JP5069415B2 - 結晶形態のイミダゾール誘導体 - Google Patents

結晶形態のイミダゾール誘導体 Download PDF

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JP5069415B2
JP5069415B2 JP2006065731A JP2006065731A JP5069415B2 JP 5069415 B2 JP5069415 B2 JP 5069415B2 JP 2006065731 A JP2006065731 A JP 2006065731A JP 2006065731 A JP2006065731 A JP 2006065731A JP 5069415 B2 JP5069415 B2 JP 5069415B2
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ethyl
dimethyl
phenyl
amino
imidazo
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JP2006249089A5 (enExample
JP2006249089A (ja
Inventor
直昭 春田
朋希 加藤
ジェーン リー チエン
豊治 沼田
ビンセント トラスク アンドリュー
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Raqualia Pharma Inc
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Raqualia Pharma Inc
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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JP2006065731A 2005-03-11 2006-03-10 結晶形態のイミダゾール誘導体 Expired - Lifetime JP5069415B2 (ja)

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US66059205P 2005-03-11 2005-03-11
US60/660,592 2005-03-11

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JP2006249089A JP2006249089A (ja) 2006-09-21
JP2006249089A5 JP2006249089A5 (enExample) 2009-04-16
JP5069415B2 true JP5069415B2 (ja) 2012-11-07

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MX2011003166A (es) 2008-09-25 2011-04-27 Merck Frosst Canada Ltd Derivados de sulfonilurea beta-carbolina como antagonistas del receptor ep4.
CA2754702C (en) * 2009-04-22 2016-06-07 Yukinori Take Selective ep4 antagonistic substance for treatment of cancer
CA2789665C (en) * 2010-02-22 2020-06-16 Askat Inc. Use of ep4 receptor antagonists in the treatment of il-23 mediated diseases
RU2451680C1 (ru) 2011-02-21 2012-05-27 Общество С Ограниченной Ответственностью "Научно-Исследовательская Компания "Медбиофарм" Клатратный комплекс циклодекстрина или арабиногалактана с 9-фенил-симм-октагидроселеноксантеном, способ его получения (варианты), фармацевтическая композиция и лекарственное средство
RU2464042C1 (ru) * 2011-03-31 2012-10-20 Общество С Ограниченной Ответственностью "Научно-Исследовательская Компания "Медбиофарм" КЛАТРАТНЫЙ КОМПЛЕКС β-ЦИКЛОДЕКСТРИНА С ПРОИЗВОДНЫМ 5-ГИДРОКСИ-4-АМИНОМЕТИЛ-1-ЦИКЛОГЕКСИЛ(ИЛИ ЦИКЛОГЕПТИЛ)-3-АЛКОКСИКАРБОНИЛИНДОЛА, СПОСОБ ЕГО ПОЛУЧЕНИЯ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И ЛЕКАРСТВЕННОЕ СРЕДСТВО
US10391086B2 (en) 2013-03-19 2019-08-27 Askat Inc. Use of EP4 receptor antagonists in the treatment of cartilage disease
KR20150130404A (ko) * 2013-03-19 2015-11-23 에스크엣 인크. 연골질환 치료에서의 ep4 수용체 길항제의 용도
US12109218B2 (en) 2014-12-09 2024-10-08 Aratana Therapeutics, Inc. Compositions of grapiprant and methods for using the same
TWI664969B (zh) 2014-03-06 2019-07-11 雅瑞塔那醫療公司 格拉匹綸(ｇｒａｐｉｐｒａｎｔ)組合物及其使用方法
CA2997692A1 (en) * 2014-03-06 2015-09-11 Aratana Therapeutics, Inc. Crystalline forms of grapiprant
US10342785B2 (en) 2016-11-04 2019-07-09 Askat Inc. Use of EP4 receptor antagonists for the treatment of NASH-associated liver cancer
CN112292128A (zh) 2018-04-16 2021-01-29 阿瑞斯医疗有限公司 Ep4抑制剂和其用途
WO2019245590A1 (en) 2018-06-18 2019-12-26 Avista Pharma Solutions, Inc. Chemical compounds
US20210315909A1 (en) * 2018-07-11 2021-10-14 Arrys Therapeutics, Inc. Polymorphic compounds and uses thereof
IL280051B2 (en) * 2018-07-11 2024-03-01 Arrys Therapeutics Inc EP4 inhibitors and their synthesis
CA3128024A1 (en) 2019-01-30 2020-08-06 Avista Pharma Solutions, Inc. Chemical compounds
US11512088B2 (en) 2019-01-30 2022-11-29 Avista Pharma Solutions, Inc. Synthetic process and intermediates
US11254675B2 (en) 2019-08-12 2022-02-22 Cadila Healthcare Limited Process for preparation of grapiprant
WO2021226162A1 (en) 2020-05-05 2021-11-11 Arrys Therapeutics, Inc. Ep4 antagonists and their use in the treatment of proliferative diseases
CA3223173A1 (en) * 2021-07-30 2023-02-02 Raqualia Pharma Inc. Crystalline forms
CN116478155B (zh) * 2022-01-17 2025-06-13 洛阳惠中兽药有限公司 一种格拉匹伦及其中间体的制备方法
CN117800905A (zh) * 2022-09-26 2024-04-02 洛阳惠中兽药有限公司 4-(2,6-二甲基-3-硝基吡啶-4-基氨基)苯乙基氨基甲酸苄基酯的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL110296A (en) * 1993-07-16 1999-12-31 Smithkline Beecham Corp Imidazole compounds process for their preparation and pharmaceutical compositions containing them
HN2001000224A (es) 2000-10-19 2002-06-13 Pfizer Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti - inflamatorios y analgesicos.
BR0309200A (pt) * 2002-04-12 2005-02-22 Pfizer Uso de ligandos receptores ep4 no tratamento de doenças envolvidas com a il-6

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DE602006014516D1 (enExample) 2010-07-08
CN101137656B (zh) 2010-12-22
PL1861400T3 (pl) 2010-09-30
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CA2600510A1 (en) 2006-09-14
ZA200707568B (en) 2009-09-30
AR055567A1 (es) 2007-08-22
KR20070103484A (ko) 2007-10-23
JP2006249089A (ja) 2006-09-21
TW200643021A (en) 2006-12-16
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ATE469150T1 (de) 2010-06-15
BRPI0608819B8 (pt) 2021-05-25
RU2357968C1 (ru) 2009-06-10
CN101137656A (zh) 2008-03-05
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EP1861400B1 (en) 2010-05-26
US20090018158A1 (en) 2009-01-15
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AU2006221699A1 (en) 2006-09-14
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US7960407B2 (en) 2011-06-14
IL185145A0 (en) 2007-12-03
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