JP4771595B2 - 遠心分離装置及び流体成分を分離するための方法 - Google Patents
遠心分離装置及び流体成分を分離するための方法 Download PDFInfo
- Publication number
- JP4771595B2 JP4771595B2 JP2000604951A JP2000604951A JP4771595B2 JP 4771595 B2 JP4771595 B2 JP 4771595B2 JP 2000604951 A JP2000604951 A JP 2000604951A JP 2000604951 A JP2000604951 A JP 2000604951A JP 4771595 B2 JP4771595 B2 JP 4771595B2
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- Prior art keywords
- fluid
- fluid chamber
- separation vessel
- outlet
- outlet port
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- Expired - Lifetime
Links
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
- A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0427—Platelets; Thrombocytes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
- B04B2005/045—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation having annular separation channels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
- B04B2005/0471—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with additional elutriation separation of different particles
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Centrifugal Separators (AREA)
- External Artificial Organs (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Cyclones (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/270,105 US6334842B1 (en) | 1999-03-16 | 1999-03-16 | Centrifugal separation apparatus and method for separating fluid components |
| US09/270,105 | 1999-03-16 | ||
| PCT/US2000/005921 WO2000054886A1 (en) | 1999-03-16 | 2000-03-07 | Centrifugal separation apparatus and method for separating fluid components |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007057445A Division JP4964627B2 (ja) | 1999-03-16 | 2007-03-07 | 流体成分を分離するための方法 |
| JP2007057440A Division JP4425938B2 (ja) | 1999-03-16 | 2007-03-07 | 遠心分離装置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002538956A JP2002538956A (ja) | 2002-11-19 |
| JP2002538956A5 JP2002538956A5 (enExample) | 2011-02-17 |
| JP4771595B2 true JP4771595B2 (ja) | 2011-09-14 |
Family
ID=23029929
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000604951A Expired - Lifetime JP4771595B2 (ja) | 1999-03-16 | 2000-03-07 | 遠心分離装置及び流体成分を分離するための方法 |
| JP2007057440A Expired - Lifetime JP4425938B2 (ja) | 1999-03-16 | 2007-03-07 | 遠心分離装置 |
| JP2007057445A Expired - Lifetime JP4964627B2 (ja) | 1999-03-16 | 2007-03-07 | 流体成分を分離するための方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007057440A Expired - Lifetime JP4425938B2 (ja) | 1999-03-16 | 2007-03-07 | 遠心分離装置 |
| JP2007057445A Expired - Lifetime JP4964627B2 (ja) | 1999-03-16 | 2007-03-07 | 流体成分を分離するための方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US6334842B1 (enExample) |
| EP (4) | EP1847323B1 (enExample) |
| JP (3) | JP4771595B2 (enExample) |
| AT (4) | ATE472373T1 (enExample) |
| DE (4) | DE60044623D1 (enExample) |
| ES (4) | ES2348153T3 (enExample) |
| WO (1) | WO2000054886A1 (enExample) |
Families Citing this family (116)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6334842B1 (en) | 1999-03-16 | 2002-01-01 | Gambro, Inc. | Centrifugal separation apparatus and method for separating fluid components |
| JP3817091B2 (ja) * | 1999-07-02 | 2006-08-30 | テルモ株式会社 | 細胞数測定装置 |
| US6524231B1 (en) * | 1999-09-03 | 2003-02-25 | Baxter International Inc. | Blood separation chamber with constricted interior channel and recessed passage |
| US7651474B2 (en) | 1999-10-01 | 2010-01-26 | Caridianbct, Inc. | Method and apparatus for leukoreduction of red blood cells |
| ATE537907T1 (de) | 2000-11-02 | 2012-01-15 | Caridianbct Inc | Vorrichtungen, systeme und verfahren zur fluidtrennung |
| JP4299452B2 (ja) * | 2000-11-28 | 2009-07-22 | テルモ株式会社 | 血小板採取装置 |
| US6579219B2 (en) * | 2001-04-09 | 2003-06-17 | Medtronic, Inc. | Centrifuge bag and methods of use |
| US6835316B2 (en) | 2001-04-09 | 2004-12-28 | Medtronic, Inc. | Clam shell blood reservoir holder with index line |
| EP1423204B1 (en) * | 2001-04-09 | 2010-07-21 | Arteriocyte Medical Systems, Inc. | Microncentrifuge and drive therefor |
| US6610002B2 (en) * | 2001-04-09 | 2003-08-26 | Medtronic, Inc. | Method for handling blood sample to ensure blood components are isolated |
| US6582350B2 (en) * | 2001-04-09 | 2003-06-24 | Medtronic, Inc. | Centrifuge container having curved linear shape |
| US6890291B2 (en) * | 2001-06-25 | 2005-05-10 | Mission Medical, Inc. | Integrated automatic blood collection and processing unit |
| EP1454135B1 (en) * | 2001-12-05 | 2009-01-21 | CaridianBCT, Inc. | Methods and apparatus for separation of blood components |
| EP2208502B1 (en) * | 2001-12-10 | 2019-05-08 | Terumo BCT, Inc. | Disposable assembly for an apheresis system |
| US20030173274A1 (en) * | 2002-02-01 | 2003-09-18 | Frank Corbin | Blood component separation device, system, and method including filtration |
| US7479123B2 (en) | 2002-03-04 | 2009-01-20 | Therakos, Inc. | Method for collecting a desired blood component and performing a photopheresis treatment |
| US7211037B2 (en) | 2002-03-04 | 2007-05-01 | Therakos, Inc. | Apparatus for the continuous separation of biological fluids into components and method of using same |
| WO2003089027A2 (en) * | 2002-04-16 | 2003-10-30 | Gambro, Inc. | Blood component processing system, apparatus and method |
| WO2003089926A2 (en) * | 2002-04-19 | 2003-10-30 | Mission Medical, Inc. | Integrated automatic blood processing unit |
| US20030205538A1 (en) | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
| US7832566B2 (en) | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
| US7845499B2 (en) | 2002-05-24 | 2010-12-07 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US20060278588A1 (en) | 2002-05-24 | 2006-12-14 | Woodell-May Jennifer E | Apparatus and method for separating and concentrating fluids containing multiple components |
| US7699767B2 (en) | 2002-07-31 | 2010-04-20 | Arryx, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
| US7118676B2 (en) * | 2003-09-04 | 2006-10-10 | Arryx, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
| US11243494B2 (en) | 2002-07-31 | 2022-02-08 | Abs Global, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
| US7297272B2 (en) * | 2002-10-24 | 2007-11-20 | Fenwal, Inc. | Separation apparatus and method |
| CA2527667C (en) * | 2003-07-02 | 2013-03-12 | Gambro, Inc. | Monitoring and control system for blood processing |
| US7327443B2 (en) * | 2004-07-01 | 2008-02-05 | Gambro Bct, Inc | Stroboscopic LED light source for blood processing apparatus |
| US20050049539A1 (en) * | 2003-09-03 | 2005-03-03 | O'hara Gerald P. | Control system for driving fluids through an extracorporeal blood circuit |
| US7671975B2 (en) * | 2004-07-01 | 2010-03-02 | Caridianbct, Inc. | Blood processing apparatus with dedicated stroboscopic controller for LED source |
| US20060086675A1 (en) * | 2004-10-22 | 2006-04-27 | Cryofacets, Inc. | System, chamber, and method for fractionation and elutriation of fluids containing particulate components |
| US20060147895A1 (en) * | 2004-10-22 | 2006-07-06 | Cryofacets, Inc. | System, chamber, and method for fractionation, elutriation, and decontamination of fluids containing cellular components |
| US7476209B2 (en) * | 2004-12-21 | 2009-01-13 | Therakos, Inc. | Method and apparatus for collecting a blood component and performing a photopheresis treatment |
| US7866485B2 (en) | 2005-02-07 | 2011-01-11 | Hanuman, Llc | Apparatus and method for preparing platelet rich plasma and concentrates thereof |
| EP2666494B1 (en) * | 2005-02-07 | 2018-01-17 | Hanuman LLC | Platelet rich plasma concentrate apparatus and method |
| US7708152B2 (en) * | 2005-02-07 | 2010-05-04 | Hanuman Llc | Method and apparatus for preparing platelet rich plasma and concentrates thereof |
| US7473216B2 (en) * | 2005-04-21 | 2009-01-06 | Fresenius Hemocare Deutschland Gmbh | Apparatus for separation of a fluid with a separation channel having a mixer component |
| EP1933899A1 (en) * | 2005-10-05 | 2008-06-25 | Gambro BCT, Inc. | Method and apparatus for leukoreduction of red blood cells |
| US7386815B2 (en) * | 2005-10-27 | 2008-06-10 | International Business Machines Corporation | Test yield estimate for semiconductor products created from a library |
| WO2007070301A2 (en) * | 2005-12-05 | 2007-06-21 | Regeneration Technologies, Inc. | Vascular graft sterilization and decellularization |
| US8567609B2 (en) | 2006-05-25 | 2013-10-29 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| WO2008021623A1 (en) * | 2006-08-10 | 2008-02-21 | Gambro Bct, Inc. | Method and apparatus for recirculating elutriation fluids |
| US20080041772A1 (en) * | 2006-08-17 | 2008-02-21 | Gambro Bct, Inc. | Blood Processing Apparatus with Robust Outflow Process Control |
| WO2008021633A2 (en) | 2006-08-17 | 2008-02-21 | Caridianbct, Inc. | Blood processing apparatus with robust outflow process control |
| CA2657229A1 (en) * | 2006-08-17 | 2008-02-21 | Caridianbct, Inc. | Blood processing apparatus with robust automated process control |
| US8328024B2 (en) | 2007-04-12 | 2012-12-11 | Hanuman, Llc | Buoy suspension fractionation system |
| US7806276B2 (en) | 2007-04-12 | 2010-10-05 | Hanuman, Llc | Buoy suspension fractionation system |
| US7857744B2 (en) * | 2007-06-19 | 2010-12-28 | Caridianbct, Inc. | Blood processing apparatus with flared cell capture chamber and method |
| US8057376B2 (en) * | 2007-12-18 | 2011-11-15 | Caridianbct, Inc. | Blood processing apparatus with sealed diffuser in optical control apparatus |
| WO2009085350A1 (en) * | 2007-12-27 | 2009-07-09 | Caridianbct, Inc. | Blood processing apparatus with controlled cell capture chamber trigger |
| US8075468B2 (en) * | 2008-02-27 | 2011-12-13 | Fenwal, Inc. | Systems and methods for mid-processing calculation of blood composition |
| US8685258B2 (en) * | 2008-02-27 | 2014-04-01 | Fenwal, Inc. | Systems and methods for conveying multiple blood components to a recipient |
| PL2259774T3 (pl) | 2008-02-27 | 2013-04-30 | Biomet Biologics Llc | Sposoby i kompozycje dla wprowadzania antagonisty receptora interleukiny-1 |
| US8337711B2 (en) * | 2008-02-29 | 2012-12-25 | Biomet Biologics, Llc | System and process for separating a material |
| US8012077B2 (en) * | 2008-05-23 | 2011-09-06 | Biomet Biologics, Llc | Blood separating device |
| US20100015690A1 (en) * | 2008-07-16 | 2010-01-21 | Ortho-Clinical Diagnostics, Inc. | Use of fluid aspiration/dispensing tip as a microcentrifuge tube |
| US7963901B2 (en) * | 2008-09-12 | 2011-06-21 | Caridianbct, Inc. | Blood processing apparatus with cell capture chamber with protruding inlet |
| US7951059B2 (en) * | 2008-09-18 | 2011-05-31 | Caridianbct, Inc. | Blood processing apparatus with optical reference control |
| US7828709B2 (en) | 2008-09-30 | 2010-11-09 | Caridianbct, Inc. | Blood processing apparatus with incipient spill-over detection |
| WO2010074929A2 (en) * | 2008-12-22 | 2010-07-01 | Caridianbct, Inc. | Blood processing apparatus with digitally controlled linear voltage regulator for optical pulses |
| US8187475B2 (en) | 2009-03-06 | 2012-05-29 | Biomet Biologics, Llc | Method and apparatus for producing autologous thrombin |
| US8313954B2 (en) | 2009-04-03 | 2012-11-20 | Biomet Biologics, Llc | All-in-one means of separating blood components |
| US9011800B2 (en) * | 2009-07-16 | 2015-04-21 | Biomet Biologics, Llc | Method and apparatus for separating biological materials |
| EP3391970B1 (en) | 2009-10-06 | 2020-01-22 | Sartorius Stedim North America Inc. | Method and apparatus for manipulating particles |
| US8535210B2 (en) * | 2009-12-11 | 2013-09-17 | Terumo Bct, Inc. | System for blood separation with shielded extraction port and optical control |
| CA2793648C (en) * | 2010-03-18 | 2017-06-06 | Syngen, Inc. | System for purifying certain cell populations in blood or bone marrow by depleting others |
| US8591391B2 (en) | 2010-04-12 | 2013-11-26 | Biomet Biologics, Llc | Method and apparatus for separating a material |
| US10908066B2 (en) | 2010-11-16 | 2021-02-02 | 1087 Systems, Inc. | Use of vibrational spectroscopy for microfluidic liquid measurement |
| US8556794B2 (en) | 2010-11-19 | 2013-10-15 | Kensey Nash Corporation | Centrifuge |
| US8469871B2 (en) | 2010-11-19 | 2013-06-25 | Kensey Nash Corporation | Centrifuge |
| US8317672B2 (en) | 2010-11-19 | 2012-11-27 | Kensey Nash Corporation | Centrifuge method and apparatus |
| US8870733B2 (en) | 2010-11-19 | 2014-10-28 | Kensey Nash Corporation | Centrifuge |
| US8394006B2 (en) | 2010-11-19 | 2013-03-12 | Kensey Nash Corporation | Centrifuge |
| US20220031925A1 (en) | 2010-11-19 | 2022-02-03 | Dsm Ip Assets B.V. | Centrifuge |
| EP2590697B1 (en) | 2011-06-13 | 2015-03-04 | Terumo BCT, Inc. | System for blood separation with side-tapped separation chamber |
| EP2815776B1 (en) | 2011-06-13 | 2016-02-03 | Terumo BCT, Inc. | System for blood separation with gravity valve for controlling a side-tapped separation chamber |
| US10385307B2 (en) | 2011-12-21 | 2019-08-20 | Lonza Walkersville, Inc. | Scalable process for therapeutic cell concentration and residual clearance |
| US9327296B2 (en) | 2012-01-27 | 2016-05-03 | Fenwal, Inc. | Fluid separation chambers for fluid processing systems |
| US9033858B2 (en) | 2012-02-02 | 2015-05-19 | Fenwal, Inc. | Method and apparatus for concentrating platelets from platelet-rich plasma |
| WO2013152253A1 (en) | 2012-04-05 | 2013-10-10 | Terumo Bct, Inc. | Syestem and method for collecting and treating plasma protein fractions |
| US9421317B2 (en) * | 2012-06-08 | 2016-08-23 | Pall Corporation | Cell harvesting device and system |
| US9642956B2 (en) | 2012-08-27 | 2017-05-09 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| WO2014052496A1 (en) | 2012-09-25 | 2014-04-03 | Stem Cell Partners Llc | Method and apparatus for preparing single donor thrombin serum |
| WO2014127122A1 (en) | 2013-02-18 | 2014-08-21 | Terumo Bct, Inc. | System for blood separation with a separation chamber having an internal gravity valve |
| US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
| US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
| US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
| US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
| US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
| US8961904B2 (en) | 2013-07-16 | 2015-02-24 | Premium Genetics (Uk) Ltd. | Microfluidic chip |
| US11796449B2 (en) | 2013-10-30 | 2023-10-24 | Abs Global, Inc. | Microfluidic system and method with focused energy apparatus |
| US10618060B2 (en) | 2013-12-20 | 2020-04-14 | Terumo Bct, Inc. | Centrifuge safety mechanism |
| EP3660140A1 (en) | 2014-01-31 | 2020-06-03 | DSM IP Assets B.V. | Adipose tissue processing centrifuge and methods of use |
| WO2015148978A1 (en) | 2014-03-28 | 2015-10-01 | Terumo Bct, Inc. | Gain in separation processes with control loop |
| CN106574240B (zh) | 2014-08-14 | 2021-03-30 | 泰尔茂比司特公司 | 加工颗粒 |
| JP2018509615A (ja) | 2015-02-19 | 2018-04-05 | プレミアム ジェネティクス (ユーケー) リミテッド | 走査型赤外線測定システム |
| US9713810B2 (en) | 2015-03-30 | 2017-07-25 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
| US9757721B2 (en) | 2015-05-11 | 2017-09-12 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
| EP3124063B1 (en) | 2015-07-29 | 2019-04-10 | Fenwal, Inc. | Five-port blood separation chamber and methods of using the same |
| ES2960079T3 (es) | 2016-10-03 | 2024-02-29 | Terumo Bct Inc | Dispositivo centrífugo de separación de fluidos |
| WO2018071862A1 (en) | 2016-10-13 | 2018-04-19 | Terumo Bct, Inc. | Collecting components of a fluid |
| CN106823475B (zh) * | 2017-02-07 | 2023-01-24 | 重庆科技学院 | 一种血液分流器 |
| US12115471B2 (en) * | 2017-07-03 | 2024-10-15 | Trustees Of Tufts College | Aqueous two-phase system for the separation and recovery of mammalian cells from contaminated cultures |
| WO2019226790A1 (en) | 2018-05-23 | 2019-11-28 | Abs Global, Inc. | Systems and methods for particle focusing in microchannels |
| KR102063865B1 (ko) * | 2018-06-20 | 2020-01-08 | 울산과학기술원 | 원심력 기반 혈소판 분리 및 검진 장치 |
| CN111686326B (zh) | 2019-03-12 | 2024-04-26 | 泰尔茂株式会社 | 治疗方法、分离方法及过滤器组装体 |
| JP2020151465A (ja) | 2019-03-12 | 2020-09-24 | テルモ株式会社 | 治療方法、分離方法およびフィルター組立体 |
| WO2020210220A1 (en) | 2019-04-12 | 2020-10-15 | Terumo Bct, Inc. | Cell washing chamber for blood processing centrifuge |
| WO2020215011A1 (en) | 2019-04-18 | 2020-10-22 | Abs Global, Inc. | System and process for continuous addition of cryoprotectant |
| US11628439B2 (en) | 2020-01-13 | 2023-04-18 | Abs Global, Inc. | Single-sheath microfluidic chip |
| EP4232601A4 (en) | 2020-10-21 | 2024-10-09 | ABS Global, Inc. | METHODS AND SYSTEMS FOR PROCESSING GENETIC SAMPLES TO DETERMINE IDENTITY OR DETECT CONTAMINATION |
| EP4248190A4 (en) | 2020-11-23 | 2024-12-25 | ABS Global, Inc. | MODULAR FLOW CYTOMETRY SYSTEMS AND METHODS FOR PROCESSING SAMPLES |
| US12343738B2 (en) | 2021-04-05 | 2025-07-01 | Fenwal, Inc. | Continuous flow centrifugation chambers |
| WO2023009539A1 (en) * | 2021-07-26 | 2023-02-02 | Georgia Tech Research Corporation | Rapid, label-free antibiotic susceptibility of bacteria directly from positive blood or bodily fluid/culture |
| US11912974B2 (en) * | 2021-12-06 | 2024-02-27 | Hossein HEIDARI | Assembly and method for spatiotemporal control of chemical, biological, and biochemical reactions |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58219959A (ja) * | 1982-06-15 | 1983-12-21 | インタ−ナショナル ビジネス マシ−ンズ コ−ポレ−ション | 遠心分離機アセンブリ |
| JPS6295156A (ja) * | 1985-10-18 | 1987-05-01 | コ−ブ・ラボラトリ−ズ・インコ−ポレ−テツド | 遠心分離機 |
| JPS62294454A (ja) * | 1986-03-28 | 1987-12-21 | コ−ブ・ラボラトリ−ズ・インコ−ポレ−テツド | 遠心分離機 |
| WO1998050163A1 (en) * | 1997-05-08 | 1998-11-12 | Cobe Laboratories, Inc. | Tubing set, apparatus, and method for separation of fluid components |
Family Cites Families (113)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1684870A (en) | 1927-10-17 | 1928-09-18 | Frank D Lewis | Centrifugal concentrating and amalgamating apparatus of the vertical type |
| US2616619A (en) | 1948-08-30 | 1952-11-04 | Norman A Macleod | Method and apparatus for centrifugal elutriation |
| US2878995A (en) | 1953-08-24 | 1959-03-24 | Gen Motors Corp | Centrifuge for liquids |
| SE372429B (enExample) | 1970-11-24 | 1974-12-23 | Escher Wyss Ag | |
| US3957931A (en) * | 1970-12-18 | 1976-05-18 | Mass Transfer Limited | Fluid-fluid contact method and apparatus |
| FR2180589B1 (enExample) | 1972-04-21 | 1975-03-21 | Loison Robert | |
| US4934995A (en) | 1977-08-12 | 1990-06-19 | Baxter International Inc. | Blood component centrifuge having collapsible inner liner |
| US3825175A (en) | 1973-06-06 | 1974-07-23 | Atomic Energy Commission | Centrifugal particle elutriator and method of use |
| ZA762830B (en) * | 1975-05-21 | 1977-04-27 | Norton Co | Trickling filters media for biological filters |
| US4007871A (en) | 1975-11-13 | 1977-02-15 | International Business Machines Corporation | Centrifuge fluid container |
| US4010894A (en) | 1975-11-21 | 1977-03-08 | International Business Machines Corporation | Centrifuge fluid container |
| US4059967A (en) * | 1976-02-19 | 1977-11-29 | The Community Blood Council Of Greater New York, Inc. | Process for freezing blood platelets |
| US4425112A (en) | 1976-02-25 | 1984-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Flow-through centrifuge |
| DE2658926A1 (de) | 1976-12-24 | 1978-06-29 | Heraeus Christ Gmbh | Zentrifuge zum waschen von blut |
| US4091989A (en) | 1977-01-04 | 1978-05-30 | Schlutz Charles A | Continuous flow fractionation and separation device and method |
| US4430072A (en) | 1977-06-03 | 1984-02-07 | International Business Machines Corporation | Centrifuge assembly |
| US4094461A (en) | 1977-06-27 | 1978-06-13 | International Business Machines Corporation | Centrifuge collecting chamber |
| US4419089A (en) | 1977-07-19 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Blood cell separator |
| US4356958A (en) | 1977-07-19 | 1982-11-02 | The United States Of America As Represented By The Secretary Of Health And Human Services | Blood cell separator |
| US5217427A (en) | 1977-08-12 | 1993-06-08 | Baxter International Inc. | Centrifuge assembly |
| US5006103A (en) | 1977-08-12 | 1991-04-09 | Baxter International Inc. | Disposable container for a centrifuge |
| US5571068A (en) | 1977-08-12 | 1996-11-05 | Baxter International Inc. | Centrifuge assembly |
| US4198972A (en) * | 1978-04-17 | 1980-04-22 | Pharmachem Corporation | Blood and blood component storage bags |
| US4387848A (en) | 1977-10-03 | 1983-06-14 | International Business Machines Corporation | Centrifuge assembly |
| US4146172A (en) | 1977-10-18 | 1979-03-27 | Baxter Travenol Laboratories, Inc. | Centrifugal liquid processing system |
| US4386730A (en) | 1978-07-21 | 1983-06-07 | International Business Machines Corporation | Centrifuge assembly |
| US4187979A (en) | 1978-09-21 | 1980-02-12 | Baxter Travenol Laboratories, Inc. | Method and system for fractionating a quantity of blood into the components thereof |
| US4413771A (en) | 1979-09-10 | 1983-11-08 | E. I. Du Pont De Nemours And Company | Method and apparatus for centrifugal separation |
| US4413772A (en) | 1979-09-10 | 1983-11-08 | E. I. Du Pont De Nemours And Company | Apparatus for centrifugal separation |
| US4269718A (en) | 1980-05-05 | 1981-05-26 | The Institutes Of Medical Sciences | Process and device for centrifugal separation of platelets |
| US4268393A (en) | 1980-05-05 | 1981-05-19 | The Institutes Of Medical Sciences | Apparatus for centrifugal separation of platelet-rich plasma |
| US4350283A (en) | 1980-07-01 | 1982-09-21 | Beckman Instruments, Inc. | Centrifugal elutriator rotor |
| US4316576A (en) | 1980-11-06 | 1982-02-23 | Baxter Travenol Laboratories, Inc. | Method and chamber for separating granulocytes from whole blood |
| EP0057907B1 (en) | 1981-02-05 | 1986-12-30 | Asahi Kasei Kogyo Kabushiki Kaisha | Apparatus for separating blood components |
| US4322298A (en) | 1981-06-01 | 1982-03-30 | Advanced Blood Component Technology, Inc. | Centrifugal cell separator, and method of use thereof |
| US4421503A (en) | 1981-07-09 | 1983-12-20 | Haemonetics Corporation | Fluid processing centrifuge and apparatus thereof |
| US4416654A (en) | 1981-09-03 | 1983-11-22 | Haemonetics Corporation | Pheresis apparatus |
| US4464167A (en) | 1981-09-03 | 1984-08-07 | Haemonetics Corporation | Pheresis apparatus |
| US4680025A (en) | 1982-08-24 | 1987-07-14 | Baxter Travenol Laboratories, Inc. | Blood component collection systems and methods |
| US4610846A (en) | 1983-08-18 | 1986-09-09 | Hans Martin | Compartmentalized centrifugation chamber |
| US4701267B1 (en) | 1984-03-15 | 1996-03-12 | Asahi Medical Co | Method for removing leukocytes |
| DE3410286C2 (de) | 1984-03-21 | 1986-01-23 | Fresenius AG, 6380 Bad Homburg | Verfahren zur Trennung von Blut sowie Vorrichtung zur Durchführung des Verfahrens |
| US4776964A (en) | 1984-08-24 | 1988-10-11 | William F. McLaughlin | Closed hemapheresis system and method |
| US4846974A (en) | 1985-11-14 | 1989-07-11 | Norfolk Scientific, Inc. | Centrifuge system and fluid container therefor |
| US4708710A (en) | 1986-03-27 | 1987-11-24 | E. I. Du Pont De Nemours And Company | Particle separation process |
| US4936998A (en) | 1986-03-28 | 1990-06-26 | Asahi Medical Co., Ltd. | Filter medium for selectively removing leucocytes |
| US4915847A (en) | 1987-08-04 | 1990-04-10 | Baxter International Inc. | Cryoglobulin separation |
| US4933291A (en) | 1986-12-22 | 1990-06-12 | Eastman Kodak Company | Centrifugable pipette tip and pipette therefor |
| DE3700122A1 (de) | 1987-01-03 | 1988-07-14 | Manfred Lutz | Kammer zur trennung eines teilchengemisches nach dem gegenstromzentrifugationsverfahren |
| US5213970A (en) | 1987-01-23 | 1993-05-25 | Board Of Regents, The University Of Texas System | Method for obtaining soluble antitumor factor |
| US5632893A (en) | 1987-01-30 | 1997-05-27 | Baxter Internatinoal Inc. | Enhanced yield blood processing systems with angled interface control surface |
| US4834890A (en) | 1987-01-30 | 1989-05-30 | Baxter International Inc. | Centrifugation pheresis system |
| US5656163A (en) | 1987-01-30 | 1997-08-12 | Baxter International Inc. | Chamber for use in a rotating field to separate blood components |
| US5628915A (en) | 1987-01-30 | 1997-05-13 | Baxter International Inc. | Enhanced yield blood processing systems and methods establishing controlled vortex flow conditions |
| US5370802A (en) | 1987-01-30 | 1994-12-06 | Baxter International Inc. | Enhanced yield platelet collection systems and methods |
| US5641414A (en) * | 1987-01-30 | 1997-06-24 | Baxter International Inc. | Blood processing systems and methods which restrict in flow of whole blood to increase platelet yields |
| US5076911A (en) | 1987-01-30 | 1991-12-31 | Baxter International Inc. | Centrifugation chamber having an interface detection surface |
| US5792372A (en) * | 1987-01-30 | 1998-08-11 | Baxter International, Inc. | Enhanced yield collection systems and methods for obtaining concentrated platelets from platelet-rich plasma |
| DE3711177A1 (de) | 1987-04-02 | 1988-10-13 | Dornier System Gmbh | Verfahren und vorrichtung zum betrieb von wirbelschicht-reaktoren |
| US4808151A (en) | 1987-04-27 | 1989-02-28 | E. I. Du Pont De Nemours And Company | Simplified method for the preparation of human lymphokine activated killer cells |
| US4939087A (en) | 1987-05-12 | 1990-07-03 | Washington State University Research Foundation, Inc. | Method for continuous centrifugal bioprocessing |
| US4939081A (en) | 1987-05-27 | 1990-07-03 | The Netherlands Cancer Institute | Cell-separation |
| SE458342B (sv) | 1987-07-06 | 1989-03-20 | Alfa Laval Ab | Centrifugalseparator innefattande en rotor med en separeringskammare bestaaende av tvaa avdelningar |
| US4798579A (en) | 1987-10-30 | 1989-01-17 | Beckman Instruments, Inc. | Rotor for centrifuge |
| US4851126A (en) | 1987-11-25 | 1989-07-25 | Baxter International Inc. | Apparatus and methods for generating platelet concentrate |
| US4936820A (en) | 1988-10-07 | 1990-06-26 | Baxter International Inc. | High volume centrifugal fluid processing system and method for cultured cell suspensions and the like |
| US5078671A (en) | 1988-10-07 | 1992-01-07 | Baxter International Inc. | Centrifugal fluid processing system and method |
| CA1334189C (en) | 1988-10-07 | 1995-01-31 | T. Michael Dennehey | Centrifugal fluid processing system and method |
| US5344561A (en) | 1989-05-09 | 1994-09-06 | Pall Corporation | Device for depletion of the leucocyte content of blood and blood components |
| US5229012A (en) | 1989-05-09 | 1993-07-20 | Pall Corporation | Method for depletion of the leucocyte content of blood and blood components |
| US5316667A (en) | 1989-05-26 | 1994-05-31 | Baxter International Inc. | Time based interface detection systems for blood processing apparatus |
| EP0406485A1 (en) | 1989-07-03 | 1991-01-09 | NPBI Nederlands Produktielaboratorium voor Bloedtransfusieapparatuur en Infusievloeistoffen B.V. | A method for the removal of leukocytes from a leukocyte-containing suspension and filter unit for use with the method |
| EP0408462B1 (en) | 1989-07-14 | 1995-06-21 | Terumo Kabushiki Kaisha | Filter material for seizure of leukocytes and method for production thereof |
| US5152905A (en) | 1989-09-12 | 1992-10-06 | Pall Corporation | Method for processing blood for human transfusion |
| US5100564A (en) | 1990-11-06 | 1992-03-31 | Pall Corporation | Blood collection and processing system |
| JP2523938B2 (ja) | 1989-09-18 | 1996-08-14 | テルモ株式会社 | 血小板純化用フィルタ― |
| US5089146A (en) | 1990-02-12 | 1992-02-18 | Miles Inc. | Pre-storage filtration of platelets |
| US5224921A (en) | 1990-05-31 | 1993-07-06 | Baxter International Inc. | Small volume collection chamber |
| US5217627A (en) | 1990-11-06 | 1993-06-08 | Pall Corporation | System and method for processing biological fluid |
| FR2671985B1 (fr) | 1991-01-30 | 1993-04-09 | Snecma | Filtre a huile centrifuge avec collecte des particules. |
| US5282982A (en) | 1991-07-12 | 1994-02-01 | Wells John R | Blood washing method |
| DE4126341C1 (enExample) | 1991-08-09 | 1993-01-28 | Fresenius Ag, 6380 Bad Homburg, De | |
| DE4132965A1 (de) | 1991-10-04 | 1993-04-08 | Fresenius Ag | Vorrichtung zur trennung von medien in deren bestandteile |
| AU663160B2 (en) | 1991-12-23 | 1995-09-28 | Baxter International Inc. | Centrifuge |
| US5804079A (en) | 1991-12-23 | 1998-09-08 | Baxter International Inc. | Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes |
| US5549834A (en) | 1991-12-23 | 1996-08-27 | Baxter International Inc. | Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes |
| WO1993012887A1 (en) | 1991-12-23 | 1993-07-08 | Baxter International Inc. | Centrifugal processing system with direct access drawer |
| US5437624A (en) | 1993-08-23 | 1995-08-01 | Cobe Laboratories, Inc. | Single needle recirculation system for harvesting blood components |
| US5672346A (en) | 1992-07-27 | 1997-09-30 | Indiana University Foundation | Human stem cell compositions and methods |
| DE4226974C2 (de) | 1992-08-14 | 1994-08-11 | Fresenius Ag | Verfahren und Vorrichtung zur kontinuierlichen Aufbereitung einer Zellsuspension |
| US5397479A (en) | 1993-04-26 | 1995-03-14 | International Remote Imaging Systems, Inc. | Composition and method for enrichment of white blood cells from whole human blood |
| WO1994025086A1 (en) | 1993-04-27 | 1994-11-10 | Haemonetics Corporation | Apheresis apparatus and method |
| EP0653062B1 (en) | 1993-05-28 | 2003-05-02 | Baxter International Inc. | Continuous centrifugation process for the separation of biologic components from heterogeneous cell populations |
| US5547591A (en) | 1993-06-01 | 1996-08-20 | Asahi Medical Co., Ltd. | Method for separating a blood material into blood components by centrifugation, and centrifugal apparatus |
| US5409813A (en) | 1993-09-30 | 1995-04-25 | Systemix, Inc. | Method for mammalian cell separation from a mixture of cell populations |
| US5704889A (en) | 1995-04-14 | 1998-01-06 | Cobe Laboratories, Inc. | Spillover collection of sparse components such as mononuclear cells in a centrifuge apparatus |
| US5704888A (en) * | 1995-04-14 | 1998-01-06 | Cobe Laboratories, Inc. | Intermittent collection of mononuclear cells in a centrifuge apparatus |
| US5674173A (en) | 1995-04-18 | 1997-10-07 | Cobe Laboratories, Inc. | Apparatus for separating particles |
| JP4304264B2 (ja) | 1995-04-18 | 2009-07-29 | カリディアンビーシーティ、 インコーポレイテッド | 粒子分離方法および装置 |
| US5913768A (en) | 1995-04-18 | 1999-06-22 | Cobe Laboratories, Inc. | Particle filter apparatus |
| US5958250A (en) * | 1995-06-07 | 1999-09-28 | Baxter International Inc. | Blood processing systems and methods which optically derive the volume of platelets contained in a plasma constituent |
| US5720716A (en) | 1995-06-07 | 1998-02-24 | Cobe Laboratories, Inc. | Extracorporeal blood processing methods and apparatus |
| US5702357A (en) | 1995-06-07 | 1997-12-30 | Cobe Laboratories, Inc. | Extracorporeal blood processing methods and apparatus |
| US5865785A (en) | 1996-02-23 | 1999-02-02 | Baxter International Inc. | Systems and methods for on line finishing of cellular blood products like platelets harvested for therapeutic purposes |
| US5846439A (en) * | 1996-02-28 | 1998-12-08 | Marshfield Medical Research & Education Foundation, A Division Of Marshfield Clinic | Method of concentrating waterborne protozoan parasites |
| US5904645A (en) | 1996-05-15 | 1999-05-18 | Cobe Laboratories | Apparatus for reducing turbulence in fluid flow |
| JP2000510045A (ja) * | 1996-05-15 | 2000-08-08 | コウブ ラボラトリーズ,インコーポレイテッド | 流体の流れの乱れを低減する方法および装置 |
| US5792038A (en) | 1996-05-15 | 1998-08-11 | Cobe Laboratories, Inc. | Centrifugal separation device for providing a substantially coriolis-free pathway |
| US6334842B1 (en) | 1999-03-16 | 2002-01-01 | Gambro, Inc. | Centrifugal separation apparatus and method for separating fluid components |
| US6354986B1 (en) * | 2000-02-16 | 2002-03-12 | Gambro, Inc. | Reverse-flow chamber purging during centrifugal separation |
| US7120254B2 (en) * | 2000-10-30 | 2006-10-10 | Geocodex Llc | Cryptographic system and method for geolocking and securing digital information |
| USD445029S1 (en) * | 2001-01-30 | 2001-07-17 | Saint-Gobain Norpro Corporation | Packing element |
| US6931429B2 (en) * | 2001-04-27 | 2005-08-16 | Left Gate Holdings, Inc. | Adaptable wireless proximity networking |
-
1999
- 1999-03-16 US US09/270,105 patent/US6334842B1/en not_active Expired - Lifetime
-
2000
- 2000-03-07 ES ES07016078T patent/ES2348153T3/es not_active Expired - Lifetime
- 2000-03-07 AT AT07014571T patent/ATE472373T1/de not_active IP Right Cessation
- 2000-03-07 AT AT07016078T patent/ATE472374T1/de not_active IP Right Cessation
- 2000-03-07 ES ES07014571T patent/ES2348151T3/es not_active Expired - Lifetime
- 2000-03-07 DE DE60044623T patent/DE60044623D1/de not_active Expired - Lifetime
- 2000-03-07 AT AT06022465T patent/ATE420726T1/de not_active IP Right Cessation
- 2000-03-07 DE DE60036906T patent/DE60036906T2/de not_active Expired - Lifetime
- 2000-03-07 ES ES06022465T patent/ES2317400T3/es not_active Expired - Lifetime
- 2000-03-07 AT AT00923072T patent/ATE376886T1/de not_active IP Right Cessation
- 2000-03-07 EP EP07014571A patent/EP1847323B1/en not_active Expired - Lifetime
- 2000-03-07 EP EP00923072A patent/EP1082176B1/en not_active Expired - Lifetime
- 2000-03-07 EP EP06022465A patent/EP1745852B1/en not_active Expired - Lifetime
- 2000-03-07 WO PCT/US2000/005921 patent/WO2000054886A1/en not_active Ceased
- 2000-03-07 ES ES00923072T patent/ES2292438T3/es not_active Expired - Lifetime
- 2000-03-07 JP JP2000604951A patent/JP4771595B2/ja not_active Expired - Lifetime
- 2000-03-07 EP EP07016078A patent/EP1854545B1/en not_active Expired - Lifetime
- 2000-03-07 DE DE60041426T patent/DE60041426D1/de not_active Expired - Lifetime
- 2000-03-07 DE DE60044624T patent/DE60044624D1/de not_active Expired - Lifetime
- 2000-10-30 US US09/698,079 patent/US6514189B1/en not_active Expired - Lifetime
-
2001
- 2001-11-01 US US09/985,050 patent/US7029430B2/en not_active Expired - Lifetime
-
2006
- 2006-02-07 US US11/348,524 patent/US7549956B2/en not_active Expired - Lifetime
-
2007
- 2007-03-07 JP JP2007057440A patent/JP4425938B2/ja not_active Expired - Lifetime
- 2007-03-07 JP JP2007057445A patent/JP4964627B2/ja not_active Expired - Lifetime
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58219959A (ja) * | 1982-06-15 | 1983-12-21 | インタ−ナショナル ビジネス マシ−ンズ コ−ポレ−ション | 遠心分離機アセンブリ |
| JPS6295156A (ja) * | 1985-10-18 | 1987-05-01 | コ−ブ・ラボラトリ−ズ・インコ−ポレ−テツド | 遠心分離機 |
| JPS62294454A (ja) * | 1986-03-28 | 1987-12-21 | コ−ブ・ラボラトリ−ズ・インコ−ポレ−テツド | 遠心分離機 |
| WO1998050163A1 (en) * | 1997-05-08 | 1998-11-12 | Cobe Laboratories, Inc. | Tubing set, apparatus, and method for separation of fluid components |
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