JP4989628B2 - グリコヘモグロビン濃度測定方法および濃度測定装置 - Google Patents
グリコヘモグロビン濃度測定方法および濃度測定装置 Download PDFInfo
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- JP4989628B2 JP4989628B2 JP2008507483A JP2008507483A JP4989628B2 JP 4989628 B2 JP4989628 B2 JP 4989628B2 JP 2008507483 A JP2008507483 A JP 2008507483A JP 2008507483 A JP2008507483 A JP 2008507483A JP 4989628 B2 JP4989628 B2 JP 4989628B2
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- 108091005995 glycated hemoglobin Proteins 0.000 claims description 29
- 238000002360 preparation method Methods 0.000 claims description 13
- 210000003743 erythrocyte Anatomy 0.000 claims description 6
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- INGWEZCOABYORO-UHFFFAOYSA-N 2-(furan-2-yl)-7-methyl-1h-1,8-naphthyridin-4-one Chemical compound N=1C2=NC(C)=CC=C2C(O)=CC=1C1=CC=CO1 INGWEZCOABYORO-UHFFFAOYSA-N 0.000 description 16
- 108010002255 deoxyhemoglobin Proteins 0.000 description 16
- 102000001554 Hemoglobins Human genes 0.000 description 14
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- 206010012601 diabetes mellitus Diseases 0.000 description 7
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 6
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- 230000002949 hemolytic effect Effects 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 206010018910 Haemolysis Diseases 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000007872 degassing Methods 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- 230000008588 hemolysis Effects 0.000 description 2
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- 125000003545 alkoxy group Chemical group 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/74—Optical detectors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/721—Haemoglobin
- G01N33/723—Glycosylated haemoglobin
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N2021/3129—Determining multicomponents by multiwavelength light
- G01N2021/3137—Determining multicomponents by multiwavelength light with selection of wavelengths after the sample
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
- G01N2021/3144—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths for oxymetry
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
- G01N2030/8822—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving blood
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/05—Flow-through cuvettes
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Description
3 試料調整ユニット
5 測光機構
53B 受光素子(受光部)
Claims (8)
- カラムクロマトグラフィを利用してグリコヘモグロビン濃度を測定する方法であって、
測定波長を、417〜427nm、520〜526nm、または583〜589nmに設定する、グリコヘモグロビン濃度測定方法。 - 測定波長を、417〜427nmに設定する、請求項1に記載のグリコヘモグロビン濃度測定方法。
- 測定波長を419〜425nmに設定する、請求項1に記載のグリコヘモグロビン濃度測定方法。
- 血液中の赤血球から調製した試料を用いてグリコヘモグロビン濃度を測定する、請求項1〜請求項3のいずれか1項に記載のグリコヘモグロビン濃度測定方法。
- 光源からの光を試料に照射し、そのときに試料から進行してくる光を受光部において受光する測光機構を備え、カラムクロマトグラフィを利用してグリコヘモグロビン濃度を測定するグリコヘモグロビン濃度測定装置であって、
上記測光機構は、417〜427nm、520〜526nm、または583〜589nmの光を、受光部において受光させることができるように構成されている、グリコヘモグロビン濃度測定装置。 - 上記測光機構は、417〜427nmの光を上記受光部において受光させることができるように構成されている、請求項5に記載のグリコヘモグロビン濃度測定装置。
- 上記測光機構は、419〜425nmの光を上記受光部において受光させることができるように構成されている、請求項5に記載のグリコヘモグロビン濃度測定装置。
- 血液中の赤血球から試料を調製するための試料調製機構をさらに備えている、請求項5〜請求項7のいずれか1項に記載のグリコヘモグロビン濃度測定装置。
Priority Applications (1)
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JP2008507483A JP4989628B2 (ja) | 2006-03-24 | 2007-03-23 | グリコヘモグロビン濃度測定方法および濃度測定装置 |
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JP2006082101 | 2006-03-24 | ||
JP2006082101 | 2006-03-24 | ||
JP2008507483A JP4989628B2 (ja) | 2006-03-24 | 2007-03-23 | グリコヘモグロビン濃度測定方法および濃度測定装置 |
PCT/JP2007/056111 WO2007111283A1 (ja) | 2006-03-24 | 2007-03-23 | グリコヘモグロビン濃度測定方法および濃度測定装置 |
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JPWO2007111283A1 JPWO2007111283A1 (ja) | 2009-08-13 |
JP4989628B2 true JP4989628B2 (ja) | 2012-08-01 |
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Country Status (5)
Country | Link |
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US (1) | US8021887B2 (ja) |
EP (1) | EP2015053B1 (ja) |
JP (1) | JP4989628B2 (ja) |
CN (1) | CN101484793B (ja) |
WO (1) | WO2007111283A1 (ja) |
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Publication number | Priority date | Publication date | Assignee | Title |
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EP2820412B1 (en) * | 2012-03-01 | 2017-12-27 | Services Pétroliers Schlumberger | System and method for characterizing crude oil fractions |
CN106290168A (zh) * | 2015-05-18 | 2017-01-04 | 深圳迈瑞生物医疗电子股份有限公司 | 光检测单元、使用该光检测单元的液相色谱分析装置及液相色谱分析方法 |
US10527594B2 (en) * | 2016-04-20 | 2020-01-07 | Arkray, Inc. | Liquid chromatography measurement method, liquid chromatography measurement instrument, and liquid chromatography measurement program storage medium |
RU2645943C1 (ru) * | 2016-10-04 | 2018-02-28 | Общество с ограниченной ответственностью "ТЕЛЕБИОМЕТ" | Способ неинвазивного определения концентраций компонентов крови |
JP7215146B2 (ja) * | 2018-12-21 | 2023-01-31 | 東ソー株式会社 | 吸光光度検出器 |
WO2020159599A1 (en) * | 2019-01-29 | 2020-08-06 | Siemens Healthcare Diagnostics Inc. | TURBIDITY NORMALIZATION ALGORITHM AND METHODS OF REDUCING INTRALIPID/LIPEMIA INTERFERENCE IN HEMOGLOBIN A1c ASSAYS |
Citations (8)
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JPH05256851A (ja) * | 1992-03-16 | 1993-10-08 | Hitachi Ltd | 糖化ヘモグロビンの測定方法及び装置 |
JPH0611510A (ja) * | 1992-03-05 | 1994-01-21 | Boehringer Mannheim Gmbh | ヘモグロビン誘導体の測定のための免疫学的方法 |
JPH06308120A (ja) * | 1993-04-27 | 1994-11-04 | Sekisui Chem Co Ltd | 糖化ヘモグロビン測定用管理物質およびその製造法 |
JPH08159954A (ja) * | 1994-12-07 | 1996-06-21 | Tosoh Corp | グリコヘモグロビン測定用の吸光度計 |
JPH08262027A (ja) * | 1995-02-24 | 1996-10-11 | F Hoffmann La Roche Ag | 全ヘモグロビン含量測定用試薬 |
JPH11142326A (ja) * | 1997-11-07 | 1999-05-28 | Kdk Corp | グリコヘモグロビン測定用の吸光度計 |
WO2002027330A1 (fr) * | 2000-09-28 | 2002-04-04 | Arkray, Inc. | Procede de quantification d'hemoglobine et procede de mesure du taux de glycation d'hemoglobine |
JP2002369814A (ja) * | 2001-04-19 | 2002-12-24 | Samsung Electronics Co Ltd | 非侵襲的なヘモグロビン濃度及び酸素飽和度のモニタリング方法並びに装置 |
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JPH08233824A (ja) * | 1994-12-19 | 1996-09-13 | Bio Rad Lab Inc | カラム再生をしないクロマトグラフィによる糖化ヘモグロビンの連続測定法 |
JP2001074748A (ja) * | 1999-09-08 | 2001-03-23 | Arkray Inc | グリコヘモグロビンの分析方法および装置 |
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-
2007
- 2007-03-23 JP JP2008507483A patent/JP4989628B2/ja active Active
- 2007-03-23 EP EP07739552.3A patent/EP2015053B1/en active Active
- 2007-03-23 US US12/225,526 patent/US8021887B2/en active Active
- 2007-03-23 WO PCT/JP2007/056111 patent/WO2007111283A1/ja active Application Filing
- 2007-03-23 CN CN2007800187891A patent/CN101484793B/zh active Active
Patent Citations (8)
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JPH0611510A (ja) * | 1992-03-05 | 1994-01-21 | Boehringer Mannheim Gmbh | ヘモグロビン誘導体の測定のための免疫学的方法 |
JPH05256851A (ja) * | 1992-03-16 | 1993-10-08 | Hitachi Ltd | 糖化ヘモグロビンの測定方法及び装置 |
JPH06308120A (ja) * | 1993-04-27 | 1994-11-04 | Sekisui Chem Co Ltd | 糖化ヘモグロビン測定用管理物質およびその製造法 |
JPH08159954A (ja) * | 1994-12-07 | 1996-06-21 | Tosoh Corp | グリコヘモグロビン測定用の吸光度計 |
JPH08262027A (ja) * | 1995-02-24 | 1996-10-11 | F Hoffmann La Roche Ag | 全ヘモグロビン含量測定用試薬 |
JPH11142326A (ja) * | 1997-11-07 | 1999-05-28 | Kdk Corp | グリコヘモグロビン測定用の吸光度計 |
WO2002027330A1 (fr) * | 2000-09-28 | 2002-04-04 | Arkray, Inc. | Procede de quantification d'hemoglobine et procede de mesure du taux de glycation d'hemoglobine |
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Publication number | Publication date |
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EP2015053B1 (en) | 2016-06-15 |
JPWO2007111283A1 (ja) | 2009-08-13 |
US8021887B2 (en) | 2011-09-20 |
CN101484793A (zh) | 2009-07-15 |
EP2015053A4 (en) | 2014-03-05 |
WO2007111283A1 (ja) | 2007-10-04 |
EP2015053A1 (en) | 2009-01-14 |
US20090317912A1 (en) | 2009-12-24 |
CN101484793B (zh) | 2012-07-04 |
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