JP5062698B2 - 光学的測定装置、光学的測定方法、及び光学的測定プログラムを格納した記憶媒体 - Google Patents
光学的測定装置、光学的測定方法、及び光学的測定プログラムを格納した記憶媒体 Download PDFInfo
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- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
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- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
- G01N2021/3144—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths for oxymetry
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
- G01N2021/4797—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium time resolved, e.g. analysis of ballistic photons
Description
Yamamoto K, Niwayama M, Shiga T et al: Accurate NIRS measurement of muscle oxygenation by correcting the influence of a subcutaneous fat layer. Proc SPIE, 1998, 3194: 166-173. Niwayama M, Lin L, Shao J et al: Quantitative measurement of muscle hemoglobin oxygenation using near-infrared spectroscopy with correction for the influence of a subcutaneous fat layer. Rev Sci Instrum, 2000, 71: 4571-4575. Kienle A, Patterson MS, Dognitz N et al: Noninvasive determination of the optical properties of two-layered turbid media. Appl Opt, 1998, 37: 779-791. Fabbri F, Sassaroli A, Henry ME et al: Optical measurements of absorption changes in two-layered diffusive media. Phys Med Biol, 2004, 49:1183-1201. Shimada M, Hoshi Y, Yamada Y: Simple algorithm for the measurement of absorption coefficients of a two-layered medium by spatially resolved and time-resolved reflectance. 2005, Appl Opt, 44:7554-63. van der Zee P, Delpy DT: Simulation of the point spread function for light in tissue by a Monte Carlo method. Adv Exp Med Biol, 1987, 215: 179-191. Wan S, Anderson RR, Parrish JA: Analytical modeling for the optical properties of skin with in vitro and in vivo applications. Photochem Photobiol, 1981, 34: 493-499. Mitic G, Kozer J, Otto J et al: Time-gated transillumination of biological tissues and tissuelike phantoms. 1994, Appl Opt, 33: 6699-6710. Zaccanti G, Taddeucci A, Barilli M et al: Optical properties of biological tissues. 1995, Proc. SPIE, 2389: 513-521. Matcher SJ, Elwell CE, Cooper CE et al: Performance Comparison of Several Published Tissue Near-Infrared Spectroscopy Algorithms. Anal Biochem, 1995, 227: 54-68.
本発明の他の態様では、前記受光手段は、前記発光手段から前記第1の所定距離だけ離間した第1の受光部と、前記発光手段から前記第2の所定距離だけ離間した第2の受光部と、で構成される。
次に、ステップ116では、酸素飽和度StO2を次式により求める。
ステップ118では、求めた酸素化ヘモグロビン濃度[HbO2]、脱酸素化ヘモグロビン濃度[Hb]、酸素飽和度StO2を出力部22に出力させる。
12 プローブ
14 駆動装置
16 制御部(空間的傾き算出手段、演算手段)
18 操作部(入力手段)
20 メモリ(記憶手段)
22 出力部
24 LED(発光手段)
26A PD(第1の受光部)
26B PD(第2の受光部)
30 組織
32 LEDドライバ
34 I−Vコンバータ
36 アンプ
Claims (8)
- 少なくとも浅層及び深層を含む複数の層で形成された測定対象の層状形成体に光を照射する発光手段と、
前記発光手段から発光された光のうち前記浅層及び深層を通過した光を受光するように前記発光手段から第1の所定距離だけ離間した位置で受光すると共に、前記発光手段から発光された光のうち前記浅層及び深層を通過した光であって前記第1の所定距離だけ離間した位置で受光した光とは前記深層の通過距離が異なる光を受光するように前記発光手段から第2の所定距離だけ離間した位置で受光する受光手段と、
前記第1の所定距離だけ離間した位置で受光した光及び前記第2の所定距離だけ離間した位置で受光した光の各々の光強度に基づいて空間的傾きSを求める空間的傾き算出手段と、
前記深層における光の吸収度合いを演算するための演算パラメータa,b,cを前記浅層の厚さ毎に記憶した記憶手段と、
前記浅層の厚さを入力する入力手段と、
入力された前記浅層の厚さに応じた前記演算パラメータa,b,cを前記記憶手段から読み出し、当該読み出した演算パラメータa,b,cを含む前記空間的傾きSの二次関数aS 2 +bS+cに基づいて前記深層における光の吸収度合いを求める演算手段と、
を備えた光学的測定装置。 - 前記層状形成体は生体の一部であり、前記浅層は脂肪組織であり、前記深層は筋組織であることを特徴とする請求項1記載の光学的測定装置。
- 前記演算手段は、前記光の吸収度合いに基づいて、酸素化ヘモグロビン濃度、脱酸素化ヘモグロビン濃度、及び酸素飽和度の少なくとも一つをさらに求めることを特徴とする請求項2記載の光学的測定装置。
- 前記受光手段は、前記発光手段から前記第1の所定距離だけ離間した第1の受光部と、前記発光手段から前記第2の所定距離だけ離間した第2の受光部と、で構成されたことを特徴とする請求項1に記載の光学的測定装置。
- 前記受光手段は、前記発光手段から前記第1の所定距離だけ離間した第1の受光部と、前記発光手段から前記第2の所定距離だけ離間した第2の受光部と、で構成されたことを特徴とする請求項2に記載の光学的測定装置。
- 前記受光手段は、前記発光手段から前記第1の所定距離だけ離間した第1の受光部と、前記発光手段から前記第2の所定距離だけ離間した第2の受光部と、で構成されたことを特徴とする請求項3に記載の光学的測定装置。
- 少なくとも浅層及び深層を含む複数の層で形成された測定対象の層状形成体に光を照射し、
照射された光のうち前記浅層及び深層を通過した光を受光するように光の照射位置から第1の所定距離だけ離間した位置で受光すると共に、照射された光のうち前記浅層及び深層を通過した光であって前記第1の所定距離だけ離間した位置で受光した光とは前記深層の通過距離が異なる光を受光するように前記照射位置から第2の所定距離だけ離間した位置で受光し、
前記第1の所定距離だけ離間した位置で受光した光及び前記第2の所定距離だけ離間した位置で受光した光の各々の光強度と、前記第1の所定距離及び前記第2の所定距離と、に基づいて空間的傾きSを求め、
前記浅層の厚さを入力し、
前記深層における光の吸収の度合いを演算するための演算パラメータa,b,cを前記浅層の厚さ毎に記憶した記憶手段から、入力された前記浅層の厚さに応じた前記演算パラメータa,b,cを読み出し、当該読み出した演算パラメータa,b,cを含む前記空間的傾きSの二次関数aS 2 +bS+cに基づいて前記深層における光の吸収の度合いを求めることを含む光学的測定方法。 - 少なくとも浅層及び深層を含む複数の層で形成された測定対象の層状形成体に光を照射させるステップと、
照射された光のうち前記浅層及び深層を通過した光を受光するように光の照射位置から第1の所定距離だけ離間した位置で受光すると共に、照射された光のうち前記浅層及び深層を通過した光であって前記第1の所定距離だけ離間した位置で受光した光とは前記深層の通過距離が異なる光を受光するように前記照射位置から第2の所定距離だけ離間した位置で受光させるステップと、
前記第1の所定距離だけ離間した位置で受光した光及び前記第2の所定距離だけ離間した位置で受光した光の各々の光強度と、前記第1の所定距離及び前記第2の所定距離と、に基づいて空間的傾きSを求めるステップと、
前記浅層の厚さを入力するステップと、
前記深層における光の吸収の度合いを演算するための演算パラメータa,b,cを前記浅層の厚さ毎に記憶した記憶手段から、入力された前記浅層の厚さに応じた前記演算パラメータa,b,cを読み出し、当該読み出した演算パラメータa,b,cを含む前記空間的傾きSの二次関数aS 2 +bS+cに基づいて前記深層における光の吸収の度合いを求めるステップと、
を含む処理をコンピュータに実行させるための光学的測定プログラムを格納した記憶媒体。
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WO2005005970A1 (ja) * | 2003-07-11 | 2005-01-20 | Mitsui Mining & Smelting Co., Ltd. | 軽油の液種識別装置および軽油の液種識別方法 |
WO2005005971A1 (ja) * | 2003-07-11 | 2005-01-20 | Mitsui Mining & Smelting Co., Ltd. | 流量・液種検知装置および流量・液種検知方法、ならびに、液種検知装置および液種検知方法 |
US10390742B2 (en) | 2014-01-29 | 2019-08-27 | Kohken Medical Co., Ltd. | Non-invasive monitor for measuring regional saturation of oxygen |
US11064919B2 (en) | 2014-01-29 | 2021-07-20 | Kohken Medical Co., Ltd. | Non-invasive monitor for measuring regional saturation of oxygen |
WO2022065390A1 (ja) | 2020-09-25 | 2022-03-31 | 国立大学法人静岡大学 | 測定感度算出方法、測定感度算出装置、測定感度算出プログラム、及び光学的測定装置 |
Also Published As
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JPWO2007139192A1 (ja) | 2009-10-15 |
CN101454654A (zh) | 2009-06-10 |
US8369914B2 (en) | 2013-02-05 |
CN101454654B (zh) | 2011-04-06 |
EP2034294A4 (en) | 2009-08-05 |
KR20090011030A (ko) | 2009-01-30 |
WO2007139192A1 (ja) | 2007-12-06 |
EP2034294A1 (en) | 2009-03-11 |
EP2034294B1 (en) | 2011-09-14 |
KR101041727B1 (ko) | 2011-06-14 |
US20090209836A1 (en) | 2009-08-20 |
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