JP5020818B2 - 生物学的試料中の核酸を検出するための方法及び組成物 - Google Patents

生物学的試料中の核酸を検出するための方法及び組成物 Download PDF

Info

Publication number
JP5020818B2
JP5020818B2 JP2007520409A JP2007520409A JP5020818B2 JP 5020818 B2 JP5020818 B2 JP 5020818B2 JP 2007520409 A JP2007520409 A JP 2007520409A JP 2007520409 A JP2007520409 A JP 2007520409A JP 5020818 B2 JP5020818 B2 JP 5020818B2
Authority
JP
Japan
Prior art keywords
capture
probe
target
nucleic acid
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2007520409A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008504842A5 (https=
JP2008504842A (ja
Inventor
ベッカー，マイケル・エム
マジレッシ，マーダド，アール
Original Assignee
ジェン−プローブ・インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ジェン−プローブ・インコーポレーテッド filed Critical ジェン−プローブ・インコーポレーテッド
Publication of JP2008504842A publication Critical patent/JP2008504842A/ja
Publication of JP2008504842A5 publication Critical patent/JP2008504842A5/ja
Application granted granted Critical
Publication of JP5020818B2 publication Critical patent/JP5020818B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2007520409A 2004-07-01 2005-06-29 生物学的試料中の核酸を検出するための方法及び組成物 Expired - Fee Related JP5020818B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58542104P 2004-07-01 2004-07-01
US60/585,421 2004-07-01
PCT/US2005/023555 WO2006007567A2 (en) 2004-07-01 2005-06-29 Methods and compositions to detect nucleic acids in a biological sample

Publications (3)

Publication Number Publication Date
JP2008504842A JP2008504842A (ja) 2008-02-21
JP2008504842A5 JP2008504842A5 (https=) 2008-05-29
JP5020818B2 true JP5020818B2 (ja) 2012-09-05

Family

ID=35457287

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007520409A Expired - Fee Related JP5020818B2 (ja) 2004-07-01 2005-06-29 生物学的試料中の核酸を検出するための方法及び組成物

Country Status (9)

Country Link
US (3) US8034554B2 (https=)
EP (1) EP1778867B1 (https=)
JP (1) JP5020818B2 (https=)
AT (1) ATE466107T1 (https=)
AU (2) AU2005262357B2 (https=)
CA (1) CA2572472C (https=)
DE (1) DE602005020943D1 (https=)
DK (1) DK1778867T3 (https=)
WO (1) WO2006007567A2 (https=)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2572472C (en) 2004-07-01 2013-08-13 Gen-Probe Incorporated Methods and compositions to detect nucleic acids in a biological sample
EP1819835B1 (en) 2004-12-08 2010-08-04 Gen-Probe Incorporated Detection of nucleic acids from multiple types of human papillomaviruses
ATE551433T1 (de) * 2005-05-06 2012-04-15 Gen Probe Inc Verfahren und produkte zum erfassen von nukleinsäurezielen
US8632970B2 (en) * 2005-05-09 2014-01-21 Affymetrix, Inc. Multiplex capture of nucleic acids
US20070072223A1 (en) * 2005-09-16 2007-03-29 Primera Biosystems, Inc. Compositions and methods for purifying nucleic acids
WO2007047912A2 (en) 2005-10-17 2007-04-26 Gen-Probe Incorporated Compositions and methods to detect legionella pneumophila nucleic acid
DK1991694T3 (da) 2006-02-13 2016-08-01 Fluidigm Canada Inc Genekspressionsanalyse med grundstoftagget oligonukleotid
CA2651946A1 (en) * 2006-05-12 2007-11-22 Gen-Probe Incorporated Compositions and methods to detect enterococci nucleic acid
DE602007012045D1 (de) 2006-06-06 2011-03-03 Gen Probe Inc Markierte oligonukleotide und ihre verwendung in nukleinsäureverstärkungsverfahren
WO2008052774A2 (en) * 2006-10-31 2008-05-08 Noxxon Pharma Ag Methods for detection of a single- or double-stranded nucleic acid molecule
WO2008055915A2 (en) * 2006-11-06 2008-05-15 Clondiag Gmbh Device and process for assays using binding members
AU2014200826B2 (en) * 2006-11-06 2016-01-14 Clondiag Gmbh Assays
AU2016202243B2 (en) * 2006-11-06 2017-12-14 Clondiag Gmbh Assays
EP3095873B1 (en) 2006-12-21 2018-04-18 Gen-Probe Incorporated Methods and compositions for nucleic acid amplification
EP1978111B1 (en) 2007-04-02 2013-03-27 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of Pseudomonas aeruginosa
AU2008280121B2 (en) * 2007-07-23 2015-02-26 Clondiag Gmbh Assays
US20090162845A1 (en) * 2007-12-20 2009-06-25 Elazar Rabbani Affinity tag nucleic acid and protein compositions, and processes for using same
US7595164B2 (en) * 2007-12-26 2009-09-29 Gen-Probe Incorporated Compositions and methods to detect Candida albicans nucleic acid
US20090215050A1 (en) * 2008-02-22 2009-08-27 Robert Delmar Jenison Systems and methods for point-of-care amplification and detection of polynucleotides
US10316352B2 (en) * 2008-05-13 2019-06-11 Gen-Probe Incorporated Methods of capturing a target nucleic acid for amplification and detection using an inactivatable target capture oligomer
AU2009262870B2 (en) * 2008-05-30 2014-03-20 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of Salmonella
EP2853601B1 (en) * 2008-07-18 2016-09-21 TrovaGene, Inc. Methods for PCR-based detection of "ultra short" nucleic acid sequences
CN102292457B (zh) * 2008-11-25 2014-04-09 简·探针公司 检测小rna的组合物和方法及其用途
EP2910647A1 (en) 2008-12-30 2015-08-26 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of listeria
CA3128851C (en) 2009-06-23 2025-05-27 Gen-Probe Incorporated COMPOSITIONS AND METHODS FOR DETECTING A NUCLEIC ACID FROM MOLLICUTES
US8512955B2 (en) 2009-07-01 2013-08-20 Gen-Probe Incorporated Methods and compositions for nucleic acid amplification
EP2473624B1 (en) 2009-08-31 2019-05-01 Gen-Probe Incorporated Dengue virus assay
EP3040425B1 (en) 2010-02-17 2019-08-28 Gen-Probe Incorporated Compostions and methods to detect atopobium vaginae nucleic acid
EP2561094B1 (en) 2010-04-21 2017-03-29 Gen-Probe Incorporated Compositions, methods and kits to detect herpes simplex virus nucleic acid
WO2012030856A2 (en) 2010-08-30 2012-03-08 Gen-Probe Incorporated Compositions, methods and reaction mixtures for the detection of xenotropic murine leukemia virus-related virus
EP2616555B1 (en) * 2010-09-16 2017-11-08 Gen-Probe Incorporated Capture probes immobilizable via l-nucleotide tail
EP2625297B1 (en) 2010-10-04 2018-10-10 Gen-Probe Prodesse, Inc. Compositions, methods and kits to detect adenovirus nucleic acids
US9255293B2 (en) 2010-11-01 2016-02-09 Gen-Probe Incorporated Integrated capture and amplification of target nucleic acid for sequencing
EP2683833B1 (en) 2011-03-10 2018-09-26 Gen-Probe Incorporated Methods for the selection and optimization of oligonucleotide tag sequences
WO2012149034A1 (en) 2011-04-25 2012-11-01 Gen-Probe Incorporated Compositions and methods for detecting bv-associated bacterial nucleic acid
EP3009522B1 (en) 2011-07-15 2019-09-04 Gen-Probe Incorporated Method for detecting hepatitis a virus nucleic acids in single-plex or multiplex assays
EP3620533B1 (en) 2011-09-06 2023-01-18 Gen-Probe Incorporated Closed nucleic acid structures
WO2013036928A1 (en) 2011-09-08 2013-03-14 Gen-Probe Incorporated Compositions and methods for detecting bv-associated bacterial nucleic acid
US9175337B2 (en) 2011-09-21 2015-11-03 Gen-Probe Incorporated Methods for amplifying nucleic acid using tag-mediated displacement
AU2012316218B2 (en) 2011-09-26 2016-03-17 Gen-Probe Incorporated Algorithms for sequence determinations
DE102011120550B4 (de) 2011-12-05 2013-11-07 Gen-Probe Prodesse, Inc. Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren
US10655165B2 (en) * 2012-02-01 2020-05-19 Gen-Probe Incorporated Asymmetric hairpin target capture oligomers
CA2865281C (en) 2012-02-24 2021-11-23 Gen-Probe Prodesse, Inc. Detection of shiga toxin genes in bacteria
JP6196611B2 (ja) * 2012-03-05 2017-09-13 日本碍子株式会社 標的核酸の検出方法
AU2013205110B2 (en) 2012-04-24 2016-10-13 Gen-Probe Incorporated Compositions, Methods and Kits to Detect Herpes Simplex Virus Nucleic Acids
AU2013205064B2 (en) 2012-06-04 2015-07-30 Gen-Probe Incorporated Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid
EP2890814B1 (en) 2012-08-30 2019-11-13 Gen-Probe Incorporated Multiphase nucleic acid amplification
AU2013205122B2 (en) 2012-10-11 2016-11-10 Gen-Probe Incorporated Compositions and Methods for Detecting Human Papillomavirus Nucleic Acid
AU2013205090B2 (en) 2012-12-07 2016-07-28 Gen-Probe Incorporated Compositions and Methods for Detecting Gastrointestinal Pathogen Nucleic Acid
US9708658B2 (en) * 2013-03-19 2017-07-18 New England Biolabs, Inc. Enrichment of target sequences
EP4299767A3 (en) 2013-08-14 2024-03-27 Gen-Probe Incorporated Compositions and methods for detecting hev nucleic acid
CN111484992B (zh) 2014-02-28 2024-04-02 简·探针公司 从含有甲醛的液基细胞学防腐剂中的样本分离核酸的方法
DE102015017080B3 (de) 2014-02-28 2024-01-04 Gen-Probe Incorporated Verfahren zur Isolierung von Nukleinsäure von zytologischen Proben in flüssigen Konservierungsmitteln, die Formaldehyd enthalten
US10093989B2 (en) 2014-10-20 2018-10-09 Gen-Probe Incorporated Red blood cell lysis solution
EP3242956B1 (en) 2015-01-09 2020-06-17 Gen-Probe Incorporated Methods and compositions for diagnosing bacterial vaginosis
US20160258938A1 (en) * 2015-03-04 2016-09-08 Headway Technologies, Inc. Method of detecting an analyte in a sample
US10550438B2 (en) 2015-03-16 2020-02-04 Gen-Probe Incorporated Methods and compositions for detecting bacterial nucleic acid
US11111549B2 (en) 2016-01-04 2021-09-07 Gen-Probe Incorporated Methods and compositions for detecting Candida species
BR112018016240A2 (pt) 2016-02-11 2019-01-02 Htg Molecular Diagnostics Inc método de sequência alvo direta que utiliza proteção da nuclease
JP6584986B2 (ja) * 2016-03-18 2019-10-02 株式会社東芝 核酸検出方法
EP3448998B1 (en) 2016-04-27 2020-06-03 Gen-Probe Incorporated Blood cell lysis reagent
JP6803930B2 (ja) 2016-06-10 2021-01-06 ジェン−プローブ・インコーポレーテッド Ｚｉｋａウイルス核酸を検出するための組成物および方法
WO2018075633A2 (en) 2016-10-19 2018-04-26 Gen-Probe Incorporated Compositions and methods for detecting or quantifying hepatitis c virus
US10508313B2 (en) 2016-11-21 2019-12-17 Gen-Probe Incorporated Compositions and methods for detecting or quantifying Hepatitis B virus
US10844425B2 (en) 2017-03-24 2020-11-24 Gen-Probe Incorporated Compositions and methods for detecting or quantifying parainfluenza virus
JP6956800B2 (ja) 2017-03-25 2021-11-02 ジェン−プローブ・インコーポレーテッド アデノウイルス、メタニューモウイルス、および／またはライノウイルス核酸を検出するための組成物、方法、およびキット
CN110612354B (zh) 2017-05-11 2025-02-11 简·探针公司 用于分离靶核酸的组合物和方法
EP4276201A3 (en) 2017-06-07 2024-01-17 Gen-Probe Incorporated Detecting babesia species nucleic acid in a sample
US12006542B2 (en) * 2017-06-09 2024-06-11 University Of Houston System Force-modulated hybridization for visualizing nucleic acid length and function
US11859257B2 (en) 2017-08-11 2024-01-02 Gen-Probe Incorporated Compositions and methods for detecting Staphylococcus aureus
CA3082909C (en) 2017-11-17 2023-07-25 Gen-Probe Incorporated Compositions and methods for detecting c1orf43 nucleic acid
WO2019118550A1 (en) 2017-12-13 2019-06-20 Gen-Probe Incorporated Methods for biological sample processing
EP3724354A1 (en) 2017-12-15 2020-10-21 Gen-Probe Incorporated Compositions and methods for detecting toxigenic clostridium difficile
JP7358395B2 (ja) 2018-02-06 2023-10-10 ジェン－プローブ・インコーポレーテッド 遠赤染料プローブ製剤
AU2019286648B2 (en) 2018-06-13 2023-11-23 Gen-Probe Incorporated Compositions and methods for detecting group B Streptococcus nucleic acid
WO2020028631A1 (en) 2018-08-01 2020-02-06 Gen-Probe Incorporated Compositions and methods for detecting nucleic acids of epstein-barr virus
AU2019326462C1 (en) * 2018-08-21 2026-02-12 Gen-Probe Incorporated Compositions and methods for amplifying, detecting or quantifying human cytomegalovirus
JP7389111B2 (ja) 2018-08-24 2023-11-29 ジェン－プローブ・インコーポレーテッド 細菌の核酸を検出し、細菌性膣炎を診断するための組成物および方法
CN109337956B (zh) * 2018-09-07 2022-08-19 上海思路迪生物医学科技有限公司 基于ngs技术富集多基因茎环探针设计方法及试剂盒
CA3116895A1 (en) 2018-10-22 2020-04-30 Gen-Probe Incorporated Compositions and methods for amplifying, detecting or quantifying human polyomavirus bk virus
TW202030333A (zh) 2018-12-20 2020-08-16 美商簡 探針公司 用於檢測瘧原蟲物種核酸之組成物及方法
EP3914732A1 (en) 2019-01-25 2021-12-01 Gen-Probe Incorporated Detection of drug-resistant mycoplasma genitalium
EP3942078A1 (en) 2019-03-22 2022-01-26 Gen-Probe Incorporated Compositions and methods for detecting group a streptococcus
KR102336454B1 (ko) * 2019-06-17 2021-12-08 강릉원주대학교산학협력단 핵산 검출 방법
WO2021003331A1 (en) 2019-07-03 2021-01-07 Gen-Probe Incorporated Oligonucleotides for use in determining the presence of trichomonas vaginalis in a sample
CN116287111A (zh) 2019-11-14 2023-06-23 简·探针公司 用于捕获靶核酸的组合物和方法
US20230117369A1 (en) 2020-03-04 2023-04-20 Gen-Probe Incorporated Compositions and methods for detecting sars-cov-2 nucleaic acid
WO2021224873A1 (en) 2020-05-07 2021-11-11 Grifols Diagnostic Solutions Inc. Methods and compositions for detecting sars-cov-2 nucleic acid
US20240158834A1 (en) 2021-03-15 2024-05-16 Gen-Probe Incorporated Compositions and methods for biological sample processing
AU2022273052A1 (en) 2021-05-14 2023-11-30 Gen-Probe Incorporated Compositions and methods for detecting human adenovirus nucleic acid
JP7813304B2 (ja) 2021-07-01 2026-02-12 ジェン－プローブ・インコーポレーテッド 核酸増幅のための酵素製剤および反応混合物
CA3226812A1 (en) 2021-07-27 2023-02-02 Gen-Probe Incorporated Compositions and methods for detecting gastrointestinal pathogens
CN114107446A (zh) * 2021-12-16 2022-03-01 福建和瑞基因科技有限公司 一种核酸的检测试剂盒及其检测方法
CN114250224B (zh) * 2021-12-16 2024-02-27 福建和瑞基因科技有限公司 一种用于提取或检测样本中小分子rna的核酸组合物及其试剂盒和方法
WO2024054924A1 (en) 2022-09-08 2024-03-14 Gen-Probe Incorporated Method of detecting nucleic acid analytes using dual-specificity primers
WO2024081776A1 (en) 2022-10-13 2024-04-18 Gen-Probe Incorporated Cellularity control for nucleic acid assays
WO2024081040A1 (en) * 2022-10-15 2024-04-18 Renato Rozental Material and method for diagnosis of traumatic brain injury
WO2024137379A2 (en) 2022-12-19 2024-06-27 Gen-Probe Incorporated Compositions and methods for detecting gastrointestinal pathogens
WO2024161179A1 (en) 2023-01-31 2024-08-08 Mobidiag Oy Compositions and methods for detecting stx nucleic acids
WO2024192338A1 (en) 2023-03-16 2024-09-19 Gen-Probe Incorporated Compositions and methods for detecting gastrointestinal parasites
EP4455303A1 (en) 2023-04-28 2024-10-30 Mobidiag Oy Nucleic acid amplification process controls
EP4455304A1 (en) 2023-04-28 2024-10-30 Mobidiag Oy Nucleic acid amplification process controls
EP4454758A1 (en) 2023-04-28 2024-10-30 Mobidiag Oy Nucleic acid amplification process controls
WO2026050332A1 (en) 2024-08-29 2026-03-05 Gen-Probe Incorporated Methods and compositions for amplifying and/or detecting rotavirus nucleic acids

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4174384A (en) 1975-06-30 1979-11-13 Syva Company Fluorescence quenching with immunological pairs in immunoassays
CA1190838A (en) 1981-07-17 1985-07-23 Cavit Akin Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer
FI63596C (fi) 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
US4556643A (en) 1982-07-26 1985-12-03 Agracetus Assay method and probe for polynucleotide sequences
US5288609A (en) 1984-04-27 1994-02-22 Enzo Diagnostics, Inc. Capture sandwich hybridization method and composition
CA1260372A (en) 1984-04-27 1989-09-26 Elazar Rabbani Hybridization method for the detection of genetic materials
US6221581B1 (en) 1984-04-27 2001-04-24 Enzo Diagnostics, Inc. Processes for detecting polynucleotides, determining genetic mutations or defects in genetic material, separating or isolating nucleic acid of interest from samples, and useful compositions of matter and multihybrid complex compositions
US4766062A (en) 1984-05-07 1988-08-23 Allied Corporation Displacement polynucleotide assay method and polynucleotide complex reagent therefor
US5268266A (en) 1984-05-07 1993-12-07 Genetics Institute, Inc. Process and nucleic acid construct for producing reagent complexes useful in determining target nucleotide sequences
US4824776A (en) 1985-07-25 1989-04-25 Molecular Biosystems, Inc. Method for increasing the sensitivity of nucleic acid hybridization assays
US4725536A (en) 1985-09-19 1988-02-16 Genetics Institute, Inc. Reagent polynucleotide complex with multiple target binding regions, and kit and methods
US4752566A (en) 1985-12-17 1988-06-21 Genetics Institute, Inc. Displacement polynucleotide method and reagent complex employing labeled probe polynucleotide
US4818680A (en) 1985-12-18 1989-04-04 Mary Collins Method and kit involving displacement and rehybridization of labeled polynucleotide
CA1273552A (en) 1985-12-23 1990-09-04 Michael J. Heller Fluorescent stokes shift probes for polynucleotide hybridization assays
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
ZA877772B (en) 1986-10-23 1988-04-20 Amoco Corporation Target and background capture methods and apparatus for affinity assays
US5283174A (en) 1987-09-21 1994-02-01 Gen-Probe, Incorporated Homogenous protection assay
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5118801A (en) * 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
ATE142272T1 (de) 1989-01-19 1996-09-15 Behringwerke Ag Nukleinsäure-amplifikation unter verwendung eines einzelprimers
WO1990010717A1 (en) 1989-03-10 1990-09-20 Gene-Trak Systems Preventing interference with affinity capture schemes
ATE118824T1 (de) 1989-03-10 1995-03-15 Amoco Corp Immobilisierte oligonukleotidsonden und ihre verwendungen.
US5589335A (en) * 1989-04-05 1996-12-31 Amoco Corporation Hybridization promotion reagents
DE69032847T2 (de) 1989-06-30 1999-05-12 Chiron Corp., Emeryville, Calif. Hydrophobe Nukleinsäure-Sonde
US5439793A (en) 1990-07-19 1995-08-08 Syntex (U.S.A.) Inc. Method for producing a polynucleotide having an intramolecularly base-paired structure
US5849481A (en) 1990-07-27 1998-12-15 Chiron Corporation Nucleic acid hybridization assays employing large comb-type branched polynucleotides
EP0529070A1 (en) 1991-02-27 1993-03-03 Amoco Corporation Methods for improving the sensitivity of hybridization assays
US5445933A (en) 1992-09-15 1995-08-29 Boehringer Mannheim Corporation Strand displacement assay and complex useful therefor
EP0601889A2 (en) * 1992-12-10 1994-06-15 Maine Medical Center Research Institute Nucleic acid probes
US6576419B1 (en) 1993-07-23 2003-06-10 University Of Utah Research Foundation Assay procedure using fluorogenic tracers
CA2105364A1 (en) 1993-09-01 1995-03-02 Eric T. Kool Stem-loop oligonucleotides containing parallel and antiparallel binding domains
US6156501A (en) 1993-10-26 2000-12-05 Affymetrix, Inc. Arrays of modified nucleic acid probes and methods of use
US6129828A (en) * 1996-09-06 2000-10-10 Nanogen, Inc. Apparatus and methods for active biological sample preparation
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5681697A (en) 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
US5861273A (en) 1993-12-21 1999-01-19 Celtrix Phamraceuticals, Inc. Chromosomal expression of heterologous genes in bacterial cells
US5631148A (en) 1994-04-22 1997-05-20 Chiron Corporation Ribozymes with product ejection by strand displacement
EP0763050B1 (en) 1994-06-01 2000-01-05 Hybridon, Inc. Branched oligonucleotide as pathogen-inhibitory agents
US5731148A (en) 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
US5770365A (en) * 1995-08-25 1998-06-23 Tm Technologies, Inc. Nucleic acid capture moieties
CA2239683A1 (en) 1995-12-22 1997-07-03 Dade Behring Marburg Gmbh Homogeneous amplification and detection of nucleic acids
AU713667B2 (en) 1996-04-12 1999-12-09 Phri Properties, Inc. Detection probes, kits and assays
US20030054376A1 (en) * 1997-07-07 2003-03-20 Mullis Kary Banks Dual bead assays using cleavable spacers and/or ligation to improve specificity and sensitivity including related methods and apparatus
JP2000514307A (ja) * 1996-07-16 2000-10-31 ジェン―プローブ・インコーポレーテッド 増加した標的特異的ｔ▲下ｍ▼を持つ修飾オリゴヌクレオチドを用いた核酸配列の検出および増幅のための方法
US5965363A (en) 1996-09-19 1999-10-12 Genetrace Systems Inc. Methods of preparing nucleic acids for mass spectrometric analysis
US6025133A (en) 1996-12-30 2000-02-15 Gen-Probe Incorporated Promoter-sequestered oligonucleoside and method of use
EP0975807B1 (en) * 1997-05-02 2006-09-27 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
ATE478090T1 (de) 1997-10-27 2010-09-15 Boston Probes Inc SICH AUF ßPNA MOLECULAR BEACONSß BEZIEHENDE VERFAHREN, TESTSÄTZE UND ZUSAMMENSETZUNGEN
AU762728B2 (en) * 1998-07-02 2003-07-03 Gen-Probe Incorporated Molecular torches
US6399302B1 (en) 1998-08-21 2002-06-04 University Of Virginia Patent Foundation Signal generating oligonucleotide-based biosensor
US6472522B1 (en) 1998-08-27 2002-10-29 Bayer Corporation Purification of oligomers using dual-end selection
CA2361201A1 (en) 1999-01-28 2000-08-03 Medical College Of Georgia Research Institute, Inc. Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
WO2000071740A1 (en) * 1999-05-24 2000-11-30 The Public Health Research Institute Of The City Of New York, Inc. High specificity hairpin antisense oligonucleotides
US7052844B2 (en) * 1999-12-21 2006-05-30 Ingeneus, Inc. Purification of DS-DNA using heteropolymeric capture probes and a triplex, quadruplex or homologous duplex binding mechanism
WO2001094625A2 (en) * 2000-06-06 2001-12-13 Tm Bioscience Corporation Capture moieties for nucleic acids and uses thereof
US6451588B1 (en) * 2000-06-30 2002-09-17 Pe Corporation (Ny) Multipartite high-affinity nucleic acid probes
US6596490B2 (en) 2000-07-14 2003-07-22 Applied Gene Technologies, Inc. Nucleic acid hairpin probes and uses thereof
WO2002048401A2 (en) 2000-12-11 2002-06-20 Alexion Pharmaceuticals, Inc. Nested oligonucleotides containing hairpin for nucleic acid amplification
USH2220H1 (en) 2001-08-10 2008-07-01 Snp Consortium Identification and mapping of single nucleotide polymorphisms in the human genome
US7371580B2 (en) * 2001-08-24 2008-05-13 Agilent Technologies, Inc. Use of unstructured nucleic acids in assaying nucleic acid molecules
US7345155B2 (en) * 2001-11-02 2008-03-18 Gen-Probe Incorporated Probes, compositions and kits for determining the presence of Mycoplasma genitalium in a test sample
WO2003100095A1 (en) 2002-05-08 2003-12-04 Arkray, Inc. Method of detecting target nucleic acid
US7851150B2 (en) 2002-12-18 2010-12-14 Third Wave Technologies, Inc. Detection of small nucleic acids
US7741031B2 (en) * 2003-03-07 2010-06-22 The Public Health Research Institute Of The City Of New York Optically decodable microcarries, arrays and methods
WO2005004794A2 (en) 2003-06-09 2005-01-20 Alnylam Pharmaceuticals Inc. Method of treating neurodegenerative disease
US20050037362A1 (en) 2003-08-11 2005-02-17 Eppendorf Array Technologies, S.A. Detection and quantification of siRNA on microarrays
CA2572472C (en) 2004-07-01 2013-08-13 Gen-Probe Incorporated Methods and compositions to detect nucleic acids in a biological sample
US20060292616A1 (en) 2005-06-23 2006-12-28 U.S. Genomics, Inc. Single molecule miRNA-based disease diagnostic methods

Also Published As

Publication number Publication date
US20110250599A1 (en) 2011-10-13
AU2009238261B2 (en) 2011-11-17
ATE466107T1 (de) 2010-05-15
JP2008504842A (ja) 2008-02-21
EP1778867A2 (en) 2007-05-02
WO2006007567A2 (en) 2006-01-19
US20120231551A1 (en) 2012-09-13
WO2006007567A3 (en) 2006-03-30
US8034554B2 (en) 2011-10-11
US8460869B2 (en) 2013-06-11
DE602005020943D1 (de) 2010-06-10
EP1778867B1 (en) 2010-04-28
CA2572472C (en) 2013-08-13
AU2009238261A1 (en) 2009-12-03
AU2005262357A1 (en) 2006-01-19
DK1778867T3 (da) 2010-08-02
CA2572472A1 (en) 2006-01-19
AU2005262357B2 (en) 2009-10-29
US20060068417A1 (en) 2006-03-30
US8551766B2 (en) 2013-10-08

Similar Documents

Publication Publication Date Title
JP5020818B2 (ja) 生物学的試料中の核酸を検出するための方法及び組成物
JP6674984B2 (ja) 核酸の非特異的標的の捕捉方法
CN110612354B (zh) 用于分离靶核酸的组合物和方法
CN114728263A (zh) 用于捕获靶核酸的组合物和方法
AU2011203508B2 (en) Methods of nonspecific target capture of nucleic acids

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080409

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20080409

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110104

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110331

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110407

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110506

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20110912

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120123

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120423

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20120517

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20120613

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

Ref document number: 5020818

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20150622

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20150622

Year of fee payment: 3

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: R3D02

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees