JP4689274B2 - 新規なシタラビン・モノホスフェートプロドラッグ - Google Patents

新規なシタラビン・モノホスフェートプロドラッグ Download PDF

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Publication number
JP4689274B2
JP4689274B2 JP2004550339A JP2004550339A JP4689274B2 JP 4689274 B2 JP4689274 B2 JP 4689274B2 JP 2004550339 A JP2004550339 A JP 2004550339A JP 2004550339 A JP2004550339 A JP 2004550339A JP 4689274 B2 JP4689274 B2 JP 4689274B2
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compound
liver
agent
ara
cytarabine
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JP2006507308A5 (https=
JP2006507308A (ja
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セルジュ・アシュ・ボワイェ
マーク・ディ・エライオン
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リガンド・ファーマシューティカルズ・インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2004550339A 2002-10-31 2003-10-31 新規なシタラビン・モノホスフェートプロドラッグ Expired - Fee Related JP4689274B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US42321102P 2002-10-31 2002-10-31
US42325902P 2002-10-31 2002-10-31
US60/423,259 2002-10-31
US60/423,211 2002-10-31
PCT/US2003/034690 WO2004041837A1 (en) 2002-10-31 2003-10-31 Novel cytarabine monophosphate prodrugs

Publications (3)

Publication Number Publication Date
JP2006507308A JP2006507308A (ja) 2006-03-02
JP2006507308A5 JP2006507308A5 (https=) 2006-12-28
JP4689274B2 true JP4689274B2 (ja) 2011-05-25

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Family Applications (2)

Application Number Title Priority Date Filing Date
JP2004550339A Expired - Fee Related JP4689274B2 (ja) 2002-10-31 2003-10-31 新規なシタラビン・モノホスフェートプロドラッグ
JP2004550353A Expired - Fee Related JP5046219B2 (ja) 2002-10-31 2003-10-31 １，３−プロパン−１−アリールジオールの新規環状リン酸ジエステルおよびそのプロドラッグへの使用

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JP2004550353A Expired - Fee Related JP5046219B2 (ja) 2002-10-31 2003-10-31 １，３−プロパン−１−アリールジオールの新規環状リン酸ジエステルおよびそのプロドラッグへの使用

Country Status (13)

Country Link
US (4) US7151092B2 (https=)
EP (2) EP1556398B1 (https=)
JP (2) JP4689274B2 (https=)
KR (2) KR101115210B1 (https=)
AT (1) ATE442375T1 (https=)
AU (2) AU2003286816B2 (https=)
BR (2) BR0315795A (https=)
CA (2) CA2503729C (https=)
DE (1) DE60329211D1 (https=)
IL (2) IL167984A (https=)
MX (2) MXPA05004503A (https=)
PL (2) PL212929B1 (https=)
WO (2) WO2004041837A1 (https=)

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JP5631414B2 (ja) * 2010-01-15 2014-11-26 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ ホスホ置換アルコキシアミン化合物
WO2011113174A1 (zh) * 2010-03-15 2011-09-22 Gao Feng 阿糖胞苷衍生物及其在抗癌抗肿瘤中的用途
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Also Published As

Publication number Publication date
JP5046219B2 (ja) 2012-10-10
JP2006504791A (ja) 2006-02-09
WO2004041834A2 (en) 2004-05-21
BR0315795A (pt) 2005-09-13
IL167990A (en) 2010-12-30
WO2004041834A3 (en) 2004-07-01
US7151092B2 (en) 2006-12-19
PL376327A1 (en) 2005-12-27
KR20050083879A (ko) 2005-08-26
AU2003287389A1 (en) 2004-06-07
IL167984A (en) 2011-09-27
CA2503729C (en) 2012-09-18
US20070021388A1 (en) 2007-01-25
KR101026294B1 (ko) 2011-03-31
ATE442375T1 (de) 2009-09-15
US20070037774A1 (en) 2007-02-15
KR20050072776A (ko) 2005-07-12
CA2503730C (en) 2011-10-18
BR0315806A (pt) 2005-09-13
US20040192651A1 (en) 2004-09-30
US20040092476A1 (en) 2004-05-13
AU2003287389B2 (en) 2010-08-12
EP1556393A2 (en) 2005-07-27
US7148349B2 (en) 2006-12-12
EP1556393B1 (en) 2013-12-25
MXPA05004504A (es) 2005-08-16
PL376474A1 (en) 2005-12-27
CA2503729A1 (en) 2004-05-21
EP1556398B1 (en) 2009-09-09
EP1556398A1 (en) 2005-07-27
PL212929B1 (pl) 2012-12-31
WO2004041837A1 (en) 2004-05-21
US7553826B2 (en) 2009-06-30
KR101115210B1 (ko) 2012-04-12
AU2003286816A1 (en) 2004-06-07
CA2503730A1 (en) 2004-05-21
JP2006507308A (ja) 2006-03-02
US7498320B2 (en) 2009-03-03
AU2003286816B2 (en) 2010-08-19
MXPA05004503A (es) 2005-08-16
DE60329211D1 (de) 2009-10-22

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