JP4678895B2 - 新規な塞栓形成組成物 - Google Patents
新規な塞栓形成組成物 Download PDFInfo
- Publication number
- JP4678895B2 JP4678895B2 JP50784297A JP50784297A JP4678895B2 JP 4678895 B2 JP4678895 B2 JP 4678895B2 JP 50784297 A JP50784297 A JP 50784297A JP 50784297 A JP50784297 A JP 50784297A JP 4678895 B2 JP4678895 B2 JP 4678895B2
- Authority
- JP
- Japan
- Prior art keywords
- composition
- biocompatible
- polymer
- catheter
- biocompatible solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 138
- 230000010102 embolization Effects 0.000 title description 37
- 239000002904 solvent Substances 0.000 claims abstract description 39
- 239000002245 particle Substances 0.000 claims abstract description 38
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 42
- 229920000642 polymer Polymers 0.000 claims description 33
- 230000002792 vascular Effects 0.000 claims description 27
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 229910052715 tantalum Inorganic materials 0.000 claims description 14
- 229920000219 Ethylene vinyl alcohol Polymers 0.000 claims description 12
- 229920001577 copolymer Polymers 0.000 claims description 11
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 8
- 238000012800 visualization Methods 0.000 claims description 8
- 230000017531 blood circulation Effects 0.000 claims description 6
- 239000002872 contrast media Substances 0.000 abstract description 50
- 229920000249 biocompatible polymer Polymers 0.000 abstract description 21
- 210000004204 blood vessel Anatomy 0.000 abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 12
- 231100000216 vascular lesion Toxicity 0.000 abstract description 3
- 238000000034 method Methods 0.000 description 25
- 206010002329 Aneurysm Diseases 0.000 description 21
- 239000002244 precipitate Substances 0.000 description 16
- 238000002347 injection Methods 0.000 description 14
- 239000007924 injection Substances 0.000 description 14
- 210000004369 blood Anatomy 0.000 description 11
- 239000008280 blood Substances 0.000 description 11
- 208000032843 Hemorrhage Diseases 0.000 description 10
- 230000000740 bleeding effect Effects 0.000 description 10
- 239000000725 suspension Substances 0.000 description 10
- 239000007788 liquid Substances 0.000 description 8
- 238000011282 treatment Methods 0.000 description 8
- 239000000178 monomer Substances 0.000 description 6
- 229920001747 Cellulose diacetate Polymers 0.000 description 5
- 208000034158 bleeding Diseases 0.000 description 5
- 239000004715 ethylene vinyl alcohol Substances 0.000 description 5
- 238000001556 precipitation Methods 0.000 description 5
- 206010028980 Neoplasm Diseases 0.000 description 4
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 4
- 238000013019 agitation Methods 0.000 description 4
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 4
- UFRKOOWSQGXVKV-UHFFFAOYSA-N ethene;ethenol Chemical compound C=C.OC=C UFRKOOWSQGXVKV-UHFFFAOYSA-N 0.000 description 4
- 238000002594 fluoroscopy Methods 0.000 description 4
- 238000011065 in-situ storage Methods 0.000 description 4
- 230000003902 lesion Effects 0.000 description 4
- 238000006116 polymerization reaction Methods 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 208000022211 Arteriovenous Malformations Diseases 0.000 description 3
- 206010003226 Arteriovenous fistula Diseases 0.000 description 3
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 3
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 description 3
- 239000005977 Ethylene Substances 0.000 description 3
- 230000005744 arteriovenous malformation Effects 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 229920002301 cellulose acetate Polymers 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 231100000252 nontoxic Toxicity 0.000 description 3
- 230000003000 nontoxic effect Effects 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 238000004062 sedimentation Methods 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000012276 Endovascular treatment Methods 0.000 description 2
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- 239000012298 atmosphere Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000005194 fractionation Methods 0.000 description 2
- 208000030304 gastrointestinal bleeding Diseases 0.000 description 2
- 238000005227 gel permeation chromatography Methods 0.000 description 2
- 230000002163 immunogen Effects 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- BPUBBGLMJRNUCC-UHFFFAOYSA-N oxygen(2-);tantalum(5+) Chemical compound [O-2].[O-2].[O-2].[O-2].[O-2].[Ta+5].[Ta+5] BPUBBGLMJRNUCC-UHFFFAOYSA-N 0.000 description 2
- XQYZDYMELSJDRZ-UHFFFAOYSA-N papaverine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 XQYZDYMELSJDRZ-UHFFFAOYSA-N 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 238000000710 polymer precipitation Methods 0.000 description 2
- 229920000098 polyolefin Polymers 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 229910001936 tantalum oxide Inorganic materials 0.000 description 2
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- 229930008281 A03AD01 - Papaverine Natural products 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 229920001651 Cyanoacrylate Polymers 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 1
- MWCLLHOVUTZFKS-UHFFFAOYSA-N Methyl cyanoacrylate Chemical group COC(=O)C(=C)C#N MWCLLHOVUTZFKS-UHFFFAOYSA-N 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 208000032851 Subarachnoid Hemorrhage Diseases 0.000 description 1
- 239000004830 Super Glue Substances 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 206010047163 Vasospasm Diseases 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 description 1
- 238000002583 angiography Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229940125681 anticonvulsant agent Drugs 0.000 description 1
- 239000001961 anticonvulsive agent Substances 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 229920006217 cellulose acetate butyrate Polymers 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- NLCKLZIHJQEMCU-UHFFFAOYSA-N cyano prop-2-enoate Chemical compound C=CC(=O)OC#N NLCKLZIHJQEMCU-UHFFFAOYSA-N 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 230000003073 embolic effect Effects 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 238000012282 endovascular technique Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- FGBJXOREULPLGL-UHFFFAOYSA-N ethyl cyanoacrylate Chemical compound CCOC(=O)C(=C)C#N FGBJXOREULPLGL-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229920002313 fluoropolymer Polymers 0.000 description 1
- 239000004811 fluoropolymer Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229920006158 high molecular weight polymer Polymers 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 238000002697 interventional radiology Methods 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 229960001789 papaverine Drugs 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920002239 polyacrylonitrile Polymers 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000002685 polymerization catalyst Substances 0.000 description 1
- 239000003505 polymerization initiator Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 238000002601 radiography Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 239000003106 tissue adhesive Substances 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 229920003176 water-insoluble polymer Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
- A61K49/0414—Particles, beads, capsules or spheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
- A61K49/0414—Particles, beads, capsules or spheres
- A61K49/0419—Microparticles, microbeads, microcapsules, microspheres, i.e. having a size or diameter higher or equal to 1 micrometer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Materials Engineering (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/507,863 | 1995-07-27 | ||
| US08/508,248 US5580568A (en) | 1995-07-27 | 1995-07-27 | Cellulose diacetate compositions for use in embolizing blood vessels |
| US08/508,248 | 1995-07-27 | ||
| US08/507,863 US5667767A (en) | 1995-07-27 | 1995-07-27 | Compositions for use in embolizing blood vessels |
| EP96925568A EP0847240B1 (en) | 1995-07-27 | 1996-07-29 | Novel embolizing compositions |
| PCT/US1996/012436 WO1997004657A1 (en) | 1995-07-27 | 1996-07-29 | Novel embolizing compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007290383A Division JP5183157B2 (ja) | 1995-07-27 | 2007-11-08 | 新規な塞栓形成組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2000505045A JP2000505045A (ja) | 2000-04-25 |
| JP2000505045A5 JP2000505045A5 (enExample) | 2004-08-26 |
| JP4678895B2 true JP4678895B2 (ja) | 2011-04-27 |
Family
ID=27238028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50784297A Expired - Lifetime JP4678895B2 (ja) | 1995-07-27 | 1996-07-29 | 新規な塞栓形成組成物 |
Country Status (9)
| Country | Link |
|---|---|
| EP (2) | EP0847240B1 (enExample) |
| JP (1) | JP4678895B2 (enExample) |
| CN (1) | CN1079642C (enExample) |
| AT (2) | ATE284715T1 (enExample) |
| AU (1) | AU6604396A (enExample) |
| CA (1) | CA2215356C (enExample) |
| DE (2) | DE69634056T2 (enExample) |
| ES (2) | ES2194110T3 (enExample) |
| WO (1) | WO1997004657A1 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6103254A (en) * | 1996-05-31 | 2000-08-15 | Micro Therapeutics, Inc. | Methods for sterilizing male mammals |
| CA2252718A1 (en) | 1996-05-31 | 1997-12-04 | Richard J. Greff | Compositions for use in embolizing blood vessels |
| EP0904089B1 (en) * | 1996-05-31 | 2002-09-11 | Micro Therapeutics, Inc. | Sterilization of female mammals |
| US5830178A (en) * | 1996-10-11 | 1998-11-03 | Micro Therapeutics, Inc. | Methods for embolizing vascular sites with an emboilizing composition comprising dimethylsulfoxide |
| JP4717164B2 (ja) * | 1996-07-29 | 2011-07-06 | マイクロ・セラピューティクス・インコーポレーテッド | ジメチルスルホキシドを含有した塞栓組成物でもって管腔サイトに塞栓を形成するための新規な方法 |
| US5785642A (en) * | 1996-10-18 | 1998-07-28 | Micro Therapeutics, Inc. | Methods for treating urinary incontinence in mammals |
| WO1998047532A1 (en) * | 1997-04-24 | 1998-10-29 | Nycomed Imaging As | Embolus therapy using insoluble microparticles or vesicles containing contrast agents |
| US6569417B2 (en) | 1997-10-10 | 2003-05-27 | Micro Therapeutics, Inc. | Methods for treating urinary incontinence in mammals |
| US6309420B1 (en) * | 1997-10-14 | 2001-10-30 | Parallax Medical, Inc. | Enhanced visibility materials for implantation in hard tissue |
| US7572263B2 (en) | 1998-04-01 | 2009-08-11 | Arthrocare Corporation | High pressure applicator |
| AU3203599A (en) | 1998-04-01 | 1999-10-18 | Parallax Medical, Inc. | Pressure applicator for hard tissue implant placement |
| US6238335B1 (en) | 1998-12-11 | 2001-05-29 | Enteric Medical Technologies, Inc. | Method for treating gastroesophageal reflux disease and apparatus for use therewith |
| US6251064B1 (en) | 1998-12-11 | 2001-06-26 | Enteric Medical Technologies, Inc. | Method for creating valve-like mechanism in natural body passageway |
| US7132582B2 (en) | 2003-05-30 | 2006-11-07 | Council Of Scientific And Industrial Research | Catalytic process for the preparation of isolongifolene |
| US6303100B1 (en) * | 1999-03-19 | 2001-10-16 | Micro Therapeutics, Inc. | Methods for inhibiting the formation of potential endoleaks associated with endovascular repair of abdominal aortic aneurysms |
| AU6168699A (en) | 1999-03-24 | 2000-10-09 | Parallax Medical, Inc. | Non-compliant system for delivery of implant material |
| US6241719B1 (en) * | 1999-05-13 | 2001-06-05 | Micro Therapeutics, Inc. | Method for forming a radioactive stent |
| JP5148030B2 (ja) | 1999-05-21 | 2013-02-20 | タイコ ヘルスケア グループ リミテッド パートナーシップ | 新規の高粘度塞栓形成組成物 |
| US6273916B1 (en) | 1999-09-02 | 2001-08-14 | Cook Incorporated | Method and apparatus for strengthening vertebral bodies |
| US6783515B1 (en) | 1999-09-30 | 2004-08-31 | Arthrocare Corporation | High pressure delivery system |
| JP4871476B2 (ja) | 2000-03-13 | 2012-02-08 | バイオコンパティブルズ ユーケー リミテッド | 塞栓組成物 |
| US7459142B2 (en) * | 2002-06-06 | 2008-12-02 | Micro Therapeutics, Inc. | High viscosity embolizing compositions comprising prepolymers |
| US20050065434A1 (en) * | 2003-09-22 | 2005-03-24 | Bavaro Vincent P. | Polymeric marker with high radiopacity for use in medical devices |
| CN100479865C (zh) * | 2003-10-27 | 2009-04-22 | 玛丽亚·赫曼纳斯·吉哈德斯·斯德赫斯 | 空气处理方法和装置 |
| US8048086B2 (en) * | 2004-02-25 | 2011-11-01 | Femasys Inc. | Methods and devices for conduit occlusion |
| US8360000B2 (en) | 2005-11-28 | 2013-01-29 | Japan Science And Technology Agency | Flocked medical instrument to be placed in the body, method of producing the medical instrument to be placed in the body and apparatus for producing the medical instrument to be placed in the body |
| CN100453125C (zh) * | 2006-11-22 | 2009-01-21 | 山东赛克赛斯药业科技有限公司 | 非粘附性医用液体栓塞剂及其应用 |
| JP2010515493A (ja) * | 2007-01-12 | 2010-05-13 | ヤンファン リー， | Ｘ線不透過性生物分解微小球型血管栓塞材料 |
| CN102100929B (zh) * | 2010-08-27 | 2013-10-02 | 上海微创医疗器械（集团）有限公司 | 一种栓塞材料及其制备方法 |
| CN102266591A (zh) * | 2011-06-17 | 2011-12-07 | 微创医疗器械(上海)有限公司 | 一种基于胶原蛋白的新型液体栓塞材料及其制备方法 |
| CN102552108B (zh) * | 2012-01-17 | 2014-06-04 | 汤小国 | 一种液体栓塞剂及其制备方法 |
| CN103126973B (zh) * | 2013-02-01 | 2015-02-18 | 安徽四正医药科技有限公司 | 用于血管瘤治疗的多糖水凝胶液体栓塞剂及其制备方法 |
| CA2925606A1 (en) * | 2015-04-23 | 2016-10-23 | Covidien Lp | Resorbable oxidized cellulose embolization solution |
| CN108079366A (zh) * | 2017-01-24 | 2018-05-29 | 珠海神平医疗科技有限公司 | 一种液体栓塞材料及其制备方法 |
| CN107875436B (zh) * | 2017-11-10 | 2020-02-18 | 杭州华微医疗科技有限公司 | 一种负载碳酸氢钠粉末的液体栓塞剂组合物及其应用 |
| CN108785691A (zh) * | 2018-07-06 | 2018-11-13 | 中南大学湘雅二医院 | 一种对微小病灶进行定位检测的人造结节及定位方法 |
| CN110964131B (zh) | 2018-09-29 | 2022-11-22 | 诺维新材有限公司 | 含有多羟基的聚合物及其制备方法和用途 |
| EP4192435A4 (en) * | 2020-09-04 | 2024-07-31 | Blackswan Vascular, Inc. | LIQUID EMBOLIC COMPOSITIONS WITH CONTROLLED RELEASE OF RADIO-DENSITY AND THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF |
| US11801058B2 (en) * | 2021-03-04 | 2023-10-31 | Accumedical Beijing Ltd. | Liquid embolic compositions |
| CN116407667A (zh) * | 2021-12-31 | 2023-07-11 | 神泓医疗科技(上海)有限公司 | 液体栓塞剂及其制备方法和应用 |
| CN116370694A (zh) * | 2021-12-31 | 2023-07-04 | 神泓医疗科技(上海)有限公司 | 液体栓塞剂及其制备方法和应用 |
| CN116407666A (zh) * | 2021-12-31 | 2023-07-11 | 神泓医疗科技(上海)有限公司 | 液体栓塞剂及其制备方法和应用 |
| CN114344551B (zh) * | 2021-12-31 | 2023-06-16 | 神泓医疗科技(上海)有限公司 | 液体栓塞组合物及其应用、医疗介入器械和介入治疗药物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4079124A (en) * | 1976-04-21 | 1978-03-14 | Medi-Physics, Inc. | Method of preparing X-ray contrast media containing ores of hafnium, tantalum and tungsten |
| US4268495A (en) * | 1979-01-08 | 1981-05-19 | Ethicon, Inc. | Injectable embolization and occlusion solution |
| DE3486088T2 (de) * | 1983-08-31 | 1993-09-30 | Sky Polymers | Einspritzbare physiologisch unbedenkliche polymerzusammensetzungen. |
| US4795741A (en) * | 1987-05-06 | 1989-01-03 | Biomatrix, Inc. | Compositions for therapeutic percutaneous embolization and the use thereof |
| DE69114782T2 (de) * | 1990-08-08 | 1996-04-18 | Takeda Chemical Industries Ltd | Intravaskulär embolisierendes Mittel mit Gehalt an einem die Angiogenesis hemmenden Stoff. |
| JP3040551B2 (ja) * | 1991-09-05 | 2000-05-15 | 株式会社カネカメディックス | 人工塞栓形成用高分子溶液 |
| JP3203382B2 (ja) * | 1992-03-13 | 2001-08-27 | 国立循環器病センター総長 | 人工塞栓形成用高分子溶液 |
| JP2736339B2 (ja) * | 1992-09-30 | 1998-04-02 | 株式会社日本感光色素研究所 | 動脈瘤の液体塞栓材料 |
| US5443454A (en) * | 1992-12-09 | 1995-08-22 | Terumo Kabushiki Kaisha | Catheter for embolectomy |
-
1996
- 1996-07-29 AU AU66043/96A patent/AU6604396A/en not_active Abandoned
- 1996-07-29 ES ES96925568T patent/ES2194110T3/es not_active Expired - Lifetime
- 1996-07-29 JP JP50784297A patent/JP4678895B2/ja not_active Expired - Lifetime
- 1996-07-29 EP EP96925568A patent/EP0847240B1/en not_active Expired - Lifetime
- 1996-07-29 EP EP02075574A patent/EP1208855B1/en not_active Expired - Lifetime
- 1996-07-29 DE DE69634056T patent/DE69634056T2/de not_active Expired - Lifetime
- 1996-07-29 WO PCT/US1996/012436 patent/WO1997004657A1/en not_active Ceased
- 1996-07-29 AT AT02075574T patent/ATE284715T1/de active
- 1996-07-29 CA CA002215356A patent/CA2215356C/en not_active Expired - Fee Related
- 1996-07-29 CN CN96196007A patent/CN1079642C/zh not_active Expired - Fee Related
- 1996-07-29 ES ES02075574T patent/ES2232711T3/es not_active Expired - Lifetime
- 1996-07-29 AT AT96925568T patent/ATE235268T1/de active
- 1996-07-29 DE DE69626992T patent/DE69626992T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU6604396A (en) | 1997-02-26 |
| JP2000505045A (ja) | 2000-04-25 |
| DE69634056T2 (de) | 2005-12-08 |
| ATE235268T1 (de) | 2003-04-15 |
| DE69634056D1 (de) | 2005-01-20 |
| EP0847240B1 (en) | 2003-03-26 |
| CA2215356C (en) | 2009-08-25 |
| DE69626992D1 (de) | 2003-04-30 |
| ES2194110T3 (es) | 2003-11-16 |
| DE69626992T2 (de) | 2003-12-18 |
| CN1192654A (zh) | 1998-09-09 |
| CA2215356A1 (en) | 1997-02-13 |
| ATE284715T1 (de) | 2005-01-15 |
| EP1208855A1 (en) | 2002-05-29 |
| EP1208855B1 (en) | 2004-12-15 |
| CN1079642C (zh) | 2002-02-27 |
| EP0847240A4 (en) | 2000-01-19 |
| EP0847240A1 (en) | 1998-06-17 |
| ES2232711T3 (es) | 2005-06-01 |
| WO1997004657A1 (en) | 1997-02-13 |
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