JP4979907B2 - プラスミノーゲンアクチベーターインヒビター抑制剤 - Google Patents
プラスミノーゲンアクチベーターインヒビター抑制剤 Download PDFInfo
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- JP4979907B2 JP4979907B2 JP2005232929A JP2005232929A JP4979907B2 JP 4979907 B2 JP4979907 B2 JP 4979907B2 JP 2005232929 A JP2005232929 A JP 2005232929A JP 2005232929 A JP2005232929 A JP 2005232929A JP 4979907 B2 JP4979907 B2 JP 4979907B2
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- inhibitor
- plasminogen activator
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- activator inhibitor
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- 102000010752 Plasminogen Inactivators Human genes 0.000 title claims description 15
- 108010077971 Plasminogen Inactivators Proteins 0.000 title claims description 15
- 239000002797 plasminogen activator inhibitor Substances 0.000 title claims description 15
- 239000003112 inhibitor Substances 0.000 title claims description 13
- 235000006040 Prunus persica var persica Nutrition 0.000 claims description 20
- 239000000284 extract Substances 0.000 claims description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 239000002253 acid Substances 0.000 claims description 12
- 235000013305 food Nutrition 0.000 claims description 12
- 240000005809 Prunus persica Species 0.000 claims description 8
- 230000017531 blood circulation Effects 0.000 claims description 7
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 7
- 239000002904 solvent Substances 0.000 claims description 7
- 239000004480 active ingredient Substances 0.000 claims description 6
- 238000000605 extraction Methods 0.000 claims description 6
- ZCSDEGFPWXFQLB-UHFFFAOYSA-N Kaempferol 3-O-beta-D-glucorhamnoside Natural products OC1C(O)C(OC2C(C(O)C(O)C(CO)O2)O)C(C)OC1OC(C(C1=C(O)C=C(O)C=C1O1)=O)=C1C1=CC=C(O)C=C1 ZCSDEGFPWXFQLB-UHFFFAOYSA-N 0.000 claims description 5
- ZCSDEGFPWXFQLB-SFIZVBBHSA-N Multifloein B Natural products O([C@@H]1[C@@H](O)[C@H](O)[C@H](OC2=C(c3ccc(O)cc3)Oc3c(c(O)cc(O)c3)C2=O)O[C@H]1C)[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 ZCSDEGFPWXFQLB-SFIZVBBHSA-N 0.000 claims description 5
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- ZCSDEGFPWXFQLB-WRHRXROUSA-N multiflorin B Chemical compound O([C@@H]1O[C@H]([C@@H]([C@@H](O)[C@H]1O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C)C(C(C1=C(O)C=C(O)C=C1O1)=O)=C1C1=CC=C(O)C=C1 ZCSDEGFPWXFQLB-WRHRXROUSA-N 0.000 claims description 5
- 239000008346 aqueous phase Substances 0.000 claims description 4
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- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
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- 230000000694 effects Effects 0.000 description 11
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- 102000012335 Plasminogen Activator Inhibitor 1 Human genes 0.000 description 6
- 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 description 6
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- 102000013566 Plasminogen Human genes 0.000 description 3
- 108010051456 Plasminogen Proteins 0.000 description 3
- 102000001938 Plasminogen Activators Human genes 0.000 description 3
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- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 2
- 235000003840 Amygdalus nana Nutrition 0.000 description 2
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-ZSJDYOACSA-N Heavy water Chemical compound [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 2
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 2
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- 239000002021 butanolic extract Substances 0.000 description 2
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 2
- 229940074393 chlorogenic acid Drugs 0.000 description 2
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- 235000012000 cholesterol Nutrition 0.000 description 2
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 2
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
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- 102000004190 Enzymes Human genes 0.000 description 1
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- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- VDWSYBFEQXWINA-UHFFFAOYSA-N Martinoside Natural products C1=C(O)C(OC)=CC=C1CCOC1C(O)C(OC2C(C(O)C(O)C(C)O2)O)C(OC(=O)C=CC=2C=C(O)C(OC)=CC=2)C(CO)O1 VDWSYBFEQXWINA-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
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- 244000141353 Prunus domestica Species 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical class OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical class CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 1
- CSCPPACGZOOCGX-WFGJKAKNSA-N acetone d6 Chemical compound [2H]C([2H])([2H])C(=O)C([2H])([2H])[2H] CSCPPACGZOOCGX-WFGJKAKNSA-N 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 230000003579 anti-obesity Effects 0.000 description 1
- 125000000637 arginyl group Chemical class N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 239000002585 base Substances 0.000 description 1
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- 229910052791 calcium Inorganic materials 0.000 description 1
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- 238000007796 conventional method Methods 0.000 description 1
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- 235000005911 diet Nutrition 0.000 description 1
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Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Description
(1)モモ及び/又はノモモの花及び/又は蕾を、含水エタノールで抽出し、抽出溶媒を除去し、しかる後、水相の存在下、n−ヘキサン可溶分、酢酸エチル可溶分、n−ブチルアルコール可溶分を除去し、残った水相より水分を除去して得られた抽出物を有効成分として含有する、プラスミノーゲンアクチベーターインヒビター抑制剤。
(2)前記抽出物が、プルナシン酸、ネオプルナシン酸、ムルチノサイドA、ムルチフロリンB及びそれらの塩から選択される1種乃至は2種以上を有効成分として含有するものであることを特徴とする、(1)に記載のプラスミノーゲンアクチベーターインヒビター抑制剤。
ネオプルナシン酸の物性:白色無晶形粉末
1H NMR (500 MHz, 重水+アセトン-d6) δ 7.38-7.33 (5H, m), 5.36 (1H, s), 4.14 (1H, d, J=8 Hz), 3.76 (1H, dd, J=12.5, 2 Hz), 3.59 (1H, dd, J=6, 12.5 Hz), 3.31-3.14 (4H, m)
ヒドロキシプロピルセルロース 3質量%
結晶セルロース 40質量%
デンプン 46質量%
ステアリン酸マグネシウム 1質量%
Claims (3)
- モモ及び/又はノモモの花及び/又は蕾を、含水エタノールで抽出し、抽出溶媒を除去し、しかる後、水相の存在下、n−ヘキサン可溶分、酢酸エチル可溶分、n−ブチルアルコール可溶分を除去し、残った水相より水分を除去して得られた抽出物を有効成分として含有する、プラスミノーゲンアクチベーターインヒビター抑制剤(食品組成物の態様を除く)。
- 血流量を改善する目的で使用されるものであることを特徴とする、請求項1又は2に記載のプラスミノーゲンアクチベーターインヒビター抑制剤(食品組成物の態様を除く)。
Priority Applications (1)
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JP2005232929A JP4979907B2 (ja) | 2005-08-11 | 2005-08-11 | プラスミノーゲンアクチベーターインヒビター抑制剤 |
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JP2005232929A JP4979907B2 (ja) | 2005-08-11 | 2005-08-11 | プラスミノーゲンアクチベーターインヒビター抑制剤 |
Publications (3)
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JP2007045771A JP2007045771A (ja) | 2007-02-22 |
JP2007045771A5 JP2007045771A5 (ja) | 2008-07-24 |
JP4979907B2 true JP4979907B2 (ja) | 2012-07-18 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109490446A (zh) * | 2018-12-31 | 2019-03-19 | 云南中医学院 | 一种同时测定地蜈蚣药材中5种黄酮类化合物的方法 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6279667B2 (ja) * | 2016-07-29 | 2018-02-14 | 株式会社オフィスワタナベ | モモの抽出物を含有する組成物 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001302439A (ja) * | 2000-04-25 | 2001-10-31 | Matsukawa Kagaku:Kk | 白桃花から抽出した抽出物を含有する化粧料 |
JP2003055249A (ja) * | 2001-08-08 | 2003-02-26 | Ryuei Soken:Kk | 栄養補助食品 |
JP2004244389A (ja) * | 2003-02-14 | 2004-09-02 | Ryuei Soken:Kk | 栄養補助食品 |
-
2005
- 2005-08-11 JP JP2005232929A patent/JP4979907B2/ja active Active
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109490446A (zh) * | 2018-12-31 | 2019-03-19 | 云南中医学院 | 一种同时测定地蜈蚣药材中5种黄酮类化合物的方法 |
CN109490446B (zh) * | 2018-12-31 | 2021-04-27 | 云南中医学院 | 一种同时测定地蜈蚣药材中5种黄酮类化合物的方法 |
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