ATE466107T1 - Verfahren und zusammensetzungen zum nachweis von nukleinsäuren in einer biologischen probe - Google Patents
Verfahren und zusammensetzungen zum nachweis von nukleinsäuren in einer biologischen probeInfo
- Publication number
- ATE466107T1 ATE466107T1 AT05767727T AT05767727T ATE466107T1 AT E466107 T1 ATE466107 T1 AT E466107T1 AT 05767727 T AT05767727 T AT 05767727T AT 05767727 T AT05767727 T AT 05767727T AT E466107 T1 ATE466107 T1 AT E466107T1
- Authority
- AT
- Austria
- Prior art keywords
- capture
- nucleic acid
- hairpin
- methods
- sample
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title abstract 5
- 108020004707 nucleic acids Proteins 0.000 title abstract 4
- 102000039446 nucleic acids Human genes 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 239000012472 biological sample Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000000523 sample Substances 0.000 abstract 7
- 238000001514 detection method Methods 0.000 abstract 2
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 230000009870 specific binding Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58542104P | 2004-07-01 | 2004-07-01 | |
PCT/US2005/023555 WO2006007567A2 (en) | 2004-07-01 | 2005-06-29 | Methods and compositions to detect nucleic acids in a biological sample |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE466107T1 true ATE466107T1 (de) | 2010-05-15 |
Family
ID=35457287
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05767727T ATE466107T1 (de) | 2004-07-01 | 2005-06-29 | Verfahren und zusammensetzungen zum nachweis von nukleinsäuren in einer biologischen probe |
Country Status (9)
Country | Link |
---|---|
US (3) | US8034554B2 (de) |
EP (1) | EP1778867B1 (de) |
JP (1) | JP5020818B2 (de) |
AT (1) | ATE466107T1 (de) |
AU (2) | AU2005262357B2 (de) |
CA (1) | CA2572472C (de) |
DE (1) | DE602005020943D1 (de) |
DK (1) | DK1778867T3 (de) |
WO (1) | WO2006007567A2 (de) |
Families Citing this family (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1778867B1 (de) | 2004-07-01 | 2010-04-28 | Gen-Probe Incorporated | Verfahren und zusammensetzungen zum nachweis von nukleinsäuren in einer biologischen probe |
DE602005022759D1 (de) | 2004-12-08 | 2010-09-16 | Gen Probe Inc | Nukleinsäuredetektion aus verschiedenen typen des humanen papillomavirus |
EP1877581B1 (de) * | 2005-05-06 | 2012-03-28 | Gen-Probe Incorporated | Verfahren und produkte zum erfassen von nukleinsäurezielen |
US8632970B2 (en) * | 2005-05-09 | 2014-01-21 | Affymetrix, Inc. | Multiplex capture of nucleic acids |
EP1924591A4 (de) * | 2005-09-16 | 2009-04-15 | Primera Biosystems Inc | Zusammensetzungen und verfahren zur reinigung von nukleinsäuren |
WO2007047912A2 (en) | 2005-10-17 | 2007-04-26 | Gen-Probe Incorporated | Compositions and methods to detect legionella pneumophila nucleic acid |
WO2007093050A1 (en) * | 2006-02-13 | 2007-08-23 | Olga Ornatsky | Gene expression assays conducted by elemental analysis |
ATE514794T1 (de) * | 2006-05-12 | 2011-07-15 | Gen Probe Inc | Zusammensetzungen und verfahren für den nachweis von enterokokken-nukleinsäuren |
PL2017356T3 (pl) | 2006-06-06 | 2012-03-30 | Gen Probe Inc | Znakowane oligonukleotydy i ich zastosowanie w sposobach amplifikacji kwasu nukleinowego |
US20100062436A1 (en) * | 2006-10-31 | 2010-03-11 | Noxxon Pharma Ag | Methods for Detection of a Single- or Double-Stranded Nucleic Acid Molecule |
AU2014200826B2 (en) * | 2006-11-06 | 2016-01-14 | Clondiag Gmbh | Assays |
CN103497991A (zh) * | 2006-11-06 | 2014-01-08 | 科隆迪亚戈有限公司 | 使用结合元件用于分析的装置和方法 |
AU2016202243B2 (en) * | 2006-11-06 | 2017-12-14 | Clondiag Gmbh | Assays |
EP3095873B1 (de) | 2006-12-21 | 2018-04-18 | Gen-Probe Incorporated | Verfahren und zusammensetzungen zur amplifizierung von nukleinsäuren |
EP1978111B1 (de) | 2007-04-02 | 2013-03-27 | Gen-Probe Incorporated | Zusammensetzungen, Kits und zugehörige Verfahren zur Erkennung und/oder Überwachung von Pseudomonas aeruginosa |
JP5859203B2 (ja) | 2007-07-23 | 2016-02-10 | クロンデイアグ・ゲーエムベーハー | アッセイ |
US20090162845A1 (en) * | 2007-12-20 | 2009-06-25 | Elazar Rabbani | Affinity tag nucleic acid and protein compositions, and processes for using same |
CA2715991A1 (en) * | 2007-12-26 | 2009-07-09 | Gen-Probe Incorporated | Amplification oligomers and methods to detect candida albicans 26s rrna or encoding dna |
US20090215050A1 (en) * | 2008-02-22 | 2009-08-27 | Robert Delmar Jenison | Systems and methods for point-of-care amplification and detection of polynucleotides |
EP2806037B1 (de) | 2008-05-13 | 2016-09-21 | Gen-Probe Incorporated | Inaktivierbare Target-Capture-Oligomere zur Verwendung bei der selektiven Hybridisierung und beim Fangen von Zielnukleinsäuresequenzen |
WO2009158119A2 (en) | 2008-05-30 | 2009-12-30 | Gen-Probe Incorporated | Compositions, kits and related methods for the detection and/or monitoring of salmonella |
EP2853601B1 (de) * | 2008-07-18 | 2016-09-21 | TrovaGene, Inc. | Verfahren für den PCR-basierten Nachweis ultrakurzer Nukleinsäuresequenzen |
WO2010068473A1 (en) * | 2008-11-25 | 2010-06-17 | Gen-Probe Incorporated | Compositions and methods for detecting small rnas, and uses thereof |
EP2389449B1 (de) | 2008-12-30 | 2015-02-18 | Gen-Probe Incorporated | Zusammensetzungen, kits und damit verbundene verfahren zum nachweis und/oder überwachen von listerien |
EP2446057B1 (de) | 2009-06-23 | 2014-11-19 | Gen-Probe Incorporated | Zusammensetzungen und verfahren für den nukleinsäurenachweis aus mollicutes |
WO2011003020A1 (en) | 2009-07-01 | 2011-01-06 | Gen-Probe Incorporated | Methods and compositions for nucleic acid amplification |
EP2473624B1 (de) | 2009-08-31 | 2019-05-01 | Gen-Probe Incorporated | Test für dengue-virus |
WO2011103274A1 (en) | 2010-02-17 | 2011-08-25 | Gen-Probe Incorporated | Compositions and methods to detect atopobium vaginae nucleic acid |
WO2011133811A2 (en) | 2010-04-21 | 2011-10-27 | Gen-Probe Incorporated | Compositions, methods and kits to detect herpes simplex virus nucleic acid |
WO2012030856A2 (en) | 2010-08-30 | 2012-03-08 | Gen-Probe Incorporated | Compositions, methods and reaction mixtures for the detection of xenotropic murine leukemia virus-related virus |
EP2616555B1 (de) | 2010-09-16 | 2017-11-08 | Gen-Probe Incorporated | Über l-nukleotidenden immobilisierbare fängersonden |
EP2625297B1 (de) | 2010-10-04 | 2018-10-10 | Gen-Probe Prodesse, Inc. | Zusammensetzungen, verfahren und kits für den nachweis von adenovirus-nukleinsäuren |
EP2635703B1 (de) | 2010-11-01 | 2018-03-21 | Gen-Probe Incorporated | Integriertes binden und amplifikation von zielnukleinsäuren zum sequenzieren |
EP2683833B1 (de) | 2011-03-10 | 2018-09-26 | Gen-Probe Incorporated | Verfahren zur auswahl und optimierung von oligonukleotid-tagsequenzen |
AU2012249751B2 (en) | 2011-04-25 | 2016-11-03 | Gen-Probe Incorporated | Compositions and methods for detecting BV-associated bacterial nucleic acid |
AU2012284307A1 (en) | 2011-07-15 | 2013-05-09 | Gen-Probe Incorporated | Compositions and method for detecting human parvovirus nucleic acid and for detecting hepatitis A virus nucleic acids in single-plex or multiplex assays |
AU2012304537B2 (en) | 2011-09-06 | 2015-08-20 | Gen-Probe Incorporated | Closed nucleic acid structures |
US9663829B2 (en) | 2011-09-08 | 2017-05-30 | Gen-Probe Incorporated | Compositions and methods for detecting BV-associated bacterial nucleic acid |
EP2758547B1 (de) | 2011-09-21 | 2015-09-16 | Gen-Probe Incorporated | Verfahren zur amplifikation von nukleinsäuren unter verwendung von tag-vermittelter verschiebung |
US10152569B2 (en) | 2011-09-26 | 2018-12-11 | Gen-Probe Incorporated | Algorithms for sequence determinations |
DE102011120550B4 (de) | 2011-12-05 | 2013-11-07 | Gen-Probe Prodesse, Inc. | Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren |
AU2013205603B2 (en) * | 2012-02-01 | 2016-03-17 | Gen-Probe Incorporated | Asymmetric hairpin target capture oligomers |
AU2013205010B2 (en) | 2012-02-24 | 2016-10-20 | Gen-Probe Incorporated | Detection of Shiga toxin genes in bacteria |
EP2824180B1 (de) * | 2012-03-05 | 2019-04-03 | NGK Insulators, Ltd. | Verfahren zur detektion einer zielnucleinsäure |
AU2013205110B2 (en) | 2012-04-24 | 2016-10-13 | Gen-Probe Incorporated | Compositions, Methods and Kits to Detect Herpes Simplex Virus Nucleic Acids |
AU2013205064B2 (en) | 2012-06-04 | 2015-07-30 | Gen-Probe Incorporated | Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid |
ES2761920T3 (es) | 2012-08-30 | 2020-05-21 | Gen Probe Inc | Amplificación de ácido nucleico multifásica |
AU2013205122B2 (en) | 2012-10-11 | 2016-11-10 | Gen-Probe Incorporated | Compositions and Methods for Detecting Human Papillomavirus Nucleic Acid |
AU2013205090B2 (en) | 2012-12-07 | 2016-07-28 | Gen-Probe Incorporated | Compositions and Methods for Detecting Gastrointestinal Pathogen Nucleic Acid |
US9567632B2 (en) * | 2013-03-19 | 2017-02-14 | New England Biolabs, Inc. | Enrichment of target sequences |
EP3033437B1 (de) | 2013-08-14 | 2023-11-08 | Gen-Probe Incorporated | Zusammensetzungen und verfahren zur detektion von hev-nukleinsäure |
EP3670663A1 (de) | 2014-02-28 | 2020-06-24 | Gen-Probe Incorporated | Verfahren zur isolierung von nukleinsäure aus proben in flüssigkeitsbasierten zytologischen konservierungsmitteln mit formaldehyd |
GB2528344B (en) | 2014-02-28 | 2018-10-31 | Gen Probe Inc | Method of isolating nucleic acid from specimens in liquid-based cytology preservatives containing formaldehyde |
GB2536745B (en) | 2014-10-20 | 2019-06-26 | Gen Probe Inc | Red Blood cell lysis solution |
JP6944873B2 (ja) | 2015-01-09 | 2021-10-06 | ジェン−プローブ・インコーポレーテッド | 細菌性膣症を診断するための方法および組成物 |
US20160258938A1 (en) * | 2015-03-04 | 2016-09-08 | Headway Technologies, Inc. | Method of detecting an analyte in a sample |
US10550438B2 (en) | 2015-03-16 | 2020-02-04 | Gen-Probe Incorporated | Methods and compositions for detecting bacterial nucleic acid |
EP4249609A3 (de) | 2016-01-04 | 2023-12-20 | Gen-Probe Incorporated | Verfahren und zusammensetzungen zum nachweis von candida-spezies |
AU2017218112B2 (en) * | 2016-02-11 | 2022-08-04 | Htg Molecular Diagnostics, Inc. | Method of direct target sequencing using nuclease protection |
JP6584986B2 (ja) * | 2016-03-18 | 2019-10-02 | 株式会社東芝 | 核酸検出方法 |
CA3021914A1 (en) | 2016-04-27 | 2017-11-02 | Gen-Probe Incorporated | Blood cell lysis reagent |
EP3985131A1 (de) | 2016-06-10 | 2022-04-20 | Gen-Probe Incorporated | Zusammensetzungen und verfahren für den nachweis von zikavirus-nukleinsäure |
AU2017346854A1 (en) | 2016-10-19 | 2019-05-30 | Gen-Probe Incorporated | Compositions and methods for detecting or quantifying hepatitis C virus |
US10508313B2 (en) | 2016-11-21 | 2019-12-17 | Gen-Probe Incorporated | Compositions and methods for detecting or quantifying Hepatitis B virus |
EP3601617B3 (de) | 2017-03-24 | 2024-03-20 | Gen-Probe Incorporated | Zusammensetzungen und verfahren zum nachweis oder zur quantifizierung des parainfluenzavirus |
EP4219768A3 (de) | 2017-03-25 | 2023-10-11 | Gen-Probe Incorporated | Zusammensetzungen, verfahren und kits zum nachweis von metapneumovirus-nukleinsäuren |
AU2018265274B2 (en) | 2017-05-11 | 2021-10-07 | Gen-Probe Incorporated | Compositions and methods for isolating target nucleic acids |
WO2018226798A1 (en) | 2017-06-07 | 2018-12-13 | Gen-Probe Incorporated | Detecting babesia species nucleic acid in a sample |
WO2018227182A2 (en) * | 2017-06-09 | 2018-12-13 | University Of Houston System | Force-modulated hybridization for visualizing nucleic acid length and function |
CA3072452A1 (en) | 2017-08-11 | 2019-02-14 | Gen-Probe Incorporated | Compositions and methods for detecting staphylococcus aureus |
US11377688B2 (en) | 2017-11-17 | 2022-07-05 | Gen-Probe Incorporated | Compositions and methods for detecting C1orf43 nucleic acid |
WO2019118550A1 (en) | 2017-12-13 | 2019-06-20 | Gen-Probe Incorporated | Methods for biological sample processing |
JP2021506274A (ja) | 2017-12-15 | 2021-02-22 | ジェン−プローブ・インコーポレーテッド | 毒素産生Clostridium difficileを検出するための組成物および方法 |
CH716454B1 (de) | 2018-06-13 | 2023-05-15 | Gen Probe Inc | Zusammensetzungen und Verfahren zum Nachweis der Nukleinsäure von Gruppe-B-Streptococcus. |
EP3830302B1 (de) | 2018-08-01 | 2022-10-05 | Gen-Probe Incorporated | Zusammensetzungen und verfahren zum nachweis von nukleinsäuren des epstein-barr-virus |
AU2019326462A1 (en) | 2018-08-21 | 2021-03-25 | Gen-Probe Incorporated | Compositions and methods for amplifying, detecting or quantifying human cytomegalovirus |
CA3108906A1 (en) | 2018-08-24 | 2020-02-27 | Gen-Probe Incorporated | Compositions and methods for detecting bacterial nucleic acid and diagnosing bacterial vaginosis |
CN109337956B (zh) * | 2018-09-07 | 2022-08-19 | 上海思路迪生物医学科技有限公司 | 基于ngs技术富集多基因茎环探针设计方法及试剂盒 |
WO2020086546A1 (en) | 2018-10-22 | 2020-04-30 | Gen-Probe Incorporated | Compositions and methods for amplifying, detecting or quantifying human polyomavirus bk virus |
TW202030333A (zh) | 2018-12-20 | 2020-08-16 | 美商簡 探針公司 | 用於檢測瘧原蟲物種核酸之組成物及方法 |
AU2020210753A1 (en) | 2019-01-25 | 2021-09-02 | Gen-Probe Incorporated | Detection of drug-resistant mycoplasma genitalium |
US20220098647A1 (en) | 2019-03-22 | 2022-03-31 | Gen-Probe Incorporated | Compositions and Methods for Detecting Group A Streptococcus |
KR102336454B1 (ko) * | 2019-06-17 | 2021-12-08 | 강릉원주대학교산학협력단 | 핵산 검출 방법 |
CN114096683A (zh) | 2019-07-03 | 2022-02-25 | 简·探针公司 | 用于确定样品中阴道毛滴虫的存在的寡核苷酸 |
US20220396786A1 (en) | 2019-11-14 | 2022-12-15 | Gen-Probe Incorporated | Compositions and Methods for Capturing Target Nucleic Acids |
JP2023516683A (ja) | 2020-03-04 | 2023-04-20 | ジェン-プローブ・インコーポレーテッド | SARS-CoV-2核酸を検出するための組成物および方法 |
WO2021224873A1 (en) | 2020-05-07 | 2021-11-11 | Grifols Diagnostic Solutions Inc. | Methods and compositions for detecting sars-cov-2 nucleic acid |
JP2024510996A (ja) | 2021-03-15 | 2024-03-12 | ジェン-プローブ・インコーポレーテッド | 生物学的サンプル処理のための組成物および方法 |
CA3218222A1 (en) | 2021-05-14 | 2022-11-17 | Gen-Probe Incorporated | Compositions and methods for detecting human adenovirus nucleic acid |
AU2022304654A1 (en) | 2021-07-01 | 2023-12-14 | Gen-Probe Incorporated | Enzyme formulations and reaction mixtures for nucleic acid amplification |
WO2023010008A1 (en) | 2021-07-27 | 2023-02-02 | Gen-Probe Incorporated | Compositions and methods for detecting gastrointestinal pathogens |
CN114107446A (zh) * | 2021-12-16 | 2022-03-01 | 福建和瑞基因科技有限公司 | 一种核酸的检测试剂盒及其检测方法 |
CN114250224B (zh) * | 2021-12-16 | 2024-02-27 | 福建和瑞基因科技有限公司 | 一种用于提取或检测样本中小分子rna的核酸组合物及其试剂盒和方法 |
WO2024054924A1 (en) | 2022-09-08 | 2024-03-14 | Gen-Probe Incorporated | Method of detecting nucleic acid analytes using dual-specificity primers |
Family Cites Families (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4174384A (en) * | 1975-06-30 | 1979-11-13 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
CA1190838A (en) | 1981-07-17 | 1985-07-23 | Cavit Akin | Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer |
FI63596C (fi) * | 1981-10-16 | 1983-07-11 | Orion Yhtymae Oy | Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser |
US4556643A (en) * | 1982-07-26 | 1985-12-03 | Agracetus | Assay method and probe for polynucleotide sequences |
US6221581B1 (en) * | 1984-04-27 | 2001-04-24 | Enzo Diagnostics, Inc. | Processes for detecting polynucleotides, determining genetic mutations or defects in genetic material, separating or isolating nucleic acid of interest from samples, and useful compositions of matter and multihybrid complex compositions |
CA1260372A (en) * | 1984-04-27 | 1989-09-26 | Elazar Rabbani | Hybridization method for the detection of genetic materials |
US5288609A (en) * | 1984-04-27 | 1994-02-22 | Enzo Diagnostics, Inc. | Capture sandwich hybridization method and composition |
US4766062A (en) * | 1984-05-07 | 1988-08-23 | Allied Corporation | Displacement polynucleotide assay method and polynucleotide complex reagent therefor |
US5268266A (en) * | 1984-05-07 | 1993-12-07 | Genetics Institute, Inc. | Process and nucleic acid construct for producing reagent complexes useful in determining target nucleotide sequences |
US4824776A (en) * | 1985-07-25 | 1989-04-25 | Molecular Biosystems, Inc. | Method for increasing the sensitivity of nucleic acid hybridization assays |
US4725536A (en) * | 1985-09-19 | 1988-02-16 | Genetics Institute, Inc. | Reagent polynucleotide complex with multiple target binding regions, and kit and methods |
US4752566A (en) * | 1985-12-17 | 1988-06-21 | Genetics Institute, Inc. | Displacement polynucleotide method and reagent complex employing labeled probe polynucleotide |
US4818680A (en) * | 1985-12-18 | 1989-04-04 | Mary Collins | Method and kit involving displacement and rehybridization of labeled polynucleotide |
CA1273552A (en) | 1985-12-23 | 1990-09-04 | Michael J. Heller | Fluorescent stokes shift probes for polynucleotide hybridization assays |
ZA877772B (en) * | 1986-10-23 | 1988-04-20 | Amoco Corporation | Target and background capture methods and apparatus for affinity assays |
US5714380A (en) * | 1986-10-23 | 1998-02-03 | Amoco Corporation | Closed vessel for isolating target molecules and for performing amplification |
US5283174A (en) * | 1987-09-21 | 1994-02-01 | Gen-Probe, Incorporated | Homogenous protection assay |
US5124246A (en) * | 1987-10-15 | 1992-06-23 | Chiron Corporation | Nucleic acid multimers and amplified nucleic acid hybridization assays using same |
US5118801A (en) * | 1988-09-30 | 1992-06-02 | The Public Health Research Institute | Nucleic acid process containing improved molecular switch |
CA2008096A1 (en) * | 1989-01-19 | 1990-07-19 | Samuel Rose | Nucleic acid amplification using single primer |
EP0481999B1 (de) * | 1989-03-10 | 1997-07-23 | VYSIS, Inc. | Interferenzverhinderung mit affinitätseinfangschemas |
AU5269590A (en) * | 1989-03-10 | 1990-10-09 | Gene-Trak Systems | Immobilized oligonucleotide probes and uses therefor |
US5589335A (en) * | 1989-04-05 | 1996-12-31 | Amoco Corporation | Hybridization promotion reagents |
ATE174926T1 (de) * | 1989-06-30 | 1999-01-15 | Chiron Corp | Hydrophobe nukleinsäure-sonde |
US5439793A (en) * | 1990-07-19 | 1995-08-08 | Syntex (U.S.A.) Inc. | Method for producing a polynucleotide having an intramolecularly base-paired structure |
US5849481A (en) * | 1990-07-27 | 1998-12-15 | Chiron Corporation | Nucleic acid hybridization assays employing large comb-type branched polynucleotides |
WO1992015708A1 (en) * | 1991-02-27 | 1992-09-17 | Amoco Corporation | Methods for improving the sensitivity of hybridization assays |
US5445933A (en) * | 1992-09-15 | 1995-08-29 | Boehringer Mannheim Corporation | Strand displacement assay and complex useful therefor |
EP0601889A2 (de) * | 1992-12-10 | 1994-06-15 | Maine Medical Center Research Institute | Nukleinsäure-Sonden |
US6576419B1 (en) * | 1993-07-23 | 2003-06-10 | University Of Utah Research Foundation | Assay procedure using fluorogenic tracers |
US5514546A (en) * | 1993-09-01 | 1996-05-07 | Research Corporation Technologies, Inc. | Stem-loop oligonucleotides containing parallel and antiparallel binding domains |
US6156501A (en) * | 1993-10-26 | 2000-12-05 | Affymetrix, Inc. | Arrays of modified nucleic acid probes and methods of use |
US6129828A (en) * | 1996-09-06 | 2000-10-10 | Nanogen, Inc. | Apparatus and methods for active biological sample preparation |
US5925517A (en) * | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
US5538848A (en) * | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
US5681697A (en) * | 1993-12-08 | 1997-10-28 | Chiron Corporation | Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor |
US5861273A (en) | 1993-12-21 | 1999-01-19 | Celtrix Phamraceuticals, Inc. | Chromosomal expression of heterologous genes in bacterial cells |
US5631148A (en) * | 1994-04-22 | 1997-05-20 | Chiron Corporation | Ribozymes with product ejection by strand displacement |
DE69514351T2 (de) * | 1994-06-01 | 2000-08-10 | Hybridon Inc | Verzweigte Oligonukleotide als pathogenhemmende Mittel |
US5731148A (en) * | 1995-06-07 | 1998-03-24 | Gen-Probe Incorporated | Adduct protection assay |
US5770365A (en) * | 1995-08-25 | 1998-06-23 | Tm Technologies, Inc. | Nucleic acid capture moieties |
JP2001517925A (ja) * | 1995-12-22 | 2001-10-09 | ベーリングウエルケ、アクティエンゲゼルシャフト | 核酸の均質増幅および検出 |
JP3898228B2 (ja) * | 1996-04-12 | 2007-03-28 | ザ パブリック ヘルス リサーチ インスティチュート オブ ザ シティー オブ ニューヨーク インク | 検出プローブ、キット及びアッセイ |
US20030054376A1 (en) * | 1997-07-07 | 2003-03-20 | Mullis Kary Banks | Dual bead assays using cleavable spacers and/or ligation to improve specificity and sensitivity including related methods and apparatus |
CA2260749A1 (en) * | 1996-07-16 | 1998-01-22 | Gen-Probe Incorporated | Methods for detecting rna analytes using modified probes |
US5965363A (en) * | 1996-09-19 | 1999-10-12 | Genetrace Systems Inc. | Methods of preparing nucleic acids for mass spectrometric analysis |
US6025133A (en) * | 1996-12-30 | 2000-02-15 | Gen-Probe Incorporated | Promoter-sequestered oligonucleoside and method of use |
DK0975807T3 (da) * | 1997-05-02 | 2007-01-29 | Gen Probe Inc | To-trins hybridisering og indfangning af et polynukleotid |
US6534273B2 (en) * | 1997-05-02 | 2003-03-18 | Gen-Probe Incorporated | Two-step hybridization and capture of a polynucleotide |
WO1999022018A2 (en) | 1997-10-27 | 1999-05-06 | Boston Probes, Inc. | Methods, kits and compositions pertaining to pna molecular beacons |
AU762728B2 (en) * | 1998-07-02 | 2003-07-03 | Gen-Probe Incorporated | Molecular torches |
AU5492499A (en) * | 1998-08-21 | 2000-03-14 | University Of Virginia Patent Foundation | Signal generating oligonucleotide-based biosensor |
DE69912443T2 (de) * | 1998-08-27 | 2004-08-19 | Bayer Corporation, Medfield | Oligomerreinigung durch selektion mittels zweier enden |
EP1147204A1 (de) * | 1999-01-28 | 2001-10-24 | Medical College Of Georgia Research Institute, Inc. | Zusammensetzung und verfahren zur in vivo und in vitro abschwächung der genexpression mittels dobbelsträngigem rna |
CA2374421A1 (en) * | 1999-05-24 | 2000-11-30 | The Public Health Research Institute Of The City Of New York, Inc. | High specificity hairpin antisense oligonucleotides |
US7052844B2 (en) * | 1999-12-21 | 2006-05-30 | Ingeneus, Inc. | Purification of DS-DNA using heteropolymeric capture probes and a triplex, quadruplex or homologous duplex binding mechanism |
JP2003535599A (ja) * | 2000-06-06 | 2003-12-02 | ティーエム バイオサイエンス コーポレイション | 核酸の捕捉部とその使用 |
US6451588B1 (en) * | 2000-06-30 | 2002-09-17 | Pe Corporation (Ny) | Multipartite high-affinity nucleic acid probes |
US6596490B2 (en) | 2000-07-14 | 2003-07-22 | Applied Gene Technologies, Inc. | Nucleic acid hairpin probes and uses thereof |
EP1366191A2 (de) * | 2000-12-11 | 2003-12-03 | Alexion Pharmaceuticals, Inc. | 'nested' haarnadelförmige oligonukleotide zur amplifizierung von nukleinsäure |
USH2220H1 (en) | 2001-08-10 | 2008-07-01 | Snp Consortium | Identification and mapping of single nucleotide polymorphisms in the human genome |
US7371580B2 (en) | 2001-08-24 | 2008-05-13 | Agilent Technologies, Inc. | Use of unstructured nucleic acids in assaying nucleic acid molecules |
US7214780B2 (en) * | 2001-11-02 | 2007-05-08 | Gen-Probe Incorporated | Probes, compositions and kits for determining the presence of Mycoplasma pneuomoniae in a test sample |
WO2003100095A1 (fr) * | 2002-05-08 | 2003-12-04 | Arkray, Inc. | Procede de detection d'un acide nucleique cible |
US7851150B2 (en) * | 2002-12-18 | 2010-12-14 | Third Wave Technologies, Inc. | Detection of small nucleic acids |
DE602004021569D1 (de) | 2003-03-07 | 2009-07-30 | Univ New Jersey Med | Optisch dekodierbare mikroträger, arrays und verfahren |
AU2004255557B2 (en) * | 2003-06-09 | 2010-06-10 | Alnylam Pharmaceuticals, Inc. | Method of treating neurodegenerative disease |
US20050037362A1 (en) | 2003-08-11 | 2005-02-17 | Eppendorf Array Technologies, S.A. | Detection and quantification of siRNA on microarrays |
EP1778867B1 (de) | 2004-07-01 | 2010-04-28 | Gen-Probe Incorporated | Verfahren und zusammensetzungen zum nachweis von nukleinsäuren in einer biologischen probe |
US20060292616A1 (en) * | 2005-06-23 | 2006-12-28 | U.S. Genomics, Inc. | Single molecule miRNA-based disease diagnostic methods |
-
2005
- 2005-06-29 EP EP05767727A patent/EP1778867B1/de active Active
- 2005-06-29 JP JP2007520409A patent/JP5020818B2/ja not_active Expired - Fee Related
- 2005-06-29 US US11/173,915 patent/US8034554B2/en not_active Expired - Fee Related
- 2005-06-29 CA CA2572472A patent/CA2572472C/en active Active
- 2005-06-29 DK DK05767727.0T patent/DK1778867T3/da active
- 2005-06-29 AU AU2005262357A patent/AU2005262357B2/en not_active Ceased
- 2005-06-29 AT AT05767727T patent/ATE466107T1/de not_active IP Right Cessation
- 2005-06-29 DE DE602005020943T patent/DE602005020943D1/de active Active
- 2005-06-29 WO PCT/US2005/023555 patent/WO2006007567A2/en active Application Filing
-
2009
- 2009-11-13 AU AU2009238261A patent/AU2009238261B2/en not_active Ceased
-
2010
- 2010-07-28 US US12/845,640 patent/US8551766B2/en active Active
-
2011
- 2011-04-14 US US13/087,282 patent/US8460869B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP2008504842A (ja) | 2008-02-21 |
AU2009238261A1 (en) | 2009-12-03 |
EP1778867A2 (de) | 2007-05-02 |
US20110250599A1 (en) | 2011-10-13 |
US20120231551A1 (en) | 2012-09-13 |
WO2006007567A3 (en) | 2006-03-30 |
US8034554B2 (en) | 2011-10-11 |
CA2572472C (en) | 2013-08-13 |
US20060068417A1 (en) | 2006-03-30 |
CA2572472A1 (en) | 2006-01-19 |
US8460869B2 (en) | 2013-06-11 |
JP5020818B2 (ja) | 2012-09-05 |
EP1778867B1 (de) | 2010-04-28 |
DE602005020943D1 (de) | 2010-06-10 |
US8551766B2 (en) | 2013-10-08 |
AU2005262357B2 (en) | 2009-10-29 |
DK1778867T3 (da) | 2010-08-02 |
AU2005262357A1 (en) | 2006-01-19 |
WO2006007567A2 (en) | 2006-01-19 |
AU2009238261B2 (en) | 2011-11-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE466107T1 (de) | Verfahren und zusammensetzungen zum nachweis von nukleinsäuren in einer biologischen probe | |
FI3872187T3 (fi) | Koostumuksia ja menetelmiä näytteiden identifioinnin parantamiseksi indeksoiduissa nukleiinihappokirjastoissa | |
WO2001092572A1 (fr) | Ensemble et procede de determination du type de hla | |
EP2366803A3 (de) | Zusammensetzungen und Verfahren zum Nacheis des West Nil Viruses. | |
IS8314A (is) | Ákvörðun fjölkirnisraðar | |
EP1716257B8 (de) | Neue primer und sonden zum nachweis von parvovirus b19 | |
CN101275165A (zh) | 用于鉴定亚甲基四氢叶酸还原酶(mthfr)基因型的核酸引物组和探针 | |
KR20210038541A (ko) | 핵산 검출 방법 | |
CA2525413A1 (en) | Compositions, methods and kits for determining the presence of trichomonas vaginalis in a test sample | |
ATE522606T1 (de) | Verfahren zum nachweis von apfelmosaikvirus, primersatz für den nachweis und kit für den nachweis | |
AU2023201805B2 (en) | Blood cell lysis reagent | |
KR930004477A (ko) | 미코박테리아 프라이머 및 탐침 | |
ATE485391T1 (de) | Zusammensetzungen, methoden und testssysteme zur bestimmung der präsenz von cryptosporidium organismen in einer testprobe | |
CA2747479C (en) | Methods and reagents for shortening incubation times in hybridization assays | |
ATE366325T1 (de) | Verfahren zum nachweisen von mikroorganismen in einer probe | |
ATE492649T1 (de) | Microarray-basiertes verfahren zur amplifikation und detektion von nukleinsäuren in einem kontinuierlichen prozess | |
WO2008068636A3 (en) | Blocking agents comprising non-natural nucleic acids and detection methods using such blocking agents | |
ATE466105T1 (de) | Verfahren, zusammensetzungen und kits zur anreicherung und zum nachweis von mikroorganismen | |
KR20070100531A (ko) | 쌍이온 화합물을 이용한 핵산 혼성화 특이성을 증가시키는방법 | |
ATE440968T1 (de) | Verfahren zur diagnostizierung von aspirinunverträglichkeit | |
CA2549059A1 (en) | Oligonucleotides for the detection of hepatitis b virus | |
ATE463583T1 (de) | Verfahren zum nachweis von chlamydia trachomatis und kit dafür | |
ATE472613T1 (de) | Nukleinsäuresequenzen, die sich als primer und sonden bei der amplifikation und dem nachweis von hsv-dna verwenden lassen, sowie verfahren zur amplifikation und zum nachweis von hsv-dna unter einsatz einer amplifikation auf transkriptionsbasis | |
EP1323835A3 (de) | Methode zur Bestimmung einer Biospezies in einer Testprobe und dafür verwendeter Testsatz | |
ATE307906T1 (de) | Verfahren zum nachweis von gram-positiven bakterien |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |