JP4776774B2 - 心血管疾患の予防及び治療用オステオプロテゲリン含有組成物 - Google Patents
心血管疾患の予防及び治療用オステオプロテゲリン含有組成物 Download PDFInfo
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- JP4776774B2 JP4776774B2 JP2000544345A JP2000544345A JP4776774B2 JP 4776774 B2 JP4776774 B2 JP 4776774B2 JP 2000544345 A JP2000544345 A JP 2000544345A JP 2000544345 A JP2000544345 A JP 2000544345A JP 4776774 B2 JP4776774 B2 JP 4776774B2
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
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- Cell Biology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/064,832 US6790823B1 (en) | 1998-04-23 | 1998-04-23 | Compositions and methods for the prevention and treatment of cardiovascular diseases |
| US09/064,832 | 1998-04-23 | ||
| PCT/US1999/008793 WO1999053942A1 (en) | 1998-04-23 | 1999-04-21 | Compositions comprising osteoprotegerin for the prevention and treatment of cardiovascular diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002512199A JP2002512199A (ja) | 2002-04-23 |
| JP2002512199A5 JP2002512199A5 (OSRAM) | 2009-12-17 |
| JP4776774B2 true JP4776774B2 (ja) | 2011-09-21 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2000544345A Expired - Fee Related JP4776774B2 (ja) | 1998-04-23 | 1999-04-21 | 心血管疾患の予防及び治療用オステオプロテゲリン含有組成物 |
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| Country | Link |
|---|---|
| US (1) | US6790823B1 (OSRAM) |
| EP (1) | EP1073456B1 (OSRAM) |
| JP (1) | JP4776774B2 (OSRAM) |
| AT (1) | ATE303817T1 (OSRAM) |
| AU (1) | AU757806B2 (OSRAM) |
| CA (1) | CA2325360C (OSRAM) |
| DE (1) | DE69927147T2 (OSRAM) |
| DK (1) | DK1073456T3 (OSRAM) |
| ES (1) | ES2248998T3 (OSRAM) |
| SI (1) | SI1073456T1 (OSRAM) |
| WO (1) | WO1999053942A1 (OSRAM) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL117175A (en) | 1995-02-20 | 2005-11-20 | Sankyo Co | Osteoclastogenesis inhibitory factor protein |
| DE951551T1 (de) | 1996-12-23 | 2000-09-14 | Immunex Corp., Seattle | Ligand für rezeptor aktivator of nf-kappa b, ligand ist mitglied der tnf superfamilie |
| ES2263204T5 (es) | 1997-04-15 | 2013-10-14 | Daiichi Sankyo Company, Limited | Nueva proteína y proceso para producir la misma |
| US6316408B1 (en) | 1997-04-16 | 2001-11-13 | Amgen Inc. | Methods of use for osetoprotegerin binding protein receptors |
| RO128635A2 (ro) | 1997-04-16 | 2013-07-30 | Amgen Inc. | Anticorp sau fragment al acestuia care se leagă la opgbp şi utilizarea acestuia, utilizarea unei forme solubile de odar, şi metodă de identificare a unui compus care descreşte activitatea opgbp |
| JP4380067B2 (ja) * | 1998-04-23 | 2009-12-09 | 味の素株式会社 | 抗血栓活性物質及びグリコカリシンの検出法 |
| EP2009025B1 (en) | 1998-05-14 | 2011-07-27 | Immunex Corporation | Method of inhibiting osteoclast activity |
| AU2002253133B2 (en) * | 2001-04-03 | 2008-02-28 | Societe Des Produits Nestle S.A. | Osteoprotegerin in milk |
| US7198798B2 (en) * | 2001-05-10 | 2007-04-03 | University Of Washington | Methods and devices for promoting endothelial morphogenesis |
| ES2437992T3 (es) | 2001-05-25 | 2014-01-15 | Human Genome Sciences, Inc. | Anticuerpos que se unen inmunoespecíficamente a los receptores de TRAIL |
| US8649843B2 (en) * | 2001-11-24 | 2014-02-11 | Ben A. Arnold | Automated calcium scoring of the aorta |
| JP4761710B2 (ja) | 2002-04-05 | 2011-08-31 | アムジェン インコーポレイテッド | 選択的ｏｐｇｌ経路インヒビターとしてのヒト抗ｏｐｇｌ中和抗体 |
| US7585840B2 (en) | 2002-04-10 | 2009-09-08 | Merck Serono S.A. | Use of osteoprotegerin for the treatment and/or prevention of fibrotic disease |
| BR0309095A (pt) * | 2002-04-10 | 2005-02-09 | Applied Research Systems | Uso de osteoprotegerina para o tratamento e/ou prevenção de doença fibrótica |
| EP1807436B1 (en) | 2004-10-25 | 2014-06-18 | Intezyne Technologies Inc. | Heterobifunctional poly(ethylene glycol) and uses thereof |
| EP1833958A4 (en) | 2005-01-04 | 2009-01-14 | Intezyne Technologies Inc | SYNTHESIS OF HYBRID BLOCK COPOLYMERS AND USES THEREOF |
| US7561727B2 (en) * | 2005-06-02 | 2009-07-14 | Nordic Bioscience Imaging A/S | Method of deriving a quantitative measure of a degree of calcification of an aorta |
| US7463758B2 (en) * | 2005-06-02 | 2008-12-09 | Nordio Bioscience A/S | Method of deriving a quantitative measure of a degree of calcification of an aorta |
| EP2433644A1 (en) | 2010-09-22 | 2012-03-28 | IMBA-Institut für Molekulare Biotechnologie GmbH | Breast cancer therapeutics |
| FR2970870A1 (fr) * | 2011-01-31 | 2012-08-03 | Centre Nat Rech Scient | Modulation de la proliferation des cellules epitheliales de l'unite epidermo-pilo-sebacee via rank |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997023614A1 (en) * | 1995-12-22 | 1997-07-03 | Amgen Inc. | Osteoprotegerin |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| AU648505B2 (en) | 1989-05-19 | 1994-04-28 | Amgen, Inc. | Metalloproteinase inhibitor |
| US5580722A (en) * | 1989-07-18 | 1996-12-03 | Oncogene Science, Inc. | Methods of determining chemicals that modulate transcriptionally expression of genes associated with cardiovascular disease |
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1998
- 1998-04-23 US US09/064,832 patent/US6790823B1/en not_active Expired - Fee Related
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1999
- 1999-04-21 AU AU36605/99A patent/AU757806B2/en not_active Ceased
- 1999-04-21 EP EP99918766A patent/EP1073456B1/en not_active Expired - Lifetime
- 1999-04-21 SI SI9930826T patent/SI1073456T1/sl unknown
- 1999-04-21 CA CA002325360A patent/CA2325360C/en not_active Expired - Fee Related
- 1999-04-21 WO PCT/US1999/008793 patent/WO1999053942A1/en not_active Ceased
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- 1999-04-21 ES ES99918766T patent/ES2248998T3/es not_active Expired - Lifetime
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- 1999-04-21 JP JP2000544345A patent/JP4776774B2/ja not_active Expired - Fee Related
- 1999-04-21 DE DE69927147T patent/DE69927147T2/de not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997023614A1 (en) * | 1995-12-22 | 1997-07-03 | Amgen Inc. | Osteoprotegerin |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2325360A1 (en) | 1999-10-28 |
| DE69927147T2 (de) | 2006-01-26 |
| ES2248998T3 (es) | 2006-03-16 |
| WO1999053942A1 (en) | 1999-10-28 |
| EP1073456B1 (en) | 2005-09-07 |
| SI1073456T1 (sl) | 2005-12-31 |
| ATE303817T1 (de) | 2005-09-15 |
| US6790823B1 (en) | 2004-09-14 |
| JP2002512199A (ja) | 2002-04-23 |
| DK1073456T3 (da) | 2005-10-24 |
| CA2325360C (en) | 2008-11-04 |
| WO1999053942A8 (en) | 1999-12-02 |
| AU3660599A (en) | 1999-11-08 |
| AU757806B2 (en) | 2003-03-06 |
| DE69927147D1 (de) | 2005-10-13 |
| EP1073456A1 (en) | 2001-02-07 |
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