JP5042441B2 - マグネシウム置換ハイドロキシアパタイト - Google Patents

マグネシウム置換ハイドロキシアパタイト Download PDF

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Publication number
JP5042441B2
JP5042441B2 JP2002569161A JP2002569161A JP5042441B2 JP 5042441 B2 JP5042441 B2 JP 5042441B2 JP 2002569161 A JP2002569161 A JP 2002569161A JP 2002569161 A JP2002569161 A JP 2002569161A JP 5042441 B2 JP5042441 B2 JP 5042441B2
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JP
Japan
Prior art keywords
magnesium
hydroxyapatite
substituted
hap
ion source
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2002569161A
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English (en)
Japanese (ja)
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JP2004532172A5 (enExample
JP2004532172A (ja
Inventor
イー． リーマン、リチャード
スチャネック、ヴォイチェフ
シュク、パベル
エス． テンフイセン、キボー
チェン、チュン−ウェイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rutgers State University of New Jersey
Ethicon Inc
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Rutgers State University of New Jersey
Ethicon Inc
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Publication of JP2004532172A publication Critical patent/JP2004532172A/ja
Publication of JP2004532172A5 publication Critical patent/JP2004532172A5/ja
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Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00—Phosphorus; Compounds thereof
    • C01B25/16—Oxyacids of phosphorus; Salts thereof
    • C01B25/26—Phosphates
    • C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/802—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics
    • A61K6/807—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics comprising magnesium oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
    • A61K6/838—Phosphorus compounds, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
    • C04B35/447—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on phosphates, e.g. hydroxyapatite
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/62605—Treating the starting powders individually or as mixtures
    • C04B35/6261—Milling
    • C04B35/62615—High energy or reactive ball milling
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/30—Constituents and secondary phases not being of a fibrous nature
    • C04B2235/32—Metal oxides, mixed metal oxides, or oxide-forming salts thereof, e.g. carbonates, nitrates, (oxy)hydroxides, chlorides
    • C04B2235/3205—Alkaline earth oxides or oxide forming salts thereof, e.g. beryllium oxide
    • C04B2235/3206—Magnesium oxides or oxide-forming salts thereof
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/30—Constituents and secondary phases not being of a fibrous nature
    • C04B2235/32—Metal oxides, mixed metal oxides, or oxide-forming salts thereof, e.g. carbonates, nitrates, (oxy)hydroxides, chlorides
    • C04B2235/3205—Alkaline earth oxides or oxide forming salts thereof, e.g. beryllium oxide
    • C04B2235/3208—Calcium oxide or oxide-forming salts thereof, e.g. lime
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/30—Constituents and secondary phases not being of a fibrous nature
    • C04B2235/32—Metal oxides, mixed metal oxides, or oxide-forming salts thereof, e.g. carbonates, nitrates, (oxy)hydroxides, chlorides
    • C04B2235/3205—Alkaline earth oxides or oxide forming salts thereof, e.g. beryllium oxide
    • C04B2235/3208—Calcium oxide or oxide-forming salts thereof, e.g. lime
    • C04B2235/3212—Calcium phosphates, e.g. hydroxyapatite
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/30—Constituents and secondary phases not being of a fibrous nature
    • C04B2235/44—Metal salt constituents or additives chosen for the nature of the anions, e.g. hydrides or acetylacetonate
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/30—Constituents and secondary phases not being of a fibrous nature
    • C04B2235/44—Metal salt constituents or additives chosen for the nature of the anions, e.g. hydrides or acetylacetonate
    • C04B2235/442—Carbonates
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/30—Constituents and secondary phases not being of a fibrous nature
    • C04B2235/44—Metal salt constituents or additives chosen for the nature of the anions, e.g. hydrides or acetylacetonate
    • C04B2235/443—Nitrates or nitrites
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/30—Constituents and secondary phases not being of a fibrous nature
    • C04B2235/44—Metal salt constituents or additives chosen for the nature of the anions, e.g. hydrides or acetylacetonate
    • C04B2235/444—Halide containing anions, e.g. bromide, iodate, chlorite
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/30—Constituents and secondary phases not being of a fibrous nature
    • C04B2235/44—Metal salt constituents or additives chosen for the nature of the anions, e.g. hydrides or acetylacetonate
    • C04B2235/447—Phosphates or phosphites, e.g. orthophosphate or hypophosphite
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/12—All metal or with adjacent metals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Ceramic Engineering (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Manufacturing & Machinery (AREA)
  • Materials Engineering (AREA)
  • Structural Engineering (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Birds (AREA)
  • Materials For Medical Uses (AREA)
  • Cosmetics (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Prostheses (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
JP2002569161A 2001-03-06 2002-03-05 マグネシウム置換ハイドロキシアパタイト Expired - Fee Related JP5042441B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/800,127 US6921544B2 (en) 2001-03-06 2001-03-06 Magnesium-substituted hydroxyapatites
US09/800,127 2001-03-06
PCT/US2002/006605 WO2002069986A1 (en) 2001-03-06 2002-03-05 Magnesium-substituted hydroxyapatites

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008192220A Division JP4847495B2 (ja) 2001-03-06 2008-07-25 マグネシウム置換ハイドロキシアパタイト

Publications (3)

Publication Number Publication Date
JP2004532172A JP2004532172A (ja) 2004-10-21
JP2004532172A5 JP2004532172A5 (enExample) 2005-12-22
JP5042441B2 true JP5042441B2 (ja) 2012-10-03

Family

ID=25177553

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002569161A Expired - Fee Related JP5042441B2 (ja) 2001-03-06 2002-03-05 マグネシウム置換ハイドロキシアパタイト
JP2008192220A Expired - Fee Related JP4847495B2 (ja) 2001-03-06 2008-07-25 マグネシウム置換ハイドロキシアパタイト

Family Applications After (1)

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JP2008192220A Expired - Fee Related JP4847495B2 (ja) 2001-03-06 2008-07-25 マグネシウム置換ハイドロキシアパタイト

Country Status (6)

Country Link
US (3) US6921544B2 (enExample)
EP (1) EP1365782B1 (enExample)
JP (2) JP5042441B2 (enExample)
AT (1) ATE466563T1 (enExample)
DE (1) DE60236256D1 (enExample)
WO (1) WO2002069986A1 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3806061B2 (ja) * 2002-05-21 2006-08-09 富士通株式会社 金属修飾アパタイト含有膜の形成方法、これに用いられるコーティング液、および金属修飾アパタイト含有膜で被覆された部位を有する電子機器
WO2005068621A1 (ja) * 2003-12-26 2005-07-28 The Circle For The Promotion Of Science And Engineering アパタイト粒子及びその作製方法、遺伝子複合体、並びに遺伝子導入方法
JP4617175B2 (ja) * 2005-03-07 2011-01-19 Ｈｏｙａ株式会社 吸着剤および吸着装置
ITMI20051370A1 (it) * 2005-07-19 2007-01-20 Fin Ceramica Faenza S R L Processo per la preparazione di un sostituto osseo biomimetico e suoi usi
AU2007205961B2 (en) * 2006-01-12 2013-03-14 Rutgers, The State University Biomimetic hydroxyapatite synthesis
US8287914B2 (en) * 2006-01-12 2012-10-16 Rutgers, The State University Of New Jersey Biomimetic hydroxyapatite synthesis
US20100040668A1 (en) * 2006-01-12 2010-02-18 Rutgers, The State University Of New Jersey Biomimetic Hydroxyapatite Composite Materials and Methods for the Preparation Thereof
KR100741227B1 (ko) 2006-03-27 2007-07-19 서청교 발포유리 경량단열재 및 그의 제조방법
GB0609815D0 (en) * 2006-05-18 2006-06-28 Univ Belfast Process for preparing hydroxylapatite
DE602008005987D1 (de) * 2007-02-22 2011-05-19 Corning Inc Substrate für zellkultur und herstellungsverfahren dafür
BRPI0809676B1 (pt) * 2007-04-04 2019-05-14 Otsuka Chemical Co., Ltd. Titanato de potássio, método para produção do mesmo, material de fricção e composição de resina
EP2022447A1 (en) * 2007-07-09 2009-02-11 Astra Tech AB Nanosurface
US20110008460A1 (en) * 2008-01-11 2011-01-13 Rutgers, The State University Of New Jersey Biomimetic hydroxyapatite composite materials and methods for the preparation thereof
DE102008010210A1 (de) * 2008-02-20 2009-08-27 Innotere Gmbh Zubereitung für Magnesiumammoniumphosphat-Zemente
GB0900269D0 (en) * 2009-01-08 2009-02-11 Univ Aberdeen Silicate-substituted hydroxyapatite
WO2010094813A1 (es) * 2009-02-10 2010-08-26 Azurebio, S. L. Material de regeneración ósea a partir de combinaciones de monetita con otros compuestos de calcio bioactivos
US9358122B2 (en) 2011-01-07 2016-06-07 K2M, Inc. Interbody spacer
SG11201703878SA (en) * 2014-11-14 2017-06-29 Univ Nanyang Tech Bioresorbable-magnesium composite
RU2617103C1 (ru) * 2015-11-20 2017-04-20 Федеральное государственное бюджетное образовательное учреждение высшего образования "Саратовский государственный технический университет имени Гагарина Ю.А." (СГТУ имени Гагарина Ю.А.) Способ получения магний-замещенного гидроксиапатита
CN116947003A (zh) * 2017-04-27 2023-10-27 武礼伟仁株式会社 羟基磷灰石、化妆品和食品及其生产方法
EP3786109A4 (en) * 2018-04-27 2022-01-19 Bioapatite, Inc. HYDROXYLAPATITE
JP7244901B2 (ja) * 2018-12-28 2023-03-23 株式会社バイオアパタイト ハイドロキシアパタイト、その製造方法及びβ－ＴＣＰの製造方法
CN111888521B (zh) * 2020-06-11 2021-12-17 上海禾麦医学科技有限公司 骨修复材料及其制备方法
CA3220437A1 (en) 2021-05-20 2022-11-24 Smile Makers, Llc Oral hygiene compositions and methods of use
CN113930649B (zh) * 2021-09-27 2022-07-26 西北工业大学 一种镁基生物复合材料高速搅拌摩擦制备方法
JP2026016041A (ja) * 2024-07-22 2026-02-03 国立研究開発法人産業技術総合研究所 リン酸カルシウムの結晶の製造方法、ブロック材の製造方法及び多孔体の製造方法並びにリン酸カルシウム結晶、ブロック材、多孔体、骨補填材、口腔用骨補填材及び口腔ケア用品

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JP3082503B2 (ja) * 1993-02-26 2000-08-28 株式会社神戸製鋼所 人工骨製造用前駆体および人工骨の製法
JPH0797202A (ja) * 1993-09-28 1995-04-11 Mitsui Toatsu Chem Inc リン酸カルシウム系球状アパタイトの製造方法
JPH0797201A (ja) * 1993-09-28 1995-04-11 Mitsui Toatsu Chem Inc リン酸カルシウム系球状アパタイトの製造方法
US6027742A (en) 1995-05-19 2000-02-22 Etex Corporation Bioresorbable ceramic composites
US5783217A (en) 1995-11-07 1998-07-21 Etex Corporation Low temperature calcium phosphate apatite and a method of its manufacture
US5830480A (en) * 1996-05-09 1998-11-03 The Trustees Of The University Of Pennsylvania Stabilization of sol-gel derived silica-based glass
JPH10102288A (ja) * 1996-09-24 1998-04-21 Queen Mary & Westfield College リン酸カルシウム化合物のコーティング方法
GB9727048D0 (en) 1997-12-22 1998-02-18 Abonetics Ltd Process for the preparation of magnesium and carbonate substituted hydroxyapatite
IT1299563B1 (it) 1998-07-17 2000-03-16 Giovanni Dolci Uso odontostomatologico di materiali a base apatitica nanostrutturati
JP2001089114A (ja) * 1999-09-21 2001-04-03 Maruo Calcium Co Ltd 無機分散剤、懸濁重合用安定剤、重合体粒子、不飽和ポリエステル樹脂組成物、トナー組成物、並びに無機分散剤の製造方法

Also Published As

Publication number Publication date
JP4847495B2 (ja) 2011-12-28
US20020127260A1 (en) 2002-09-12
JP2004532172A (ja) 2004-10-21
US7704529B2 (en) 2010-04-27
US20100331168A1 (en) 2010-12-30
EP1365782A4 (en) 2004-06-30
US8337904B2 (en) 2012-12-25
DE60236256D1 (de) 2010-06-17
JP2008290939A (ja) 2008-12-04
EP1365782A1 (en) 2003-12-03
WO2002069986A1 (en) 2002-09-12
EP1365782B1 (en) 2010-05-05
US6921544B2 (en) 2005-07-26
US20050186249A1 (en) 2005-08-25
ATE466563T1 (de) 2010-05-15

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