JP5080988B2 - 線維性疾患のためのモデルとしての遺伝子導入動物 - Google Patents

線維性疾患のためのモデルとしての遺伝子導入動物 Download PDF

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JP5080988B2
JP5080988B2 JP2007556601A JP2007556601A JP5080988B2 JP 5080988 B2 JP5080988 B2 JP 5080988B2 JP 2007556601 A JP2007556601 A JP 2007556601A JP 2007556601 A JP2007556601 A JP 2007556601A JP 5080988 B2 JP5080988 B2 JP 5080988B2
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fra
fibrotic
mice
cells
pulmonary fibrosis
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JP2008531004A5 (https=
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エルヴィン ヴァグナー
ロベルト エフェル
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ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A01K67/027—New or modified breeds of vertebrates
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/02—Cells from transgenic animals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Environmental Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
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  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Husbandry (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2007556601A 2005-02-22 2006-02-22 線維性疾患のためのモデルとしての遺伝子導入動物 Expired - Lifetime JP5080988B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05003759.7 2005-02-22
EP05003759A EP1692935A1 (en) 2005-02-22 2005-02-22 Transgenic animal as a model for human pulmonary disease
PCT/EP2006/060183 WO2006089910A1 (en) 2005-02-22 2006-02-22 Transgenic animal as a model for fibrotic diseases

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JP2012096064A Division JP5642729B2 (ja) 2005-02-22 2012-04-03 線維性疾患のためのモデルとしての遺伝子導入動物

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JP2008531004A JP2008531004A (ja) 2008-08-14
JP2008531004A5 JP2008531004A5 (https=) 2012-06-07
JP5080988B2 true JP5080988B2 (ja) 2012-11-21

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JP2007556601A Expired - Lifetime JP5080988B2 (ja) 2005-02-22 2006-02-22 線維性疾患のためのモデルとしての遺伝子導入動物
JP2012096064A Expired - Lifetime JP5642729B2 (ja) 2005-02-22 2012-04-03 線維性疾患のためのモデルとしての遺伝子導入動物

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US (1) US7807864B2 (https=)
EP (2) EP1692935A1 (https=)
JP (2) JP5080988B2 (https=)
CA (1) CA2598859C (https=)
DK (1) DK1855524T3 (https=)
ES (1) ES2391467T3 (https=)
WO (1) WO2006089910A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012143248A (ja) * 2005-02-22 2012-08-02 Boehringer Ingelheim Internatl Gmbh 線維性疾患のためのモデルとしての遺伝子導入動物

Families Citing this family (10)

* Cited by examiner, † Cited by third party
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EP1482310A1 (en) * 2003-05-30 2004-12-01 Bayer HealthCare AG Relaxin as an independent risk factor predicting mortality
ES2338971B1 (es) * 2008-09-08 2011-03-11 Fundacion Centro Nacional De Investigaciones Oncologicas Carlos Iii Modelo animal para el estudio de la angiogenesis y linfoangiogenesis in vivo.
US20120240246A1 (en) * 2009-11-17 2012-09-20 St. Jude Children's Research Hospital Variant Calpastatins and Variant Calpains for Modulating the Activity or Stability of Calpain
KR101547283B1 (ko) 2013-08-28 2015-08-25 한국화학연구원 호흡기 염증 동물모델 및 이의 용도
KR101759346B1 (ko) 2016-08-30 2017-07-19 한국화학연구원 폐 섬유증 동물모델 및 이의 용도
CN111154802B (zh) * 2018-11-08 2023-05-02 中国科学院分子细胞科学卓越创新中心 Ecm1基因敲除小鼠在抗肝纤维化药物筛选中的应用
CN110604098B (zh) * 2019-09-23 2021-09-07 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） 一种类风湿关节炎合并间质性肺病动物模型的构建方法
CN113234136A (zh) * 2020-01-23 2021-08-10 上海循曜生物科技有限公司 一种治疗纤维化性疾病的相关靶点及其应用
EP4357458A1 (en) 2022-10-19 2024-04-24 Universitätsmedizin der Johannes Gutenberg-Universität Mainz Inhibitors for fra-1 and fra-2 for use in the treatment of organ or tissue fibrosis
CN117981712B (zh) * 2023-07-24 2025-02-28 南京鼓楼医院 一种腺病毒诱导肺纤维化急性加重动物模型的建立方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1140969T3 (da) * 1998-12-14 2007-09-17 Univ Miami Bindevævsvækstfaktorfragmenter og fremgangsmåder og anvendelser deraf
EP1692935A1 (en) * 2005-02-22 2006-08-23 Boehringer Ingelheim International GmbH Transgenic animal as a model for human pulmonary disease

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012143248A (ja) * 2005-02-22 2012-08-02 Boehringer Ingelheim Internatl Gmbh 線維性疾患のためのモデルとしての遺伝子導入動物

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Publication number Publication date
EP1855524A1 (en) 2007-11-21
JP5642729B2 (ja) 2014-12-17
JP2008531004A (ja) 2008-08-14
EP1855524B1 (en) 2012-08-01
US20060195916A1 (en) 2006-08-31
WO2006089910A1 (en) 2006-08-31
US7807864B2 (en) 2010-10-05
DK1855524T3 (da) 2012-10-22
EP1692935A1 (en) 2006-08-23
JP2012143248A (ja) 2012-08-02
CA2598859C (en) 2013-10-01
CA2598859A1 (en) 2006-08-31
ES2391467T3 (es) 2012-11-27

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