WO2000071740A1 - High specificity hairpin antisense oligonucleotides - Google Patents
High specificity hairpin antisense oligonucleotides Download PDFInfo
- Publication number
- WO2000071740A1 WO2000071740A1 PCT/US2000/014133 US0014133W WO0071740A1 WO 2000071740 A1 WO2000071740 A1 WO 2000071740A1 US 0014133 W US0014133 W US 0014133W WO 0071740 A1 WO0071740 A1 WO 0071740A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sequence
- antisense oligonucleotides
- antisense oligonucleotide
- loop
- stem
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
- C12N2310/3181—Peptide nucleic acid, PNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00937684A EP1185681A1 (en) | 1999-05-24 | 2000-05-23 | High specificity hairpin antisense oligonucleotides |
CA002374421A CA2374421A1 (en) | 1999-05-24 | 2000-05-23 | High specificity hairpin antisense oligonucleotides |
AU52823/00A AU5282300A (en) | 1999-05-24 | 2000-05-23 | High specificity hairpin antisense oligonucleotides |
JP2000620117A JP2003500064A (en) | 1999-05-24 | 2000-05-23 | Highly specific hairpin antisense oligonucleotides |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13556099P | 1999-05-24 | 1999-05-24 | |
US60/135,560 | 1999-05-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000071740A1 true WO2000071740A1 (en) | 2000-11-30 |
Family
ID=22468629
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/014133 WO2000071740A1 (en) | 1999-05-24 | 2000-05-23 | High specificity hairpin antisense oligonucleotides |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1185681A1 (en) |
JP (1) | JP2003500064A (en) |
AU (1) | AU5282300A (en) |
CA (1) | CA2374421A1 (en) |
WO (1) | WO2000071740A1 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6893868B2 (en) | 1997-02-20 | 2005-05-17 | Onco Immunin, Inc. | Homo-doubly labeled compositions for the detection of enzyme activity in biological samples |
US6936687B1 (en) | 1997-02-20 | 2005-08-30 | Onco Immunin, Inc. | Compositions for the detection of enzyme activity in biological samples and methods of use thereof |
US7312302B2 (en) | 1997-02-20 | 2007-12-25 | Oncolmmunin, Inc. | Compositions for the detection of enzyme activity in biological samples and methods of use thereof |
US8034554B2 (en) * | 2004-07-01 | 2011-10-11 | Gen-Probe Incorporated | Methods and compositions to detect nucleic acids in a biological sample |
US8399222B2 (en) | 2008-11-25 | 2013-03-19 | Gen-Probe Incorporated | Compositions and methods for detecting small RNAs, and uses thereof |
EP2774990A1 (en) * | 2013-03-08 | 2014-09-10 | Dr. Diederichs Lifre Science GmbH | Loop-shRNAs |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2781598B1 (en) * | 2011-11-16 | 2018-08-08 | Osaka City University | Nucleic acid molecule for inhibiting activity of rnai molecule |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5514546A (en) * | 1993-09-01 | 1996-05-07 | Research Corporation Technologies, Inc. | Stem-loop oligonucleotides containing parallel and antiparallel binding domains |
-
2000
- 2000-05-23 JP JP2000620117A patent/JP2003500064A/en active Pending
- 2000-05-23 CA CA002374421A patent/CA2374421A1/en not_active Abandoned
- 2000-05-23 WO PCT/US2000/014133 patent/WO2000071740A1/en not_active Application Discontinuation
- 2000-05-23 EP EP00937684A patent/EP1185681A1/en not_active Withdrawn
- 2000-05-23 AU AU52823/00A patent/AU5282300A/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5514546A (en) * | 1993-09-01 | 1996-05-07 | Research Corporation Technologies, Inc. | Stem-loop oligonucleotides containing parallel and antiparallel binding domains |
Non-Patent Citations (1)
Title |
---|
JENDIS ET AL.: "Inhibition of replication of fresh HIV type 1 patient isolates by a polypurine tract-specific self-complementary oligodeoxynucleotide", AIDS RESEARCH AND HUMAN RETROVIRUSES, vol. 12, no. 12, 1996, pages 1161 - 1168, XP002930541 * |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6893868B2 (en) | 1997-02-20 | 2005-05-17 | Onco Immunin, Inc. | Homo-doubly labeled compositions for the detection of enzyme activity in biological samples |
US6936687B1 (en) | 1997-02-20 | 2005-08-30 | Onco Immunin, Inc. | Compositions for the detection of enzyme activity in biological samples and methods of use thereof |
US7312302B2 (en) | 1997-02-20 | 2007-12-25 | Oncolmmunin, Inc. | Compositions for the detection of enzyme activity in biological samples and methods of use thereof |
US7541143B2 (en) | 1997-02-20 | 2009-06-02 | Oncoimmunin, Inc. | Homo-doubly labeled compositions for the detection of enzyme activity in biological samples |
US7879574B2 (en) | 1997-02-20 | 2011-02-01 | Oncoimmunin, Inc. | Compositions for the detection of enzyme activity in biological samples and methods of use thereof |
US8034554B2 (en) * | 2004-07-01 | 2011-10-11 | Gen-Probe Incorporated | Methods and compositions to detect nucleic acids in a biological sample |
US20110250599A1 (en) * | 2004-07-01 | 2011-10-13 | Gen-Probe Incorporated | Methods and Compositions to Detect Nucleic Acids in a Biological Sample |
US8460869B2 (en) * | 2004-07-01 | 2013-06-11 | Gen-Probe Incorporated | Methods and compositions to detect nucleic acids in a biological sample |
US8551766B2 (en) | 2004-07-01 | 2013-10-08 | Gen-Probe Incorporated | Methods and compositions to detect nucleic acids in a biological sample |
US8399222B2 (en) | 2008-11-25 | 2013-03-19 | Gen-Probe Incorporated | Compositions and methods for detecting small RNAs, and uses thereof |
US8951730B2 (en) | 2008-11-25 | 2015-02-10 | Gen-Probe Incorporated | Compositions for detecting small RNAs |
EP2774990A1 (en) * | 2013-03-08 | 2014-09-10 | Dr. Diederichs Lifre Science GmbH | Loop-shRNAs |
Also Published As
Publication number | Publication date |
---|---|
CA2374421A1 (en) | 2000-11-30 |
AU5282300A (en) | 2000-12-12 |
JP2003500064A (en) | 2003-01-07 |
EP1185681A1 (en) | 2002-03-13 |
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