JP5042631B2 - アポトーシス腫瘍細胞上に露出した細胞内抗原をターゲッティングすることによって腫瘍細胞を死滅させる方法 - Google Patents

アポトーシス腫瘍細胞上に露出した細胞内抗原をターゲッティングすることによって腫瘍細胞を死滅させる方法 Download PDF

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JP5042631B2
JP5042631B2 JP2006542802A JP2006542802A JP5042631B2 JP 5042631 B2 JP5042631 B2 JP 5042631B2 JP 2006542802 A JP2006542802 A JP 2006542802A JP 2006542802 A JP2006542802 A JP 2006542802A JP 5042631 B2 JP5042631 B2 JP 5042631B2
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antibody
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cancer
antibodies
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JP2007515165A (ja
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エリザベス イー． エバンス
マーク ジェイ． パリス
ディーパック エム． サハスラブデ
アーネスト エス． スミス
モーリス ザウダラー
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バクシネックス インコーポレーティッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2006542802A 2003-12-04 2004-12-06 アポトーシス腫瘍細胞上に露出した細胞内抗原をターゲッティングすることによって腫瘍細胞を死滅させる方法 Expired - Fee Related JP5042631B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US52657203P 2003-12-04 2003-12-04
US60/526,572 2003-12-04
US53168803P 2003-12-23 2003-12-23
US60/531,688 2003-12-23
PCT/US2004/040573 WO2005055936A2 (en) 2003-12-04 2004-12-06 Methods of killing tumor cells by targeting internal antigens exposed on apoptotic tumor cells

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JP2007515165A JP2007515165A (ja) 2007-06-14
JP2007515165A5 JP2007515165A5 (https=) 2008-01-31
JP5042631B2 true JP5042631B2 (ja) 2012-10-03

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US (2) US20050158323A1 (https=)
EP (1) EP1708751B1 (https=)
JP (1) JP5042631B2 (https=)
CN (1) CN1913921B (https=)
AT (1) ATE526037T1 (https=)
AU (1) AU2004296184B2 (https=)
CA (1) CA2548180C (https=)
IL (1) IL176007A (https=)
NZ (1) NZ547591A (https=)
WO (1) WO2005055936A2 (https=)

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Publication number Publication date
US20050158323A1 (en) 2005-07-21
CN1913921B (zh) 2012-02-22
EP1708751A2 (en) 2006-10-11
US20090081210A1 (en) 2009-03-26
IL176007A0 (en) 2006-10-05
ATE526037T1 (de) 2011-10-15
EP1708751B1 (en) 2011-09-28
IL176007A (en) 2012-03-29
JP2007515165A (ja) 2007-06-14
NZ547591A (en) 2009-11-27
AU2004296184B2 (en) 2010-12-16
WO2005055936A2 (en) 2005-06-23
EP1708751A4 (en) 2007-11-07
CN1913921A (zh) 2007-02-14
CA2548180A1 (en) 2005-06-23
WO2005055936A3 (en) 2005-11-03
AU2004296184A1 (en) 2005-06-23
CA2548180C (en) 2014-02-04

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