CN101123955B - 5HT2c受体调节剂组合物及其制药用途 - Google Patents

5HT2c受体调节剂组合物及其制药用途 Download PDF

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Publication number
CN101123955B
CN101123955B CN2005800437436A CN200580043743A CN101123955B CN 101123955 B CN101123955 B CN 101123955B CN 2005800437436 A CN2005800437436 A CN 2005800437436A CN 200580043743 A CN200580043743 A CN 200580043743A CN 101123955 B CN101123955 B CN 101123955B
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benzazepine
methyl
tetrahydro
mammal
chloro
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Expired - Fee Related
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Chinese (zh)
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CN101123955A (zh
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多米尼克·P·贝汉
布赖恩·M·史密斯
克里斯蒂娜·比耶宁
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Arena Pharmaceuticals Inc
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Arena Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Liquid Crystal Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
CN2005800437436A 2004-12-23 2005-12-21 5HT2c受体调节剂组合物及其制药用途 Expired - Fee Related CN101123955B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US63866704P 2004-12-23 2004-12-23
US60/638,667 2004-12-23
US68890105P 2005-06-08 2005-06-08
US60/688,901 2005-06-08
PCT/US2005/046654 WO2006071740A2 (en) 2004-12-23 2005-12-21 5ht2c receptor modulator compositions and methods of use

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN201210077623XA Division CN102631349A (zh) 2004-12-23 2005-12-21 5HT2c受体调节剂组合物和使用方法
CN2012100775843A Division CN102627607A (zh) 2004-12-23 2005-12-21 5HT2c受体调节剂组合物和使用方法

Publications (2)

Publication Number Publication Date
CN101123955A CN101123955A (zh) 2008-02-13
CN101123955B true CN101123955B (zh) 2012-05-30

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CN2005800437436A Expired - Fee Related CN101123955B (zh) 2004-12-23 2005-12-21 5HT2c受体调节剂组合物及其制药用途
CN2012100775843A Pending CN102627607A (zh) 2004-12-23 2005-12-21 5HT2c受体调节剂组合物和使用方法
CN201210077623XA Pending CN102631349A (zh) 2004-12-23 2005-12-21 5HT2c受体调节剂组合物和使用方法

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CN2012100775843A Pending CN102627607A (zh) 2004-12-23 2005-12-21 5HT2c受体调节剂组合物和使用方法
CN201210077623XA Pending CN102631349A (zh) 2004-12-23 2005-12-21 5HT2c受体调节剂组合物和使用方法

Country Status (24)

Country Link
US (4) US8153621B2 (https=)
EP (3) EP2111859A1 (https=)
JP (1) JP4886700B2 (https=)
KR (3) KR101519441B1 (https=)
CN (3) CN101123955B (https=)
AT (1) ATE442135T1 (https=)
AU (1) AU2005322183B2 (https=)
BR (1) BRPI0515862A2 (https=)
CA (1) CA2588941A1 (https=)
CY (1) CY1109629T1 (https=)
DE (1) DE602005016601D1 (https=)
DK (1) DK1833473T3 (https=)
EA (2) EA201100129A1 (https=)
ES (1) ES2331656T3 (https=)
HR (1) HRP20090641T1 (https=)
IL (2) IL183565A0 (https=)
NZ (2) NZ589951A (https=)
PL (1) PL1833473T3 (https=)
PT (1) PT1833473E (https=)
RS (1) RS50997B (https=)
SG (1) SG158168A1 (https=)
SI (1) SI1833473T1 (https=)
WO (1) WO2006071740A2 (https=)
ZA (1) ZA200705165B (https=)

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US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
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JP5249031B2 (ja) 2005-09-01 2013-07-31 イーライ リリー アンド カンパニー ５−ＨＴ２Ｃ受容体アゴニストとしての６−Ｎ結合型へテロ環置換された２，３，４，５−テトラヒドロ−１Ｈ−ベンゾ［ｄ］アゼピン
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KR101770979B1 (ko) * 2010-05-21 2017-08-24 애브비 인코포레이티드 5­ｈｔ 수용체의 조절제 및 이의 사용방법
KR20130112848A (ko) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. 5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법
KR20130138770A (ko) 2010-09-01 2013-12-19 아레나 파마슈티칼스, 인크. 광학적으로 활성 산을 갖는 로르카세린의 염
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