JP4982837B2 - 海洋付着菌用抗菌剤 - Google Patents
海洋付着菌用抗菌剤 Download PDFInfo
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- JP4982837B2 JP4982837B2 JP2003389037A JP2003389037A JP4982837B2 JP 4982837 B2 JP4982837 B2 JP 4982837B2 JP 2003389037 A JP2003389037 A JP 2003389037A JP 2003389037 A JP2003389037 A JP 2003389037A JP 4982837 B2 JP4982837 B2 JP 4982837B2
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Description
海洋微生物の供試菌株として、海洋に広く存在するグラム陰性菌のPseudoalteromonas carrageenovoraを用いた。この菌株は、塩化物イオンを必要とし、40℃以上で死滅することが知られている。
表1に示す各種アミノ酸およびイミダゾールを滅菌濾過海水中に溶解し、アミノ酸液を調製した。
3.2重量%の銀を含む銀−スポジュメン(10mg)と滅菌濾過海水で一定濃度(100mM)に稀釈した各種アミノ酸溶液(1mL)を攪拌混合し、1時間室温にて放置し、アミノ酸−銀錯体を形成させた。その後、室温にて12,000rpmで3分間遠心し、無機固体(下層)を除去し、アミノ酸−銀錯体液(上層)を回収した。このアミノ酸−銀錯体液をI液とする。
L字管にMB培地(5mL)および予め調製しておいた菌液を初期濃度5〜8×106cell/mLになるように加え、25℃、50rpmにて対数増殖期まで振とう培養した。培養液にI液(1mL)を加え、さらに25℃、50rpmにて振とうしながら所定時間毎に培養液をサンプリングし、各サンプルの吸光度(OD660nm)を測定し、増殖曲線を作成した。同様にI液の代わりに、海水(1mL)を添加したもの(blank)、アミノ酸またはイミダゾールのみを含む溶液(1mL)を添加したもの(control)、アミノ酸またはイミダゾールを含まず銀イオンを含む溶液(1mL)のみを添加したもの(−AA+Ag)について、増殖曲線を作成した。増殖曲線を図1〜図12に示す。
錯体を担持する担体は、モンモリロナイト(クニピアF・クニミネ工業株式会社)、スメクタイト化合物(スメクトンSA・クニミネ工業株式会社)、ヘクトライト(合成スメクタイト・コープケミカル株式会社)の3種類の粘土鉱物を用いた。
アミノ酸液とAgNO3溶液をモル比でアミノ酸:銀=3:1になるように混合し、攪拌し、錯体を形成させた。これに担体0.5gを添加し、混合し、さらに50℃にて15時間攪拌した。次いで、この混合物から遠心分離および洗浄により沈殿物を回収した。沈殿物を60℃、5時間乾燥し、この乾燥物をアミノ酸−銀錯体担持抗菌剤とした。
アミノ酸−銀錯体担持抗菌剤(10mg)を海水5mL中に添加し、この溶液をL字管中のP.Carrageenovora菌液(初期濃度5〜8×106cell/mL)へ添加し、50rpm、25℃にて、5時間振とう培養した後、サンプリングした。このサンプルを海水で段階希釈し、MB寒天培地(各3枚ずつ)にプレーティングした後、30℃にて20時間培養した。次いで、各プレート上の細胞数をカウントし、3枚のプレートの平均値を計算した。表2に、この結果を示す。
Claims (5)
- 抗菌剤であって、
ヒスチジン−銀錯体、メチオニン−銀錯体、及びイミダゾール−銀錯体からなる群より選択される少なくとも1種を含み、海水環境下で用いることを特徴とする海洋付着菌用抗菌剤。 - ヒスチジン−銀錯体、メチオニン−銀錯体、及びイミダゾール−銀錯体からなる群より選択される少なくとも1種を担体に担持させてなる請求項1に記載の海洋付着菌用抗菌剤。
- 担体がモンモリロナイト、スメクタイト化合物またはヘクトライトである、請求項2に記載の抗菌剤。
- 請求項1〜3のいずれかに記載の抗菌剤を含む、水中生物付着防止用塗料組成物。
- 請求項4に記載の塗料組成物を海水中で使用される対象物に塗布することを特徴とする該対象物への海洋生物の付着を防止する方法。
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Cited By (1)
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CN103461382A (zh) * | 2013-08-08 | 2013-12-25 | 广东药学院 | 载银改性蒙脱土抗菌剂及其制备方法和应用 |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101287805B (zh) * | 2005-09-06 | 2011-11-02 | 诺华丝国际股份有限公司 | 海洋防污涂料组合物 |
CN100413811C (zh) * | 2005-09-16 | 2008-08-27 | 广东三水大鸿制釉有限公司 | 一种用于抛光砖成膜的纳米黏土改性硅化合物组合物及制备方法 |
JP2007223917A (ja) * | 2006-02-21 | 2007-09-06 | Nippon Chem Ind Co Ltd | 抗菌剤 |
JP4976930B2 (ja) * | 2007-06-20 | 2012-07-18 | ライオン株式会社 | 液体洗濯助剤組成物 |
JP5787587B2 (ja) * | 2011-04-18 | 2015-09-30 | 株式会社ネオス | 塩素イオンを含有する溶液中でヒスチジン銀錯体の殺菌活性を維持する方法および液状抗菌剤組成物 |
JP5787589B2 (ja) * | 2011-04-19 | 2015-09-30 | 株式会社ネオス | 塩素イオンを含有する溶液中でヒスチジン銀錯体の殺菌活性を発揮させる方法、液状添加剤組成物および液状抗菌性組成物 |
EP2708125A4 (en) | 2011-05-11 | 2014-10-22 | Nippon Soda Co | CONSERVATIVE FOR CONSTRUCTION MATERIALS |
JP5882605B2 (ja) * | 2011-06-14 | 2016-03-09 | 株式会社ゼンシン | 抗菌組成物の製造方法 |
JP2013035796A (ja) * | 2011-08-09 | 2013-02-21 | Nippon Soda Co Ltd | 固体材料 |
CN104798740A (zh) * | 2015-03-26 | 2015-07-29 | 巢湖市翔宇渔具有限公司 | 一种具有杀菌功能的渔网 |
BR112018067655A2 (pt) * | 2016-03-02 | 2019-01-02 | Oil Dri Corp Of America | aplicação de materiais porosos para inibição / interrupção de detecção de quórum bacteriano |
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CN103461382A (zh) * | 2013-08-08 | 2013-12-25 | 广东药学院 | 载银改性蒙脱土抗菌剂及其制备方法和应用 |
CN103461382B (zh) * | 2013-08-08 | 2015-07-01 | 广东药学院 | 载银改性蒙脱土抗菌剂及其制备方法和应用 |
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