JP4741182B2 - 人間の皮膚へ活性剤を投与するための装置 - Google Patents
人間の皮膚へ活性剤を投与するための装置 Download PDFInfo
- Publication number
- JP4741182B2 JP4741182B2 JP2003528528A JP2003528528A JP4741182B2 JP 4741182 B2 JP4741182 B2 JP 4741182B2 JP 2003528528 A JP2003528528 A JP 2003528528A JP 2003528528 A JP2003528528 A JP 2003528528A JP 4741182 B2 JP4741182 B2 JP 4741182B2
- Authority
- JP
- Japan
- Prior art keywords
- component
- article
- barrier layer
- skin
- flange
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
しかし、このようなバリア層またはカップを使用しても、移動の問題は残っている。製造の観点から、バリア層とその周囲間のボーダーラインを処理することは困難である。接着剤および医薬はいずれにしも移動する傾向がある。更に、多くの医薬接着剤は保管または使用時に冷却流出(cold-flow)する傾向がある。
本発明は人間の皮膚に接着する接着剤面を有する物品に関し、前記物品は、連続層を構成する第一構成成分、および第一構成成分の接着剤面の凹凸もしくは凹み(indentations)に設置された少なくとも第二構成成分を含み、第二構成成分はカップ形バリア層により第一構成成分から分離し、前記バリア層はフランジへ延びたリムを有する。
本発明は人間の皮膚へ接着する接着剤面を有する物品に関し、前記物品は、連続層を構成する第一構成成分、および前記第一構成成分の接着剤面の凹凸もしくは凹みに位置する少なくとも第二構成成分を含み、前記第二構成成分はカップ形バリア層により前記第一構成成分から分離し、前記バリア層はフランジへ延びたリムを有し、前記第二構成成分は0.045mmよりも薄い平均厚を有する層で前記フランジ上に存在することを特徴とする。
Claims (9)
- 人間の皮膚へ接着する接着剤面を有する物品であって、
連続層を構成する第一構成成分、および前記第一構成成分の接着剤面内の凹みに位置する少なくとも第二構成成分を含み、
前記第二構成成分はカップ形バリア層により前記第一構成成分から分離した領域内にあり、
前記バリア層のカップ形状はフランジへ延びたリムを有し、
前記第二構成成分は0.045mmよりも薄い平均厚を有する層において前記フランジ上に存在し、
前記第二構成成分は一またはそれ以上の活性成分を含み、
前記活性成分はタコ、イボ、または硬化皮膚の処置に適していることを特徴とする、物品。 - 前記第二構成成分は0.040mmよりも薄い平均厚を有する層において前記フランジ上にのみ存在することを特徴とする、請求項1の物品。
- 前記バリア層はポリマーフィルムを含むことを特徴とする、請求項1または2の物品。
- 前記バリア層は金属フォイルを含むことを特徴とする、請求項1または2の物品。
- 前記バリア層はポリマーフィルムかつ/または金属フォイルの一またはそれ以上の層のラミネートを含むことを特徴とする、請求項1または2の物品。
- 前記第二構成成分は接着剤を含むことを特徴とする、請求項1から5のいずれか1の物品。
- 前記物品は皮膚貼付用品であることを特徴とする、請求項1から6のいずれか1の物品。
- 前記活性成分はサリチル酸であることを特徴とする、請求項1から7のいずれか1の物品。
- 前記物品は一またはそれ以上の活性成分の局部投与に使用されるものであることを特徴とする、請求項1から8のいずれか1の物品。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200101374 | 2001-09-21 | ||
DKPA200101374 | 2001-09-21 | ||
PCT/DK2002/000614 WO2003024431A1 (en) | 2001-09-21 | 2002-09-20 | Device for the administration of an active agent to the human skin |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005503403A JP2005503403A (ja) | 2005-02-03 |
JP4741182B2 true JP4741182B2 (ja) | 2011-08-03 |
Family
ID=8160718
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003528528A Expired - Fee Related JP4741182B2 (ja) | 2001-09-21 | 2002-09-20 | 人間の皮膚へ活性剤を投与するための装置 |
Country Status (9)
Country | Link |
---|---|
US (1) | US8197843B2 (ja) |
EP (1) | EP1427398B1 (ja) |
JP (1) | JP4741182B2 (ja) |
AT (1) | ATE375148T1 (ja) |
CA (1) | CA2457114C (ja) |
DE (1) | DE60222917T2 (ja) |
DK (1) | DK1427398T3 (ja) |
ES (1) | ES2294173T3 (ja) |
WO (1) | WO2003024431A1 (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1532167B1 (en) | 2002-07-17 | 2012-01-25 | Cytos Biotechnology AG | Molecular antigen arrays using a virus like particle derived from the ap205 coat protein |
US20040202708A1 (en) * | 2003-04-14 | 2004-10-14 | 3M Innovative Properties Company | Transdermal drug delivery device with translucent inorganic barrier layer |
DE102010064358A1 (de) * | 2010-12-29 | 2012-07-05 | Acino Ag | Transdermales Applikationssystem mit überstehender Backingfolie |
DE102018130469A1 (de) * | 2018-11-30 | 2020-06-04 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit Diffusionsbarriere |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4573996A (en) * | 1984-01-03 | 1986-03-04 | Jonergin, Inc. | Device for the administration of an active agent to the skin or mucosa |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3339546A (en) * | 1963-12-13 | 1967-09-05 | Squibb & Sons Inc | Bandage for adhering to moist surfaces |
EP0040862A1 (en) * | 1979-01-11 | 1981-12-02 | Key Pharmaceuticals, Inc. | Burn matrix, method of its preparation and delivery device comprising said matrix |
DK147035C (da) | 1980-12-05 | 1984-09-03 | Coloplast As | Hudplade |
US4725272A (en) * | 1981-06-29 | 1988-02-16 | Alza Corporation | Novel bandage for administering beneficial drug |
JPS5838212A (ja) | 1981-09-01 | 1983-03-05 | Daikyo Yakuhin Kogyo Kk | 貼付剤およびその製造方法 |
DE3423293C2 (de) | 1984-06-23 | 1995-08-24 | Lohmann Therapie Syst Lts | Selbstklebendes Pflaster |
JPS6327710Y2 (ja) | 1985-09-28 | 1988-07-27 | ||
US4710191A (en) * | 1985-12-16 | 1987-12-01 | Jonergin, Inc. | Therapeutic device for the administration of medicaments |
DK157899C (da) | 1987-12-15 | 1990-09-03 | Coloplast As | Hudpladeprodukt |
DK169711B1 (da) | 1993-01-15 | 1995-01-23 | Coloplast As | Hudpladeprodukt |
US5466465A (en) | 1993-12-30 | 1995-11-14 | Harrogate Holdings, Limited | Transdermal drug delivery system |
AU2264799A (en) * | 1998-01-30 | 1999-08-16 | Coloplast A/S | An article having a surface showing adhesive properties |
WO1999040888A1 (en) * | 1998-02-13 | 1999-08-19 | Buck Carol J | Compositions and methods of treating keratin-related disorders and conditions |
US6303140B1 (en) | 1999-10-13 | 2001-10-16 | Schering-Plough Healthcare Products, Inc. | Medicated device for warts, corns, calluses and nails |
-
2002
- 2002-09-20 DE DE60222917T patent/DE60222917T2/de not_active Expired - Lifetime
- 2002-09-20 US US10/490,278 patent/US8197843B2/en active Active
- 2002-09-20 ES ES02776903T patent/ES2294173T3/es not_active Expired - Lifetime
- 2002-09-20 EP EP02776903A patent/EP1427398B1/en not_active Expired - Lifetime
- 2002-09-20 DK DK02776903T patent/DK1427398T3/da active
- 2002-09-20 JP JP2003528528A patent/JP4741182B2/ja not_active Expired - Fee Related
- 2002-09-20 WO PCT/DK2002/000614 patent/WO2003024431A1/en active IP Right Grant
- 2002-09-20 CA CA2457114A patent/CA2457114C/en not_active Expired - Fee Related
- 2002-09-20 AT AT02776903T patent/ATE375148T1/de not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4573996A (en) * | 1984-01-03 | 1986-03-04 | Jonergin, Inc. | Device for the administration of an active agent to the skin or mucosa |
Also Published As
Publication number | Publication date |
---|---|
EP1427398A1 (en) | 2004-06-16 |
US20050019383A1 (en) | 2005-01-27 |
DK1427398T3 (da) | 2008-02-04 |
ES2294173T3 (es) | 2008-04-01 |
US8197843B2 (en) | 2012-06-12 |
JP2005503403A (ja) | 2005-02-03 |
CA2457114C (en) | 2010-11-23 |
ATE375148T1 (de) | 2007-10-15 |
CA2457114A1 (en) | 2003-03-27 |
DE60222917D1 (de) | 2007-11-22 |
EP1427398B1 (en) | 2007-10-10 |
DE60222917T2 (de) | 2008-08-07 |
WO2003024431A1 (en) | 2003-03-27 |
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