JP4763132B2 - マンガン組成物及びｍｒｉのための方法 - Google Patents
マンガン組成物及びｍｒｉのための方法 Download PDFInfo
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- JP4763132B2 JP4763132B2 JP2000579122A JP2000579122A JP4763132B2 JP 4763132 B2 JP4763132 B2 JP 4763132B2 JP 2000579122 A JP2000579122 A JP 2000579122A JP 2000579122 A JP2000579122 A JP 2000579122A JP 4763132 B2 JP4763132 B2 JP 4763132B2
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- manganese
- calcium
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- BENFPBJLMUIGGD-UHFFFAOYSA-I trisodium;2-[2-[carboxylatomethyl-[[3-hydroxy-2-methyl-5-(phosphonatooxymethyl)pyridin-4-yl]methyl]amino]ethyl-[[3-hydroxy-5-[[hydroxy(oxido)phosphoryl]oxymethyl]-2-methylpyridin-4-yl]methyl]amino]acetate;manganese(2+) Chemical compound [H+].[H+].[H+].[Na+].[Na+].[Na+].[Mn+2].CC1=NC=C(COP([O-])([O-])=O)C(CN(CCN(CC([O-])=O)CC=2C(=C(C)N=CC=2COP([O-])([O-])=O)[O-])CC([O-])=O)=C1[O-] BENFPBJLMUIGGD-UHFFFAOYSA-I 0.000 description 1
- 231100000691 up-and-down procedure Toxicity 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/184,835 | 1998-11-02 | ||
| US09/184,835 US5980863A (en) | 1998-11-02 | 1998-11-02 | Manganese compositions and methods for MRI |
| PCT/US1999/024993 WO2000025671A1 (en) | 1998-11-02 | 1999-10-26 | Manganese compositions and methods for mri |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002528473A JP2002528473A (ja) | 2002-09-03 |
| JP2002528473A5 JP2002528473A5 (enExample) | 2006-11-30 |
| JP4763132B2 true JP4763132B2 (ja) | 2011-08-31 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000579122A Expired - Fee Related JP4763132B2 (ja) | 1998-11-02 | 1999-10-26 | マンガン組成物及びｍｒｉのための方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5980863A (enExample) |
| EP (1) | EP1126785B1 (enExample) |
| JP (1) | JP4763132B2 (enExample) |
| KR (1) | KR100692720B1 (enExample) |
| CN (1) | CN1325286A (enExample) |
| AT (1) | ATE434406T1 (enExample) |
| AU (1) | AU754294B2 (enExample) |
| CA (1) | CA2349342C (enExample) |
| DE (1) | DE69941029D1 (enExample) |
| NO (1) | NO327611B1 (enExample) |
| NZ (1) | NZ511592A (enExample) |
| WO (1) | WO2000025671A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60316410T2 (de) * | 2002-02-05 | 2008-06-19 | Bristol-Myers Squibb Co. | N-substituierte 3-hydroxy-4-pyridinone und diese enthaltende pharmazeutika |
| US6869591B2 (en) * | 2002-03-26 | 2005-03-22 | Barnes-Jewish Hospital | Paramagnetic particles that provide improved relaxivity |
| JP4614281B2 (ja) * | 2002-12-16 | 2011-01-19 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 磁気共鳴撮像方法並びに該方法に用いられる化合物 |
| US20050106100A1 (en) * | 2003-09-03 | 2005-05-19 | Harris Thomas D. | Compounds containing matrix metalloproteinase substrates and methods of their use |
| US20050197614A1 (en) * | 2004-03-04 | 2005-09-08 | Wilson Pritchard | Occlusive biomedical devices, punctum plugs, and methods of use thereof |
| JP2006282604A (ja) * | 2005-04-01 | 2006-10-19 | Fuji Photo Film Co Ltd | 金属キレート構造を有するグリセリンエステル誘導体 |
| JP2009500410A (ja) * | 2005-06-30 | 2009-01-08 | ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー | イメージング剤としてのヒドラジドコンジュゲート |
| US20080081021A1 (en) * | 2006-09-29 | 2008-04-03 | Mehmet Bilgen | Manganese-enhanced magnetic resonance imaging of neurons using electrical stimulation |
| US8414866B2 (en) * | 2007-12-17 | 2013-04-09 | Ge Healthcare As | Method of magnetic resonance imaging of the heart with paramagnetic MN2+ |
| WO2011003818A2 (en) | 2009-07-06 | 2011-01-13 | Cmc Contrast Ab | Diagnostic method |
| CN103656690B (zh) * | 2012-09-11 | 2016-04-27 | 南京逐陆医药科技有限公司 | 一种氯化锰口服溶液的制备方法 |
| KR101683635B1 (ko) | 2014-12-29 | 2016-12-09 | 가천대학교 산학협력단 | 락테이트 금속염을 포함하는 암 치료용 약학 조성물 |
| US10233205B2 (en) | 2015-08-07 | 2019-03-19 | Auburn University | Magnetic resonance imaging contrast agent capable of detecting hydrogen peroxide and reducing reactive oxygen species |
| KR102868782B1 (ko) | 2018-01-12 | 2025-10-13 | (주)메티메디제약 | 만성 염증성 질환의 치료 방법 |
| JP2020069470A (ja) * | 2018-10-29 | 2020-05-07 | 株式会社げんてん本店 | リポソームの製造方法、及び、リポソーム含有液の製造方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01259850A (ja) * | 1987-09-25 | 1989-10-17 | Salutar Inc | Ｍｎ（ＩＩ）配位組成物を使用するＮＭＲ像形成 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1965535A (en) * | 1933-03-01 | 1934-07-03 | Pfizer Charles & Co | Stable calcium gluconate solution and process of making same |
| FR2126134A1 (en) * | 1971-02-26 | 1972-10-06 | Ates Ibrahim | Cyclophosphamide/magnesium compsns - with enhanced cytostatic activity |
| US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
| DE3316703A1 (de) * | 1983-05-04 | 1984-11-08 | Schering AG, 1000 Berlin und 4709 Bergkamen | Orales kontrastmittel fuer die kernspintomographie und dessen herstellung |
| SE465907B (sv) * | 1984-11-01 | 1991-11-18 | Nyegaard & Co As | Diagnosticeringsmedel innehaallande en paramagnetisk metall |
| US5082649A (en) * | 1987-06-30 | 1992-01-21 | Mallinckrodt Medical, Inc. | Method for enhancing the safety of metal-ligand chelates as magnetic resonance imaging agents by addition of calcium ions |
| US4915933A (en) * | 1986-06-26 | 1990-04-10 | The University Of New Mexico | Mixed complexes as shift and contrast reagents in NMR imaging and spectroscopy |
| AU608759B2 (en) * | 1986-08-04 | 1991-04-18 | Amersham Health Salutar Inc | NMR imaging with paramagnetic polyvalents metal salts of poly-(acid-alkylene-amido)-alkanes |
| US5078986A (en) * | 1989-02-15 | 1992-01-07 | Mallinckrodt Medical, Inc. | Method for enhancing magnetic resonance imaging using an image altering agent containing an excess of chelating agent |
| US5143716A (en) * | 1991-02-01 | 1992-09-01 | Unger Evan C | Phosphorylated sugar alcohols, Mono- and Di-Saccharides as contrast agents for use in magnetic resonance imaging of the gastrointestinal region |
| US5330742A (en) * | 1991-08-05 | 1994-07-19 | Mallinckrodt Medical, Inc. | Methods and compositions for magnetic resonance imaging |
| US5250284A (en) * | 1991-10-15 | 1993-10-05 | Arnon Krongrad | Method for increasing nuclear magnetic resonance signals in living biological tissue using zinc |
| US5344640A (en) * | 1991-10-22 | 1994-09-06 | Mallinckrodt Medical, Inc. | Preparation of apatite particles for medical diagnostic imaging |
| JP2911674B2 (ja) * | 1992-02-20 | 1999-06-23 | 明治乳業株式会社 | 消化管造影用組成物 |
| US5401492A (en) * | 1992-12-17 | 1995-03-28 | Sterling Winthrop, Inc. | Water insoluble non-magnetic manganese particles as magnetic resonance contract enhancement agents |
| GB9416768D0 (en) * | 1994-08-18 | 1994-10-12 | Nycomed Innovation Ab | Compositions |
| AU688565B2 (en) * | 1994-08-18 | 1998-03-12 | Nycomed Imaging As | Compositions |
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1998
- 1998-11-02 US US09/184,835 patent/US5980863A/en not_active Expired - Lifetime
-
1999
- 1999-10-26 JP JP2000579122A patent/JP4763132B2/ja not_active Expired - Fee Related
- 1999-10-26 DE DE69941029T patent/DE69941029D1/de not_active Expired - Lifetime
- 1999-10-26 AT AT99961531T patent/ATE434406T1/de not_active IP Right Cessation
- 1999-10-26 EP EP99961531A patent/EP1126785B1/en not_active Expired - Lifetime
- 1999-10-26 CN CN99813002A patent/CN1325286A/zh active Pending
- 1999-10-26 NZ NZ511592A patent/NZ511592A/xx unknown
- 1999-10-26 WO PCT/US1999/024993 patent/WO2000025671A1/en not_active Ceased
- 1999-10-26 CA CA2349342A patent/CA2349342C/en not_active Expired - Fee Related
- 1999-10-26 AU AU18086/00A patent/AU754294B2/en not_active Ceased
- 1999-10-26 KR KR1020017005278A patent/KR100692720B1/ko not_active Expired - Fee Related
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2001
- 2001-04-19 NO NO20011946A patent/NO327611B1/no not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01259850A (ja) * | 1987-09-25 | 1989-10-17 | Salutar Inc | Ｍｎ（ＩＩ）配位組成物を使用するＮＭＲ像形成 |
Also Published As
| Publication number | Publication date |
|---|---|
| NZ511592A (en) | 2002-09-27 |
| AU1808600A (en) | 2000-05-22 |
| WO2000025671A9 (en) | 2000-10-26 |
| NO327611B1 (no) | 2009-08-31 |
| CA2349342A1 (en) | 2000-05-11 |
| AU754294B2 (en) | 2002-11-14 |
| EP1126785A4 (en) | 2006-05-17 |
| JP2002528473A (ja) | 2002-09-03 |
| ATE434406T1 (de) | 2009-07-15 |
| EP1126785A1 (en) | 2001-08-29 |
| CN1325286A (zh) | 2001-12-05 |
| DE69941029D1 (de) | 2009-08-06 |
| NO20011946L (no) | 2001-04-19 |
| EP1126785B1 (en) | 2009-06-24 |
| KR100692720B1 (ko) | 2007-03-09 |
| CA2349342C (en) | 2011-07-12 |
| NO20011946D0 (no) | 2001-04-19 |
| US5980863A (en) | 1999-11-09 |
| WO2000025671A1 (en) | 2000-05-11 |
| KR20010103622A (ko) | 2001-11-23 |
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