JP5116207B2 - 神経保護、抗うつおよび抗虚血活性を有する新規アダマンタン誘導体、およびその製造法 - Google Patents

神経保護、抗うつおよび抗虚血活性を有する新規アダマンタン誘導体、およびその製造法 Download PDF

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JP5116207B2
JP5116207B2 JP2004254373A JP2004254373A JP5116207B2 JP 5116207 B2 JP5116207 B2 JP 5116207B2 JP 2004254373 A JP2004254373 A JP 2004254373A JP 2004254373 A JP2004254373 A JP 2004254373A JP 5116207 B2 JP5116207 B2 JP 5116207B2
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JP2005075832A (ja
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フランチェスコ・マコヴェク
ロベルト・アルトゥシ
シモーナ・ツァンツォーラ
ルーチョ・クラウディオ・ロヴァティ
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Rottapharm SpA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/30—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to nitro or nitroso groups
    • C07C279/32—N-nitroguanidines
    • C07C279/36—Substituted N-nitroguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2004254373A 2003-09-02 2004-09-01 神経保護、抗うつおよび抗虚血活性を有する新規アダマンタン誘導体、およびその製造法 Expired - Fee Related JP5116207B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000668A ITTO20030668A1 (it) 2003-09-02 2003-09-02 Derivati dell'adamantano dotati di attivita' neuroprotettiva, antidepressiva e anti-ischemica e procedimento per la loro preparazione.
ITTO2003A000668 2003-09-02

Publications (2)

Publication Number Publication Date
JP2005075832A JP2005075832A (ja) 2005-03-24
JP5116207B2 true JP5116207B2 (ja) 2013-01-09

Family

ID=34131246

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004254373A Expired - Fee Related JP5116207B2 (ja) 2003-09-02 2004-09-01 神経保護、抗うつおよび抗虚血活性を有する新規アダマンタン誘導体、およびその製造法

Country Status (9)

Country Link
US (1) US7145037B2 (fr)
EP (1) EP1512679B1 (fr)
JP (1) JP5116207B2 (fr)
AT (1) ATE517079T1 (fr)
AU (1) AU2004206990A1 (fr)
CA (1) CA2479613A1 (fr)
ES (1) ES2369888T3 (fr)
IT (1) ITTO20030668A1 (fr)
PT (1) PT1512679E (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7982070B2 (en) 2006-03-21 2011-07-19 Wisconsin Alumni Research Foundation Ionizable isotopic labeling reagents for relative quantification by mass spectrometry
US7977511B2 (en) * 2006-04-07 2011-07-12 Ssv Therapeutics, Inc. Carnitine conjugates of adamantanamines and neramexane derivatives as dual prodrugs for various uses
WO2008103421A1 (fr) * 2007-02-21 2008-08-28 Ssv Therapeutics, Inc. Adamantanamines et sels de néramexane d'acides thiomolybdiques et thiotungsténiques
DE102007022007A1 (de) * 2007-05-08 2008-11-13 Schebo Biotech Ag Neuartike Pharmazeutika, Verfahren zu ihrer Herstellung und ihre Verwendung in der Prophylaxe und Therapie von ZNS-Erkrankungen und Diabetes
WO2010019712A1 (fr) * 2008-08-12 2010-02-18 The Trustees Of The University Of Pennsylvania Modulation du virus de la grippe
US8557836B2 (en) * 2008-09-16 2013-10-15 The Trustees Of The University Of Pennsylvania Spiro-piperidine inhibitors
US8592216B2 (en) 2009-04-15 2013-11-26 Wisconsin Alumni Research Foundation Labeling peptides with tertiary amines and other basic functional groups for improved mass spectrometric analysis
US9301950B2 (en) * 2009-08-21 2016-04-05 The Trustees Of The University Of Pennsylvania Adamantane analogs
US20110065762A1 (en) * 2009-09-11 2011-03-17 Jizhou Wang Methods of use of antiviral compounds
US8440720B2 (en) * 2009-09-11 2013-05-14 Influmedix, Inc. Methods of use of antiviral compounds
JP5562716B2 (ja) * 2010-05-12 2014-07-30 花王株式会社 電位依存性カチオンチャネル抑制剤
US9884832B2 (en) 2011-12-06 2018-02-06 The Trustees Of The University Of Pennsylvania Inhibitors targeting drug-resistant influenza A
EP3713558A4 (fr) * 2017-11-22 2021-10-13 Panorama Research Inc. Composés de nitrate d'aminoadamantyle et leur utilisation pour traiter des troubles du système nerveux central

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US28836A (en) * 1860-06-26 Improvement in plows
GB1274652A (en) 1968-08-27 1972-05-17 Lilly Industries Ltd Adamantanyl-alkylamine derivatives and their preparation
US4007181A (en) * 1974-02-11 1977-02-08 The Upjohn Company Adamantyl containing guanidines
ATE94384T1 (de) 1989-04-14 1993-10-15 Merz & Co Gmbh & Co Verwendung von adamantan-derivaten zur praevention und behandlung der cerebralen ischaemie.
EP0532642A1 (fr) 1990-05-25 1993-03-24 STATE OF OREGON, acting through OREGON STATE BOARD OF HIGHER EDUCATION, acting for OREGON HEALTH SC. UNIV. AND UNIV. OF OREGON Guanidines substituees ayant un coefficient de liaison eleve avec le recepteur sigma et utilisation de ces substances
DK1032556T3 (da) 1997-10-21 2008-03-25 Wyeth Corp Farmaceutisk aktive forbindelser og anvendelsesfremgangsmåder
GB9726388D0 (en) * 1997-12-12 1998-02-11 Cerebrus Ltd Chemical compounds
GB9802225D0 (en) * 1998-02-02 1998-04-01 Cerebrus Ltd Chemical compounds
GB9803536D0 (en) 1998-02-19 1998-04-15 Black James Foundation Histamine H,receptor ligands
US6645968B2 (en) 1999-08-03 2003-11-11 Abbott Laboratories Potassium channel openers
ITTO20010110A1 (it) * 2001-02-08 2002-08-08 Rotta Research Lab Nuovi derivati benzamidinici dotati di attivita' anti-infiammatoria ed immunosoppressiva.
WO2003024401A2 (fr) 2001-09-18 2003-03-27 Bristol-Myers Squibb Company Piperazinones de modulation de l'activite des recepteurs des chimiokines

Also Published As

Publication number Publication date
ITTO20030668A1 (it) 2005-03-03
AU2004206990A1 (en) 2005-03-17
EP1512679B1 (fr) 2011-07-20
ES2369888T3 (es) 2011-12-07
EP1512679A1 (fr) 2005-03-09
US20050049312A1 (en) 2005-03-03
CA2479613A1 (fr) 2005-03-02
US7145037B2 (en) 2006-12-05
PT1512679E (pt) 2011-08-03
JP2005075832A (ja) 2005-03-24
ATE517079T1 (de) 2011-08-15

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