JP4927240B2 - ポリマーを使用して粘度付与したヒドロアルコール組成物 - Google Patents
ポリマーを使用して粘度付与したヒドロアルコール組成物 Download PDFInfo
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- JP4927240B2 JP4927240B2 JP53091098A JP53091098A JP4927240B2 JP 4927240 B2 JP4927240 B2 JP 4927240B2 JP 53091098 A JP53091098 A JP 53091098A JP 53091098 A JP53091098 A JP 53091098A JP 4927240 B2 JP4927240 B2 JP 4927240B2
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Images
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dentistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Environmental Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (3)
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| US08/781,095 | 1997-01-09 | ||
| US08/781,095 US6582711B1 (en) | 1997-01-09 | 1997-01-09 | Hydroalcoholic compositions thickened using polymers |
| PCT/US1997/023680 WO1998030095A1 (en) | 1997-01-09 | 1997-12-18 | Hydroalcoholic compositions thickened using polymers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2010242066A Division JP2011042680A (ja) | 1997-01-09 | 2010-10-28 | ポリマーを使用して粘度付与したヒドロアルコール組成物 |
Publications (3)
| Publication Number | Publication Date |
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| JP2001508442A JP2001508442A (ja) | 2001-06-26 |
| JP2001508442A5 JP2001508442A5 (enExample) | 2005-08-11 |
| JP4927240B2 true JP4927240B2 (ja) | 2012-05-09 |
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| JP53091098A Expired - Fee Related JP4927240B2 (ja) | 1997-01-09 | 1997-12-18 | ポリマーを使用して粘度付与したヒドロアルコール組成物 |
| JP2010242066A Pending JP2011042680A (ja) | 1997-01-09 | 2010-10-28 | ポリマーを使用して粘度付与したヒドロアルコール組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010242066A Pending JP2011042680A (ja) | 1997-01-09 | 2010-10-28 | ポリマーを使用して粘度付与したヒドロアルコール組成物 |
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| Country | Link |
|---|---|
| US (3) | US6582711B1 (enExample) |
| EP (1) | EP0963158B1 (enExample) |
| JP (2) | JP4927240B2 (enExample) |
| AU (1) | AU735255B2 (enExample) |
| CA (1) | CA2275529A1 (enExample) |
| DE (1) | DE69723583T2 (enExample) |
| WO (1) | WO1998030095A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011042680A (ja) * | 1997-01-09 | 2011-03-03 | 3M Co | ポリマーを使用して粘度付与したヒドロアルコール組成物 |
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| US7566460B2 (en) * | 1995-06-22 | 2009-07-28 | 3M Innovative Properties Company | Stable hydroalcoholic compositions |
| US6623744B2 (en) * | 1995-06-22 | 2003-09-23 | 3M Innovative Properties Company | Stable hydroalcoholic compositions |
| CA2224798A1 (en) * | 1995-06-22 | 1997-01-09 | Matthew T. Scholz | Stable hydroalcoholic compositions |
| US6045817A (en) * | 1997-09-26 | 2000-04-04 | Diversey Lever, Inc. | Ultramild antibacterial cleaning composition for frequent use |
| US6586000B2 (en) * | 1999-12-16 | 2003-07-01 | Dermatrends, Inc. | Hydroxide-releasing agents as skin permeation enhancers |
| US6846846B2 (en) * | 2001-10-23 | 2005-01-25 | The Trustees Of Columbia University In The City Of New York | Gentle-acting skin disinfectants |
| US7879365B2 (en) * | 2002-02-07 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Zinc salt compositions for the prevention of dermal and mucosal irritation |
| US7745425B2 (en) * | 2002-02-07 | 2010-06-29 | The Trustees Of Columbia University In The City Of New York | Non-irritating compositions containing zinc salts |
| EP1480517A4 (en) * | 2002-02-07 | 2007-08-22 | Univ Columbia | ZINC SALT COMPOSITIONS FOR PREVENTING MOLECULAR BREAST EXTRACTION THROUGH SPERMICIDES AND MICROBICIDES |
| US20040018163A1 (en) * | 2002-04-29 | 2004-01-29 | Wei Yu | Cosmetic compositions comprising at least one dimethicone, at least one linear hydrocarbon wax and at least one compatibilizing agent |
| IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
| JP2006505583A (ja) | 2002-10-25 | 2006-02-16 | フォーミックス エルティーディー. | 化粧剤および医薬用フォーム |
| US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
| US9211259B2 (en) | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
| US7700076B2 (en) | 2002-10-25 | 2010-04-20 | Foamix, Ltd. | Penetrating pharmaceutical foam |
| US7704518B2 (en) | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
| US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
| US20080138296A1 (en) | 2002-10-25 | 2008-06-12 | Foamix Ltd. | Foam prepared from nanoemulsions and uses |
| US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
| US7285576B2 (en) * | 2003-03-12 | 2007-10-23 | 3M Innovative Properties Co. | Absorbent polymer compositions, medical articles, and methods |
| CN102319409A (zh) * | 2003-07-17 | 2012-01-18 | 纽约市哥伦比亚大学托管会 | 含有季铵化合物及精油和/或精油成分的协同组合的抗微生物组合物 |
| MXPA06002163A (es) * | 2003-08-25 | 2006-05-22 | Foamix Ltd | Espuma farmaceutica de penetracion. |
| US20050186281A1 (en) * | 2003-09-26 | 2005-08-25 | Mionix Corporation | Antimicrobial sanitizing composition |
| EP1668105B1 (en) | 2003-09-29 | 2018-10-17 | Deb IP Limited | High alcohol content gel-like and foaming compositions |
| US20050215458A1 (en) * | 2003-10-02 | 2005-09-29 | Mionix Corporation | Cleaning and sanitizing wipes |
| US20050095215A1 (en) * | 2003-11-03 | 2005-05-05 | Popp Karl F. | Antimicrobial shampoo compositions |
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| US7745509B2 (en) * | 2003-12-05 | 2010-06-29 | 3M Innovative Properties Company | Polymer compositions with bioactive agent, medical articles, and methods |
| US20050123590A1 (en) * | 2003-12-05 | 2005-06-09 | 3M Innovative Properties Company | Wound dressings and methods |
| US20070184222A1 (en) * | 2004-04-20 | 2007-08-09 | University Of Rochester | Hydrogel-supported porous semiconductor devices |
| US20060074029A1 (en) * | 2004-10-04 | 2006-04-06 | Scott Leece | Topical antimicrobial composition having improved moisturization properties |
| US20060093571A1 (en) * | 2004-10-29 | 2006-05-04 | Jan Glinski | Hair and skin protecting compositions based on esters or ethers of betulin |
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| DE102004062775A1 (de) | 2004-12-21 | 2006-06-29 | Stockhausen Gmbh | Alkoholischer Pumpschaum |
| CA2594189A1 (en) * | 2005-01-05 | 2006-07-13 | Dow Global Technologies Inc. | Enhanced efficacy of fungicides in paper and paperboard |
| JP2008531740A (ja) | 2005-03-07 | 2008-08-14 | デブ ワールドワイド ヘルスケア インコーポレーテッド | シリコーン・ベースの界面活性剤を含むアルコール含有量の高い発泡性組成物 |
| US20060246098A1 (en) * | 2005-03-16 | 2006-11-02 | Srinivasa Rao | Stable aqueous-based emulsion formulation comprising urea and salicylic acid and method of using same |
| EP1863434A4 (en) * | 2005-03-16 | 2012-03-07 | Taro Pharmaceuticals Usa Inc | STABLE AQUEOUS EMULSION FORMULATION COMPRISING UREA AND SALICYLIC ACID AND METHOD OF USE |
| US7651990B2 (en) * | 2005-06-13 | 2010-01-26 | 3M Innovative Properties Company | Foamable alcohol compositions comprising alcohol and a silicone surfactant, systems and methods of use |
| US20070071705A1 (en) * | 2005-09-29 | 2007-03-29 | De Oliveira Monica A M | Topical anti-microbial compositions |
| EP2754350A3 (en) * | 2005-10-25 | 2014-11-12 | Dow Global Technologies LLC | Antimicrobial composition and method |
| US20070138208A1 (en) * | 2005-12-16 | 2007-06-21 | 3M Innovative Properties Company | Dispenser |
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| ITPD20060092A1 (it) * | 2006-03-17 | 2007-09-18 | Stefano Sala | Prodotto cosmetico o farmaceutico per uso topico |
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| WO2009069006A2 (en) | 2007-11-30 | 2009-06-04 | Foamix Ltd. | Foam containing benzoyl peroxide |
| WO2009090495A2 (en) | 2007-12-07 | 2009-07-23 | Foamix Ltd. | Oil and liquid silicone foamable carriers and formulations |
| JP6117460B2 (ja) | 2007-12-31 | 2017-04-19 | スリーエム イノベイティブ プロパティズ カンパニー | ヨウ素並びに糖及び/又は糖アルコールを含有する液体殺菌組成物 |
| WO2009088894A2 (en) * | 2007-12-31 | 2009-07-16 | 3M Innovative Properties Company | Antimicrobial compositions |
| US9381150B2 (en) * | 2008-03-07 | 2016-07-05 | Kimberly-Clark Worldwide, Inc. | Alcohol antimicrobial skin sanitizing compositions including cationic compatible thickeners |
| US7842725B2 (en) | 2008-07-24 | 2010-11-30 | Ecolab USA, Inc. | Foaming alcohol compositions with selected dimethicone surfactants |
| JP5345015B2 (ja) * | 2008-12-16 | 2013-11-20 | 花王株式会社 | 手指消毒剤組成物 |
| US20120087872A1 (en) | 2009-04-28 | 2012-04-12 | Foamix Ltd. | Foamable Vehicles and Pharmaceutical Compositions Comprising Aprotic Polar Solvents and Uses Thereof |
| KR101658262B1 (ko) * | 2009-05-12 | 2016-09-22 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 정밀한 페인트 선을 생성하기 위한 마스킹 용품 및 마스킹 용품의 페인트 선 성능을 향상시키는 방법 |
| WO2011013008A2 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
| CA2769625C (en) | 2009-07-29 | 2017-04-11 | Foamix Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
| US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
| WO2011039638A2 (en) | 2009-10-02 | 2011-04-07 | Foamix Ltd. | Topical tetracycline compositions |
| DE102010004950A1 (de) * | 2010-01-18 | 2011-07-21 | Remis Gesellschaft für Entwicklung und Vertrieb von technischen Elementen mbH, 50829 | Kühlregal mit Türvorrichtung |
| KR101824754B1 (ko) * | 2010-06-24 | 2018-02-01 | 허큘레스 엘엘씨 | 오래 지속되는 이점을 제공하기 위해 케라틴 기재에 도포되는 개인 관리 조성물 첨가제 |
| CN102970995A (zh) | 2010-06-29 | 2013-03-13 | 3M创新有限公司 | 稳定的抗菌组合物及方法 |
| US20150025156A1 (en) | 2012-02-24 | 2015-01-22 | Gojo Industries, Inc. | Antimicrobial and foamable alcoholic compositions |
| CA2781379C (en) | 2012-03-26 | 2013-09-03 | Clji Ip Company, Llc | Topical formulations for the prevention of sexually transmitted disease and methods of producing the same |
| GB201211691D0 (en) | 2012-07-05 | 2012-08-15 | Reckitt Benckiser Llc | Sprayable aqueous alcoholic microbicidal compositions comprising zinc ions |
| GB201211688D0 (en) | 2012-07-02 | 2012-08-15 | Reckitt Benckiser Llc | Aqueous alcoholic microbicidal compositions comprising zinc ions |
| GB201211701D0 (en) | 2012-07-02 | 2012-08-15 | Reckitt Benckiser Llc | Aqueous alcoholic microbicidal compositions comprising zinc ions |
| GB201211702D0 (en) | 2012-07-02 | 2012-08-15 | Reckitt Benckiser Llc | Sprayable aqueous alcoholic microbicidal compostions comprising zinc ions |
| US9707162B2 (en) | 2012-11-30 | 2017-07-18 | Reckitt & Colman (Overseas) Limited | Microbicidal personal care compositions comprising metal ions |
| US9867973B2 (en) | 2013-06-17 | 2018-01-16 | Medline Industries, Inc. | Skin antiseptic applicator and methods of making and using the same |
| US11027032B2 (en) * | 2014-01-08 | 2021-06-08 | Carefusion 2200, Inc. | Systems, methods, and devices for sterilizing antiseptic solutions |
| US9511156B2 (en) | 2014-01-08 | 2016-12-06 | Carefusion 2200, Inc. | Systems, methods, and devices for sterilizing antiseptic solutions |
| CA2940494C (en) | 2014-03-14 | 2022-11-08 | Gojo Industries, Inc. | Hand sanitizers with improved aesthetics and skin-conditioning to encourage compliance with hand hygiene guidelines |
| US9970303B2 (en) | 2014-05-13 | 2018-05-15 | Entrotech, Inc. | Erosion protection sleeve |
| US10980714B2 (en) * | 2015-05-07 | 2021-04-20 | L'oreal | Cleansing scrub composition |
| US10813357B1 (en) | 2015-05-26 | 2020-10-27 | Gojo Industries, Inc. | Compositions and methods with efficacy against spores and other organisms |
| US9895455B2 (en) | 2015-06-30 | 2018-02-20 | Carefusion 2200, Inc | Systems, methods, and devices for sterilizing antiseptic solutions |
| MX2017016383A (es) * | 2015-06-30 | 2018-03-02 | Carefusion 2200 Inc | Sistemas, metodos y dispositivos para esterilizar soluciones antisepticas. |
| CN107735072B (zh) * | 2015-07-01 | 2023-09-15 | 3M创新有限公司 | 用于去除孢子的组合物 |
| KR20170043021A (ko) * | 2015-10-12 | 2017-04-20 | 에스케이하이닉스 주식회사 | 포토레지스트 패턴 코팅용 조성물 및 이를 이용한 미세패턴 형성 방법 |
| JP6741433B2 (ja) * | 2016-01-27 | 2020-08-19 | 株式会社大阪製薬 | 消毒用乳化組成物 |
| MX2020012139A (es) | 2016-09-08 | 2021-01-29 | Vyne Pharmaceuticals Inc | Composiciones y metodos para tratar rosacea y acne. |
| JP2020514405A (ja) | 2017-01-04 | 2020-05-21 | スリーエム イノベイティブ プロパティズ カンパニー | 芽胞の除去方法 |
| WO2018128966A1 (en) | 2017-01-04 | 2018-07-12 | 3M Innovative Properties Company | Methods of removing spores |
| JP6830629B2 (ja) * | 2017-03-22 | 2021-02-17 | ゼリア新薬工業株式会社 | 消毒用組成物 |
| EP3606343A1 (en) | 2017-04-04 | 2020-02-12 | Gojo Industries Inc | Methods and compounds for increasing virucidal efficacy in hydroalcoholic systems |
| AU2018275134B2 (en) * | 2017-06-02 | 2024-05-23 | Zurex Pharma, Inc. | Low-alcohol and sterilizable antimicrobial compositions and use thereof |
| WO2019215679A1 (en) | 2018-05-10 | 2019-11-14 | Protair-X Health Solutions, Inc. | Foam sanitizer composition |
| WO2022010906A1 (en) | 2020-07-06 | 2022-01-13 | Ecolab Usa Inc. | Peg-modified castor oil based compositions for microemulsifying and removing multiple oily soils |
| AU2021305611B2 (en) | 2020-07-06 | 2024-06-13 | Ecolab Usa Inc. | Foaming mixed alcohol/water compositions comprising a combination of alkyl siloxane and a hydrotrope/solubilizer |
| JP2023534927A (ja) | 2020-07-06 | 2023-08-15 | エコラボ ユーエスエー インコーポレイティド | 構造化アルコキシル化シロキサンを含む起泡性アルコール/水混合組成物 |
Family Cites Families (149)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US57A (en) * | 1836-10-19 | Hemp ant | ||
| US2054989A (en) | 1933-12-30 | 1936-09-22 | Us Ind Alcohol Co | Compositions for application to the human skin |
| US2153143A (en) | 1938-01-28 | 1939-04-04 | Eastman Kodak Co | Nondiscoloring, liquid antiseptic soap |
| US2678902A (en) | 1950-11-06 | 1954-05-18 | Colgate Palmolive Co | Hand lotion |
| US3131152A (en) | 1960-06-13 | 1964-04-28 | Allied Chem | Foam producing formulations |
| US3131154A (en) | 1961-10-25 | 1964-04-28 | Allied Chem | Foam producing compositions |
| US3824303A (en) | 1963-07-24 | 1974-07-16 | Yardley Of London Inc | Collapsible foam pre-electric shave lotion containing diester lubricants |
| US3395214A (en) | 1964-01-09 | 1968-07-30 | Scholl Mfg Co Inc | Antiperspirant composition providing a readily collapsible sprayable foam |
| US3415939A (en) | 1965-06-22 | 1968-12-10 | Roberts David | Matte cosmetic cream composition |
| US3709437A (en) | 1968-09-23 | 1973-01-09 | Hershel Earl Wright | Method and device for producing foam |
| US3840465A (en) | 1970-11-18 | 1974-10-08 | Texaco Inc | Aerosol foam composition |
| US3770648A (en) * | 1971-07-12 | 1973-11-06 | Bristol Myers Co | Anhydrous aerosol foam |
| GB1424002A (en) | 1972-05-26 | 1976-02-04 | Unilever Ltd | Hair preparations |
| US3962150A (en) | 1974-04-10 | 1976-06-08 | Richardson-Merrell Inc. | Foam producing cleansing compositions |
| US4006218A (en) | 1974-07-08 | 1977-02-01 | Johnson & Johnson | Potentiated medicaments |
| JPS5729213B2 (enExample) | 1974-11-12 | 1982-06-21 | ||
| GB1527781A (en) | 1975-10-08 | 1978-10-11 | Djuro C | Anti-inflammatory composition |
| US4202881A (en) | 1976-06-18 | 1980-05-13 | Wella Ag | Hair shampoo and conditioning lotion |
| FR2406438A1 (fr) | 1977-10-19 | 1979-05-18 | Messac Leon | Composition corporelle tonifiante, raffermissante et amincissante pour applications locales |
| US4199564A (en) | 1978-09-22 | 1980-04-22 | Masti-Kure Products Company, Inc. | Film-forming alcoholic microbicidal teat dip and method of use thereof |
| EP0014502B1 (en) | 1979-02-06 | 1983-07-27 | THE PROCTER & GAMBLE COMPANY | Soap bars |
| US4228277A (en) * | 1979-02-12 | 1980-10-14 | Hercules Incorporated | Modified nonionic cellulose ethers |
| US4666896A (en) * | 1979-04-26 | 1987-05-19 | Bristol-Myers Company | Chlorhexidine salts and compositions of same |
| US4311695A (en) | 1979-12-03 | 1982-01-19 | Dow Corning Corporation | Personal-care emulsions comprising a siloxane-oxyalkylene copolymer |
| US4511486A (en) | 1981-11-02 | 1985-04-16 | Richardson-Vicks Inc. | Method of cleaning dentures using aerated foams |
| US4440653A (en) * | 1982-03-08 | 1984-04-03 | Halliburton Company | Highly stable alcohol foams and methods of forming and using such foams |
| US4464293A (en) | 1982-04-12 | 1984-08-07 | Dobrin Robert J | Liquid cleaner-disinfectant composition for use in wiping down dental operatories |
| US4478853A (en) | 1982-05-17 | 1984-10-23 | S. C. Johnson & Son, Inc. | Skin conditioning composition |
| US4542012A (en) | 1982-07-02 | 1985-09-17 | Minnesota Mining And Manufacturing Company | Film-forming composition containing an antimicrobial agent and methods |
| US4454060A (en) * | 1983-06-09 | 1984-06-12 | Colgate-Palmolive Company | Liquid detergent composition with a cationic foam stabilizing copolymer containing pendant quaternary nitrogen groups and pendant hydrophobic groups |
| US4752612A (en) | 1983-07-01 | 1988-06-21 | Nitto Electrical Industrial Co., Ltd. | Method and percutaneously administering physiologically active agents using an alcohol adjuvant and a solvent |
| US4559226A (en) | 1983-09-06 | 1985-12-17 | Bernel Chemical Company Inc. | Self-emulsifying alkoxylate esters |
| US4485089A (en) * | 1983-10-17 | 1984-11-27 | Hercules Incorporated | Gel toothpastes |
| WO1985001876A1 (en) | 1983-10-24 | 1985-05-09 | Lockley Services Pty. Ltd. | Foamable biocide composition |
| US4501834A (en) | 1983-12-22 | 1985-02-26 | Colgate-Palmolive Company | Gels formed from anionic and cationic polymers |
| US4772592A (en) * | 1984-01-09 | 1988-09-20 | Lever Brothers Company | Skin treatment composition |
| AU560740B2 (en) * | 1984-01-09 | 1987-04-16 | Unilever Plc | Pharmaceutical emulsion comprising an organic lactate and silicone oil |
| US4921902A (en) * | 1984-02-02 | 1990-05-01 | The Dow Chemical Company | Hydrophobie associative composition containing a polymer of a water-soluble monomer and an amphiphilic monomer |
| DE3406497A1 (de) | 1984-02-23 | 1985-09-05 | Mueller Bernhard Willi Werner | Hochdisperse pharmazeutische mehrkomponentensysteme und verfahren zu ihrer herstellung |
| CA1249968A (en) | 1984-04-05 | 1989-02-14 | Kazuo Kigasawa | Ointment base |
| DE3416777C2 (de) | 1984-05-07 | 1986-11-20 | Gödecke AG, 1000 Berlin | Pharmazeutische topische Zubereitungen |
| US4584192A (en) | 1984-06-04 | 1986-04-22 | Minnesota Mining & Manufacturing Company | Film-forming composition containing an antimicrobial agent and methods of use |
| US4584189A (en) * | 1984-09-28 | 1986-04-22 | Hercules Incorporated | Bactericidal toothpastes |
| IL77224A (en) | 1984-12-12 | 1989-09-10 | Euro Celtique Sa | Antibacterial cream |
| US4695453A (en) | 1985-01-24 | 1987-09-22 | Henkel Corporation | Thickened alcoholic antimicrobial compositions |
| US4567038A (en) | 1985-03-06 | 1986-01-28 | Revlon, Inc. | Sunscreen composition for hair protection |
| US4826828A (en) | 1985-04-22 | 1989-05-02 | Avon Products, Inc. | Composition and method for reducing wrinkles |
| US4806262A (en) | 1985-08-14 | 1989-02-21 | The Procter & Gamble Company | Nonlathering cleansing mousse with skin conditioning benefits |
| US4683004A (en) | 1985-08-20 | 1987-07-28 | Union Carbide Corporation | Foamable compositions and processes for use thereof |
| US5288486A (en) * | 1985-10-28 | 1994-02-22 | Calgon Corporation | Alcohol-based antimicrobial compositions |
| CA1299098C (en) | 1985-10-28 | 1992-04-21 | John H. White | Alcohol-based antimicrobial compositions |
| AU600269B2 (en) | 1986-05-08 | 1990-08-09 | Sterling Drug Inc. | Disinfectant wipe |
| LU86429A1 (fr) * | 1986-05-16 | 1987-12-16 | Oreal | Compositions cosmetiques renfermant un polymere cationique et un polymere anionique comme agent epaississant |
| US4831023A (en) | 1986-06-27 | 1989-05-16 | Thames Pharmacal Co., Inc. | Water washable vehicles for topical use |
| JPH0678217B2 (ja) | 1986-09-18 | 1994-10-05 | 花王株式会社 | 乳化型毛髪化粧料 |
| DE3632030C2 (de) | 1986-09-20 | 1995-01-05 | Wella Ag | Verdicktes kosmetisches Mittel zur Festigung der Frisur |
| LU86756A1 (fr) | 1987-02-03 | 1988-11-17 | Oreal | Compositions cosmetiques non agressives contenant un tensio-actif moussant et un tensio-actif non ionique a deux chaines grasses |
| US4857302A (en) * | 1987-02-20 | 1989-08-15 | Decker Jr Donald F | Solubilized benzoyl peroxide and cosmetic solution including solubilized benzoyl peroxide |
| KR900007659B1 (ko) | 1987-02-23 | 1990-10-18 | 시세이도 가부시끼가이샤 | 경피 흡수촉진제 및 이를 함유하는 피부외용 제제 |
| US4792415A (en) | 1987-04-13 | 1988-12-20 | Merck & Co., Inc. | Quaternary ammonium salts of anionic gums |
| US4775529A (en) * | 1987-05-21 | 1988-10-04 | Schering Corporation | Steroid lotion |
| US4906459A (en) | 1987-10-23 | 1990-03-06 | The Procter & Gamble Company | Hair care compositions |
| US4931282A (en) | 1987-11-25 | 1990-06-05 | Minnesota Mining And Manufacturing Company | Pressure-sensitive medical sealant |
| US5225473A (en) | 1987-11-25 | 1993-07-06 | Minnesota Mining And Manufacturing Company | Pressure-sensitive adhesives |
| GB8802646D0 (en) | 1988-02-05 | 1988-03-02 | Croda Int Plc | Humectants |
| US5223261A (en) | 1988-02-26 | 1993-06-29 | Riker Laboratories, Inc. | Transdermal estradiol delivery system |
| US4897262A (en) | 1988-03-22 | 1990-01-30 | Playtex Jhirmack, Inc. | Non-aerosol hair spray composition |
| JP2942780B2 (ja) * | 1988-06-02 | 1999-08-30 | 佳正 横山 | 揮散抑制アルコール |
| DE3827561C1 (enExample) * | 1988-08-13 | 1989-12-28 | Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De | |
| US4883660A (en) | 1988-10-17 | 1989-11-28 | Thames Pharmacal Co., Inc. | Gel bases for pharmaceutical compositions |
| US5298182A (en) | 1989-01-31 | 1994-03-29 | Ciba-Geigy Corporation | Rapid ophthalmic glycol/lower alkanol cleaning and disinfecting solution and method |
| EP0381618A3 (en) | 1989-01-31 | 1992-02-26 | Ciba-Geigy Ag | Disinfecting and cleaning composition for contact lenses |
| US5232691A (en) | 1989-04-26 | 1993-08-03 | Lemole Gerald M | Protective gel composition |
| US4956170A (en) | 1989-06-28 | 1990-09-11 | S. C. Johnson & Son, Inc. | Skin moisturizing/conditioning antimicrobial alcoholic gels |
| US5100658A (en) * | 1989-08-07 | 1992-03-31 | The Procter & Gamble Company | Vehicle systems for use in cosmetic compositions |
| US5104646A (en) * | 1989-08-07 | 1992-04-14 | The Procter & Gamble Company | Vehicle systems for use in cosmetic compositions |
| US5290555A (en) | 1989-09-14 | 1994-03-01 | Revlon Consumer Products Corporation | Cosmetic compositions with structural color |
| US4983377A (en) | 1989-10-31 | 1991-01-08 | The Procter & Gamble Company | Silicone hairspray compositions |
| US4957908A (en) | 1990-01-08 | 1990-09-18 | Olin Corporation | Chitosan pyrithione as antimicrobial agent useful in personal care products |
| FR2657617B1 (fr) | 1990-01-31 | 1994-03-25 | Oreal | Emulsions huile-dans-eau a base de silicones insolubles et d'un agent emulsionnant du type acide ether carboxylique polyoxyalkylene, et leur application en cosmetique et en dermatologie. |
| FR2658076B1 (fr) | 1990-02-12 | 1992-06-12 | Sanofi Sa | Composition cosmetique contenant des copolymeres d'aminoacides, utile comme agent hydratant. |
| GB9005523D0 (en) | 1990-03-12 | 1990-05-09 | Unilever Plc | Cosmetic composition |
| US5149719A (en) | 1990-04-27 | 1992-09-22 | Minnesota Mining And Manufacturing Company | Composition for transdermal penetration of medicaments |
| US5128123A (en) | 1991-02-08 | 1992-07-07 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Clear cosmetic sticks |
| US5167950A (en) | 1991-03-28 | 1992-12-01 | S. C. Johnson & Son | High alcohol content aerosol antimicrobial mousse |
| US5164107A (en) | 1991-04-25 | 1992-11-17 | Becton, Dickinson And Company | Chlorhexidine composition useful in a surgical scrub |
| US5284486A (en) * | 1991-06-11 | 1994-02-08 | Microvena Corporation | Self-centering mechanical medical device |
| FR2677982B1 (fr) | 1991-06-24 | 1993-09-24 | Oreal | Composes polyfluoroalkylthiopoly(ethylimidazolium), procede de preparation et leur utilisation comme agents biocides. |
| GB9114255D0 (en) | 1991-07-02 | 1991-08-21 | Unilever Plc | Cosmetic composition |
| CA2074293C (en) | 1991-07-25 | 2002-03-19 | John R. Horoschak | Water-based hair fixative composition |
| DE69223322T2 (de) * | 1991-08-19 | 1998-07-02 | Procter & Gamble | Haarspraypraeparate |
| GB9118979D0 (en) | 1991-09-04 | 1991-10-23 | Unilever Plc | Cosmetic composition |
| US5180061A (en) | 1991-09-09 | 1993-01-19 | Becton, Dickinson And Company | Stable iodophor in polyurethane foam |
| EG20380A (en) | 1991-10-16 | 1999-02-28 | Richardson Vicks Inc | Enhanced skin penetration system for improved topical delivery of drugs |
| US5276079A (en) | 1991-11-15 | 1994-01-04 | Minnesota Mining And Manufacturing Company | Pressure-sensitive poly(n-vinyl lactam) adhesive composition and method for producing and using same |
| US5494533A (en) | 1991-12-12 | 1996-02-27 | Richardson-Vicks, Inc. | Method for personal cleansing |
| WO1993021899A1 (en) * | 1992-05-05 | 1993-11-11 | The Procter & Gamble Company | Acne treating composition |
| US5428095A (en) | 1992-06-09 | 1995-06-27 | Cal-West Automotive | Protective coating composition and method of using such composition |
| WO1993025179A1 (en) | 1992-06-10 | 1993-12-23 | Alberto-Culver Company | Emulsifier salt compositions for applying silicone oil to hair |
| US5460620A (en) | 1992-07-31 | 1995-10-24 | Creative Products Resource, Inc. | Method of applying in-tandem applicator pads for transdermal delivery of a therapeutic agent |
| US5690921A (en) | 1992-10-15 | 1997-11-25 | Wella Aktiengesellschaft | Hair fixing composition in the form of an aqueous solution, foam or gel |
| JP3398171B2 (ja) | 1993-03-15 | 2003-04-21 | 株式会社資生堂 | 水中油型乳化組成物 |
| US5635469A (en) | 1993-06-10 | 1997-06-03 | The Procter & Gamble Company | Foaming cleansing products |
| US5662893A (en) | 1993-06-25 | 1997-09-02 | Eastman Chemical Company | Clear pump hair spray formulations containing a linear sulfopolyester in a hydroalcoholic liquid vehicle |
| JPH08512084A (ja) * | 1993-07-01 | 1996-12-17 | ザ、プロクター、エンド、ギャンブル、カンパニー | 熱可塑性エラストマー性コポリマーとそれを含有したヘア及びスキンケア組成物 |
| US5484597A (en) | 1993-07-30 | 1996-01-16 | Chesebrough-Pond's Usa Co. | Clear hydroalcholic cosmetic microemulsions |
| US5547662A (en) * | 1993-08-27 | 1996-08-20 | Becton, Dickinson And Company | Preparation of a skin surface for a surgical procedure |
| CA2168876C (en) * | 1993-08-27 | 1999-10-26 | Kendrick Jon Hughes | Topical personal care composition containing polysiloxane-grafted adhesive polymer and drying aid |
| FR2709953B1 (fr) | 1993-09-14 | 1995-11-24 | Oreal | Composition cosmétique contenant au moins un agent tensio-actif non-ionique du type alkylpolyglycoside et/ou polyglycérolé et au moins un copolymère séquencé polydiméthylsiloxane/polyoxalkylène. |
| US5334388A (en) | 1993-09-15 | 1994-08-02 | Becton, Dickinson And Company | Antimicrobial drying substrate |
| US5512199A (en) | 1993-11-02 | 1996-04-30 | Becton Dickinson And Company | Hand wipe solution |
| IT1265001B1 (it) * | 1993-12-16 | 1996-10-17 | Zambon Spa | Composizione farmaceutica per uso topico contenente acido (s)-2-(4- isobutilfenil) propionico |
| US5549888A (en) | 1994-01-31 | 1996-08-27 | Procter & Gamble | Aqueous topical anti-acne compositions of low pH |
| US5759528A (en) | 1994-02-18 | 1998-06-02 | Institute For Advanced Skin Research, Inc. | Topical composition for promoting transdermal absorption of therapeutic agents |
| FR2717075B1 (fr) | 1994-03-14 | 1996-04-05 | Oreal | Gel aqueux de maquillage à organopolysiloxane. |
| US6086856A (en) | 1994-03-28 | 2000-07-11 | Oralcare Systems, Inc. | System for delivering foamed oral hygiene compositions |
| CA2151774C (en) | 1994-06-27 | 1999-04-06 | Minh Quang Hoang | Skin disinfecting formulations |
| JP2878130B2 (ja) | 1994-09-16 | 1999-04-05 | 株式会社大阪製薬 | 消毒剤組成物 |
| US5776430A (en) | 1994-11-01 | 1998-07-07 | Calgon Vestal, Inc. | Topical antimicrobial cleanser containing chlorhexidine gluconate and alcohol |
| CA2180745A1 (fr) * | 1994-11-25 | 1996-06-06 | Francoise Rouillard | Compositions cosmetiques ou pharmaceutiques contenant de la mangiferine ou ses derives |
| WO1996016650A1 (en) * | 1994-11-29 | 1996-06-06 | Hisamitsu Pharmaceutical Co., Inc. | Antibacterial or bactericide comprising 2-aminothiazole derivative and salts thereof |
| US5585092A (en) | 1995-04-13 | 1996-12-17 | The Procter & Gamble Company | Gel deodorant compositions |
| US6623744B2 (en) * | 1995-06-22 | 2003-09-23 | 3M Innovative Properties Company | Stable hydroalcoholic compositions |
| EP2314272A1 (en) * | 1995-06-22 | 2011-04-27 | Minnesota Mining And Manufacturing Company | Stable hydroalcoholic compositions |
| US7566460B2 (en) | 1995-06-22 | 2009-07-28 | 3M Innovative Properties Company | Stable hydroalcoholic compositions |
| CA2224798A1 (en) | 1995-06-22 | 1997-01-09 | Matthew T. Scholz | Stable hydroalcoholic compositions |
| US5733535A (en) | 1995-10-25 | 1998-03-31 | The Procter & Gamble Co. | Topical compositions containing N-acetylcysteine and odor masking materials |
| US5799841A (en) * | 1996-06-21 | 1998-09-01 | Minnesota Mining And Manufacturing Company | Drip resistant nozzle for a dispenser |
| US5897031A (en) | 1996-06-21 | 1999-04-27 | Minnesota Mining And Manufacturing Company | Dispenser for antimicrobial liquids |
| US5756077A (en) * | 1996-09-13 | 1998-05-26 | Avlon Industries, Inc. | Hair protectant composition and process for preserving chemically processed hair during subsequent chemical processing |
| US6019997A (en) | 1997-01-09 | 2000-02-01 | Minnesota Mining And Manufacturing | Hydroalcoholic compositions for transdermal penetration of pharmaceutical agents |
| US5908619A (en) | 1997-01-09 | 1999-06-01 | Minnesota Mining And Manufacturing Company | Hydroalcoholic compositions thickened using surfactant/polymer complexes |
| US6582711B1 (en) * | 1997-01-09 | 2003-06-24 | 3M Innovative Properties Company | Hydroalcoholic compositions thickened using polymers |
| US5879031A (en) * | 1997-04-23 | 1999-03-09 | Carrier Corporation | Sound baffle installation and retention device |
| GB2327881A (en) | 1997-08-06 | 1999-02-10 | Reckitt & Colman Inc | Control of dust particles |
| US5972356A (en) * | 1997-11-05 | 1999-10-26 | The Procter & Gamble Company | Personal care compositions |
| DE19842630A1 (de) * | 1998-09-17 | 2000-04-20 | Daimler Chrysler Ag | Aufsatzelement und Vorrichtung zur Positionsbestimmung oder Ausmessung eines Loches oder eines Bolzens |
| US6333039B1 (en) | 1998-09-25 | 2001-12-25 | Gojo Industries, Inc. | Opaque skin sanitizing composition |
| US6053369A (en) | 1998-09-28 | 2000-04-25 | Becton Dickinson And Company | Foam forming liquid dispensing device |
| US6183766B1 (en) * | 1999-02-12 | 2001-02-06 | The Procter & Gamble Company | Skin sanitizing compositions |
| US6423329B1 (en) | 1999-02-12 | 2002-07-23 | The Procter & Gamble Company | Skin sanitizing compositions |
| US20020040046A1 (en) * | 1999-03-31 | 2002-04-04 | Patel Jitendra P | Novel formulations comprising lipid-regulating agents |
| AU2002215331A1 (en) | 2000-10-20 | 2002-05-06 | Dipak Narula | Sanitizing hand cleanser |
| US6383997B1 (en) | 2001-07-02 | 2002-05-07 | Dragoco Gerberding & Co. Ag | High lathering antibacterial formulation |
| DE10147186A1 (de) * | 2001-09-25 | 2003-04-24 | Beiersdorf Ag | Wirkstoffkombinationen aus Polyhexamethylenbiguanid-Hydrochlorid und Distearyldimethylammoniumchlorid und Zubereitungen, solche Wirkstoffkombinationen enthaltend |
| US6846846B2 (en) | 2001-10-23 | 2005-01-25 | The Trustees Of Columbia University In The City Of New York | Gentle-acting skin disinfectants |
| US7651990B2 (en) * | 2005-06-13 | 2010-01-26 | 3M Innovative Properties Company | Foamable alcohol compositions comprising alcohol and a silicone surfactant, systems and methods of use |
| US7754770B2 (en) | 2005-06-27 | 2010-07-13 | Mason Chemical Company | Antimicrobial composition |
| US20070148101A1 (en) | 2005-12-28 | 2007-06-28 | Marcia Snyder | Foamable alcoholic composition |
-
1997
- 1997-01-09 US US08/781,095 patent/US6582711B1/en not_active Expired - Lifetime
- 1997-12-18 JP JP53091098A patent/JP4927240B2/ja not_active Expired - Fee Related
- 1997-12-18 EP EP97953377A patent/EP0963158B1/en not_active Expired - Lifetime
- 1997-12-18 CA CA002275529A patent/CA2275529A1/en not_active Abandoned
- 1997-12-18 AU AU57137/98A patent/AU735255B2/en not_active Ceased
- 1997-12-18 WO PCT/US1997/023680 patent/WO1998030095A1/en not_active Ceased
- 1997-12-18 DE DE69723583T patent/DE69723583T2/de not_active Expired - Lifetime
-
2003
- 2003-06-17 US US10/463,497 patent/US8062649B2/en not_active Expired - Fee Related
-
2007
- 2007-10-30 US US11/928,966 patent/US20080108704A1/en not_active Abandoned
-
2010
- 2010-10-28 JP JP2010242066A patent/JP2011042680A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011042680A (ja) * | 1997-01-09 | 2011-03-03 | 3M Co | ポリマーを使用して粘度付与したヒドロアルコール組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU735255B2 (en) | 2001-07-05 |
| EP0963158A1 (en) | 1999-12-15 |
| CA2275529A1 (en) | 1998-07-16 |
| US6582711B1 (en) | 2003-06-24 |
| US20080108704A1 (en) | 2008-05-08 |
| US20030215418A1 (en) | 2003-11-20 |
| JP2011042680A (ja) | 2011-03-03 |
| DE69723583T2 (de) | 2004-05-13 |
| AU5713798A (en) | 1998-08-03 |
| DE69723583D1 (de) | 2003-08-21 |
| US8062649B2 (en) | 2011-11-22 |
| JP2001508442A (ja) | 2001-06-26 |
| WO1998030095A1 (en) | 1998-07-16 |
| EP0963158B1 (en) | 2003-07-16 |
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