JP5054877B2 - 環式尿素化合物及びその調製方法 - Google Patents

環式尿素化合物及びその調製方法 Download PDF

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Publication number
JP5054877B2
JP5054877B2 JP2002510461A JP2002510461A JP5054877B2 JP 5054877 B2 JP5054877 B2 JP 5054877B2 JP 2002510461 A JP2002510461 A JP 2002510461A JP 2002510461 A JP2002510461 A JP 2002510461A JP 5054877 B2 JP5054877 B2 JP 5054877B2
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group
carbamic acid
formula
acid derivative
compound
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JP2002510461A
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Japanese (ja)
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JP2004503546A (ja
JP2004503546A5 (https=
Inventor
ギシャール，ジル
ロドリゲス，マール
プロー，セルジュ
スムティ，ヴァンサン
シャフナー，アルノー−ピエール
ブリアン，ジャン−ポール
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Centre National de la Recherche Scientifique CNRS
ImmuPharma France SA
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Centre National de la Recherche Scientifique CNRS
ImmuPharma France SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/10—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/04—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Fats And Perfumes (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2002510461A 2000-06-13 2001-06-13 環式尿素化合物及びその調製方法 Expired - Fee Related JP5054877B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0007507A FR2810039B1 (fr) 2000-06-13 2000-06-13 Composes urees cycliques et leur procede de preparation
FR00/07507 2000-06-13
PCT/FR2001/001837 WO2001096318A1 (fr) 2000-06-13 2001-06-13 Composes urees cycliques et leur procede de preparation

Publications (3)

Publication Number Publication Date
JP2004503546A JP2004503546A (ja) 2004-02-05
JP2004503546A5 JP2004503546A5 (https=) 2008-07-17
JP5054877B2 true JP5054877B2 (ja) 2012-10-24

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JP2002510461A Expired - Fee Related JP5054877B2 (ja) 2000-06-13 2001-06-13 環式尿素化合物及びその調製方法

Country Status (13)

Country Link
US (1) US7186828B2 (https=)
EP (2) EP1640368A3 (https=)
JP (1) JP5054877B2 (https=)
KR (1) KR20030031001A (https=)
AT (1) ATE386728T1 (https=)
AU (2) AU6764501A (https=)
CA (2) CA2778314C (https=)
DE (1) DE60132891T2 (https=)
DK (1) DK1289968T3 (https=)
ES (1) ES2301554T3 (https=)
FR (1) FR2810039B1 (https=)
IL (1) IL153408A0 (https=)
WO (1) WO2001096318A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006331355B2 (en) * 2005-12-29 2011-09-29 Immupharma France Sa Compositions and methods for the inhibition of phospholipase A2
CA2635356C (en) * 2005-12-29 2011-11-01 Immupharma France Sa Use of 1,3,5-triazepin-2,6-diones to treat malaria
AU2006331357B2 (en) * 2005-12-29 2012-05-17 Immupharma France Sa Compositions and methods for synthesizing novel heterocyclic therapeutics
US7777030B2 (en) 2005-12-29 2010-08-17 Centre National de la Recherge Scientifique (CNRS) Compositions and methods for the treatment and prevention of disease
JP2009522236A (ja) * 2005-12-29 2009-06-11 イミュファルマ・フランス・エスアー マラリアまたはエイズの処置のためのアザ複素環化合物
US8563115B2 (en) 2008-08-12 2013-10-22 Xerox Corporation Protective coatings for solid inkjet applications
US8191992B2 (en) * 2008-12-15 2012-06-05 Xerox Corporation Protective coatings for solid inkjet applications
EP2548869A1 (en) * 2011-07-20 2013-01-23 Cytec Technology Corp. Process for the Synthesis of N-substituted Cyclic Alkylene Ureas
CN102911130B (zh) * 2011-08-03 2015-05-20 北京师范大学 一种一锅法合成脲四元环化合物的方法、合成的脲四元环化合物
AU2014310619B2 (en) 2013-08-21 2019-07-25 Centre National De La Recherche Scientifique (Cnrs) Peptide-oligourea chimeric compounds and methods of their use
WO2016207726A1 (en) 2015-06-22 2016-12-29 Ureka Sarl Bioinspired catalysis using oligourea helical foldamers
WO2017037142A1 (en) 2015-08-31 2017-03-09 Centre National De La Recherche Scientifique (Cnrs) Foldamer helix bundle-based molecular encapsulation
WO2017182873A2 (en) 2016-04-19 2017-10-26 Ureka Sarl Peptide-oligourea foldamer compounds and methods of their use
US12434075B2 (en) * 2021-05-11 2025-10-07 Celestial Oncology Inc. Coupled robotic radiation therapy system

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2847760A1 (de) * 1978-11-03 1980-05-14 Hoechst Ag Verfahren zur herstellung von 1,3,5-triaza-2,4,6-triketo-cycloheptan- 3,5-di-essigsaeureestern
US4918186A (en) * 1986-05-06 1990-04-17 Mitsui Toatsu Chemicals, Inc. Process for producing cyclic ureas
US5610294A (en) * 1991-10-11 1997-03-11 The Du Pont Merck Pharmaceutical Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
BR9206623A (pt) * 1991-10-11 1995-05-02 Du Pont Merck Pharma Uréias cíclicas e análogas úteis como inibidoras da protease retroviral
US5637780A (en) 1993-03-30 1997-06-10 The Dupont Merck Pharmaceutical Company Method for preparing alkylating agents and their use for alkylating cyclic ureas
US5508400A (en) * 1994-04-20 1996-04-16 The Du Pont Merck Pharmaceutical Company Preparation of cyclic urea compounds
AU5310096A (en) * 1995-03-17 1996-10-08 Du Pont Merck Pharmaceutical Company, The Cyclic urea hiv protease inhibitors
US5532356A (en) * 1995-06-06 1996-07-02 The Dupont Merck Pharmaceutical Company Method for preparing N,N'-disubstituted cyclic ureas
US5532357A (en) * 1995-06-07 1996-07-02 The Dupont Merck Pharmaceutical Company Method for preparing N-monosubstituted and N,N'-disubstituted unsymmetrical cyclic ureas
WO1997008150A1 (en) 1995-08-22 1997-03-06 The Du Pont Merck Pharmaceutical Company Substituted cyclic ureas and derivatives thereof useful as retroviral protease inhibitors
BR9712755A (pt) * 1996-11-08 1999-10-19 Du Pont Pharm Co Composto, composição farmacêutica, método para o tratamento de infecção por hiv e kit farmacêutico útil para o tratamento de infecção por hiv

Also Published As

Publication number Publication date
EP1640368A2 (fr) 2006-03-29
EP1289968A1 (fr) 2003-03-12
CA2778314A1 (en) 2001-12-20
US7186828B2 (en) 2007-03-06
JP2004503546A (ja) 2004-02-05
DK1289968T3 (da) 2008-06-23
US20040044199A1 (en) 2004-03-04
FR2810039B1 (fr) 2007-05-25
CA2412782A1 (en) 2001-12-20
WO2001096318A8 (fr) 2003-05-01
CA2778314C (en) 2017-01-03
FR2810039A1 (fr) 2001-12-14
DE60132891D1 (de) 2008-04-03
KR20030031001A (ko) 2003-04-18
ATE386728T1 (de) 2008-03-15
CA2412782C (en) 2012-08-07
IL153408A0 (en) 2003-07-06
AU2001267645B2 (en) 2006-07-27
DE60132891T2 (de) 2009-03-19
WO2001096318A1 (fr) 2001-12-20
AU6764501A (en) 2001-12-24
ES2301554T3 (es) 2008-07-01
EP1289968B1 (fr) 2008-02-20
EP1640368A3 (fr) 2007-03-28

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