JP5017103B2 - 薬剤共結晶組成物および関連した使用方法 - Google Patents

薬剤共結晶組成物および関連した使用方法 Download PDF

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Publication number
JP5017103B2
JP5017103B2 JP2007516812A JP2007516812A JP5017103B2 JP 5017103 B2 JP5017103 B2 JP 5017103B2 JP 2007516812 A JP2007516812 A JP 2007516812A JP 2007516812 A JP2007516812 A JP 2007516812A JP 5017103 B2 JP5017103 B2 JP 5017103B2
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Japan
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crystal
acid
carbamazepine
degrees
angstrom
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Expired - Fee Related
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JP2007516812A
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Japanese (ja)
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JP2008503495A (ja
Inventor
マクマホン,ジエニフアー
ピーターソン,マシユー
ザウオロトコ,マイケル・ジエイ
シヤトツク,タニセ
ブアゴル,ヒツキー・マガリ
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トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド
ユニバーシテイ・オブ・サウス・フロリダ
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
JP2007516812A 2004-06-17 2005-06-16 薬剤共結晶組成物および関連した使用方法 Expired - Fee Related JP5017103B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US58066104P 2004-06-17 2004-06-17
US60/580,661 2004-06-17
US58580804P 2004-07-06 2004-07-06
US60/585,808 2004-07-06
US62148504P 2004-10-22 2004-10-22
US60/621,485 2004-10-22
US62870104P 2004-11-17 2004-11-17
US60/628,701 2004-11-17
PCT/US2005/021662 WO2006007448A2 (en) 2004-06-17 2005-06-16 Pharmaceutical co-crystal compositions and related methods of use

Publications (2)

Publication Number Publication Date
JP2008503495A JP2008503495A (ja) 2008-02-07
JP5017103B2 true JP5017103B2 (ja) 2012-09-05

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JP2007516812A Expired - Fee Related JP5017103B2 (ja) 2004-06-17 2005-06-16 薬剤共結晶組成物および関連した使用方法

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US (1) US7803786B2 (US07803786-20100928-C00028.png)
EP (1) EP1765379A4 (US07803786-20100928-C00028.png)
JP (1) JP5017103B2 (US07803786-20100928-C00028.png)
WO (1) WO2006007448A2 (US07803786-20100928-C00028.png)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003213719A1 (en) * 2002-03-01 2003-09-16 Regents Of The University Of Michigan Multiple-component solid phases containing at least one active pharmaceutical ingredient
WO2006116473A1 (en) * 2005-04-27 2006-11-02 Transform Pharmaceuticals, Inc. Novel polymorph of acetylsalicylic acid, and methods of making and using the same
EP1991229A2 (en) * 2006-02-27 2008-11-19 Vertex Pharmaceuticals Incorporated Co-crystals and pharmaceutical compositions comprising the same
CA2668464A1 (en) * 2006-11-02 2008-06-19 University Of South Florida Materials and methods for co-crystal controlled solid-state synthesis of imides and imines
TW200901889A (en) 2007-02-09 2009-01-16 Basf Se Crystalline complexes of agriculturally active organic compounds
AU2008219607B2 (en) * 2007-02-27 2013-09-12 Vertex Pharmaceuticals Incorporated Co-crystals and pharmaceutical compositions comprising the same
US8318789B2 (en) * 2007-03-23 2012-11-27 Syngenta Limited Co-crystals of propiconazole
GB0706044D0 (en) * 2007-03-28 2007-05-09 Syngenta Ltd C0-Crystals
WO2008153938A2 (en) * 2007-06-06 2008-12-18 University Of South Florida Epigallocatechin-3-gallate crystal compositions
US20100204204A1 (en) * 2007-06-06 2010-08-12 University Of South Florida Nutraceutical co-crystal compositions
DE102007030695A1 (de) * 2007-07-01 2009-01-08 Sciconcept Gmbh Co-Kristalle aus Harnstoff mit Amid- und/oder Harnstoffderivaten
ATE530546T1 (de) * 2007-08-30 2011-11-15 Vertex Pharma Kokristalle und pharmazeutische zusammensetzungen damit
GB0813709D0 (en) * 2008-07-26 2008-09-03 Univ Dundee Method and product
WO2010020856A2 (en) * 2008-08-19 2010-02-25 Adcock Ingram Healthcare (Pty) Limited Rate modulated delivery of drugs from a composite delivery system
WO2010027921A1 (en) * 2008-09-03 2010-03-11 Vertex Pharmaceuticals Incorporated Co-crystals and pharmaceutical formulations comprising the same
BRPI0923504A2 (pt) * 2008-12-11 2020-05-26 Axcentua Pharmaceuticals Ab Formas cristalinas de genisteína.
US8586587B2 (en) * 2009-02-26 2013-11-19 Thar Pharmaceuticals, Inc. Crystalline molecular complex of tadalafil and methylparaben
US20110009347A1 (en) 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
WO2011036676A2 (en) * 2009-09-23 2011-03-31 Ashwini Nangia Stable cocrystals of temozolomide
WO2011054741A2 (en) * 2009-11-06 2011-05-12 Basf Se Crystalline complexes of 4-hydroxy benzoic acid and selected pesticides
WO2011115069A1 (ja) * 2010-03-19 2011-09-22 第一三共株式会社 結晶の網羅的探索
MX339570B (es) 2010-05-11 2016-05-31 Janssen Pharmaceutica Nv Formulaciones farmaceuticas que comprenden derivados de 1-(beta-d-glucopiranosil)-2-tienil-metilbenceno como inhibidores de transportadores de glucosa dependientes de sodio.
WO2011153444A1 (en) * 2010-06-03 2011-12-08 Salix Pharmaceuticals, Ltd New forms of rifaximin and uses thereof
UA109290C2 (uk) * 2010-10-07 2015-08-10 Спільні кристали і солі інгібіторів ccr3
CA2831086A1 (en) * 2011-03-24 2012-09-27 University Of South Florida Lithium compositions
CN103288724A (zh) * 2013-05-31 2013-09-11 天津大学 一种氟尼辛与卡马西平共晶及其制备方法
US20150080567A1 (en) 2013-09-04 2015-03-19 Nalas Engineering Services Inc. Method to Produce and Scale-Up Cocrystals and Salts Via Resonant Acoustic Mixing
GB201411802D0 (en) 2014-07-02 2014-08-13 Univ Bradford Effervescent compositions
US9879038B2 (en) * 2014-07-18 2018-01-30 Jw Pharmaceutical Corporation Salt of tenofovir disoproxil
JP6830058B2 (ja) 2015-03-02 2021-02-17 武田薬品工業株式会社 ナノ共結晶を含有する懸濁液または組成物およびこれらの製造方法
CN109563024B (zh) 2016-06-13 2023-06-06 心悦生医股份有限公司 苯甲酸锂的共晶及其用途
KR102403048B1 (ko) 2016-06-13 2022-05-26 신유알엑스 인터내셔널 (타이완) 코포레이션 벤조산나트륨의 공-결정 및 그의 용도
JP2019524894A (ja) * 2016-08-19 2019-09-05 セルジーン インターナショナル ツー エスアーエールエル マリゾミブのモルフィック形態およびその使用
WO2018117177A1 (ja) 2016-12-21 2018-06-28 小野薬品工業株式会社 Brk阻害化合物
EP3581569A4 (en) 2017-02-08 2020-02-19 ONO Pharmaceutical Co., Ltd. CONNECTION WITH AGONISTIC SOMATOSTATIN RECEPTOR ACTIVITY AND PHARMACEUTICAL USE THEREOF
US11479550B2 (en) 2017-05-22 2022-10-25 Ono Pharmaceutical Co., Ltd. EP4 antagonist
TWI789495B (zh) 2018-02-22 2023-01-11 日商小野藥品工業股份有限公司 具有s1p5受體作動活性的化合物
KR102425709B1 (ko) 2018-09-20 2022-07-28 오노 야꾸힝 고교 가부시키가이샤 Dp 길항제
TW202028212A (zh) 2018-10-11 2020-08-01 日商小野藥品工業股份有限公司 Sting促效化合物
CN109796393A (zh) * 2019-01-25 2019-05-24 云南开放大学 一种吡拉西坦共晶及其制备方法
TW202114985A (zh) 2019-06-28 2021-04-16 日商小野藥品工業股份有限公司 Ep拮抗劑
JP2021054781A (ja) * 2019-09-26 2021-04-08 デボン エルエス,リミテッド 共結晶形エフィナコナゾール、及びその製造方法
JPWO2021107125A1 (US07803786-20100928-C00028.png) 2019-11-29 2021-06-03
EP4134134A4 (en) 2020-04-10 2023-12-27 ONO Pharmaceutical Co., Ltd. STING AGONIST COMPOUND
KR20220167275A (ko) 2020-04-10 2022-12-20 오노 야꾸힝 고교 가부시키가이샤 암 치료 방법
IL297900A (en) 2020-05-07 2023-01-01 Ono Pharmaceutical Co A compound with kdm5 inhibitory activity and its pharmaceutical use
WO2022102731A1 (ja) 2020-11-13 2022-05-19 小野薬品工業株式会社 Ep4拮抗薬と免疫チェックポイント阻害物質との併用によるがん治療
AU2022251752A1 (en) 2021-04-01 2023-10-12 Ono Pharmaceutical Co., Ltd. Abhd6 antagonist
CN113845438B (zh) * 2021-10-12 2023-02-21 河北大学 一种对乙酰氨基酚-吡拉西坦药物共晶及其制备方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3536809A (en) * 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) * 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) * 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
DE2256979C3 (de) * 1972-11-21 1981-05-21 Hoechst Ag, 6000 Frankfurt Verfahren zur Herstellung von Benzolsulfonylharnstoffen
US3916899A (en) * 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) * 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US5366738A (en) * 1982-07-29 1994-11-22 Merck & Co., Inc. Controlled release drug dispersion delivery device
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US5073543A (en) * 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (it) * 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
FI95269C (fi) * 1989-05-15 1996-01-10 Squibb Bristol Myers Co 2',3'-dideoksi-inosiinimonohydraatin, 2',3'-dideoksi-2',3'-didehydrot ymidiinimonohydraatin ja 2',3'-dideoksi-2'-fluori-inosiinihemihydraatin antiviraalisia, hyvin vesiliukoisia, stabiileja, kiteisiä suoloja
US6207650B1 (en) * 1989-05-15 2001-03-27 Bristol-Myers Squibb Company Antiviral, highly water soluble, stable, crystalline salts of 2′, 3′-dideoxyinosine, 2′, 3′-dideoxy-2′, 3′-didehydrothymidine and 2′, 3′-dideoxy-2′-fluoroinosine
US5120548A (en) * 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5733566A (en) * 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5580578A (en) * 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5591767A (en) * 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
IT1270594B (it) * 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
US5780058A (en) * 1995-07-21 1998-07-14 Alza Corporation Oral delivery of discrete units
US6132420A (en) * 1996-02-02 2000-10-17 Alza Corporation Osmotic delivery system and method for enhancing start-up and performance of osmotic delivery systems
MY125849A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems
AU1623099A (en) * 1997-12-22 1999-07-12 Alza Corporation Rate controlling membranes for controlled drug delivery devices
JP4173635B2 (ja) * 1997-12-29 2008-10-29 インターシア セラピューティクス,インコーポレイティド 膜プラグ保持機構を有する浸透供給装置
ATE322928T1 (de) * 1997-12-31 2006-04-15 Alza Corp Verfahren zur überwachung einer osmotischen wirkstoffabgabevorrichtung
US6245357B1 (en) * 1998-03-06 2001-06-12 Alza Corporation Extended release dosage form
US6365185B1 (en) * 1998-03-26 2002-04-02 University Of Cincinnati Self-destructing, controlled release peroral drug delivery system
US6635753B1 (en) * 1998-09-30 2003-10-21 Brantford Chemicals Inc. Process for the preparation of substantially pure stavudine and related intermediates useful in the preparation thereof
NZ511465A (en) * 1998-11-02 2003-10-31 Alza Corp Controlled delivery of active agents
US6342249B1 (en) * 1998-12-23 2002-01-29 Alza Corporation Controlled release liquid active agent formulation dosage forms
US6559293B1 (en) * 2002-02-15 2003-05-06 Transform Pharmaceuticals, Inc. Topiramate sodium trihydrate
AU2003213719A1 (en) * 2002-03-01 2003-09-16 Regents Of The University Of Michigan Multiple-component solid phases containing at least one active pharmaceutical ingredient
EP1511490A4 (en) * 2002-05-31 2009-03-11 Transform Pharmaceuticals Inc NOVEL CONAZOLE CRYSTALLINE FORMS AND RELATED METHODS, PHARMACEUTICAL COMPOSITIONS AND METHODS
CA2514092C (en) * 2003-01-21 2013-03-19 S.S.C.I., Inc. Novel cocrystallization of hydrochloric acid salt of an active agent
CA2514733A1 (en) * 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen

Also Published As

Publication number Publication date
EP1765379A2 (en) 2007-03-28
US7803786B2 (en) 2010-09-28
WO2006007448A3 (en) 2007-10-25
US20070299033A1 (en) 2007-12-27
EP1765379A4 (en) 2009-05-27
JP2008503495A (ja) 2008-02-07
WO2006007448A2 (en) 2006-01-19

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