ATE466107T1 - Verfahren und zusammensetzungen zum nachweis von nukleinsäuren in einer biologischen probe - Google Patents
Verfahren und zusammensetzungen zum nachweis von nukleinsäuren in einer biologischen probeInfo
- Publication number
- ATE466107T1 ATE466107T1 AT05767727T AT05767727T ATE466107T1 AT E466107 T1 ATE466107 T1 AT E466107T1 AT 05767727 T AT05767727 T AT 05767727T AT 05767727 T AT05767727 T AT 05767727T AT E466107 T1 ATE466107 T1 AT E466107T1
- Authority
- AT
- Austria
- Prior art keywords
- capture
- nucleic acid
- hairpin
- methods
- sample
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58542104P | 2004-07-01 | 2004-07-01 | |
| PCT/US2005/023555 WO2006007567A2 (en) | 2004-07-01 | 2005-06-29 | Methods and compositions to detect nucleic acids in a biological sample |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE466107T1 true ATE466107T1 (de) | 2010-05-15 |
Family
ID=35457287
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05767727T ATE466107T1 (de) | 2004-07-01 | 2005-06-29 | Verfahren und zusammensetzungen zum nachweis von nukleinsäuren in einer biologischen probe |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US8034554B2 (de) |
| EP (1) | EP1778867B1 (de) |
| JP (1) | JP5020818B2 (de) |
| AT (1) | ATE466107T1 (de) |
| AU (2) | AU2005262357B2 (de) |
| CA (1) | CA2572472C (de) |
| DE (1) | DE602005020943D1 (de) |
| DK (1) | DK1778867T3 (de) |
| WO (1) | WO2006007567A2 (de) |
Families Citing this family (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8034554B2 (en) | 2004-07-01 | 2011-10-11 | Gen-Probe Incorporated | Methods and compositions to detect nucleic acids in a biological sample |
| WO2006063065A2 (en) | 2004-12-08 | 2006-06-15 | Gen-Probe Incorporated | Detection of nucleic acids from multiple types of human papillomaviruses |
| ES2381279T3 (es) * | 2005-05-06 | 2012-05-24 | Gen-Probe Incorporated | Métodos y productos para la captura de ácido nucleico diana |
| US8632970B2 (en) * | 2005-05-09 | 2014-01-21 | Affymetrix, Inc. | Multiplex capture of nucleic acids |
| CA2622712A1 (en) * | 2005-09-16 | 2007-03-29 | Primera Biosystems, Inc. | Compositions and methods for purifying nucleic acids |
| EP2400037A1 (de) | 2005-10-17 | 2011-12-28 | Gen-Probe Incorporated | Zusammensetzungen und Verfahren zum Nachweisen von Legionella-pneumophila-Nukleinsäure |
| CA2640508C (en) | 2006-02-13 | 2014-04-15 | Olga Ornatsky | Gene expression assays conducted by elemental analysis |
| CA2651946A1 (en) * | 2006-05-12 | 2007-11-22 | Gen-Probe Incorporated | Compositions and methods to detect enterococci nucleic acid |
| PL2017356T3 (pl) | 2006-06-06 | 2012-03-30 | Gen Probe Inc | Znakowane oligonukleotydy i ich zastosowanie w sposobach amplifikacji kwasu nukleinowego |
| WO2008052774A2 (en) * | 2006-10-31 | 2008-05-08 | Noxxon Pharma Ag | Methods for detection of a single- or double-stranded nucleic acid molecule |
| AU2016202243B2 (en) * | 2006-11-06 | 2017-12-14 | Clondiag Gmbh | Assays |
| AU2014200826B2 (en) * | 2006-11-06 | 2016-01-14 | Clondiag Gmbh | Assays |
| US8846313B2 (en) | 2006-11-06 | 2014-09-30 | Clondiag Gmbh | Assays |
| US8198027B2 (en) | 2006-12-21 | 2012-06-12 | Gen-Probe Incorporated | Methods and compositions for nucleic acid amplification |
| EP1978111B1 (de) | 2007-04-02 | 2013-03-27 | Gen-Probe Incorporated | Zusammensetzungen, Kits und zugehörige Verfahren zur Erkennung und/oder Überwachung von Pseudomonas aeruginosa |
| CN101848765B (zh) | 2007-07-23 | 2016-03-09 | 科隆迪亚戈有限公司 | 分析方法 |
| US20090162845A1 (en) * | 2007-12-20 | 2009-06-25 | Elazar Rabbani | Affinity tag nucleic acid and protein compositions, and processes for using same |
| EP2235214B1 (de) * | 2007-12-26 | 2014-07-09 | Gen Probe Inc | Zusammensetzungen und verfahren für den nachweis von candida albicans-nukleinsäure |
| US20090215050A1 (en) * | 2008-02-22 | 2009-08-27 | Robert Delmar Jenison | Systems and methods for point-of-care amplification and detection of polynucleotides |
| EP2806037B1 (de) | 2008-05-13 | 2016-09-21 | Gen-Probe Incorporated | Inaktivierbare Target-Capture-Oligomere zur Verwendung bei der selektiven Hybridisierung und beim Fangen von Zielnukleinsäuresequenzen |
| WO2009158119A2 (en) | 2008-05-30 | 2009-12-30 | Gen-Probe Incorporated | Compositions, kits and related methods for the detection and/or monitoring of salmonella |
| ES2595489T3 (es) * | 2008-07-18 | 2016-12-30 | Trovagene, Inc. | Métodos para la detección de secuencias de ácidos nucleicos "ultracortos" basados en PCR |
| CN102292457B (zh) * | 2008-11-25 | 2014-04-09 | 简·探针公司 | 检测小rna的组合物和方法及其用途 |
| JP5793085B2 (ja) | 2008-12-30 | 2015-10-14 | ジェン−プローブ・インコーポレーテッド | Listeriaを検出およびモニターするための組成物、キットおよび関連する方法 |
| CA2768768C (en) | 2009-06-23 | 2021-08-24 | Gen-Probe Incorporated | Compositions and methods for detecting nucleic acid from mollicutes |
| EP2449132B1 (de) | 2009-07-01 | 2015-05-13 | Gen-Probe Incorporated | Verfahren und zusammensetzungen zur erweiterung von nukleinsäuren |
| WO2013132700A1 (ja) * | 2012-03-05 | 2013-09-12 | 日本碍子株式会社 | 標的核酸の検出方法 |
| US8999675B2 (en) | 2009-08-31 | 2015-04-07 | Gen-Probe Incorporated | Dengue virus assay |
| WO2011103274A1 (en) | 2010-02-17 | 2011-08-25 | Gen-Probe Incorporated | Compositions and methods to detect atopobium vaginae nucleic acid |
| EP3037555B1 (de) | 2010-04-21 | 2019-07-24 | Gen-Probe Incorporated | Zusammensetzungen, verfahren und kits für den nachweis von herpes-simplex-virusnukleinsäuren |
| EP2611932A2 (de) | 2010-08-30 | 2013-07-10 | Gen-Probe Incorporated | Zusammensetzungen, verfahren und reaktionsmischungen für den nachweis von xenotropic murine leukemia virus-related virus (xmrv) |
| CA2811333C (en) | 2010-09-16 | 2020-05-12 | Gen-Probe Incorporated | Capture probes immobilizable via l-nucleotide tail |
| EP2625297B1 (de) | 2010-10-04 | 2018-10-10 | Gen-Probe Prodesse, Inc. | Zusammensetzungen, verfahren und kits für den nachweis von adenovirus-nukleinsäuren |
| EP3388532B1 (de) | 2010-11-01 | 2021-03-10 | Gen-Probe Incorporated | Integrierte erfassung und amplifizierung von zielnukleinsäuren zur sequenzierung |
| WO2012122571A1 (en) | 2011-03-10 | 2012-09-13 | Gen-Probe Incorporated | Methods and compositions for the selection and optimization of oligonucleotide tag sequences |
| US9657352B2 (en) | 2011-04-25 | 2017-05-23 | Gen-Probe Incorporated | Compositions and methods for detecting BV-associated bacterial nucleic acid |
| WO2013012708A1 (en) | 2011-07-15 | 2013-01-24 | Gen-Probe Incorporated | Compositions and method for detecting human parvovirus nucleic acid and for detecting hepatitis a virus nucleic acids in single-plex or multiplex assays |
| EP2753712B1 (de) | 2011-09-06 | 2017-03-22 | Gen-Probe Incorporated | Geschlossene nukleinsäurestrukturen |
| WO2013036928A1 (en) | 2011-09-08 | 2013-03-14 | Gen-Probe Incorporated | Compositions and methods for detecting bv-associated bacterial nucleic acid |
| WO2013044097A1 (en) | 2011-09-21 | 2013-03-28 | Gen-Probe Incorporated | Methods for amplifying nucleic acid using tag-mediated displacement |
| WO2013049135A1 (en) | 2011-09-26 | 2013-04-04 | Gen-Probe Incorporated | Algorithms for sequence determinations |
| DE102011120550B4 (de) | 2011-12-05 | 2013-11-07 | Gen-Probe Prodesse, Inc. | Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren |
| EP3511426B1 (de) * | 2012-02-01 | 2022-08-17 | Gen-Probe Incorporated | Asymmetrische hairpin-target-capture-oligomere |
| CA3138799C (en) | 2012-02-24 | 2024-01-02 | Gen-Probe Prodesse, Inc. | Detection of shiga toxin genes in bacteria |
| AU2013205110B2 (en) | 2012-04-24 | 2016-10-13 | Gen-Probe Incorporated | Compositions, Methods and Kits to Detect Herpes Simplex Virus Nucleic Acids |
| AU2013205064B2 (en) | 2012-06-04 | 2015-07-30 | Gen-Probe Incorporated | Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid |
| US9139870B2 (en) | 2012-08-30 | 2015-09-22 | Gen-Probe Incorporated | Multiphase nucleic acid amplification |
| AU2013205122B2 (en) | 2012-10-11 | 2016-11-10 | Gen-Probe Incorporated | Compositions and Methods for Detecting Human Papillomavirus Nucleic Acid |
| AU2013205090B2 (en) | 2012-12-07 | 2016-07-28 | Gen-Probe Incorporated | Compositions and Methods for Detecting Gastrointestinal Pathogen Nucleic Acid |
| US9567632B2 (en) * | 2013-03-19 | 2017-02-14 | New England Biolabs, Inc. | Enrichment of target sequences |
| CA2920672C (en) | 2013-08-14 | 2022-12-13 | Gen-Probe Incorporated | Compositions and methods for detecting hev nucleic acid |
| WO2015130255A2 (en) | 2014-02-28 | 2015-09-03 | Jensen Deborah Christine | Method of isolating nucleic acid from specimens in liquid-based cytology preservatives containing formaldehyde |
| DE102015017080B3 (de) | 2014-02-28 | 2024-01-04 | Gen-Probe Incorporated | Verfahren zur Isolierung von Nukleinsäure von zytologischen Proben in flüssigen Konservierungsmitteln, die Formaldehyd enthalten |
| DE102015220401B4 (de) | 2014-10-20 | 2022-12-29 | Gen-Probe Incorporated | Erythrozyten-Lyselösung |
| EP3242956B1 (de) | 2015-01-09 | 2020-06-17 | Gen-Probe Incorporated | Verfahren und zusammensetzungen zur diagnose von bakterieller vaginose |
| US20160258938A1 (en) * | 2015-03-04 | 2016-09-08 | Headway Technologies, Inc. | Method of detecting an analyte in a sample |
| AU2016233298B2 (en) | 2015-03-16 | 2021-09-02 | Gen-Probe Incorporated | Methods and compositions for detecting bacterial nucleic acid and diagnosing bacterial vaginosis |
| EP4249610A3 (de) | 2016-01-04 | 2023-12-20 | Gen-Probe Incorporated | Verfahren und zusammensetzungen zum nachweis von candida-spezies |
| JP6908615B2 (ja) * | 2016-02-11 | 2021-07-28 | エイチティージー モレキュラー ダイアグノスティクス, インコーポレイテッド | ヌクレアーゼ保護を使用する直接標的シーケンシングの方法 |
| JP6584986B2 (ja) * | 2016-03-18 | 2019-10-02 | 株式会社東芝 | 核酸検出方法 |
| CA3232826A1 (en) | 2016-04-27 | 2017-11-02 | Gen-Probe Incorporated | Blood cell lysis reagent |
| EP3469103B1 (de) | 2016-06-10 | 2021-10-06 | Gen-Probe Incorporated | Zusammensetzungen und verfahren für den nachweis von zikavirus-nukleinsäure |
| JP7167013B2 (ja) | 2016-10-19 | 2022-11-08 | ジェン-プローブ・インコーポレーテッド | C型肝炎ウイルスを検出または定量するための組成物および方法 |
| US10508313B2 (en) | 2016-11-21 | 2019-12-17 | Gen-Probe Incorporated | Compositions and methods for detecting or quantifying Hepatitis B virus |
| EP3601617B3 (de) | 2017-03-24 | 2024-03-20 | Gen-Probe Incorporated | Zusammensetzungen und verfahren zum nachweis oder zur quantifizierung des parainfluenzavirus |
| FI3601618T3 (fi) | 2017-03-25 | 2024-10-24 | Gen Probe Inc | Koostumuksia, menetelmiä ja tarvikepakkauksia adenoviruksen, metapneumoviruksen ja/tai rinoviruksen nukleiinihappojen havaitsemiseksi |
| CA3062075C (en) | 2017-05-11 | 2024-04-02 | Gen-Probe Incorporated | Compositions and methods for isolating target nucleic acids |
| WO2018226798A1 (en) | 2017-06-07 | 2018-12-13 | Gen-Probe Incorporated | Detecting babesia species nucleic acid in a sample |
| WO2018227182A2 (en) * | 2017-06-09 | 2018-12-13 | University Of Houston System | Force-modulated hybridization for visualizing nucleic acid length and function |
| WO2019032809A1 (en) | 2017-08-11 | 2019-02-14 | Gen-Probe Incorporated | COMPOSITIONS AND METHODS FOR DETECTING STAPHYLOCOCCUS AUREUS |
| WO2019099629A1 (en) | 2017-11-17 | 2019-05-23 | Gen-Probe Incorporated | COMPOSITIONS AND METHODS FOR DETECTING C1orf43 NUCLEIC ACID |
| US11662281B2 (en) | 2017-12-13 | 2023-05-30 | Gen-Probe Incorporated | Compositions and methods for biological sample processing |
| JP2021506274A (ja) | 2017-12-15 | 2021-02-22 | ジェン−プローブ・インコーポレーテッド | 毒素産生Clostridium difficileを検出するための組成物および方法 |
| EP4461817A3 (de) | 2018-02-06 | 2025-01-22 | Gen-Probe Incorporated | Dunkelrote farbstoffsondenformulierungen |
| GB2597566B (en) | 2018-06-13 | 2023-02-01 | Gen Probe Inc | Compositions and methods for detecting group B streptococcus nucleic acid |
| EP3830302B1 (de) | 2018-08-01 | 2022-10-05 | Gen-Probe Incorporated | Zusammensetzungen und verfahren zum nachweis von nukleinsäuren des epstein-barr-virus |
| JP7579779B2 (ja) * | 2018-08-21 | 2024-11-08 | ジェン-プローブ・インコーポレーテッド | ヒトサイトメガロウイルスを増幅、検出、または定量化するための組成物および方法 |
| KR102868953B1 (ko) | 2018-08-24 | 2025-10-13 | 젠-프로브 인코포레이티드 | 세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법 |
| CN109337956B (zh) * | 2018-09-07 | 2022-08-19 | 上海思路迪生物医学科技有限公司 | 基于ngs技术富集多基因茎环探针设计方法及试剂盒 |
| CA3116895A1 (en) | 2018-10-22 | 2020-04-30 | Gen-Probe Incorporated | Compositions and methods for amplifying, detecting or quantifying human polyomavirus bk virus |
| TW202030333A (zh) | 2018-12-20 | 2020-08-16 | 美商簡 探針公司 | 用於檢測瘧原蟲物種核酸之組成物及方法 |
| WO2020154513A1 (en) | 2019-01-25 | 2020-07-30 | Gen-Probe Incorporated | Detection of drug-resistant mycoplasma genitalium |
| EP4389916A3 (de) | 2019-03-22 | 2024-10-16 | Gen-Probe Incorporated | Zusammensetzungen und verfahren zum nachweis von gruppe-a-streptococcus |
| KR102336454B1 (ko) * | 2019-06-17 | 2021-12-08 | 강릉원주대학교산학협력단 | 핵산 검출 방법 |
| US20220307093A1 (en) | 2019-07-03 | 2022-09-29 | Gen-Probe Incorporated | Oligonucleotides for use in determining the presence of trichomonas vaginalis in a sample |
| CN116287111A (zh) | 2019-11-14 | 2023-06-23 | 简·探针公司 | 用于捕获靶核酸的组合物和方法 |
| EP4582563A3 (de) | 2020-03-04 | 2025-10-08 | Gen-Probe Incorporated | Zusammensetzungen und verfahren zum nachweis von sars-cov-2-nukleinsäure |
| EP4146821A1 (de) | 2020-05-07 | 2023-03-15 | Grifols Diagnostic Solutions Inc. | Verfahren und zusammensetzungen zum nachweis von sars-cov-2-nukleinsäure |
| JP2024510996A (ja) | 2021-03-15 | 2024-03-12 | ジェン-プローブ・インコーポレーテッド | 生物学的サンプル処理のための組成物および方法 |
| CA3218222A1 (en) | 2021-05-14 | 2022-11-17 | Gen-Probe Incorporated | Compositions and methods for detecting human adenovirus nucleic acid |
| AU2022304654B2 (en) | 2021-07-01 | 2025-06-05 | Gen-Probe Incorporated | Enzyme formulations and reaction mixtures for nucleic acid amplification |
| WO2023010008A1 (en) | 2021-07-27 | 2023-02-02 | Gen-Probe Incorporated | Compositions and methods for detecting gastrointestinal pathogens |
| CN114250224B (zh) * | 2021-12-16 | 2024-02-27 | 福建和瑞基因科技有限公司 | 一种用于提取或检测样本中小分子rna的核酸组合物及其试剂盒和方法 |
| CN114107446A (zh) * | 2021-12-16 | 2022-03-01 | 福建和瑞基因科技有限公司 | 一种核酸的检测试剂盒及其检测方法 |
| WO2024054924A1 (en) | 2022-09-08 | 2024-03-14 | Gen-Probe Incorporated | Method of detecting nucleic acid analytes using dual-specificity primers |
| WO2024081776A1 (en) | 2022-10-13 | 2024-04-18 | Gen-Probe Incorporated | Cellularity control for nucleic acid assays |
| WO2024081040A1 (en) * | 2022-10-15 | 2024-04-18 | Renato Rozental | Material and method for diagnosis of traumatic brain injury |
| EP4638804A2 (de) | 2022-12-19 | 2025-10-29 | Gen-Probe Incorporated | Zusammensetzungen und verfahren zum nachweis von gastrointestinalen pathogenen |
| WO2024161179A1 (en) | 2023-01-31 | 2024-08-08 | Mobidiag Oy | Compositions and methods for detecting stx nucleic acids |
| WO2024192338A1 (en) | 2023-03-16 | 2024-09-19 | Gen-Probe Incorporated | Compositions and methods for detecting gastrointestinal parasites |
| EP4455303A1 (de) | 2023-04-28 | 2024-10-30 | Mobidiag Oy | Kontrollen für nukleinsäureamplifikationsverfahren |
| EP4454758A1 (de) | 2023-04-28 | 2024-10-30 | Mobidiag Oy | Kontrollen für nukleinsäureamplifikationsverfahren |
| EP4455304A1 (de) | 2023-04-28 | 2024-10-30 | Mobidiag Oy | Kontrollen für nukleinsäureamplifikationsverfahren |
| WO2026050332A1 (en) | 2024-08-29 | 2026-03-05 | Gen-Probe Incorporated | Methods and compositions for amplifying and/or detecting rotavirus nucleic acids |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4174384A (en) | 1975-06-30 | 1979-11-13 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| CA1190838A (en) | 1981-07-17 | 1985-07-23 | Cavit Akin | Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer |
| FI63596C (fi) | 1981-10-16 | 1983-07-11 | Orion Yhtymae Oy | Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser |
| US4556643A (en) | 1982-07-26 | 1985-12-03 | Agracetus | Assay method and probe for polynucleotide sequences |
| CA1260372A (en) | 1984-04-27 | 1989-09-26 | Elazar Rabbani | Hybridization method for the detection of genetic materials |
| US5288609A (en) | 1984-04-27 | 1994-02-22 | Enzo Diagnostics, Inc. | Capture sandwich hybridization method and composition |
| US6221581B1 (en) | 1984-04-27 | 2001-04-24 | Enzo Diagnostics, Inc. | Processes for detecting polynucleotides, determining genetic mutations or defects in genetic material, separating or isolating nucleic acid of interest from samples, and useful compositions of matter and multihybrid complex compositions |
| US5268266A (en) | 1984-05-07 | 1993-12-07 | Genetics Institute, Inc. | Process and nucleic acid construct for producing reagent complexes useful in determining target nucleotide sequences |
| US4766062A (en) | 1984-05-07 | 1988-08-23 | Allied Corporation | Displacement polynucleotide assay method and polynucleotide complex reagent therefor |
| US4824776A (en) | 1985-07-25 | 1989-04-25 | Molecular Biosystems, Inc. | Method for increasing the sensitivity of nucleic acid hybridization assays |
| US4725536A (en) | 1985-09-19 | 1988-02-16 | Genetics Institute, Inc. | Reagent polynucleotide complex with multiple target binding regions, and kit and methods |
| US4752566A (en) | 1985-12-17 | 1988-06-21 | Genetics Institute, Inc. | Displacement polynucleotide method and reagent complex employing labeled probe polynucleotide |
| US4818680A (en) | 1985-12-18 | 1989-04-04 | Mary Collins | Method and kit involving displacement and rehybridization of labeled polynucleotide |
| CA1273552A (en) | 1985-12-23 | 1990-09-04 | Michael J. Heller | Fluorescent stokes shift probes for polynucleotide hybridization assays |
| US5714380A (en) | 1986-10-23 | 1998-02-03 | Amoco Corporation | Closed vessel for isolating target molecules and for performing amplification |
| ZA877772B (en) | 1986-10-23 | 1988-04-20 | Amoco Corporation | Target and background capture methods and apparatus for affinity assays |
| US5283174A (en) | 1987-09-21 | 1994-02-01 | Gen-Probe, Incorporated | Homogenous protection assay |
| US5124246A (en) | 1987-10-15 | 1992-06-23 | Chiron Corporation | Nucleic acid multimers and amplified nucleic acid hybridization assays using same |
| US5118801A (en) * | 1988-09-30 | 1992-06-02 | The Public Health Research Institute | Nucleic acid process containing improved molecular switch |
| DE69028325T2 (de) | 1989-01-19 | 1997-04-17 | Behringwerke Ag | Nukleinsäure-Amplifikation unter Verwendung eines Einzelprimers |
| EP0481999B1 (de) | 1989-03-10 | 1997-07-23 | VYSIS, Inc. | Interferenzverhinderung mit affinitätseinfangschemas |
| AU5269590A (en) | 1989-03-10 | 1990-10-09 | Gene-Trak Systems | Immobilized oligonucleotide probes and uses therefor |
| US5589335A (en) * | 1989-04-05 | 1996-12-31 | Amoco Corporation | Hybridization promotion reagents |
| DE69032847T2 (de) | 1989-06-30 | 1999-05-12 | Chiron Corp., Emeryville, Calif. | Hydrophobe Nukleinsäure-Sonde |
| US5439793A (en) | 1990-07-19 | 1995-08-08 | Syntex (U.S.A.) Inc. | Method for producing a polynucleotide having an intramolecularly base-paired structure |
| US5849481A (en) | 1990-07-27 | 1998-12-15 | Chiron Corporation | Nucleic acid hybridization assays employing large comb-type branched polynucleotides |
| EP0529070A1 (de) | 1991-02-27 | 1993-03-03 | Amoco Corporation | Verfahren zur verbesserung der empfindlichkeit von hybridisierungsassays |
| US5445933A (en) | 1992-09-15 | 1995-08-29 | Boehringer Mannheim Corporation | Strand displacement assay and complex useful therefor |
| EP0601889A2 (de) * | 1992-12-10 | 1994-06-15 | Maine Medical Center Research Institute | Nukleinsäure-Sonden |
| US6576419B1 (en) | 1993-07-23 | 2003-06-10 | University Of Utah Research Foundation | Assay procedure using fluorogenic tracers |
| CA2105364A1 (en) | 1993-09-01 | 1995-03-02 | Eric T. Kool | Stem-loop oligonucleotides containing parallel and antiparallel binding domains |
| US6156501A (en) | 1993-10-26 | 2000-12-05 | Affymetrix, Inc. | Arrays of modified nucleic acid probes and methods of use |
| US6129828A (en) * | 1996-09-06 | 2000-10-10 | Nanogen, Inc. | Apparatus and methods for active biological sample preparation |
| US5925517A (en) | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| US5681697A (en) | 1993-12-08 | 1997-10-28 | Chiron Corporation | Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor |
| US5861273A (en) | 1993-12-21 | 1999-01-19 | Celtrix Phamraceuticals, Inc. | Chromosomal expression of heterologous genes in bacterial cells |
| US5631148A (en) | 1994-04-22 | 1997-05-20 | Chiron Corporation | Ribozymes with product ejection by strand displacement |
| KR970703357A (ko) | 1994-06-01 | 1997-07-03 | 다알렌 반스톤 | 병원체-저해제로서의, 측쇄를 가지는 올리고누클레오티드(branched oligonu-cleotides as pathogen-inhibitory agents) |
| US5731148A (en) | 1995-06-07 | 1998-03-24 | Gen-Probe Incorporated | Adduct protection assay |
| US5770365A (en) * | 1995-08-25 | 1998-06-23 | Tm Technologies, Inc. | Nucleic acid capture moieties |
| WO1997023647A1 (en) | 1995-12-22 | 1997-07-03 | Behringwerke Aktiengesellschaft | Homogeneous amplification and detection of nucleic acids |
| AU713667B2 (en) | 1996-04-12 | 1999-12-09 | Phri Properties, Inc. | Detection probes, kits and assays |
| US20030054376A1 (en) * | 1997-07-07 | 2003-03-20 | Mullis Kary Banks | Dual bead assays using cleavable spacers and/or ligation to improve specificity and sensitivity including related methods and apparatus |
| US6130038A (en) | 1996-07-16 | 2000-10-10 | Gen-Probe Incorporated | Method for amplifying target nucleic acids using modified primers |
| US5965363A (en) | 1996-09-19 | 1999-10-12 | Genetrace Systems Inc. | Methods of preparing nucleic acids for mass spectrometric analysis |
| US6025133A (en) | 1996-12-30 | 2000-02-15 | Gen-Probe Incorporated | Promoter-sequestered oligonucleoside and method of use |
| DK0975807T3 (da) * | 1997-05-02 | 2007-01-29 | Gen Probe Inc | To-trins hybridisering og indfangning af et polynukleotid |
| US6534273B2 (en) | 1997-05-02 | 2003-03-18 | Gen-Probe Incorporated | Two-step hybridization and capture of a polynucleotide |
| EP1025120B1 (de) | 1997-10-27 | 2010-08-18 | Boston Probes, Inc. | Sich auf "pna molecular beacons" beziehende verfahren, testsätze und zusammensetzungen |
| AU762728B2 (en) | 1998-07-02 | 2003-07-03 | Gen-Probe Incorporated | Molecular torches |
| US6399302B1 (en) | 1998-08-21 | 2002-06-04 | University Of Virginia Patent Foundation | Signal generating oligonucleotide-based biosensor |
| WO2000012524A1 (en) | 1998-08-27 | 2000-03-09 | Bayer Corporation | Purification of oligomers using dual-end selection |
| EP2314700A1 (de) | 1999-01-28 | 2011-04-27 | Medical College of Georgia Research Institute, Inc | Zusammensetzung und Verfahren zur in vivo und in vitro Abschwächung der Genexpression mittels dobbelsträngiger RNA |
| EP1185681A1 (de) * | 1999-05-24 | 2002-03-13 | The Public Health Research Institute Of The City Of New York, Inc. | HAARNADELFöRMIGE ANTISENSE OLIGONUKLEOTIDE MIT HOHER SPEZIFITäT |
| US7052844B2 (en) * | 1999-12-21 | 2006-05-30 | Ingeneus, Inc. | Purification of DS-DNA using heteropolymeric capture probes and a triplex, quadruplex or homologous duplex binding mechanism |
| WO2001094625A2 (en) * | 2000-06-06 | 2001-12-13 | Tm Bioscience Corporation | Capture moieties for nucleic acids and uses thereof |
| US6451588B1 (en) * | 2000-06-30 | 2002-09-17 | Pe Corporation (Ny) | Multipartite high-affinity nucleic acid probes |
| US6596490B2 (en) | 2000-07-14 | 2003-07-22 | Applied Gene Technologies, Inc. | Nucleic acid hairpin probes and uses thereof |
| CA2436693A1 (en) | 2000-12-11 | 2002-06-20 | Alexion Pharmaceuticals, Inc. | Nested oligonucleotides containing hairpin for nucleic acid amplification |
| USH2220H1 (en) | 2001-08-10 | 2008-07-01 | Snp Consortium | Identification and mapping of single nucleotide polymorphisms in the human genome |
| US7371580B2 (en) * | 2001-08-24 | 2008-05-13 | Agilent Technologies, Inc. | Use of unstructured nucleic acids in assaying nucleic acid molecules |
| US7214780B2 (en) * | 2001-11-02 | 2007-05-08 | Gen-Probe Incorporated | Probes, compositions and kits for determining the presence of Mycoplasma pneuomoniae in a test sample |
| EP1500710A4 (de) | 2002-05-08 | 2006-10-04 | Arkray Inc | Verfahren zum nachweis einer zielnukleinsäure |
| US7851150B2 (en) | 2002-12-18 | 2010-12-14 | Third Wave Technologies, Inc. | Detection of small nucleic acids |
| US7741031B2 (en) | 2003-03-07 | 2010-06-22 | The Public Health Research Institute Of The City Of New York | Optically decodable microcarries, arrays and methods |
| CA2542232A1 (en) | 2003-06-09 | 2005-01-20 | Alnylam Pharmaceuticals, Inc. | Method for treating neurodegenerative disease by inhibiting alpha-synuclein |
| US20050037362A1 (en) | 2003-08-11 | 2005-02-17 | Eppendorf Array Technologies, S.A. | Detection and quantification of siRNA on microarrays |
| US8034554B2 (en) | 2004-07-01 | 2011-10-11 | Gen-Probe Incorporated | Methods and compositions to detect nucleic acids in a biological sample |
| US20060292616A1 (en) | 2005-06-23 | 2006-12-28 | U.S. Genomics, Inc. | Single molecule miRNA-based disease diagnostic methods |
-
2005
- 2005-06-29 US US11/173,915 patent/US8034554B2/en not_active Expired - Fee Related
- 2005-06-29 WO PCT/US2005/023555 patent/WO2006007567A2/en not_active Ceased
- 2005-06-29 EP EP05767727A patent/EP1778867B1/de not_active Expired - Lifetime
- 2005-06-29 DK DK05767727.0T patent/DK1778867T3/da active
- 2005-06-29 AT AT05767727T patent/ATE466107T1/de not_active IP Right Cessation
- 2005-06-29 JP JP2007520409A patent/JP5020818B2/ja not_active Expired - Fee Related
- 2005-06-29 DE DE602005020943T patent/DE602005020943D1/de not_active Expired - Lifetime
- 2005-06-29 CA CA2572472A patent/CA2572472C/en not_active Expired - Lifetime
- 2005-06-29 AU AU2005262357A patent/AU2005262357B2/en not_active Ceased
-
2009
- 2009-11-13 AU AU2009238261A patent/AU2009238261B2/en not_active Ceased
-
2010
- 2010-07-28 US US12/845,640 patent/US8551766B2/en active Active
-
2011
- 2011-04-14 US US13/087,282 patent/US8460869B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20110250599A1 (en) | 2011-10-13 |
| DE602005020943D1 (de) | 2010-06-10 |
| US8460869B2 (en) | 2013-06-11 |
| DK1778867T3 (da) | 2010-08-02 |
| AU2009238261B2 (en) | 2011-11-17 |
| EP1778867A2 (de) | 2007-05-02 |
| EP1778867B1 (de) | 2010-04-28 |
| JP2008504842A (ja) | 2008-02-21 |
| US20060068417A1 (en) | 2006-03-30 |
| AU2005262357B2 (en) | 2009-10-29 |
| JP5020818B2 (ja) | 2012-09-05 |
| US8551766B2 (en) | 2013-10-08 |
| US8034554B2 (en) | 2011-10-11 |
| WO2006007567A2 (en) | 2006-01-19 |
| AU2009238261A1 (en) | 2009-12-03 |
| CA2572472A1 (en) | 2006-01-19 |
| AU2005262357A1 (en) | 2006-01-19 |
| CA2572472C (en) | 2013-08-13 |
| US20120231551A1 (en) | 2012-09-13 |
| WO2006007567A3 (en) | 2006-03-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE466107T1 (de) | Verfahren und zusammensetzungen zum nachweis von nukleinsäuren in einer biologischen probe | |
| FI3872187T3 (fi) | Koostumuksia ja menetelmiä näytteiden identifioinnin parantamiseksi indeksoiduissa nukleiinihappokirjastoissa | |
| KR20210038541A (ko) | 핵산 검출 방법 | |
| EP2366803A3 (de) | Zusammensetzungen und Verfahren zum Nacheis des West Nil Viruses. | |
| CN101275165A (zh) | 用于鉴定亚甲基四氢叶酸还原酶(mthfr)基因型的核酸引物组和探针 | |
| CA2525413A1 (en) | Compositions, methods and kits for determining the presence of trichomonas vaginalis in a test sample | |
| AU2023201805B2 (en) | Blood cell lysis reagent | |
| ATE485391T1 (de) | Zusammensetzungen, methoden und testssysteme zur bestimmung der präsenz von cryptosporidium organismen in einer testprobe | |
| GB0317343D0 (en) | Polynucleotide sequencing | |
| ATE522606T1 (de) | Verfahren zum nachweis von apfelmosaikvirus, primersatz für den nachweis und kit für den nachweis | |
| KR930004477A (ko) | 미코박테리아 프라이머 및 탐침 | |
| CA2747479C (en) | Methods and reagents for shortening incubation times in hybridization assays | |
| CN103740824B (zh) | 一种两核苷酸实时合成测序图谱鉴定微生物种群的方法 | |
| DE50313352D1 (de) | Microarray-basiertes verfahren zur amplifikation und detektion von nukleinsäuren in einem kontinuierlichen prozess | |
| ATE466105T1 (de) | Verfahren, zusammensetzungen und kits zur anreicherung und zum nachweis von mikroorganismen | |
| CA2549059A1 (en) | Oligonucleotides for the detection of hepatitis b virus | |
| WO2003072721A3 (en) | Detection by sliding template amplification | |
| ATE463583T1 (de) | Verfahren zum nachweis von chlamydia trachomatis und kit dafür | |
| WO2005033340A3 (en) | Methods and kits for hybridizing multiple probe panels to nucleic acid samples | |
| ATE533847T1 (de) | Verfahren für den nachweis und die quantifizierung einer endogenen dna-sequenz aus weizen | |
| EP1323835A3 (de) | Methode zur Bestimmung einer Biospezies in einer Testprobe und dafür verwendeter Testsatz | |
| KR100785011B1 (ko) | 쌍이온 화합물을 이용한 핵산 혼성화 특이성을 증가시키는방법 | |
| ATE307906T1 (de) | Verfahren zum nachweis von gram-positiven bakterien | |
| ATE513924T1 (de) | Verfahren zum nachweis einer basenmutation | |
| Singer et al. | Artificial nucleic acid probes and their applications in clinical microbiology |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |