DK1855524T3 - Transgent dyr som en model for fibrotiske sygdomme - Google Patents
Transgent dyr som en model for fibrotiske sygdommeInfo
- Publication number
- DK1855524T3 DK1855524T3 DK06708450.9T DK06708450T DK1855524T3 DK 1855524 T3 DK1855524 T3 DK 1855524T3 DK 06708450 T DK06708450 T DK 06708450T DK 1855524 T3 DK1855524 T3 DK 1855524T3
- Authority
- DK
- Denmark
- Prior art keywords
- model
- transgenic animals
- fibrotic diseases
- fibrotic
- diseases
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000003176 fibrotic effect Effects 0.000 title 1
- 230000009261 transgenic effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/02—Cells from transgenic animals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Biodiversity & Conservation Biology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Animal Husbandry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05003759A EP1692935A1 (en) | 2005-02-22 | 2005-02-22 | Transgenic animal as a model for human pulmonary disease |
PCT/EP2006/060183 WO2006089910A1 (en) | 2005-02-22 | 2006-02-22 | Transgenic animal as a model for fibrotic diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1855524T3 true DK1855524T3 (da) | 2012-10-22 |
Family
ID=34933872
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK06708450.9T DK1855524T3 (da) | 2005-02-22 | 2006-02-22 | Transgent dyr som en model for fibrotiske sygdomme |
Country Status (7)
Country | Link |
---|---|
US (1) | US7807864B2 (da) |
EP (2) | EP1692935A1 (da) |
JP (2) | JP5080988B2 (da) |
CA (1) | CA2598859C (da) |
DK (1) | DK1855524T3 (da) |
ES (1) | ES2391467T3 (da) |
WO (1) | WO2006089910A1 (da) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1482310A1 (en) * | 2003-05-30 | 2004-12-01 | Bayer HealthCare AG | Relaxin as an independent risk factor predicting mortality |
EP1692935A1 (en) * | 2005-02-22 | 2006-08-23 | Boehringer Ingelheim International GmbH | Transgenic animal as a model for human pulmonary disease |
ES2338971B1 (es) * | 2008-09-08 | 2011-03-11 | Fundacion Centro Nacional De Investigaciones Oncologicas Carlos Iii | Modelo animal para el estudio de la angiogenesis y linfoangiogenesis in vivo. |
US20120240246A1 (en) * | 2009-11-17 | 2012-09-20 | St. Jude Children's Research Hospital | Variant Calpastatins and Variant Calpains for Modulating the Activity or Stability of Calpain |
KR101547283B1 (ko) | 2013-08-28 | 2015-08-25 | 한국화학연구원 | 호흡기 염증 동물모델 및 이의 용도 |
KR101759346B1 (ko) | 2016-08-30 | 2017-07-19 | 한국화학연구원 | 폐 섬유증 동물모델 및 이의 용도 |
CN110604098B (zh) * | 2019-09-23 | 2021-09-07 | 广东省中医院(广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院) | 一种类风湿关节炎合并间质性肺病动物模型的构建方法 |
EP4357458A1 (en) | 2022-10-19 | 2024-04-24 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz | Inhibitors for fra-1 and fra-2 for use in the treatment of organ or tissue fibrosis |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU773278B2 (en) * | 1998-12-14 | 2004-05-20 | University Of Miami | Connective tissue growth factor fragments and methods and uses thereof |
EP1692935A1 (en) * | 2005-02-22 | 2006-08-23 | Boehringer Ingelheim International GmbH | Transgenic animal as a model for human pulmonary disease |
-
2005
- 2005-02-22 EP EP05003759A patent/EP1692935A1/en not_active Withdrawn
-
2006
- 2006-02-21 US US11/276,249 patent/US7807864B2/en active Active
- 2006-02-22 JP JP2007556601A patent/JP5080988B2/ja active Active
- 2006-02-22 WO PCT/EP2006/060183 patent/WO2006089910A1/en active Application Filing
- 2006-02-22 EP EP06708450A patent/EP1855524B1/en active Active
- 2006-02-22 CA CA2598859A patent/CA2598859C/en not_active Expired - Fee Related
- 2006-02-22 ES ES06708450T patent/ES2391467T3/es active Active
- 2006-02-22 DK DK06708450.9T patent/DK1855524T3/da active
-
2012
- 2012-04-03 JP JP2012096064A patent/JP5642729B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
EP1855524B1 (en) | 2012-08-01 |
WO2006089910A1 (en) | 2006-08-31 |
ES2391467T3 (es) | 2012-11-27 |
CA2598859C (en) | 2013-10-01 |
EP1855524A1 (en) | 2007-11-21 |
CA2598859A1 (en) | 2006-08-31 |
JP2008531004A (ja) | 2008-08-14 |
US7807864B2 (en) | 2010-10-05 |
JP2012143248A (ja) | 2012-08-02 |
EP1692935A1 (en) | 2006-08-23 |
US20060195916A1 (en) | 2006-08-31 |
JP5642729B2 (ja) | 2014-12-17 |
JP5080988B2 (ja) | 2012-11-21 |
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