JP4902349B2 - 筋ジストロフィー進行抑制組成物 - Google Patents
筋ジストロフィー進行抑制組成物 Download PDFInfo
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- JP4902349B2 JP4902349B2 JP2006514588A JP2006514588A JP4902349B2 JP 4902349 B2 JP4902349 B2 JP 4902349B2 JP 2006514588 A JP2006514588 A JP 2006514588A JP 2006514588 A JP2006514588 A JP 2006514588A JP 4902349 B2 JP4902349 B2 JP 4902349B2
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- 229920002554 vinyl polymer Polymers 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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- A61K35/655—Aquatic animals other than those covered by groups A61K35/57 - A61K35/65
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Description
本発明は、筋ジストロフィー進行抑制組成物、すなわち、筋ジストロフィーの症状進行を抑制する効果を有する組成物に関する。詳しくは、本発明は、筋ジストロフィーの症状またはこれに関連する状態の進行抑制または改善に用いられる組成物に関する。
筋ジストロフィー症は、進行性筋委縮と筋力低下とを主症状とする筋疾患であり、Becker型筋ジストロフィー症(BMD)と、Duchenne型筋ジストロフィー症(DMD)とに大別される。中でも、DMDは最も重篤であり、新生児は生後20〜30日齢で心不全または呼吸困難により死亡することがある。筋ジストロフィーは、新生児3,500人に1人の割合で発症することが知られている。その中の1/3は両親に遺伝的要素のない発症例であり、およそ10,000人に1人の割合で健常人夫婦から患児が生まれる可能性がある。
本発明においては、組成物および飲食品の有効成分として、ホヤ類またはその加工品が使用される。
ここで、ホヤ類は、食用に供することのできるものであれば特に制限はなく、例えば、マボヤ科マボヤ属(Halocynthia)に属するホヤ類が挙げられる。好ましくは、ホヤ類は、マボヤ(Halocynthia roretzi)、アカボヤ(Halocynthia Aurantiura)、およびそれらの混合物からなる群より選択されるから選択される。より好ましくは、ホヤ類は、マボヤである。
本発明による有効成分は、筋ジストロフィー症の進行を抑制する効果を有する。すなわち、後述する実施例に示されるように、ホヤ類から調製された乾燥粉末は、ジストロフィン欠損マウスに対して顕著な体重増加作用を実際に示した(図1)。また、本発明による有効成分の投与群と非投与群のマウスの組織所見より、本発明による組成物によって病態の進行が軽減されたことが実際に確認された(図2および3)。このように、ホヤ類の乾燥粉末は、筋ジストロフィー症の進行を抑制する効果を実際に示した。よって、本発明における有効成分は、筋ジストロフィー疾患者に対し、体重増加、筋力増加といった症状の進行抑制、症状の緩和、改善効果をもたらすことができ、さらには治療効果も期待できる。また本発明の有効成分は、日本国等においてヒトが古くから食品として利用されてきたものであることから、毒性も低く、哺乳動物(例えば、ヒト、マウス、ラット、ウサギ、イヌ、ネコ、ウシ、ウマ、ブタ、サル等)に対し安全に用いることができる。
本発明による組成物は、前記したいように、ホヤ類またはその加工物を有効成分として含んでなるものである。
日本国東北地方の三陸海岸で収穫されたマボヤを、漁獲後速やかに外皮と軟体部に分離し、分離した軟体部を水洗いした後、−35℃の冷凍庫に入れ、凍結させた。
この凍結物を真空凍結乾燥機に入れて、真空度25Pa以下の条件で、−35℃から40℃まで上昇させて、24時間乾燥を行い、乾燥ホヤを得た。得られた乾燥ホヤを粉砕機で粉砕し、平均粒径約50μmの乾燥粉末を得た。
製造例で得られたホヤの乾燥粉末を試料として、生後14日目のジストロフィン欠損マウス(以下、mdxマウスという)(C57BL/10−mdx、日本クレア株式会社より入手可能)と、生後14日目の正常なマウスとを用いて下記試験を行った。なお、固形飼料としては、表1に示す組成のものを用いた。
正常マウスA群: 正常マウスに固形飼料Iと水を与えて自由摂取させた。
正常マウスB群: 正常マウスにホヤ乾燥粉末を1質量%添加した固形飼料IIと水を与えて自由摂取させた。
mdxマウスA群 :mdxマウスに固形飼料Iと水を与えて自由摂取させた。
mdxマウスB群 :mdxマウスにホヤ乾燥粉末を1質量%添加した固形飼料IIと水を与えて自由摂取させた。
上記飼育期間中の各群のマウス体重の経時変化を観察した。
結果は図1に示される通りであった。
図1の結果より、正常マウスにおいては、A群、B群のいずれも良好な体重増加を示した。一方、mdxマウスは、体重増加量が減少する傾向があるものの、本発明の組成物であるホヤ乾燥粉末を投与したB群のmdxマウスは、未投与であるA群のmdxマウスよりも体重の増加率が大きかった。このため、ホヤ乾燥粉末には、筋ジストロフィー症に対する抑制効果があることが認められた。
試験終了後、A群およびB群のmdxマウスの骨格筋切片を採取し、ヘマトキシリン・エオシン(HE)染色を行って、光学顕微鏡で筋繊維の観察した。
結果は図2および図3に示されるとおりであった。図2は、mdxマウスA群の骨格筋切片の180倍拡大写真を示し、図3は、mdxマウスB群の骨格筋切片の180倍拡大写真を示す。
したがって、A群のmdxマウスは筋ジストロフィー症によって筋繊維の崩壊、再生筋繊維の増加、湿潤細胞の増加が認められた。
したがって、本発明の組成物の投与により、病態の進行が軽減されることが認められた。
Claims (6)
- マボヤ科マボヤ属に属するホヤの可食部を有効成分として含んでなる、筋ジストロフィーの症状またはこれに関連する状態の進行抑制または改善に用いられる、組成物。
- ホヤが、マボヤ、アカボヤ、およびそれらの混合物からなる群より選択される、請求項1に記載の組成物。
- ホヤの可食部が、乾燥粉末、抽出物、および酵素処理物からなる群より選択されるものである、請求項1または2に記載の組成物。
- 医薬である、請求項1〜3のいずれか一項に記載の組成物。
- 筋ジストロフィーまたはこれに関連する疾患もしくは状態の進行抑制または改善に用いられる組成物を製造するための、マボヤ科マボヤ属に属するホヤの可食部の使用。
- ホヤの可食部が、乾燥粉末、抽出物、および酵素処理物からなる群より選択されるものである、請求項5に記載の使用。
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