CA2598859C - Transgenic animal as a model for fibrotic diseases - Google Patents
Transgenic animal as a model for fibrotic diseases Download PDFInfo
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- CA2598859C CA2598859C CA2598859A CA2598859A CA2598859C CA 2598859 C CA2598859 C CA 2598859C CA 2598859 A CA2598859 A CA 2598859A CA 2598859 A CA2598859 A CA 2598859A CA 2598859 C CA2598859 C CA 2598859C
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
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- A01K2227/105—Murine
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/02—Cells from transgenic animals
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05003759.7 | 2005-02-22 | ||
| EP05003759A EP1692935A1 (en) | 2005-02-22 | 2005-02-22 | Transgenic animal as a model for human pulmonary disease |
| PCT/EP2006/060183 WO2006089910A1 (en) | 2005-02-22 | 2006-02-22 | Transgenic animal as a model for fibrotic diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2598859A1 CA2598859A1 (en) | 2006-08-31 |
| CA2598859C true CA2598859C (en) | 2013-10-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2598859A Expired - Fee Related CA2598859C (en) | 2005-02-22 | 2006-02-22 | Transgenic animal as a model for fibrotic diseases |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7807864B2 (https=) |
| EP (2) | EP1692935A1 (https=) |
| JP (2) | JP5080988B2 (https=) |
| CA (1) | CA2598859C (https=) |
| DK (1) | DK1855524T3 (https=) |
| ES (1) | ES2391467T3 (https=) |
| WO (1) | WO2006089910A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1482310A1 (en) * | 2003-05-30 | 2004-12-01 | Bayer HealthCare AG | Relaxin as an independent risk factor predicting mortality |
| EP1692935A1 (en) * | 2005-02-22 | 2006-08-23 | Boehringer Ingelheim International GmbH | Transgenic animal as a model for human pulmonary disease |
| ES2338971B1 (es) * | 2008-09-08 | 2011-03-11 | Fundacion Centro Nacional De Investigaciones Oncologicas Carlos Iii | Modelo animal para el estudio de la angiogenesis y linfoangiogenesis in vivo. |
| US20120240246A1 (en) * | 2009-11-17 | 2012-09-20 | St. Jude Children's Research Hospital | Variant Calpastatins and Variant Calpains for Modulating the Activity or Stability of Calpain |
| KR101547283B1 (ko) | 2013-08-28 | 2015-08-25 | 한국화학연구원 | 호흡기 염증 동물모델 및 이의 용도 |
| KR101759346B1 (ko) | 2016-08-30 | 2017-07-19 | 한국화학연구원 | 폐 섬유증 동물모델 및 이의 용도 |
| CN111154802B (zh) * | 2018-11-08 | 2023-05-02 | 中国科学院分子细胞科学卓越创新中心 | Ecm1基因敲除小鼠在抗肝纤维化药物筛选中的应用 |
| CN110604098B (zh) * | 2019-09-23 | 2021-09-07 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | 一种类风湿关节炎合并间质性肺病动物模型的构建方法 |
| CN113234136A (zh) * | 2020-01-23 | 2021-08-10 | 上海循曜生物科技有限公司 | 一种治疗纤维化性疾病的相关靶点及其应用 |
| EP4357458A1 (en) | 2022-10-19 | 2024-04-24 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz | Inhibitors for fra-1 and fra-2 for use in the treatment of organ or tissue fibrosis |
| CN117981712B (zh) * | 2023-07-24 | 2025-02-28 | 南京鼓楼医院 | 一种腺病毒诱导肺纤维化急性加重动物模型的建立方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1140969T3 (da) * | 1998-12-14 | 2007-09-17 | Univ Miami | Bindevævsvækstfaktorfragmenter og fremgangsmåder og anvendelser deraf |
| EP1692935A1 (en) * | 2005-02-22 | 2006-08-23 | Boehringer Ingelheim International GmbH | Transgenic animal as a model for human pulmonary disease |
-
2005
- 2005-02-22 EP EP05003759A patent/EP1692935A1/en not_active Withdrawn
-
2006
- 2006-02-21 US US11/276,249 patent/US7807864B2/en not_active Expired - Lifetime
- 2006-02-22 EP EP06708450A patent/EP1855524B1/en not_active Expired - Lifetime
- 2006-02-22 DK DK06708450.9T patent/DK1855524T3/da active
- 2006-02-22 ES ES06708450T patent/ES2391467T3/es not_active Expired - Lifetime
- 2006-02-22 JP JP2007556601A patent/JP5080988B2/ja not_active Expired - Lifetime
- 2006-02-22 CA CA2598859A patent/CA2598859C/en not_active Expired - Fee Related
- 2006-02-22 WO PCT/EP2006/060183 patent/WO2006089910A1/en not_active Ceased
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2012
- 2012-04-03 JP JP2012096064A patent/JP5642729B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1855524A1 (en) | 2007-11-21 |
| JP5642729B2 (ja) | 2014-12-17 |
| JP2008531004A (ja) | 2008-08-14 |
| EP1855524B1 (en) | 2012-08-01 |
| US20060195916A1 (en) | 2006-08-31 |
| WO2006089910A1 (en) | 2006-08-31 |
| US7807864B2 (en) | 2010-10-05 |
| DK1855524T3 (da) | 2012-10-22 |
| EP1692935A1 (en) | 2006-08-23 |
| JP2012143248A (ja) | 2012-08-02 |
| CA2598859A1 (en) | 2006-08-31 |
| JP5080988B2 (ja) | 2012-11-21 |
| ES2391467T3 (es) | 2012-11-27 |
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