JP5060128B2 - ポリウレタンを基とするポリマーを用いた長期薬物輸送装置の製造 - Google Patents
ポリウレタンを基とするポリマーを用いた長期薬物輸送装置の製造 Download PDFInfo
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Description
この出願の発明に関連する先行技術文献情報としては、以下のものがある(国際出願日以降国際段階で引用された文献及び他国に国内移行した際に引用された文献を含む)。
本発明の目的は、ポリウレタンを基とする長期薬物輸送装置を提供することである。
a)前記容器を完全に囲うポリウレタンを基とするポリマーと、
b)少なくとも1つの活性成分と、任意で
c)少なくとも1つの薬学的に許容な担体と
を有する容器を持つものである。
a)所望の物理的大きさの二つの開口端を有し、熱可塑性ポリウレタンで作られる中空管を生産するための、精密な成形工程又は注入塑造工程と、
b)前記中空管の前記開口端の1つを封印する工程と、
c)活性体と任意で担体を含む所望の製剤を含む容器を詰める工程、又は前もって準備された小丸薬で容器を充填する工程と、
d)前記中空管の第二の開口端を封印する工程と、
e)前記活性体の所望の輸送速度を達成するために、前記薬物輸送装置を予備処理し、起動する工程とから構成される。
a)二つの開口端を有する中空管を、精密な反応で注入塑造する又はスピン鋳造する工程と、
b)前記中空管を硬化する工程と、
c)前記中空管の一つの端部を封印する工程と、
d)活性体と任意で担体を含む所望の製剤を含む容器を詰める工程、又は前もって準備された小丸薬で容器を充填する工程と、
e)前記中空管の第二の端部を封印する工程と、
f)前記活性体の所望の輸送速度を達成するために、前記薬物輸送装置を予備処理し、起動する工程とから構成される。
a)一つの開口端を有する中空管を、精密な反応注入塑造する又はスピン鋳造する工程と、
b)前記中空管を硬化する工程と、
c)活性体と任意で担体を含む所望の製剤を含む容器を詰める工程、又は前もって準備された小丸薬で容器を充填する工程と、
d)前記中空管の前記開口端を封印する工程と、
e)前記活性体の所望の輸送速度を達成するために、前記薬物輸送装置を予備処理し、起動する工程とから構成される。
i)少なくとも1つの活性成分と、任意で
ii)少なくとも1つの薬学的に許容な担体と、
iii)前記容器を完全に囲うポリウレタンを基とするポリマーとから構成される。
a)所望の物理的大きさの二つの開口端を有し、熱可塑性ポリウレタンで作られる中空管を生産するための、精密な成形工程又は注入塑造工程と、
b)前記中空管の前記開口端の一つを封印する工程と、
c)活性体と任意で担体を含む所望の製剤を含む容器を詰める工程、又は前もって準備された小丸薬で容器を充填する工程と、
d)前記中空管の第二の開口端を封印する工程と、
e)前記活性体の所望の輸送速度を達成するために、前記薬物輸送装置を予備処理し、起動する工程とから構成される。
a)二つの開口端を有する中空管を、精密な反応注入塑造する又はスピン鋳造する工程と、
b)前記中空管を硬化する工程と、
c)前記中空管の一つの端部を封印する工程と、
d)活性体と任意で担体を含む所望の製剤を含む容器を詰める工程、又は前もって準備された小丸薬で容器を充填する工程と、
e)前記中空管の第二の端部を封印する工程と、
f)前記活性体の所望の輸送速度を達成するために、前記薬物輸送装置を予備処理し、起動する工程とから構成される。
a)一つの開口端を有する中空管を、精密な反応で注入塑造する又はスピン鋳造する工程と、
b)前記中空管を硬化する工程と、
c)活性体と任意で担体を含む所望の製剤を含む容器を詰める工程、又は前もって準備された小丸薬で容器を充填する工程と、
d)前記中空管の前記開口端を封印する工程と、
e)前記活性体の所望の輸送速度を達成するために、前記薬物輸送装置を予備処理し、起動する工程とから構成される。
起動(primed)される。
Claims (12)
- 1若しくはそれ以上の活性成分を、ポリウレタン系ポリマーからの拡散によってインビトロにおいて実質的にゼロ次放出速度で放出するための移植可能な薬物輸送装置であって、この移植可能な薬物輸送装置は、
シリンダー形状の容器を提供できるように構成されたポリウレタン系ポリマーを有するものであり、前記容器は、1若しくはそれ以上の活性成分を有する有効量の固体製剤が装填された後に封止されるものであり、前記1若しくはそれ以上の活性成分及び前記ポリウレタン系ポリマーは、当該1若しくはそれ以上の活性成分及び当該ポリウレタン系ポリマーの両方が親水性の特性を示すものであるか、又は当該1若しくはそれ以上の活性成分及び当該ポリウレタン系ポリマーの両方が疎水性の特性を示すものである、のいずれかとなるように選択されるものであり、前記親水性の特性は、イオン基、カルボキシル基、エーテル基、水酸基、又はそのいずれか2つ若しくはそれ以上の混合物に由来するものであり、前記疎水性の特性は、アルキル基、シロキサン基、又はそれらの混合物に由来するものである、移植可能な薬物輸送装置。 - 請求項1記載の移植可能な薬物輸送装置において、前記薬物輸送装置は、前記少なくとも1つの活性成分の水溶性の特性に適合するために選択される条件下で予備処理され、且つ起動されるものである、移植可能な薬物輸送装置。
- 請求項1記載の移植可能な薬物輸送装置において、前記1若しくはそれ以上の活性成分及び前記ポリウレタン系ポリマーは、当該1若しくはそれ以上の活性成分及び当該ポリウレタン系ポリマーの両方が親水性の特性を示すものとなるように選択されるものである、移植可能な薬物輸送装置。
- 請求項1記載の移植可能な薬物輸送装置において、前記1若しくはそれ以上の活性成分及び前記ポリウレタン系ポリマーは、当該1若しくはそれ以上の活性成分及び当該ポリウレタン系ポリマーの両方が疎水性の特性を示すものとなるように選択されるものである、移植可能な薬物輸送装置。
- 請求項1記載の移植可能な薬物輸送装置において、前記ポリウレタンは、イオン基、カルボキシル基、エーテル基、水酸基、及びそのいずれか2つ若しくはそれ以上の混合物から成る群から選択される親水性ペンダント基を有するものである、移植可能な薬物輸送装置。
- 請求項1記載の移植可能な薬物輸送装置において、前記ポリウレタン系ポリマーは、熱可塑性ポリウレタン及び熱硬化性ポリウレタンから成る群から選択されるものである、移植可能な薬物輸送装置。
- 請求項6記載の移植可能な薬物輸送装置において、前記熱可塑性ポリウレタンは、マクロダイアル(macrodials)、ジイソシアン酸塩、二官能鎖延長剤、又はそれらの混合物を有するものである、移植可能な薬物輸送装置。
- 請求項6記載の移植可能な薬物輸送装置において、前記熱硬化性ポリウレタンは、多官能基多価アルコール、ジイソシアン酸塩、鎖延長剤、又はそれらの混合物を有するものである、移植可能な薬物輸送装置。
- 請求項8記載の移植可能な薬物輸送装置において、前記熱硬化性ポリウレタンは、高分子鎖と架橋員類とを有するものであり、前記熱硬化性ポリウレタンは、更に、前記高分子鎖における不飽和結合と、架橋員類としての架橋剤、開始剤、又はその両方とを含むものである、移植可能な薬物輸送装置。
- 請求項1記載の移植可能な薬物輸送装置において、この移植可能な薬物輸送装置は、時間、温度、及び媒体から成る群から選択される1若しくはそれ以上のパラメータのもとで予備処理され且つ起動されるものであり、前記媒体は、前記1若しくはそれ以上の活性成分の所望の輸送速度に影響を与えるために選択されるものである、移植可能な薬物輸送装置。
- 請求項1記載の移植可能な薬物輸送装置において、前記固体製剤は、前記ポリウレタン系ポリマーを介した前記1若しくはそれ以上の活性成分のインビトロにおける実質的なゼロ次放出速度に必要ではない1若しくはそれ以上の薬学的に許容可能な担体を含むものである、移植可能な薬物輸送装置。
- 請求項11記載の移植可能な薬物輸送装置において、前記1若しくはそれ以上の薬学的に許容可能な担体は、Fickの拡散法則によって調節される前記1若しくはそれ以上の活性成分のインビトロにおける実質的なゼロ次放出速度に必要ではないものである、移植可能な薬物輸送装置。
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US49413203P | 2003-08-11 | 2003-08-11 | |
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CA2437639A CA2437639C (en) | 2003-08-11 | 2003-08-18 | Long term drug delivery devices with polyurethane based polymers and their manufacture |
CA2,437,639 | 2003-08-18 | ||
PCT/IB2004/002823 WO2005013936A2 (en) | 2003-08-11 | 2004-08-11 | Manufacture of long term drug delivery devices with polyurethane based polymers |
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Cited By (1)
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JP2013049678A (ja) * | 2003-08-11 | 2013-03-14 | Endo Pharmaceuticals Valera Inc | ポリウレタン系ポリマーを用いた長期薬物輸送装置の製造 |
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