JP4848101B2 - 徐放性マイクロペレット - Google Patents

徐放性マイクロペレット Download PDF

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Publication number
JP4848101B2
JP4848101B2 JP2001248426A JP2001248426A JP4848101B2 JP 4848101 B2 JP4848101 B2 JP 4848101B2 JP 2001248426 A JP2001248426 A JP 2001248426A JP 2001248426 A JP2001248426 A JP 2001248426A JP 4848101 B2 JP4848101 B2 JP 4848101B2
Authority
JP
Japan
Prior art keywords
water
sustained
layer
release
soluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2001248426A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003055199A5 (enExample
JP2003055199A (ja
Inventor
文郎 米田
文也 浜野
栄作 北野
哲矢 細野
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujimoto Brothers Co Ltd
Original Assignee
Fujimoto Brothers Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2001248426A priority Critical patent/JP4848101B2/ja
Application filed by Fujimoto Brothers Co Ltd filed Critical Fujimoto Brothers Co Ltd
Priority to US10/486,898 priority patent/US20040208930A1/en
Priority to DK02760617.7T priority patent/DK1417960T3/da
Priority to EP02760617A priority patent/EP1417960B1/en
Priority to CA2459472A priority patent/CA2459472C/en
Priority to PCT/JP2002/008245 priority patent/WO2003015758A1/ja
Priority to AT02760617T priority patent/ATE531360T1/de
Priority to AU2002327085A priority patent/AU2002327085B9/en
Priority to ES02760617T priority patent/ES2375624T3/es
Publication of JP2003055199A publication Critical patent/JP2003055199A/ja
Priority to US11/889,744 priority patent/US8512744B2/en
Publication of JP2003055199A5 publication Critical patent/JP2003055199A5/ja
Application granted granted Critical
Publication of JP4848101B2 publication Critical patent/JP4848101B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2001248426A 2001-08-17 2001-08-17 徐放性マイクロペレット Expired - Lifetime JP4848101B2 (ja)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP2001248426A JP4848101B2 (ja) 2001-08-17 2001-08-17 徐放性マイクロペレット
ES02760617T ES2375624T3 (es) 2001-08-17 2002-08-12 Microgranulados de liberación controlada y procedimiento para su producción.
EP02760617A EP1417960B1 (en) 2001-08-17 2002-08-12 Sustained release micropellets and process for producing the same
CA2459472A CA2459472C (en) 2001-08-17 2002-08-12 Sustained release micropellets and process for producing the same
PCT/JP2002/008245 WO2003015758A1 (en) 2001-08-17 2002-08-12 Sustained release micropellets and process for producing the same
AT02760617T ATE531360T1 (de) 2001-08-17 2002-08-12 Mikrokügelchen mit verzögerter freisetzung und verfahren zu ihrer herstellung
US10/486,898 US20040208930A1 (en) 2001-08-17 2002-08-12 Sustained release micropellets and process for producing the same
DK02760617.7T DK1417960T3 (da) 2001-08-17 2002-08-12 Mikropellets med vedvarende frisætning og fremgangsmåde til fremstilling heraf
AU2002327085A AU2002327085B9 (en) 2001-08-17 2002-08-12 Sustained release micropellets and process for producing the same
US11/889,744 US8512744B2 (en) 2001-08-17 2007-08-16 Sustained release micropellets and process for producing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2001248426A JP4848101B2 (ja) 2001-08-17 2001-08-17 徐放性マイクロペレット

Publications (3)

Publication Number Publication Date
JP2003055199A JP2003055199A (ja) 2003-02-26
JP2003055199A5 JP2003055199A5 (enExample) 2008-10-16
JP4848101B2 true JP4848101B2 (ja) 2011-12-28

Family

ID=19077585

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001248426A Expired - Lifetime JP4848101B2 (ja) 2001-08-17 2001-08-17 徐放性マイクロペレット

Country Status (9)

Country Link
US (2) US20040208930A1 (enExample)
EP (1) EP1417960B1 (enExample)
JP (1) JP4848101B2 (enExample)
AT (1) ATE531360T1 (enExample)
AU (1) AU2002327085B9 (enExample)
CA (1) CA2459472C (enExample)
DK (1) DK1417960T3 (enExample)
ES (1) ES2375624T3 (enExample)
WO (1) WO2003015758A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
KR20020059653A (ko) 1999-10-29 2002-07-13 그린 마틴, 브라이언 쥐 테슬리 서방성 하이드로코돈 제형
US6733783B2 (en) 2000-10-30 2004-05-11 Euro-Celtique S.A. Controlled release hydrocodone formulations
WO2005025736A1 (en) * 2003-09-05 2005-03-24 University Of Massachusetts Amphiphilic polymer capsules and related methods of interfacial assembly
CA2552064A1 (en) * 2003-12-31 2005-07-21 Actavis Group Hf Atomoxetine formulations
WO2006038134A1 (en) * 2004-10-01 2006-04-13 Firmenich Sa Perfuming or flavouring microcapsules comprising an explosion suppressant
WO2006070930A1 (en) 2004-12-27 2006-07-06 Eisai R & D Management Co., Ltd. Method for stabilizing anti-dementia drug
US20070129402A1 (en) * 2004-12-27 2007-06-07 Eisai Research Institute Sustained release formulations
EP1878444B1 (en) * 2005-04-28 2015-09-09 Eisai R&D Management Co., Ltd. Composition containing anti-dementia drug
US20080069891A1 (en) 2006-09-15 2008-03-20 Cima Labs, Inc. Abuse resistant drug formulation
US8445018B2 (en) 2006-09-15 2013-05-21 Cima Labs Inc. Abuse resistant drug formulation
EP2568977A1 (en) 2010-05-11 2013-03-20 Cima Labs Inc. Alcohol-resistant metoprolol-containing extended- release oral dosage forms
US20250228771A1 (en) * 2022-04-01 2025-07-17 EMPLICURE AB (publ) Alkaline intraoral products

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6058890B2 (ja) * 1978-10-20 1985-12-23 東洋醸造株式会社 抗生物質細粒剤の製造法およびそれを用いる複粒剤
JPS583510A (ja) * 1981-06-29 1983-01-10 住友電気工業株式会社 海底ケ−ブル等の埋設機の積卸方法
JPS5835110A (ja) * 1981-08-28 1983-03-01 Tetsuo Kato 徐放性マイクロカプセル
JPS5944311A (ja) * 1982-09-07 1984-03-12 Santen Pharmaceut Co Ltd 徐放性顆粒およびその製造法
US4777049A (en) * 1983-12-01 1988-10-11 Alza Corporation Constant release system with pulsed release
GB2150434B (en) * 1983-12-01 1987-11-04 Alza Corp Constant rate release systems
DK62184D0 (da) * 1984-02-10 1984-02-10 Benzon As Alfred Diffusionsovertrukket polydepotpraeparat
US4753802A (en) * 1986-03-19 1988-06-28 Alza Corporation Verapamil dosage form
JPH0832625B2 (ja) * 1987-01-29 1996-03-29 武田薬品工業株式会社 有核顆粒およびその製造法
US5026560A (en) * 1987-01-29 1991-06-25 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
US4931285A (en) * 1988-04-28 1990-06-05 Alza Corporation Aqueous based pharmaceutical coating composition for dosage forms
US5202128A (en) * 1989-01-06 1993-04-13 F. H. Faulding & Co. Limited Sustained release pharmaceutical composition
HU205851B (en) * 1989-01-31 1992-07-28 Int Pharma Agentur Systhem of regulated release of the active components and process for producing it
JP2820829B2 (ja) * 1991-03-07 1998-11-05 武田薬品工業株式会社 有核散剤およびその製造方法
US5229135A (en) * 1991-11-22 1993-07-20 Prographarm Laboratories Sustained release diltiazem formulation
IT1264020B (it) * 1993-01-28 1996-09-09 Recordati Chem Pharm Procedimento per la preparazione di microgranuli idonei alla sospensione in liquidi
WO1995003052A1 (en) * 1993-07-22 1995-02-02 Warner-Lambert Company Controlled release tacrine drug delivery systems and methods for preparing same
JPH0789849A (ja) * 1993-09-20 1995-04-04 Fujisawa Pharmaceut Co Ltd 徐放性製剤
US6077533A (en) * 1994-05-25 2000-06-20 Purdue Pharma L.P. Powder-layered oral dosage forms
US5411745A (en) * 1994-05-25 1995-05-02 Euro-Celtique, S.A. Powder-layered morphine sulfate formulations
JPH10139659A (ja) * 1996-09-10 1998-05-26 Freunt Ind Co Ltd 球形粒子群、その製造方法及びそれを用いた球形粒子製剤
TW477702B (en) * 1997-10-23 2002-03-01 Dev Center Biotechnology Controlled release tacrine dosage form
SE9704869D0 (sv) * 1997-12-22 1997-12-22 Astra Ab New pharmaceutical formulaton II
FR2794646B1 (fr) * 1999-06-09 2001-09-21 Ethypharm Lab Prod Ethiques Microgranules de sulfate de morphine, procede de preparation et composition les contenant

Also Published As

Publication number Publication date
AU2002327085B9 (en) 2008-08-14
US20090011034A1 (en) 2009-01-08
EP1417960B1 (en) 2011-11-02
AU2002327085B8 (en) 2008-02-28
CA2459472C (en) 2010-12-14
US8512744B2 (en) 2013-08-20
AU2002327085B2 (en) 2008-02-14
JP2003055199A (ja) 2003-02-26
WO2003015758A1 (en) 2003-02-27
ATE531360T1 (de) 2011-11-15
DK1417960T3 (da) 2012-02-20
EP1417960A1 (en) 2004-05-12
CA2459472A1 (en) 2003-02-27
US20040208930A1 (en) 2004-10-21
EP1417960A4 (en) 2008-08-13
ES2375624T3 (es) 2012-03-02

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