JP5023253B2 - Composition for preventing and treating fatigue and fatigue - Google Patents
Composition for preventing and treating fatigue and fatigue Download PDFInfo
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本発明は、疲労感、倦怠感の予防及び治療用組成物に関する。 The present invention relates to a composition for preventing and treating fatigue and fatigue.
自律神経失調症や更年期障害、その他いわゆる心身症の症状として現れる代表的な症状として、疲労感と倦怠感とがある。これらは不定愁訴症候群症状であり、体のどこが悪いのかはっきりしない、検査をしてもどこが悪いのかはっきりしない症状として知られている。不定愁訴症候群は、病気ではなく、原因がはっきりしないことから、西洋医学にとっては全く無力な状況にある。しかしながら、不定愁訴は、特に更年期を迎えた方々にとっては深刻な悩みであり、その解決策として滋養強壮剤や健康食品にそれを求める人も多い。現在、日本だけでなく世界の市場では多種多様の健康食品が氾濫しているが、健康食品に求める機能に関する市場調査では、「疲労回復」が常に上位に挙がっており、需要は満足されていないのが現状である。 Typical symptoms that appear as symptoms of autonomic ataxia, menopause, and other so-called psychosomatic symptoms include fatigue and fatigue. These are symptoms of indefinite complaint syndrome, and it is not clear where the body is bad, and it is known that it is not clear where the test is wrong. Indefinite complaint syndrome is not a disease, and the cause is unclear, so it is completely powerless for Western medicine. However, indefinite complaints are a serious problem, especially for those who have entered menopause, and many people seek nutritional tonics and health foods as a solution. Currently, a wide variety of health foods are flooding not only in Japan but also in the world market. However, market research on the functions required of health foods has always raised “fatigue recovery” at the top, and demand is not satisfied. is the current situation.
一方「東洋医学」では生薬治療により様々な植物が古くから利用されているが、これらはあくまで患者の治療目的で利用されるのであり、疲労感や倦怠感の予防及び治療目的で研究された例は、一部の漢方薬と称される生薬を除いては、知られていない。 On the other hand, "Oriental Medicine" has been using various plants for a long time due to herbal medicine treatment, but these are only used for the purpose of treatment of patients, and examples studied for the purpose of preventing and treating fatigue and fatigue. Are not known, except for some herbal medicines called Kampo medicines.
また、ビタミンＢ群作用物質は、肉体疲労、病中病後、食欲不振、栄養障害、発熱性消耗性疾患などの栄養補給、滋養強壮、虚弱体質の改善又は回復などの効果を目的として利用されている。Ｂ群のビタミンには相助作用があり、複数成分を一緒に服用すると効果的と言われる。また、ビタミンＢ群作用物質は、余分に摂取された分は体内に貯蔵されず、すべて排泄される特徴があり、従来から滋養強壮剤、栄養補給剤、栄養補助食品などの分野で広く利用されている。 In addition, vitamin B group active substances are used for the purpose of physical fatigue, post-disease illness, loss of appetite, nutritional disorders, febrile debilitating diseases and other nutritional supplements, nutrition tonicity, improvement or recovery of weakness Yes. Group B vitamins have a synergistic effect and are said to be effective when taken together. In addition, vitamin B group active substances are not stored in the body but are all excreted, and have been widely used in fields such as nutritional tonics, nutritional supplements, and dietary supplements. ing.
不定愁訴改善に関する技術に関しては、まずパンテチン、朝鮮人参及びビタミンＥの三成分を配合した不定愁訴改善剤（特許文献１参照）が開示されている。また、全身倦怠感、肩こり等の不定愁訴症候群症状の回復を目的として、γ−オリザノール及び生姜、唐辛子、胡椒の辛味成分及びカフェインなどの中枢神経刺激成分を有効成分とする自律神経機能向上剤（特許文献２参照）も開示されている。さらに、肌あれや肌のくすみ等の症状を改善するとともに、日常のイライラ感などの不定愁訴の症状を緩和する目的で、セリ（Oenanthe javanica (Bl.) DC. ）及び／又はその抽出物を含有してなる健康食品（特許文献３参照）が、女性や４０代以降の男性における更年期／成熟期不定愁訴症候群の発症予防または症状緩和の目的で、ブドウ属（Vitis）特に真ブドウ亜属植物（Euvitis）及びイタドリなどのタデ科植物を含有する経口組成物（特許文献４参照）が、自律神経失調に基づく全身倦怠疲労感、易疲労、肩、首等のこり等の不定愁訴症候群症状に対して有効な自律神経機能向上効果を目的として、フェルラ酸、クロロゲン酸、カフェ酸及びそれらの薬学的に許容される塩の群から選ばれる化合物からなる自律神経機能向上剤（特許文献５参照）が、不定愁訴症候群の改善目的で、マメ科植物のシナガワハギ属（学名：Melilotus officinalis (L.) Pall）、セリ科植物のツボクサ属（学名：Centella asiatica (L.) Urban）、イチョウ科植物のイチョウ属（学名：Ginkgo biloba Linn.）の植物由来の抽出物を含む組成物（特許文献６参照）が開示されている。 Regarding the technique for improving indefinite complaints, first, an indefinite complaint improving agent (see Patent Document 1) containing three ingredients of pantethine, ginseng and vitamin E is disclosed. In addition, for the purpose of recovery of indefinite complaint syndrome symptoms such as general malaise and stiff shoulders, an agent for improving autonomic nervous function comprising γ-oryzanol and ginger, chili, pungent components of pepper, and central nerve stimulating components such as caffeine as active ingredients (See Patent Document 2) is also disclosed. Furthermore, for the purpose of improving the symptoms such as rough skin and dullness, and alleviating the symptoms of indefinite complaints such as daily irritation, seri ( Oenanthe javanica (Bl.) DC.) And / or its extract health food comprising (see Patent Document 3), for the purpose of preventing the onset or relief of symptoms of menopause / maturity malaise syndrome in men women and after 40s, grape genus (Vitis) especially true vine subgenus plants ( Euvitis ) and oral compositions containing terrestrial plants such as Japanese knotweed (see patent document 4) An effective autonomic nervous function-improving effect comprising a compound selected from the group of ferulic acid, chlorogenic acid, caffeic acid and pharmaceutically acceptable salts thereof (see Patent Document 5) There, in the improvement purpose of malaise syndrome, melilotus of leguminous plants (scientific name: Melilotus officinalis (L.) Pall) , Centella genus Umbelliferae plants (scientific name: Centella asiatica (L.) Urban) , of ginkgo family plant The composition (refer patent document 6) containing the plant-derived extract of the ginkgo genus (scientific name: Ginkgo biloba Linn.) Is disclosed.
本発明の課題は、疲労感、倦怠感の予防及び治療用組成物、飲食品を提供することにある。 An object of the present invention is to provide a composition for preventing and treating fatigue and fatigue and food and drink.
本発明者らは、当該課題を解決するため、優れた疲労感、倦怠感の予防及び治療用組成物を得るべく鋭意研究を重ねた結果、特定の植物及び／又はその抽出物を用いることにより、優れた疲労感、倦怠感の予防・治療作用を発揮すると共に、長期服用しての安全性等の面においても問題のない組成物であることを見出し、本発明を完成するに至った。 In order to solve the problem, the present inventors have conducted extensive research to obtain a composition for the prevention and treatment of excellent fatigue and fatigue, and as a result, by using a specific plant and / or an extract thereof. The present inventors have found that the composition exhibits excellent fatigue and fatigue preventive / therapeutic effects and has no problems in terms of safety after long-term use, and has completed the present invention.
すなわち本発明においては、唐古特白刺（Nitraria tangutorum Bohr.），雪霊芝（Arenaria kansuensis Maxim.），唐古特青蘭（Dracocephalum tanguticum Maxim.），長筒馬先蒿（Pedicularis longiflora Rudol-var.tubiformis），独一味（Lamiophlomis rotata Benth. Kudo），手掌参（Gymnadenia conopsea R. Br.），水柏枝（Myricaria germanica (L.) Desv.），蕨麻（Potentilla anserina L.），高山辣根菜（Pegaeophyton scapiflorum Hook.f.et Thoms. Marq. et Airy-Shaw）から選ばれる１種又は２種以上の植物及び／又はその抽出物を配合することを特徴とする疲労感、倦怠感の予防及び治療用組成物、飲食品とする。さらにビタミンＢ群作用物質を含有させて疲労感、倦怠感の予防及び治療用組成物、飲食品とする。 That is, in the present invention, Karako Tokushirotoge (Nitraria tangutorum Bohr.), Yukireishiba (Arenaria kansuensis Maxim.), Karako Tokuao orchid (Dracocephalum tanguticum Maxim.), Long tubular horse destination蒿 (Pedicularis longiflora Rudol-var.tubiformis) , Doichimi ( Lamiophlomis rotata Benth. Kudo), palm ginseng ( Gymnadenia conopsea R. Br.), Minamata ( Myricaria germanica (L.) Desv.), Sasa ( Potentilla anserina L.), Takayama Sone ( Pegaeophyton) scapiflorum Hook.f.et Thoms.Marq. et Airy-Shaw) for the prevention and treatment of fatigue and malaise characterized by blending one or more plants and / or extracts thereof It is set as a composition and food-drinks. Furthermore, a vitamin B group active substance is contained to provide a composition for preventing and treating fatigue and fatigue, and a food and drink.
本発明により、優れた疲労感、倦怠感の予防及び治療用組成物を提供することができる。 The present invention can provide an excellent composition for preventing and treating fatigue and fatigue.
以下、本発明の実施の形態について詳しく説明する。 Hereinafter, embodiments of the present invention will be described in detail.
本発明において配合する特定の植物としては、唐古特白刺（Nitraria tangutorum Bohr.），雪霊芝（Arenaria kansuensis Maxim.），唐古特青蘭（Dracocephalum tanguticum Maxim.），長筒馬先蒿（Pedicularis longiflora Rudol-var.tubiformis），独一味（Lamiophlomis rotata Benth. Kudo），手掌参（Gymnadenia conopsea R. Br.），水柏枝（Myricaria germanica (L.) Desv.），蕨麻（Potentilla anserina L.），高山辣根菜（Pegaeophyton scapiflorum Hook.f.et Thoms. Marq. et Airy-Shaw）が挙げられる。 The particular plant to be blended in the present invention, Karako Tokushirotoge (Nitraria tangutorum Bohr.), Yukireishiba (Arenaria kansuensis Maxim.), Karako Tokuao orchid (Dracocephalum tanguticum Maxim.), Long tubular horse destination蒿 (Pedicularis longiflora Rudol -var.tubiformis), monologue ( Lamiophlomis rotata Benth. Kudo), ginseng ( Gymnadenia conopsea R. Br.), Minamata ( Myricaria germanica (L.) Desv.), urn ( Potentilla anserina L.), Examples include Takayama Sone vegetable ( Pegaeophyton scapiflorum Hook.f.et Thoms.Marq. Et Airy-Shaw).
本発明に係る 唐古特白刺（Nitraria tangutorum Bohr.）は、ハマビシ科（Zygophyllaceae）ニトラリア属（Nitraria）植物で、チベットなどに多く分布する。花期は5〜6月、果期は7〜8月で赤い果実がなる。果実が胃の病気などに利用される。その他、消化不良、感冒などに効くとして知られている
雪霊芝（Arenaria kansuensis Maxim.）は、ナデシコ科（Caryophyllaceae）アレナリア属（Arenaria）植物で、チベット、甘粛、青海、四川西部など中国で多く分布する多年生の矮小草本である。石灰岩の高山の石の割れ目や、あるいは草原に生える。インフルエンザ、肺炎、黄疸、肋骨疼痛、淋痛を治すとして知られる。
Nitraria tangutorum Bohr. According to the present invention is a plant belonging to the genus Nitraria ( Zygophyllaceae ) and is widely distributed in Tibet and the like. The flowering period is from May to June and the fruiting period is from July to August. Fruits are used for stomach diseases. Other, indigestion, Yukireishiba known as effective against such as the common cold (Arenaria kansuensis Maxim.) Is, in the Caryophyllaceae (Caryophyllaceae) Arenaria species (Arenaria) plant, Tibet, Gansu, Qinghai, Sichuan western and much more in China It is a distributed perennial dwarf herb. It grows on cracks in alpine stones of limestone or in grasslands. Known to cure influenza, pneumonia, jaundice, rib pain, colic.
唐古特青蘭（Dracocephalum tanguticum Maxim.）は、シソ科（Lamiaceae）ドラコセファルム属（Dracocephalum）植物で、タングートセイランとも言われる植物である。チベット、四川、甘粛、青海など中国で多く分布する多年生草本で、開花期は7〜8月、山腹、渓流の周辺、畦などに生える。根を含めた全草が生薬として用いられ、胃炎、潰瘍病、肝炎、肝肥大を治すとして知られている。 Dracocephalum tanguticum Maxim. Is a plant belonging to the genus Damicocephalum ( Lamiaceae ) and is also called Tangut Ceylan. Tibet, Sichuan, Gansu, Qinghai and many other perennial herbs are found in China. The flowering period is July-August, growing on mountainsides, mountain streams, and coral. Whole herbs including roots are used as herbal medicines and are known to cure gastritis, ulcer disease, hepatitis, and liver hypertrophy.
長筒馬先蒿（Pedicularis longiflora Rudol-var.tubiformis）は、ゴマノハグサ科（Scrophulariaceae）シオガマギク属（Pedicularis）植物で、チベット、四川、雲南などの中国に多く分布し、主に花が生薬として用いられてきた植物である。高さ10〜20cm、開花期は5〜10月の低い草本で、高山の草原及び渓流のそばに生える。中国では、清熱し湿を除く、肝炎、胆嚢炎、小便が膿血を帯びるものを治すとして知られている。 Pedicularis longiflora Rudol-var.tubiformis is a plant belonging to the genus Scrophulariaceae ( Pedicularis ) and is widely distributed in China such as Tibet, Sichuan and Yunnan, and flowers have been mainly used as herbal medicines. It is a plant. 10-20cm in height, flowering season is a low herb in May-October and grows near alpine meadows and mountain streams. In China, it is known to cure hepatitis, cholecystitis, and urinary septicemia, excluding dampness and moisture.
独一味（Lamiophlomis rotata Benth. Kudo）は、シソ科（Lamiaceae）独一味属（Lamiophlomis）植物で、チベット、四川、甘粛などの中国高原地帯に多く分布する多年生の小型草本である。開花期は5〜7月で、高山の極度に風化した砕石原や、高山の草地に生える。根及び根茎、あるいは全草が生薬として知られている。 German gang (Lamiophlomis rotata Benth. Kudo) is, in the Labiatae (Lamiaceae) Germany gang belonging to the genus (Lamiophlomis) plant, Tibet, Sichuan, is a small herbaceous perennial to be distributed more in China highlands, such as Gansu. The flowering period is from May to July, and it grows in the extremely weathered crushed stone fields and alpine grasslands. Roots and rhizomes or whole plants are known as herbal medicines.
手掌参（Gymnadenia conopsea R. Br.）は、ラン科（Orchidaceae）テガタチドリ属（Gymnadenia）植物で、和名ではテガタチドリとして知られている。中国の四川、華北、東北、西北などで多く分布し、陰陽草（インヨウソウ）ともいう。日本では、亜高山帯から高山帯の草原に生え、ユーラシア大陸の亜寒帯にも広く分布する多年生草本である。開花期は6〜7月で、結実期は7〜8月。川や谷、やぶに生えている。塊茎を生薬として利用し、中国では、津液を生じ止渇する効果があるとして知られる。 Ginseng ( Gymnadenia conopsea R. Br.) Is a plant belonging to the genus Orchidaceae and the genus Gymnadenia . It is widely distributed in China's Sichuan, North China, Tohoku, and Northwest, and is also called Yin Yang grass. In Japan, it is a perennial herb that grows in grasslands from the subalpine to the alpine belt and is widely distributed in the subarctic region of the Eurasian continent. The flowering period is from June to July, and the fruiting period is from July to August. It grows in rivers, valleys, and bushes. Utilizing tubers as herbal medicines, it is known in China that it has the effect of generating and stopping tsuyu.
水柏枝（Myricaria germanica (L.) Desv.）は、ギョリュウ科（Tamaricaceae）水柏枝属（Myricaria）植物で、チベット、四川、甘粛、青海、山西、雲南など中国で多く分布する落葉低木で水辺、川原に生えている。若枝を生薬として利用し、麻疹不透、風湿卑痛、癬を治すとして知られる。 MizuKashiwaeda (Myricaria germanica (L.) Desv. ) Is a tamaricaceae (Tamaricaceae) Mizukashiwa Edashoku (Myricaria) plant, Tibet, Sichuan, Gansu, Qinghai, Shanxi, Yunnan, such as in many distribution to deciduous shrub in China It grows on the waterside and Kawahara. It is known to use Wakae as a herbal medicine to cure measles impermeability, baldness, and scabies.
蕨麻（Potentilla anserina L.）は、バラ科（Rosaceae）キジムシロ属（Potentilla）植物で、中国の東北、華北、西北及び西南などに多く分布する多年草草本である。道端、溝の縁、野原などの湿気の多いところに生える。生薬としては塊根を利用し、脾を健やかにし胃を益す、脾虚による下痢を治すものとして知られる。 Potentilla anserina L. is a plant belonging to the genus Rosaceae in the genus Potentilla and is a perennial herb that is widely distributed in Northeast, North China, Northwest and Southwest of China. It grows in humid places such as roadsides, groove edges and fields. It is known as a herbal medicine that uses tuberous roots to heal the spleen and benefit the stomach, and to cure diarrhea caused by spleen collapse.
高山辣根菜（Pegaeophyton scapiflorum Hook.f. et Thoms. Marq. et Airy-Shaw）は、アブラナ科（Brassicaceae）ペガエオフィトン属（Pegaeophyton）植物で、ヒマラヤからチベット、中国の横断山脈、崑崙山脈などの海抜3700〜5500ｍの中央アジア高地に分布し、荒れた礫地などに生える小型の多年草。主に清肺熱（肺経の熱を除く）を治すとして知られる。 Takayama辣根vegetables (Pegaeophyton scapiflorum Hook.f. et Thoms. Marq . Et Airy-Shaw) is, above sea level 3700 in cruciferous (Brassicaceae) Pegaeofiton genus (Pegaeophyton) plant, Tibet from the Himalayas, China transverse mountain range, such as the Kunlun Mountains A small perennial plant that grows in rough gravels and is distributed in the Central Asian highlands of ~ 5500m. Known to cure mainly clear lung fever (excluding fever of the lungs).
これら植物及び／又はその抽出物を服用することにより、疲労感、倦怠感の予防及び治療効果を発揮するのに優れた組成物が得られることについては、本発明者が初めて見出したものである。 The inventor of the present invention has found for the first time that by taking these plants and / or extracts thereof, a composition excellent in exerting preventive and therapeutic effects on fatigue and fatigue can be obtained. .
本発明にかかる植物は、本発明にかかる植物体の花穂、葉、茎、根等の何れの部分を用いても良く、それぞれの全草を用いても良く、さらにはそれぞれの植物の全草及び各部位から複数を選択、混合しても良い。これら植物をそのまま用いる場合は、服用しやすくするため、通常は乾燥後、細かく粉砕して用いる。また、これらの抽出物を用いる場合は、その抽出方法は常法であればよく、各部位を生のまま、或いは乾燥・粉砕後に抽出することができる。 The plant according to the present invention may use any part of the plant body according to the present invention, such as the spikes, leaves, stems, roots, etc., may use each whole plant, and furthermore, the whole plant of each plant. A plurality may be selected and mixed from each part. When these plants are used as they are, they are usually dried and then finely pulverized for easy use. Moreover, when using these extracts, the extraction method should just be a conventional method, and each site | part can be extracted raw or after drying and grinding | pulverization.
本発明においてこれら植物を抽出物として用いる場合、使用する植物抽出物を調製する方法についてさらに述べる。これらの抽出溶媒及び抽出方法に限定されるものではない。抽出溶媒としては、水、エタノール、及びその混合溶媒が好適に使用できる。その溶媒を留去して用いるか、留去せずに抽出液として用いることもできる。 When these plants are used as extracts in the present invention, a method for preparing the plant extract to be used will be further described. It is not limited to these extraction solvents and extraction methods. As the extraction solvent, water, ethanol, and a mixed solvent thereof can be preferably used. The solvent can be distilled off or used as an extract without evaporation.
さらには、水や二酸化炭素、エチレン、エタノールなどの１種または２種以上の超臨界流体や亜臨界流体も用いることができる。 Furthermore, 1 type, or 2 or more types of supercritical fluids and subcritical fluids, such as water, a carbon dioxide, ethylene, and ethanol, can also be used.
抽出方法としては、常圧、若しくは加圧，減圧下で、室温、冷却又は加熱した状態で含浸させて抽出する方法、水蒸気蒸留などの蒸留法を用いて抽出する方法等を用いることができ、これらの方法を単独で、又は２種以上を組み合わせて抽出を行うこともできる。このようにして得られた本発明に係る植物抽出物は、抽出物をそのまま用いることもできるが、その効果を失わない範囲で、脱臭、脱色、濃縮などの精製操作を加えたり、さらにはカラムクロマトグラフィーなどを用いて分画物として用いてもよい。これらの抽出物や、その精製物、分画物は、これらから溶媒を除去することによって乾固物とすることもでき、乾固物をさらに、アルコールなどの溶媒に可溶化した形態、或いは乳剤の形態で用いることもできる。 As the extraction method, it is possible to use a method of extraction by impregnation under normal pressure or under pressure, reduced pressure, room temperature, cooled or heated, a method of extraction using a distillation method such as steam distillation, etc. These methods can be used alone or in combination of two or more. The plant extract according to the present invention thus obtained can be used as it is, but in the range where the effect is not lost, purification operations such as deodorization, decolorization, concentration, etc. are added, and further the column You may use as a fraction using chromatography etc. These extracts, purified products, and fractions thereof can be dried by removing the solvent from them, and the dried product is further solubilized in a solvent such as alcohol, or an emulsion. It can also be used in the form.
また、これら特定の植物及び／又はその抽出物とビタミンＢ群作用物質とを組み合わせることにより、さらに優れた疲労感、倦怠感の予防及び治療用組成物を得ることができる。 In addition, by combining these specific plants and / or extracts thereof with vitamin B group active substances, a further excellent composition for preventing and treating fatigue and fatigue can be obtained.
ビタミンＢ群作用物質としては、例えば硝酸チアミン，塩酸チアミン，チアミンピロリン酸などのビタミンＢ１類、例えばベンフォチアミン，フルスルチアミン，オクトチアミン、チアミンジスルフィド，ビスベンチアミン，ビスブチアミン，ビスイブチアミン，ジセチアミン及びそれらの塩類などのビタミンＢ１誘導体、例えばリボフラビン，リン酸リボフラビン及びその塩類，酪酸リボフラビンなどのビタミンＢ２類、例えばピリドキシン，ビリドキサミン，ピリドキサール，リン酸ピリドキシン及びそれらの塩類などのビタミンＢ６類、たとえばシアノコバラミン，酢酸ヒドロキソコバラミン，メコバラミンなどのビタミンＢ１２類、更にはパンテノール，パンテチン，葉酸及びその塩，ニコチン酸及びその塩，ニコチン酸アミド，パントテン酸及びその塩類，ビオチンなどが挙げられる。このうち効果と安全性の両面で好ましいのは、ビタミンＢ１類とビタミンＢ１誘導体で、その中でもさらに好ましいものとして、硝酸チアミン，塩酸チアミン，ベンフォチアミンが挙げられ、特に好ましくは、ベンフォチアミンを挙げることができる。ベンフォチアミンは、効果の持続性の点で特に優れている。 Examples of vitamin B group active substances include vitamin B1 such as thiamine nitrate, thiamine hydrochloride, and thiamine pyrophosphate, such as benfotiamine, fursultiamine, octthiamine, thiamine disulfide, bisbenchamine, bisbutiamine, bisibutiamine, dicetiamine Vitamin B1 derivatives such as riboflavin, phosphate riboflavin and salts thereof, vitamin B2 such as riboflavin butyrate, such as vitamin B6 such as pyridoxine, biridoxamine, pyridoxal, pyridoxine phosphate and salts thereof, such as cyanocobalamin Vitamin B12 such as hydroxocobalamin acetate, mecobalamin, panthenol, pantethine, folic acid and its salt, nicotinic acid and its salt, nicotinamide, Toten acid and salts thereof, biotin, and the like. Of these, vitamin B1 and vitamin B1 derivatives are preferable in terms of both effect and safety, and more preferable examples include thiamine nitrate, thiamine hydrochloride, and benfotiamine, and particularly preferable is benfotiamine. Can be mentioned. Benfotiamine is particularly excellent in terms of sustained effect.
本発明における植物及び／又はその抽出物に対するビタミンＢ群作用物質との配合比率については、特に好ましい範囲はなく、それぞれ１日の投与量が効果に作用する。 There is no particularly preferred range for the blending ratio of the plant B and / or its extract with the vitamin B group active substance in the present invention, and the daily dose acts on the effect.
本発明に係る植物及び／又はその抽出物の有効投与量については、抽出物で用いる場合、固形換算で成人で１日２０ｍｇ〜３ｇが好ましい。２０ｍｇ以下では、ビタミンＢ群作用物質との相助作用が見られず、３ｇ以上ではそれ以上の効果を発揮できない。 About the effective dose of the plant which concerns on this invention, and / or its extract, when using with an extract, 20 mg-3g a day are preferable for an adult in solid conversion. If it is 20 mg or less, a synergistic action with vitamin B group active substances is not observed, and if it is 3 g or more, no further effect can be exhibited.
本発明に係るビタミンＢ群作用物質の有効投与量については、ビタミンＢ１類が成人で１日１〜３０ｍｇ、ビタミンＢ１誘導体が成人で５〜１００ｍｇ、ビタミンＢ２類が成人で２〜３０ｍｇ、ビタミンＢ６類が成人で１０〜１００ｍｇ、ビタミンＢ１２類が成人で６０〜１，５００μｇ、パンテノール，パンテチン，パントテン酸などが成人で５〜３０ｍｇ、ニコチン酸類が成人で１２〜６０ｍｇが好ましい。 As for the effective dose of vitamin B group active substance according to the present invention, vitamin B1 is 1 to 30 mg per day for adults, vitamin B1 derivative is 5 to 100 mg for adults, vitamin B2 is 2 to 30 mg for adults, vitamin B6 10 to 100 mg for adults, 60 to 1,500 μg for vitamin B12 for adults, 5 to 30 mg for panthenol, panthetin, pantothenic acid and the like for adults, and 12 to 60 mg for nicotinic acids for adults.
本発明の飲食品の形態については、特に限定されるものではなく、液剤，散剤，顆粒剤，錠剤，カプセル剤，トローチ剤等の使用形態をとることが可能である。形態に応じて有効成分に適切な添加剤を配合し、公知の方法で調製することができる。 It does not specifically limit about the form of the food / beverage products of this invention, It is possible to take usage forms, such as a liquid agent, a powder, a granule, a tablet, a capsule, a troche. Depending on the form, an appropriate additive can be added to the active ingredient and prepared by a known method.
以下に、本発明に係る飲食品の実施例及び試験例を挙げて本発明をさらに詳細に説明するが、本発明の技術範囲はこれによって何ら限定されるものではない。 Hereinafter, the present invention will be described in more detail with reference to examples and test examples of food and drink according to the present invention, but the technical scope of the present invention is not limited thereto.
はじめに、本発明で用いた植物抽出物の一覧を表１に示す。以下に示す抽出方法１及び抽出方法２を用いて、本発明の抽出物を調製した。 First, Table 1 shows a list of plant extracts used in the present invention. The extract of the present invention was prepared using Extraction Method 1 and Extraction Method 2 shown below.
＜抽出方法１＞
乾燥・粉砕した本発明に係る植物を、１０倍量の５０重量％エタノール水溶液に７日間室温にて浸漬し、これをろ過後、減圧下にて溶媒を除去し乾固物とすることで、本発明で用いる植物抽出物（抽出物１，抽出物３，抽出物５，抽出物７，抽出物９，抽出物１１，抽出物１３，抽出物１５，抽出物１７）を得た。
<Extraction method 1>
By immersing the dried and pulverized plant according to the present invention in a 10-fold amount of 50% by weight aqueous ethanol solution for 7 days at room temperature, filtering this, removing the solvent under reduced pressure to obtain a dried solid product, The plant extracts (Extract 1, Extract 3, Extract 5, Extract 7, Extract 9, Extract 11, Extract 13, Extract 15, Extract 17) used in the present invention were obtained.
＜抽出方法２＞
乾燥・粉砕した本発明に係る植物を、１０倍量のエタノール水溶液に７日間室温にて浸漬し、これをろ過後、減圧下にて溶媒を除去し乾固物とすることで、本発明で用いる植物抽出物抽出物２，抽出物４，抽出物６，抽出物８，抽出物１０，抽出物１２，抽出物１４，抽出物１６，抽出物１８）を得た。
<Extraction method 2>
In the present invention, the dried and pulverized plant according to the present invention is immersed in a 10-fold amount of ethanol aqueous solution for 7 days at room temperature, filtered, and then the solvent is removed under reduced pressure to obtain a dried solid product. The plant extract extract 2, extract 4, extract 6, extract 8, extract 10, extract 12, extract 14, extract 16, extract 18) to be used were obtained.
［実施例１〜１８］液剤（ドリンク剤）
(１)アミノエチルスルホン酸 ２０ｇ
(２)Ｌ−グルタミン酸ナトリウム ４００ｍｇ
(３)ローヤルゼリー ４０ｍＬ
(４)無水カフェイン ２５００ｍｇ
(５)Ｄ−ソルビトール液（７０％） ２０ｍL
(６)果糖ブドウ糖液糖 １８０ｍL
(７)本発明生薬抽出物１〜１８（原生薬換算量） ６０００ｍｇ
(８)クエン酸 適量
(９)安息香酸ナトリウム ４８０ｍｇ
(10)蒸留水 残量
製法：蒸留水に(１)〜(７)の成分を順次混合溶解した後、(８)〜(９)の成分を添加してｐＨを３．０に調整後、蒸留水にて１０００ｍLとした。
[Examples 1 to 18] Liquid (Drink)
(1) Aminoethylsulfonic acid 20g
(2) Sodium L-glutamate 400mg
(3) Royal jelly 40mL
(4) Anhydrous caffeine 2500mg
(5) D-sorbitol solution (70%) 20 mL
(6) Fructose glucose liquid sugar 180mL
(7) The present crude drug extracts 1 to 18 (raw drug equivalent amount) 6000 mg
(8) Citric acid appropriate amount
(9) Sodium benzoate 480mg
(10) Distilled water Remaining production method: After sequentially mixing and dissolving the components (1) to (7) in distilled water, adding the components (8) to (9) and adjusting the pH to 3.0, Made up to 1000 mL with distilled water.
［実施例１９〜３６］液剤（実施例１〜１８にビタミンＢ群作用物質(２)〜(３)を配合したドリンク剤）
(１)アミノエチルスルホン酸 ２０ｇ
(２)ベンフォチアミン １０００ｍｇ
(３)塩酸ピリドキシン ４００ｍｇ
(４)Ｌ−グルタミン酸ナトリウム ４００ｍｇ
(５)ローヤルゼリー ４０ｍＬ
(６)無水カフェイン ２５００ｍｇ
(７)Ｄ−ソルビトール液（７０％） ２０ｍL
(８)果糖ブドウ糖液糖 １８０ｍL
(９)本発明生薬抽出物１〜１８（原生薬換算量） ６０００ｍｇ
(10)クエン酸 適量
(11)安息香酸ナトリウム ４８０ｍｇ
(12)蒸留水 残量
製法：蒸留水に(１)〜(９)の成分を順次混合溶解した後、(10)〜(11)の成分を添加してｐＨを３．０に調整後、蒸留水にて１０００ｍLとした。
[Examples 19 to 36] Liquid preparation (drink preparations containing vitamin B group active substances (2) to (3) in Examples 1 to 18)
(1) Aminoethylsulfonic acid 20g
(2) Benfotiamine 1000mg
(3) Pyridoxine hydrochloride 400mg
(4) Sodium L-glutamate 400 mg
(5) Royal jelly 40mL
(6) Anhydrous caffeine 2500mg
(7) D-sorbitol solution (70%) 20 mL
(8) Fructose glucose liquid sugar 180mL
(9) The present crude drug extracts 1 to 18 (concentration in bulk) 6000 mg
(10) Citric acid appropriate amount
(11) Sodium benzoate 480mg
(12) Distilled water Remaining manufacturing method: After sequentially mixing and dissolving the components (1) to (9) in distilled water, adding the components (10) to (11) and adjusting the pH to 3.0, Made up to 1000 mL with distilled water.
［実施例３７］液剤（ドリンク剤）
(１)ベンフォチアミン １０００ｍｇ
(２)リン酸リボフラビンナトリウム １２０ｍｇ
(３)塩酸ピリドキシン ４００ｍｇ
(４)ニコチン酸アミド ５００ｍｇ
(５)無水カフェイン ２０００ｍｇ
(６)Ｄ−ソルビトール液（７０％） ３５ｍL
(７)液糖 ５５ｍL
(８)還元麦芽糖水飴 １５０ｇ
(９)手掌参抽出物（原生薬換算量） ３０００ｍｇ
(10)独一味抽出物（原生薬換算量） ３０００ｍｇ
(11)クエン酸 適量
(12)安息香酸ナトリウム ４８０ｍｇ
(13)香料（グレープフルーツ系） 微量
(14)蒸留水 残量
製法：蒸留水に(１)〜(10)の成分を順次混合溶解した後、(11)〜(13)の成分を添加してｐＨを３．０に調整後、蒸留水にて１０００ｍLとした。
[Example 37] Liquid agent (drink agent)
(1) Benfotiamine 1000mg
(2) Riboflavin sodium phosphate 120mg
(3) Pyridoxine hydrochloride 400mg
(4) Nicotinamide 500mg
(5) Anhydrous caffeine 2000mg
(6) D-sorbitol solution (70%) 35 mL
(7) Liquid sugar 55mL
(8) Reduced maltose starch syrup 150g
(9) Palm ginseng extract (raw material equivalent amount) 3000mg
(10) German taste extract (raw material equivalent amount) 3000mg
(11) Citric acid appropriate amount
(12) Sodium benzoate 480mg
(13) Fragrance (grapefruit)
(14) Distilled water Remaining production method: After sequentially mixing and dissolving the components (1) to (10) in distilled water, adjusting the pH to 3.0 by adding the components (11) to (13), Made up to 1000 mL with distilled water.
［実施例３８］錠剤
(１)ベンフォチアミン ３４ｇ
(２)リボフラビン ４ｇ
(３)塩酸ピリドキシン １７ｇ
(４)ニコチン酸アミド ２０ｇ
(５)ポビドン（Ｋ＝３０） ５０ｇ
(６)コハク酸トコフェロールカルシウム ３４ｇ
(７)コンドロイチン硫酸ナトリウム ２００ｇ
(８)ショ糖脂肪酸エステル ５ｇ
(９)ステアリン酸マグネシウム １０ｇ
(10)粉末還元麦芽糖水飴 適量
(11)雪霊芝乾燥エキス ３０ｇ
(12)唐古特白刺乾燥エキス ３０ｇ
(13)白糖 適量
(14)ヒドロキシプロピルメチルセルロース ２０ｇ
(15)アラビアゴム末 適量
(16)ゼラチン 適量
(17)タルク 適量
(18)沈降炭酸カルシウム 適量
(19)カルボキシメチルセルロースナトリウム ０．２ｇ
(20)カルナウバロウ 微量
製法： (１)〜(12)の成分を順次秤量し、混合均一化した。これを湿式造粒処理後、乾燥して打錠用顆粒とし、常法にて打錠を行った。さらに、(13)〜(20)の成分を用いてコーティングを施し、最終的に０．４５ｇの糖衣錠約２０００個を得た。
[Example 38] Tablet
(1) Benfotiamine 34g
(2) Riboflavin 4g
(3) Pyridoxine hydrochloride 17g
(4) Nicotinamide 20g
(5) Povidone (K = 30) 50g
(6) Tocopherol calcium succinate 34g
(7) Sodium chondroitin sulfate 200g
(8) Sucrose fatty acid ester 5g
(9) Magnesium stearate 10g
(10) Powdered reduced maltose starch syrup
(11) Snow Ganoderma Dry Extract 30g
(12) Karako special white sashimi dried extract 30g
(13) White sugar
(14) Hydroxypropyl methylcellulose 20g
(15) Arabic gum powder
(16) Appropriate amount of gelatin
(17) Appropriate amount of talc
(18) Appropriate amount of precipitated calcium carbonate
(19) Sodium carboxymethylcellulose 0.2g
(20) Carnauba wax Small amount production method: The components (1) to (12) were weighed sequentially and mixed and homogenized. This was subjected to wet granulation treatment, dried to obtain granules for tableting, and tableting was performed by a conventional method. Furthermore, coating was performed using the components (13) to (20), and finally about 2000 sugar tablets of 0.45 g were obtained.
次に、被験体として実施例１（抽出物１を含む），実施例３（抽出物３を含む），実施例５（抽出物５を含む），実施例７（抽出物７を含む），実施例９（抽出物９を含む），実施例１１（抽出物１１を含む），実施例１３（抽出物１３を含む），実施例１５（抽出物１５を含む），実施例１７（抽出物１７を含む），実施例１９（抽出物１及びビタミンＢ群作用物質を含む），実施例２１（抽出物３及びビタミンＢ群作用物質を含む），実施例２３（抽出物５及びビタミンＢ群作用物質を含む），実施例２５（抽出物７及びビタミンＢ群作用物質を含む），実施例２７（抽出物９及びビタミンＢ群作用物質を含む），実施例２９（抽出物１１及びビタミンＢ群作用物質を含む），実施例３１（抽出物１３及びビタミンＢ群作用物質を含む），実施例３３（抽出物１５及びビタミンＢ群作用物質を含む），実施例３５（抽出物１７及びビタミンＢ群作用物質を含む），比較例１（実施例１より本発明の抽出物を除いたもの）の液剤をそれぞれ用いて、疲労感及び倦怠感に対する効果を評価した。臨床試験に用いた本発明の抽出物は、全て抽出方法１を用いたものである。 Next, as subjects, Example 1 (including Extract 1), Example 3 (including Extract 3), Example 5 (including Extract 5), Example 7 (including Extract 7), Example 9 (including extract 9), Example 11 (including extract 11), Example 13 (including extract 13), Example 15 (including extract 15), Example 17 (extract) 17), Example 19 (including Extract 1 and vitamin B group active substance), Example 21 (including Extract 3 and vitamin B group active substance), Example 23 (Extract 5 and vitamin B group active substance) Active substance), Example 25 (including extract 7 and vitamin B group active substance), Example 27 (including extract 9 and vitamin B group active substance), Example 29 (extract 11 and vitamin B group active substance) Group active substance), Example 31 (including extract 13 and vitamin B group active substance) Example 33 (including extract 15 and vitamin B group active substance), Example 35 (including extract 17 and vitamin B group active substance), Comparative Example 1 (extracting the extract of the present invention from Example 1) The effect on fatigue and fatigue was evaluated using each of the liquid products. All the extracts of the present invention used in clinical trials are those using Extraction Method 1.
この液剤５０ｇを、４０歳から６５歳の慢性的な疲れを訴える女性パネラー８名（現在、治療中もしくは投薬中ではなく、また健康食品等も服用していないことを条件として選出）に対して、１日１回夕食前に投与し、臨床試験を行った。服用後１０分後のアンケートにて評価した。 Eight female panelists who complain of chronic fatigue from the age of 40 to 65 years (selected on the condition that they are not being treated or taking medication and are not taking any health foods) Administered once a day before dinner to conduct clinical trials. Evaluation was made by a questionnaire 10 minutes after taking the drug.
なお、疲労感及び倦怠感に対する改善効果の評価については、以下の４つの評価項目を指標とし、以下の判定基準（五段階官能評価）にて実施した。試験結果を表２に示す。数値はパネラー８名の平均値である。 In addition, about the evaluation of the improvement effect with respect to a feeling of fatigue and fatigue, the following four evaluation items were used as indexes, and the following criteria (five-step sensory evaluation) were used. The test results are shown in Table 2. The numerical value is an average value of eight panelists.
［評価項目］
評価項目１：気分はすっきりしましたか
評価項目２：眠気に変化はありましたか
評価項目３：疲れに変化はありましたか
評価項目４：やる気（気力・意欲）は出ましたか
[Evaluation item]
Evaluation item 1: Did you feel refreshed? Evaluation item 2: Did you change your sleepiness? Evaluation item 3: Did you change your fatigue? Evaluation item 4: Did you feel motivated?
［判定基準］
３：かなり改善した
２：改善した
１：やや改善した
０：変わらない
−１：悪くなった
[Criteria]
3: considerably improved 2: improved 1: slightly improved
0: not changed
-1: It got worse
表２より明らかなように、臨床試験の結果、本発明の実施例においては、疲労感及び倦怠感において明確な改善効果が認められた。また、ビタミンＢ群作用物質との組合せにおいては、さらに改善が確認された。よって、本発明の組成物は優れた疲労感、倦怠感の予防及び治療効果を有することが認められた。 As is clear from Table 2, as a result of clinical trials, in the examples of the present invention, clear improvement effects were observed in fatigue and fatigue. Moreover, further improvement was confirmed in the combination with vitamin B group active substances. Therefore, it was recognized that the composition of the present invention has excellent fatigue and fatigue prevention and treatment effects.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005267416A JP5023253B2 (en) | 2005-09-14 | 2005-09-14 | Composition for preventing and treating fatigue and fatigue |
Applications Claiming Priority (1)
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| CN107913299A (en) * | 2017-05-23 | 2018-04-17 | 中国科学院西北高原生物研究所 | A kind of extraction preparation method of high pulmonary fibrosis resistant activity snow ganoderma lucidum total flavones |
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| JP5036389B2 (en) * | 2007-04-23 | 2012-09-26 | 株式会社アルソア本社 | Multivitamin |
| CN101904894B (en) * | 2009-06-05 | 2012-11-07 | 天津药物研究院 | Application of lamiophlomis rotate total glycosides in preparing medicines |
| CN104855850A (en) * | 2015-04-28 | 2015-08-26 | 青海省轻工业研究所有限责任公司 | Nitraria tangutorum skin residue extract with anti-fatigue effect and preparation method thereof |
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| CN1049125C (en) * | 1994-01-13 | 2000-02-09 | 徐晓东 | Health extract |
| CN1106291A (en) * | 1994-02-04 | 1995-08-09 | 白玛加措 | Tibetan drug and its prepn. |
| CN1067275C (en) * | 1994-11-04 | 2001-06-20 | 西藏自治区太阳能研究示范中心 | Snow ganoderma lucidum oral liquid |
| FR2749303B1 (en) * | 1996-05-30 | 1998-08-07 | Berkem Sa | PROCESS FOR THE EXTRACTION OF CATECHIC POLYPHENOLS FROM POTENTILLES OBTAINED AND ITS USE |
| CN1211434A (en) * | 1997-09-12 | 1999-03-24 | 吴登举 | Oral liquid for resisting altitude stress and its preparation method |
| JP2002291441A (en) * | 2001-03-30 | 2002-10-08 | Sunstar Inc | Astragalin-containing food |
| CN1158093C (en) * | 2001-10-19 | 2004-07-21 | 江苏省中医药研究院 | Medicine composition containing yak bone for treating rhenmatism and method for making same |
| CN1416731A (en) * | 2001-11-01 | 2003-05-14 | 中国科学院西北高原生物研究所 | Blood fat-reducing anti-fatigue health food composition |
| CN1419912A (en) * | 2001-11-17 | 2003-05-28 | 郑秋生 | Cyanidenon, apigenin -7-0-beta-D-glucoside use and related medicine |
| CN1493228A (en) * | 2002-11-01 | 2004-05-05 | 南京中西制剂研究所 | Health care food containing fern extract and its preparation method |
| TWI322008B (en) * | 2003-01-31 | 2010-03-21 | Kaneka Corp | Fatigue improving agent including reduced coenzyme q10 |
| JP2005023008A (en) * | 2003-07-01 | 2005-01-27 | Sankyo Co Ltd | Internal liquid medicine composition containing vitamin b group |
| JP4472281B2 (en) * | 2003-07-23 | 2010-06-02 | 株式会社黒姫和漢薬研究所 | Components of orchidaceae and their uses |
| JPWO2005079824A1 (en) * | 2004-02-25 | 2008-01-10 | 英元 日下 | Beverages and medicines based on bamboo extract |
| CN100341529C (en) * | 2005-01-21 | 2007-10-10 | 西藏宇妥藏药研究有限公司 | Combination of Tibet medicine of containing salt and possessing medicinal effect health care, and preparation metohd |
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| CN107913299A (en) * | 2017-05-23 | 2018-04-17 | 中国科学院西北高原生物研究所 | A kind of extraction preparation method of high pulmonary fibrosis resistant activity snow ganoderma lucidum total flavones |
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