JP4812874B2 - Ｊｃウイルス遺伝子の発現を抑制するための組成物および方法 - Google Patents

Ｊｃウイルス遺伝子の発現を抑制するための組成物および方法 Download PDF

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Publication number
JP4812874B2
JP4812874B2 JP2009507985A JP2009507985A JP4812874B2 JP 4812874 B2 JP4812874 B2 JP 4812874B2 JP 2009507985 A JP2009507985 A JP 2009507985A JP 2009507985 A JP2009507985 A JP 2009507985A JP 4812874 B2 JP4812874 B2 JP 4812874B2
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dsrna
virus
nucleotides
expression
cell
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Expired - Fee Related
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JP2009507985A
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Japanese (ja)
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JP2009535039A5 (enExample
JP2009535039A (ja
Inventor
タン、パメラ
サー、ディナ
ブラムレイジ、ビルギット
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Alnylam Pharmaceuticals Inc
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Alnylam Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
JP2009507985A 2006-04-28 2007-04-27 Ｊｃウイルス遺伝子の発現を抑制するための組成物および方法 Expired - Fee Related JP4812874B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79576506P 2006-04-28 2006-04-28
US60/795,765 2006-04-28
PCT/US2007/067628 WO2007127919A2 (en) 2006-04-28 2007-04-27 Compositions and methods for inhibiting expression of a gene from the jc virus

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011066818A Division JP5398769B2 (ja) 2006-04-28 2011-03-24 Ｊｃウイルス遺伝子の発現を抑制するための組成物および方法

Publications (3)

Publication Number Publication Date
JP2009535039A JP2009535039A (ja) 2009-10-01
JP2009535039A5 JP2009535039A5 (enExample) 2011-05-12
JP4812874B2 true JP4812874B2 (ja) 2011-11-09

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Family Applications (3)

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JP2009507985A Expired - Fee Related JP4812874B2 (ja) 2006-04-28 2007-04-27 Ｊｃウイルス遺伝子の発現を抑制するための組成物および方法
JP2011066818A Expired - Fee Related JP5398769B2 (ja) 2006-04-28 2011-03-24 Ｊｃウイルス遺伝子の発現を抑制するための組成物および方法
JP2013218877A Withdrawn JP2014036665A (ja) 2006-04-28 2013-10-22 Ｊｃウイルス遺伝子の発現を抑制するための組成物および方法

Family Applications After (2)

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JP2011066818A Expired - Fee Related JP5398769B2 (ja) 2006-04-28 2011-03-24 Ｊｃウイルス遺伝子の発現を抑制するための組成物および方法
JP2013218877A Withdrawn JP2014036665A (ja) 2006-04-28 2013-10-22 Ｊｃウイルス遺伝子の発現を抑制するための組成物および方法

Country Status (4)

Country Link
US (5) US7691824B2 (enExample)
EP (1) EP2013222B1 (enExample)
JP (3) JP4812874B2 (enExample)
WO (1) WO2007127919A2 (enExample)

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US20110118340A1 (en) * 2008-02-08 2011-05-19 Muthiah Manoharan Delivery of rnai constructs to oligodendrocytes
ES2804764T3 (es) 2009-06-01 2021-02-09 Halo Bio Rnai Therapeutics Inc Polinucleótidos para la interferencia de ARN multivalente, composiciones y métodos de uso de los mismos
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EP3047023B1 (en) 2013-09-19 2019-09-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compositions and methods for inhibiting jc virus (jcv)
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Also Published As

Publication number Publication date
WO2007127919A3 (en) 2008-10-30
US7691824B2 (en) 2010-04-06
US20150240237A1 (en) 2015-08-27
JP2014036665A (ja) 2014-02-27
HK1127065A1 (en) 2009-09-18
US20130158102A1 (en) 2013-06-20
JP2009535039A (ja) 2009-10-01
US20090062225A1 (en) 2009-03-05
EP2013222A4 (en) 2009-10-21
WO2007127919A2 (en) 2007-11-08
US20100227915A1 (en) 2010-09-09
US8410261B2 (en) 2013-04-02
US20120022141A1 (en) 2012-01-26
JP2011130772A (ja) 2011-07-07
EP2013222A2 (en) 2009-01-14
US9012624B2 (en) 2015-04-21
US8058257B2 (en) 2011-11-15
EP2013222B1 (en) 2013-02-13
JP5398769B2 (ja) 2014-01-29

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