JP4890250B2 - 火傷した皮膚を治療するための方法及び組成物 - Google Patents
火傷した皮膚を治療するための方法及び組成物 Download PDFInfo
- Publication number
- JP4890250B2 JP4890250B2 JP2006522711A JP2006522711A JP4890250B2 JP 4890250 B2 JP4890250 B2 JP 4890250B2 JP 2006522711 A JP2006522711 A JP 2006522711A JP 2006522711 A JP2006522711 A JP 2006522711A JP 4890250 B2 JP4890250 B2 JP 4890250B2
- Authority
- JP
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- Prior art keywords
- skin
- indomethacin
- pharmaceutical composition
- lotion
- humidified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Description
本発明は、火傷した皮膚を治療するための方法及び組成物に関し、特に、軽度から中度の皮膚火傷の治療のためのインドメタシン及び保湿ローション製剤の局所的適用のための方法及び組成物に関する。
いくらかの従来の製剤が、日焼けした皮膚の治療のために開発されている。しかし、そのような治療はいくつかの不利益を有する。例えば、日焼けした部位に噴霧ミスト又は石油系組成物を提供する日焼けの治療は、十分に大きな熱移動効果を生じず、日焼けした部位から熱を除去しない。さらに、石油系組成物は、日焼けした皮膚の敏感及び鋭敏な部位から実質的に洗浄される必要のある残渣を生じやすい。そのような洗浄は、患部の皮膚にさらなる不快感及び刺激を引き起こしやすい。
本発明の組成物は、インドメタシン及び加湿ローションの混合物を提供する。当該混合物は、実質的に30ccの加湿ローション当たり実質的に100mgのインドメタシンを提供する。加湿ローションは、皮膚軟化剤及び湿潤剤を含んでいてもよい。加湿ローションはさらに、精製水、グリセリン、水素化ポリイソブテン、セテアリルアルコール(及び)セテアレス-20、マカダミアナッツ油、ジメチコーン、酢酸トコフェロール、ステアロキシトリメチルシラン(及び)ステアリルアルコール、パンテノール、ファルネソール、ベンジルアルコール、フェノキシエタノール、アクリレート/C10-30アルキルアクリレートクロスポリマー、水酸化ナトリウム、及びクエン酸を含んでいてもよい。加湿ローションは商品名Cetaphil(登録商標)で販売され得る。
本発明は、人間の日焼けした皮膚を治療するための方法及び組成物を提供する。当該組成物は、インドメタシン及び加湿ローションの混合物を含む。当該組成物は、日焼けした皮膚に局所的に適用され、日焼けによって引き起こされる局所的な炎症を含む日焼けした皮膚に伴う症状の非常に効果的な軽減を提供する。皮膚は、局所的製剤の存在下で、大量のインドメタシンを吸収し、且つ皮膚内及び他の組織にインドメタシンをゆっくりと放出する貯蔵器として作用すると考えられている。皮膚は、実際にインドメタシンのための補給器又は貯蔵器として作用し得る。インドメタシンは加湿ローションによって安定化及び可溶化され、当該加湿ローションが皮膚を通ってインドメタシンの吸収を高め、従って日焼けした皮膚の炎症のために薬剤を局所的に用いるのを可能にすると考えられている。インドメタシンの実験結果は、非常に優れた結果が、日焼けした皮膚を軽減することにおいて、他の抗炎症剤、例えばMotrin(登録商標)及びTolectin(登録商標)よりも達成されることを示した。
Claims (4)
- インドメタシン及び加湿ローションの混合物を含有する、放射線治療、放射線、又は紫外線のうちの一つによって生じる火傷した皮膚を治療するための局所投与用医薬組成物であって、前記加湿ローションが、精製水、グリセリン、水素化ポリイソブテン、セテアリルアルコール、セテアレス-20、マカダミアナッツ油、ジメチコーン、酢酸トコフェロール、ステアロキシトリメチルシラン、ステアリルアルコール、パンテノール、ファルネソール、ベンジルアルコール、フェノキシエタノール、アクリレート/C10-30アルキルアクリレートクロスポリマー、水酸化ナトリウム、及びクエン酸を含有する、前記医薬組成物。
- 30ccの加湿ローション当たり100mgのインドメタシンを含有する、請求項1記載の医薬組成物。
- 1日当たり1〜2度、火傷した皮膚に投与される、請求項1記載の医薬組成物。
- 前記火傷した皮膚が、第一度の火傷であり、かつ、過度の熱によって火傷した皮膚である、請求項1記載の医薬組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/636,404 US7714015B2 (en) | 2003-08-07 | 2003-08-07 | Method and composition for treating sunburned skin |
US10/636,404 | 2003-08-07 | ||
PCT/US2004/025260 WO2005016336A1 (en) | 2003-08-07 | 2004-08-05 | Method and composition for treating burned skin |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2007501792A JP2007501792A (ja) | 2007-02-01 |
JP2007501792A5 JP2007501792A5 (ja) | 2007-09-27 |
JP4890250B2 true JP4890250B2 (ja) | 2012-03-07 |
Family
ID=34116419
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006522711A Expired - Fee Related JP4890250B2 (ja) | 2003-08-07 | 2004-08-05 | 火傷した皮膚を治療するための方法及び組成物 |
Country Status (8)
Country | Link |
---|---|
US (2) | US7714015B2 (ja) |
EP (1) | EP1656135A1 (ja) |
JP (1) | JP4890250B2 (ja) |
KR (1) | KR20060037428A (ja) |
AU (1) | AU2004264332B2 (ja) |
CA (1) | CA2524921A1 (ja) |
WO (1) | WO2005016336A1 (ja) |
ZA (1) | ZA200601054B (ja) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005063173A2 (de) * | 2005-03-24 | 2005-07-14 | Beiersdorf Ag | Verwendung von zubereitungen zum schutz hauteigener enzyme |
EP2134337A4 (en) * | 2007-02-22 | 2011-11-09 | Healing Skin Llc | NOVEL COMPOSITION FOR TREATING BURNS |
US8349764B2 (en) | 2007-10-31 | 2013-01-08 | Molycorp Minerals, Llc | Composition for treating a fluid |
US20090107925A1 (en) * | 2007-10-31 | 2009-04-30 | Chevron U.S.A. Inc. | Apparatus and process for treating an aqueous solution containing biological contaminants |
KR101985886B1 (ko) * | 2013-06-24 | 2019-06-04 | 주식회사 엘지생활건강 | 인돌 화합물 및 판테놀을 포함하는 자외선에 의한 피부손상 예방 및 개선용 조성물 |
Family Cites Families (28)
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US493362A (en) * | 1893-03-14 | Check-row corn-planter | ||
US3629412A (en) * | 1969-09-19 | 1971-12-21 | Merck & Co Inc | Topical anti-inflammatory agent |
US4088754A (en) * | 1976-03-02 | 1978-05-09 | Research Corporation | Water-soluble cerium (cerous) salts in burn therapy |
GB2023000B (en) * | 1978-06-17 | 1982-10-13 | Kowa Co | Antinflammatory analgesic gelled ointments |
US4954487A (en) * | 1979-01-08 | 1990-09-04 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions |
HU185926B (en) * | 1979-09-27 | 1985-04-28 | Agostne Kahan | Process for preparing water soluble derivatives of non-steroid antiinflammatory compositions and pharmaceutical compositins containing such derivatives |
US4384000A (en) * | 1980-08-07 | 1983-05-17 | Lanier Earl W | Method for treatment of various dermatological conditions |
JPS57165313A (en) * | 1981-04-07 | 1982-10-12 | Nichibei Zoki Kk | Indomethacin for external use |
US4847283A (en) * | 1983-01-10 | 1989-07-11 | Harendza Harinxma Alfred J | Ointment and method for treating skin lesions due to herpes virus |
US4732755A (en) * | 1983-01-17 | 1988-03-22 | University Of Health Sciences/The Chicago Medical School | Skin burn treatment |
CH643138A5 (de) * | 1983-08-29 | 1984-05-30 | Mepha Ag | Indomethacin enthaltende, gelartige salbe. |
JPS60105613A (ja) * | 1983-11-15 | 1985-06-11 | Mitsubishi Chem Ind Ltd | インドメタシン外用剤 |
DE3808039A1 (de) * | 1988-03-10 | 1989-09-21 | Bauer Johann | Kombinationspraeparat, insbesondere zur behandlung von entzuendlichen prozessen |
US4933362A (en) * | 1989-06-06 | 1990-06-12 | Jack Loomstein | Sunburn treatment composition |
US5674912A (en) * | 1991-03-01 | 1997-10-07 | Warner-Lambert Company | Sunscreen-wound healing compositions and methods for preparing and using same |
ES2034891B1 (es) * | 1991-08-08 | 1993-12-16 | Cusi Lab | Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas. |
DE69430917T2 (de) * | 1993-05-19 | 2003-03-20 | Hisamitsu Pharmaceutical Co | 3-l-MENTHOXY-PROPANE-1, 2-DIOL ALS LÖSUNGSVERMITTLER UND EXTERNE ZUBEREITUNG, DIE DIESEN ENTHÄLT |
US5807569A (en) * | 1993-05-27 | 1998-09-15 | Smithkline Beecham P.L.C. | Topical composition |
US5558914A (en) * | 1994-04-11 | 1996-09-24 | Water-Jel Technologies, Inc. | Water-based formulation for the treatment of sunburn |
JP2723473B2 (ja) * | 1994-09-22 | 1998-03-09 | ブーク メデイテツク エイ/エス | 硫酸化糖類の用途 |
JP2000500449A (ja) * | 1995-11-13 | 2000-01-18 | ピットミー・インターナショナル・ナムローゼ・フェンノートシャップ | 一酸化二窒素を含む鎮痛剤、抗炎症剤、および抗発熱剤のための投与媒体とそれらの医薬組成物 |
US6337320B1 (en) * | 1996-10-11 | 2002-01-08 | Thione International, Inc. | Reparatives for ultraviolet radiation skin damage |
US20010055599A1 (en) * | 1997-05-23 | 2001-12-27 | Paul Joseph Drzewiecki | Compositions containing select liquid polyol fatty acid polyesters |
AUPP229598A0 (en) * | 1998-03-11 | 1998-04-09 | Oldfield Family Holdings Pty Limited | Treatment of sunburn |
US6274627B1 (en) * | 1999-10-12 | 2001-08-14 | Medinox, Inc. | Conjugates of dithiocarbamate disulfides with pharmacologically active agents and uses therefor |
US6399651B1 (en) * | 2000-06-29 | 2002-06-04 | L. Dean Parks | Method of treating dermatoses using avermectin compound |
IL154044A0 (en) * | 2000-07-21 | 2003-07-31 | Essentia Biosystems Inc | Multi-component pharmaceutical compositions containing a complex of a positively charged backbone and a negatively charged backbone and methods for the preparation thereof |
US20020143047A1 (en) * | 2001-01-05 | 2002-10-03 | Galer Bradley S. | Methods for treating indomethacin responsive headaches |
-
2003
- 2003-08-07 US US10/636,404 patent/US7714015B2/en not_active Expired - Fee Related
-
2004
- 2004-08-04 US US10/911,003 patent/US7705032B2/en not_active Expired - Fee Related
- 2004-08-05 CA CA002524921A patent/CA2524921A1/en not_active Abandoned
- 2004-08-05 KR KR1020067002636A patent/KR20060037428A/ko active IP Right Grant
- 2004-08-05 WO PCT/US2004/025260 patent/WO2005016336A1/en active Search and Examination
- 2004-08-05 JP JP2006522711A patent/JP4890250B2/ja not_active Expired - Fee Related
- 2004-08-05 AU AU2004264332A patent/AU2004264332B2/en not_active Ceased
- 2004-08-05 EP EP04780150A patent/EP1656135A1/en not_active Withdrawn
-
2006
- 2006-02-06 ZA ZA200601054A patent/ZA200601054B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2004264332B2 (en) | 2010-09-30 |
US7705032B2 (en) | 2010-04-27 |
WO2005016336A1 (en) | 2005-02-24 |
ZA200601054B (en) | 2007-05-30 |
JP2007501792A (ja) | 2007-02-01 |
KR20060037428A (ko) | 2006-05-03 |
CA2524921A1 (en) | 2005-02-24 |
US20050031555A1 (en) | 2005-02-10 |
US20050032877A1 (en) | 2005-02-10 |
EP1656135A1 (en) | 2006-05-17 |
US7714015B2 (en) | 2010-05-11 |
AU2004264332A1 (en) | 2005-02-24 |
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