JP4886700B2 - ５ｈｔ２ｃレセプターモジュレーターの組成物およびその使用方法 - Google Patents
５ｈｔ２ｃレセプターモジュレーターの組成物およびその使用方法 Download PDFInfo
- Publication number
- JP4886700B2 JP4886700B2 JP2007548479A JP2007548479A JP4886700B2 JP 4886700 B2 JP4886700 B2 JP 4886700B2 JP 2007548479 A JP2007548479 A JP 2007548479A JP 2007548479 A JP2007548479 A JP 2007548479A JP 4886700 B2 JP4886700 B2 JP 4886700B2
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- JP
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- Prior art keywords
- benzazepine
- tetrahydro
- methyl
- alkyl
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 239000000203 mixture Substances 0.000 title claims abstract description 226
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- 108010072553 5-HT2C Serotonin Receptor Proteins 0.000 title claims abstract description 147
- 238000000034 method Methods 0.000 title claims description 71
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- 229940044601 receptor agonist Drugs 0.000 claims abstract description 147
- 239000000018 receptor agonist Substances 0.000 claims abstract description 147
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- 125000003118 aryl group Chemical group 0.000 claims description 44
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 14
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 13
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- KTCVEIAEKPSBCJ-UHFFFAOYSA-N 7,8-dichloro-5-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine Chemical compound CC1CNCCC2=CC(Cl)=C(Cl)C=C12 KTCVEIAEKPSBCJ-UHFFFAOYSA-N 0.000 claims description 5
- KRBZRTWDEJCQIL-UHFFFAOYSA-N 7-bromo-5-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine Chemical compound CC1CNCCC2=CC=C(Br)C=C12 KRBZRTWDEJCQIL-UHFFFAOYSA-N 0.000 claims description 5
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- XTTZERNUQAFMOF-UHFFFAOYSA-N 7-chloro-5-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine Chemical compound CC1CNCCC2=CC=C(Cl)C=C12 XTTZERNUQAFMOF-UHFFFAOYSA-N 0.000 claims description 5
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- 239000002552 dosage form Substances 0.000 claims description 4
- 229910052731 fluorine Inorganic materials 0.000 claims description 4
- 125000001188 haloalkyl group Chemical group 0.000 claims description 4
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 4
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- LGUJJJJNBBUBHT-UHFFFAOYSA-N 5-ethyl-7-iodo-2,3,4,5-tetrahydro-1h-3-benzazepine Chemical compound CCC1CNCCC2=CC=C(I)C=C12 LGUJJJJNBBUBHT-UHFFFAOYSA-N 0.000 claims description 3
- TTXLZSFANXGSGY-UHFFFAOYSA-N 7,8-dichloro-5-ethyl-2,3,4,5-tetrahydro-1h-3-benzazepine Chemical compound CCC1CNCCC2=CC(Cl)=C(Cl)C=C12 TTXLZSFANXGSGY-UHFFFAOYSA-N 0.000 claims description 3
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- 150000004677 hydrates Chemical class 0.000 claims description 3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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| US63866704P | 2004-12-23 | 2004-12-23 | |
| US60/638,667 | 2004-12-23 | ||
| US68890105P | 2005-06-08 | 2005-06-08 | |
| US60/688,901 | 2005-06-08 | ||
| PCT/US2005/046654 WO2006071740A2 (en) | 2004-12-23 | 2005-12-21 | 5ht2c receptor modulator compositions and methods of use |
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| JP2008525480A JP2008525480A (ja) | 2008-07-17 |
| JP2008525480A5 JP2008525480A5 (https=) | 2009-02-05 |
| JP4886700B2 true JP4886700B2 (ja) | 2012-02-29 |
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