CA2215356C - Novel embolizing compositions - Google Patents

Novel embolizing compositions Download PDF

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Publication number
CA2215356C
CA2215356C CA002215356A CA2215356A CA2215356C CA 2215356 C CA2215356 C CA 2215356C CA 002215356 A CA002215356 A CA 002215356A CA 2215356 A CA2215356 A CA 2215356A CA 2215356 C CA2215356 C CA 2215356C
Authority
CA
Canada
Prior art keywords
composition
weight percent
biocompatible
contrast agent
tantalum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002215356A
Other languages
English (en)
French (fr)
Other versions
CA2215356A1 (en
Inventor
Richard J. Greff
Michael L. Jones
Scott Evans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Covidien LP
Original Assignee
Micro Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/508,248 external-priority patent/US5580568A/en
Priority claimed from US08/507,863 external-priority patent/US5667767A/en
Application filed by Micro Therapeutics Inc filed Critical Micro Therapeutics Inc
Publication of CA2215356A1 publication Critical patent/CA2215356A1/en
Application granted granted Critical
Publication of CA2215356C publication Critical patent/CA2215356C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414—Particles, beads, capsules or spheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414—Particles, beads, capsules or spheres
    • A61K49/0419—Microparticles, microbeads, microcapsules, microspheres, i.e. having a size or diameter higher or equal to 1 micrometer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
CA002215356A 1995-07-27 1996-07-29 Novel embolizing compositions Expired - Fee Related CA2215356C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/508,248 US5580568A (en) 1995-07-27 1995-07-27 Cellulose diacetate compositions for use in embolizing blood vessels
US08/508,248 1995-07-27
US08/507,863 US5667767A (en) 1995-07-27 1995-07-27 Compositions for use in embolizing blood vessels
US08/507,863 1995-07-27
EP96925568A EP0847240B1 (en) 1995-07-27 1996-07-29 Novel embolizing compositions

Publications (2)

Publication Number Publication Date
CA2215356A1 CA2215356A1 (en) 1997-02-13
CA2215356C true CA2215356C (en) 2009-08-25

Family

ID=27238028

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002215356A Expired - Fee Related CA2215356C (en) 1995-07-27 1996-07-29 Novel embolizing compositions

Country Status (9)

Country Link
EP (2) EP0847240B1 (enExample)
JP (1) JP4678895B2 (enExample)
CN (1) CN1079642C (enExample)
AT (2) ATE284715T1 (enExample)
AU (1) AU6604396A (enExample)
CA (1) CA2215356C (enExample)
DE (2) DE69626992T2 (enExample)
ES (2) ES2232711T3 (enExample)
WO (1) WO1997004657A1 (enExample)

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US6103254A (en) * 1996-05-31 2000-08-15 Micro Therapeutics, Inc. Methods for sterilizing male mammals
ATE223723T1 (de) * 1996-05-31 2002-09-15 Micro Therapeutics Inc Sterilisation weiblicher säugetieren
EP0928195B1 (en) 1996-05-31 2003-01-02 Micro Therapeutics, Inc. Compositions for use in embolizing blood vessels
US5830178A (en) * 1996-10-11 1998-11-03 Micro Therapeutics, Inc. Methods for embolizing vascular sites with an emboilizing composition comprising dimethylsulfoxide
AU2814697A (en) * 1996-07-29 1998-02-20 Micro Therapeutics, Inc. Novel methods for embolizing vascular sites with an embolizing composition comprising dimethylsulfoxide
US5785642A (en) * 1996-10-18 1998-07-28 Micro Therapeutics, Inc. Methods for treating urinary incontinence in mammals
CA2288292A1 (en) * 1997-04-24 1998-10-29 Nycomed Imaging As Embolus therapy using insoluble microparticles or vesicles containing contrast agents
US6569417B2 (en) 1997-10-10 2003-05-27 Micro Therapeutics, Inc. Methods for treating urinary incontinence in mammals
US6309420B1 (en) 1997-10-14 2001-10-30 Parallax Medical, Inc. Enhanced visibility materials for implantation in hard tissue
US7572263B2 (en) 1998-04-01 2009-08-11 Arthrocare Corporation High pressure applicator
AU3203599A (en) 1998-04-01 1999-10-18 Parallax Medical, Inc. Pressure applicator for hard tissue implant placement
US7132582B2 (en) 2003-05-30 2006-11-07 Council Of Scientific And Industrial Research Catalytic process for the preparation of isolongifolene
US6251064B1 (en) 1998-12-11 2001-06-26 Enteric Medical Technologies, Inc. Method for creating valve-like mechanism in natural body passageway
US6238335B1 (en) 1998-12-11 2001-05-29 Enteric Medical Technologies, Inc. Method for treating gastroesophageal reflux disease and apparatus for use therewith
US6303100B1 (en) * 1999-03-19 2001-10-16 Micro Therapeutics, Inc. Methods for inhibiting the formation of potential endoleaks associated with endovascular repair of abdominal aortic aneurysms
AU6168699A (en) 1999-03-24 2000-10-09 Parallax Medical, Inc. Non-compliant system for delivery of implant material
US6241719B1 (en) * 1999-05-13 2001-06-05 Micro Therapeutics, Inc. Method for forming a radioactive stent
EP1987847A1 (en) 1999-05-21 2008-11-05 Micro Therapeutics, Inc. Novel high viscosity embolizing compositions
CA2287112C (en) 1999-09-02 2008-02-19 Izi Medical Products, Llc Method and apparatus for strengthening vertebral bodies
US6783515B1 (en) 1999-09-30 2004-08-31 Arthrocare Corporation High pressure delivery system
WO2001068720A1 (en) 2000-03-13 2001-09-20 Biocure, Inc. Embolic compositions
US7459142B2 (en) 2002-06-06 2008-12-02 Micro Therapeutics, Inc. High viscosity embolizing compositions comprising prepolymers
US20050065434A1 (en) * 2003-09-22 2005-03-24 Bavaro Vincent P. Polymeric marker with high radiopacity for use in medical devices
CN100479865C (zh) * 2003-10-27 2009-04-22 玛丽亚·赫曼纳斯·吉哈德斯·斯德赫斯 空气处理方法和装置
US8048086B2 (en) * 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
US8360000B2 (en) 2005-11-28 2013-01-29 Japan Science And Technology Agency Flocked medical instrument to be placed in the body, method of producing the medical instrument to be placed in the body and apparatus for producing the medical instrument to be placed in the body
CN100453125C (zh) * 2006-11-22 2009-01-21 山东赛克赛斯药业科技有限公司 非粘附性医用液体栓塞剂及其应用
US20100021550A1 (en) * 2007-01-12 2010-01-28 Yanfang Li Radiopaque biodegradable vascular embolic microspheres
CN102100929B (zh) * 2010-08-27 2013-10-02 上海微创医疗器械（集团）有限公司 一种栓塞材料及其制备方法
CN102266591A (zh) * 2011-06-17 2011-12-07 微创医疗器械(上海)有限公司 一种基于胶原蛋白的新型液体栓塞材料及其制备方法
CN102552108B (zh) * 2012-01-17 2014-06-04 汤小国 一种液体栓塞剂及其制备方法
CN103126973B (zh) * 2013-02-01 2015-02-18 安徽四正医药科技有限公司 用于血管瘤治疗的多糖水凝胶液体栓塞剂及其制备方法
CA2925606A1 (en) * 2015-04-23 2016-10-23 Covidien Lp Resorbable oxidized cellulose embolization solution
WO2018137633A1 (zh) * 2017-01-24 2018-08-02 珠海神平医疗科技有限公司 一种液体栓塞材料及其制备方法
CN107875436B (zh) * 2017-11-10 2020-02-18 杭州华微医疗科技有限公司 一种负载碳酸氢钠粉末的液体栓塞剂组合物及其应用
CN108785691A (zh) * 2018-07-06 2018-11-13 中南大学湘雅二医院 一种对微小病灶进行定位检测的人造结节及定位方法
CN110964131B (zh) 2018-09-29 2022-11-22 诺维新材有限公司 含有多羟基的聚合物及其制备方法和用途
CA3191526A1 (en) * 2020-09-04 2022-03-10 Suresh S. Pai Liquid embolic compositions with controlled release of radiopaque and therapeutic compounds and methods of using the same
US11801058B2 (en) * 2021-03-04 2023-10-31 Accumedical Beijing Ltd. Liquid embolic compositions
CN116407667A (zh) * 2021-12-31 2023-07-11 神泓医疗科技(上海)有限公司 液体栓塞剂及其制备方法和应用
CN116407666A (zh) * 2021-12-31 2023-07-11 神泓医疗科技(上海)有限公司 液体栓塞剂及其制备方法和应用
CN116370694A (zh) * 2021-12-31 2023-07-04 神泓医疗科技(上海)有限公司 液体栓塞剂及其制备方法和应用
CN114344551B (zh) * 2021-12-31 2023-06-16 神泓医疗科技(上海)有限公司 液体栓塞组合物及其应用、医疗介入器械和介入治疗药物
CN116785492B (zh) * 2022-03-14 2026-08-07 神泓医疗科技(上海)有限公司 液体栓塞剂及其制备方法和应用

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JP3040551B2 (ja) * 1991-09-05 2000-05-15 株式会社カネカメディックス 人工塞栓形成用高分子溶液
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Also Published As

Publication number Publication date
DE69634056T2 (de) 2005-12-08
EP0847240A4 (en) 2000-01-19
WO1997004657A1 (en) 1997-02-13
CA2215356A1 (en) 1997-02-13
AU6604396A (en) 1997-02-26
EP1208855B1 (en) 2004-12-15
CN1192654A (zh) 1998-09-09
JP2000505045A (ja) 2000-04-25
EP1208855A1 (en) 2002-05-29
DE69626992T2 (de) 2003-12-18
ES2194110T3 (es) 2003-11-16
DE69626992D1 (de) 2003-04-30
EP0847240A1 (en) 1998-06-17
ATE284715T1 (de) 2005-01-15
ATE235268T1 (de) 2003-04-15
CN1079642C (zh) 2002-02-27
EP0847240B1 (en) 2003-03-26
DE69634056D1 (de) 2005-01-20
JP4678895B2 (ja) 2011-04-27
ES2232711T3 (es) 2005-06-01

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Effective date: 20150729