A JP 2007506899 A JP2007506899 A JP 2007506899A JP 5117183 B2 JP5117183 B2 JP 5117183B2
- Authority
- JP
- Japan
- Prior art keywords
- tinospora cordifolia
- extract
- pharmaceutical composition
- patients
- nephrotic syndrome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Description
Tinospora cordifolia extract抽出物は、Kisalaya Herbals Limited、インド国インドールから入手した。抽出物は褐色であり、苦い味のする易流動性の細粉であった。かさ密度(軽く叩いて)、pH、アルコール可溶性抽出画分、水溶性抽出画分などの分析試験による抽出物の特徴付けを行った。得られた結果は、バルク密度(軽く叩いて):0.55〜0.65/ml、pH(水中1%w/v):5〜6.8、アルコール可溶性抽出画分:乾燥物で8〜15%w/w、および水溶性抽出画分:乾燥物で95%w/w以上であった。
標準化されたTinospora cordifolia抽出物をコロイド二酸化ケイ素およびステアリン酸マグネシウムと合わせて、以下の表2に示す量で組成物を生成した。次いで、この組成物をカプセルの形にした。
再発性尿路感染の患者に実施例2のTinospora cordifolia組成物を経口投与した。患者を2群に分けた。I群は、十分な抗菌療法にもかかわらず3カ月間にわたり再発性感染に罹患し続け、解剖学的または生理学的[たとえば、妊娠に関連した]異常などの根底にある原因が見られなかった若い男女の患者からなるものであった。II群は、閉塞のような治療できる原因または根底にある泌尿生殖器結核が治されて久しいにもかかわらず、慢性再発性尿路感染が3カ月より長く、かつ最高で18カ月続いていた中高年の集団の患者からなるものであった。
原発性ネフローゼ症候群の患者において、Tinospora cordifoliaの有効性を無作為化二重盲検偽薬対照並行群間試験で評価した。患者を、5才〜60才の年齢集団20人からなる2群に分けた。第一群の患者にはプレドニソロンやメチルプレドニソロンなどのステロイドと偽薬を与えたのに対し、第二群の患者は前記のステロイドとTinospora cordifoliaで治療した。実施例2のTinospora cordifolia組成物は、ステロイドに対するアジュバント療法として、体重1kgあたり25〜35mgの投与量を数回に分け12カ月間経口投与した。
膜性増殖性糸球体腎炎/メサンギウム毛細管性糸球体腎炎(MPGN)、巣状分節性糸球体硬化症(FSGS)、巣状増殖性糸球体腎炎(FPGN)、および微小変化ネフローゼ症候群(MCNS)によって引き起こされた原発性ネフローゼ症候群の患者において、Tinospora cordifoliaの有効性を無作為化偽薬対照並行群間試験で評価した。
Claims (4)
- 合併症のある、および合併症のない慢性再発性尿路感染の治療用医薬組成物であって、標準化されたTinospora cordifolia抽出物(standardized extract of Tinospora cordifolia)を免疫アジュバントとして含み、該医薬組成物が、1日あたり20から80mg/kg体重の用量で、抗菌剤とともに20日から3ヶ月の期間にわたって投与される、医薬組成物。
- 慢性再発性尿路感染が、再発する細菌感染を原因とするものである、請求項1に記載の医薬組成物。
- 標準化されたTinospora cordifolia抽出物を含む該医薬組成物が1ヶ月の期間にわたって20−25mg/kg体重の用量で投与される、請求項1または請求項2に記載の医薬組成物。
- 該抗菌剤が、シプロフロキサシン、オフロキサシン、ノルフロキサシン、トリメトプリム−スルファメトキサゾール、アモキシシリン、ニトロフラントイン、アンピシリン、およびロメフロキサシンから選択される、請求項1−3のいずれかに記載の医薬組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56133504P | 2004-04-09 | 2004-04-09 | |
US60/561,335 | 2004-04-09 | ||
PCT/IB2005/051103 WO2005097149A2 (en) | 2004-04-09 | 2005-04-04 | Herbal extract for renal disorders |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2007532527A JP2007532527A (ja) | 2007-11-15 |
JP2007532527A5 JP2007532527A5 (ja) | 2008-05-15 |
JP5117183B2 true JP5117183B2 (ja) | 2013-01-09 |
Family
ID=35125612
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007506899A Expired - Fee Related JP5117183B2 (ja) | 2004-04-09 | 2005-04-04 | 腎障害のための薬草抽出物 |
Country Status (9)
Country | Link |
---|---|
US (1) | US7914824B2 (ja) |
EP (1) | EP1732579B1 (ja) |
JP (1) | JP5117183B2 (ja) |
CN (1) | CN1921874B (ja) |
AU (1) | AU2005230727B2 (ja) |
CA (1) | CA2555356C (ja) |
ES (1) | ES2431522T3 (ja) |
HK (1) | HK1092387A1 (ja) |
WO (1) | WO2005097149A2 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA013243B1 (ru) * | 2006-02-16 | 2010-04-30 | Проумед Экспортс Прайвит Лимитед | Способ приготовления композиции из лекарственных трав с маскированным горьким вкусом и композиция, полученная по этому способу |
JP2013043861A (ja) * | 2011-08-24 | 2013-03-04 | Japan Enviro Chemicals Ltd | 尿臭抑制剤 |
WO2018198134A2 (en) * | 2017-04-24 | 2018-11-01 | Muniyal Ayurvedic Research Centre | Herbo-mineral formulation for prevention, treatment and management of renal disorders and method of preparation thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6746990A (en) | 1989-12-19 | 1991-07-18 | Christian Kruger | Use of parts of the natural plant tinospora |
US6075024A (en) * | 1991-11-27 | 2000-06-13 | Sepracor Inc. | Methods for treating infection using optically pure (S)-lomefloxacin |
US5486160A (en) * | 1994-05-04 | 1996-01-23 | Physion S.R.L. | Device and method for the combined electropharmacological treatment of the bladder and the prostatic urethra |
US5529778A (en) * | 1994-09-13 | 1996-06-25 | Rohatgi; Surendra | Ayurvedic composition for the prophylaxis and treatment of AIDS, flu, TB and other immuno-deficiencies and the process for preparing the same |
US6136316A (en) * | 1996-04-17 | 2000-10-24 | Dabur Research Foundation | Hepatoprotective compositions and composition for treatment of conditions related to hepatitis B and E infection |
US5886029A (en) * | 1997-09-05 | 1999-03-23 | Dhaliwal; Kirpal S. | Method and composition for treatment of diabetes |
IN183805B (ja) | 1998-01-29 | 2000-04-22 | Bhabha Atomic Res Ct | |
IN191359B (ja) * | 1999-04-20 | 2003-11-29 | Nat Inst Immunology | |
US6428785B1 (en) * | 1999-10-28 | 2002-08-06 | Immunolytics Inc. | Method and composition for treating prostate cancer |
WO2002053166A1 (en) | 2000-12-28 | 2002-07-11 | Wockhardt Limited | Use of tinospora extract in the treatment of immune system-modulated disorders |
GB0116942D0 (en) * | 2001-07-11 | 2001-09-05 | Sahajanand Biotech Private Ltd | Herbal formulation |
-
2005
- 2005-04-04 CA CA2555356A patent/CA2555356C/en active Active
- 2005-04-04 EP EP05718625.6A patent/EP1732579B1/en active Active
- 2005-04-04 AU AU2005230727A patent/AU2005230727B2/en not_active Ceased
- 2005-04-04 JP JP2007506899A patent/JP5117183B2/ja not_active Expired - Fee Related
- 2005-04-04 WO PCT/IB2005/051103 patent/WO2005097149A2/en active Application Filing
- 2005-04-04 CN CN2005800051905A patent/CN1921874B/zh not_active Expired - Fee Related
- 2005-04-04 ES ES05718625T patent/ES2431522T3/es active Active
- 2005-04-04 US US10/591,023 patent/US7914824B2/en active Active
-
2006
- 2006-12-22 HK HK06114084.2A patent/HK1092387A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AU2005230727B2 (en) | 2011-05-12 |
CA2555356A1 (en) | 2005-10-20 |
WO2005097149A3 (en) | 2006-05-18 |
EP1732579A2 (en) | 2006-12-20 |
CN1921874A (zh) | 2007-02-28 |
ES2431522T3 (es) | 2013-11-26 |
US20080274212A1 (en) | 2008-11-06 |
JP2007532527A (ja) | 2007-11-15 |
EP1732579A4 (en) | 2009-09-16 |
US7914824B2 (en) | 2011-03-29 |
WO2005097149A2 (en) | 2005-10-20 |
CN1921874B (zh) | 2012-08-08 |
HK1092387A1 (en) | 2007-02-09 |
EP1732579B1 (en) | 2013-07-17 |
AU2005230727A1 (en) | 2005-10-20 |
CA2555356C (en) | 2015-06-16 |
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