JP4587294B2 - Ｐｄｅ４インヒビターとしての２−ヒドロキシ−６−フェニルフェナントリジン - Google Patents

Ｐｄｅ４インヒビターとしての２−ヒドロキシ−６−フェニルフェナントリジン Download PDF

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Publication number
JP4587294B2
JP4587294B2 JP2004532133A JP2004532133A JP4587294B2 JP 4587294 B2 JP4587294 B2 JP 4587294B2 JP 2004532133 A JP2004532133 A JP 2004532133A JP 2004532133 A JP2004532133 A JP 2004532133A JP 4587294 B2 JP4587294 B2 JP 4587294B2
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10brs
4ars
methoxy
hydrogen
dimethoxy
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JP2005539043A (ja
JP2005539043A5 (https=
Inventor
カウツ ウルリッヒ
シュミット ベアーテ
フロッカーツィ ディーター
グルントラー ゲアハルト
ナーフェ リュディガー
フンメル ロルフ−ペーター
シュトゥルム エルンスト
ハッツェルマン アルミン
バルズィヒ ヨハネス
マルクス デーゲンハルト
クレイ ハンス−ペーター
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Takeda GmbH
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Nycomed GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • AIDS & HIV (AREA)
JP2004532133A 2002-08-29 2003-08-28 Ｐｄｅ４インヒビターとしての２−ヒドロキシ−６−フェニルフェナントリジン Expired - Fee Related JP4587294B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02019335 2002-08-29
PCT/EP2003/009547 WO2004019944A1 (en) 2002-08-29 2003-08-28 2-hydroxy-6-phenylphenanthridines as pde-4 inhibitors

Publications (3)

Publication Number Publication Date
JP2005539043A JP2005539043A (ja) 2005-12-22
JP2005539043A5 JP2005539043A5 (https=) 2006-10-12
JP4587294B2 true JP4587294B2 (ja) 2010-11-24

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ID=31970271

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JP2004532133A Expired - Fee Related JP4587294B2 (ja) 2002-08-29 2003-08-28 Ｐｄｅ４インヒビターとしての２−ヒドロキシ−６−フェニルフェナントリジン

Country Status (9)

Country Link
US (2) US7329676B2 (https=)
EP (1) EP1539164B1 (https=)
JP (1) JP4587294B2 (https=)
AT (1) ATE348616T1 (https=)
AU (1) AU2003255493B8 (https=)
CA (1) CA2495827C (https=)
DE (1) DE60310576T2 (https=)
ES (1) ES2279215T3 (https=)
WO (1) WO2004019944A1 (https=)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
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PL2589599T4 (pl) * 2004-03-03 2015-06-30 Takeda Gmbh Nowe hydroksy-6-heteroarylofenantrydyny i ich zastosowanie jako inhibitorów PDE4
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GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
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WO2007045477A2 (en) 2005-10-21 2007-04-26 Novartis Ag Human antibodies against il-13 and therapeutic uses
GB0526244D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
PT2322525E (pt) 2006-04-21 2013-12-26 Novartis Ag Derivados de purina para utilização como agonistas do recetor de adenosina a2a
JP2010508315A (ja) 2006-10-30 2010-03-18 ノバルティス アーゲー 抗炎症剤としてのヘテロ環式化合物
RS51644B (sr) 2007-01-10 2011-10-31 Irm Llc. Jedinjenja i preparati kao inhibitori kanal aktivirajuće proteaze
CN101687851B (zh) 2007-05-07 2013-02-27 诺瓦提斯公司 有机化合物
ES2460897T3 (es) 2007-10-04 2014-05-14 F. Hoffmann-La Roche Ag Derivados de ciclopropil aril amida y usos de los mismos
CL2008003651A1 (es) 2007-12-10 2009-06-19 Novartis Ag Compuestos derivados de 3,5-diamino-6-cloropirazinamida sustituida; composicion farmaceutica; combinacion farmaceutica; y uso en el tratamiento de una condición inflamatoria o alergica, en particular una enfermedad inflamatoria u obstructiva de las vias respiratorias.
AU2009203693B2 (en) 2008-01-11 2012-06-07 Novartis Ag Pyrimidines as kinase inhibitors
CA2727196A1 (en) 2008-06-10 2009-12-17 Novartis Ag Organic compounds
PL2391366T3 (pl) 2009-01-29 2013-04-30 Novartis Ag Podstawione benzimidazole do leczenia gwiaździaków
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
EA201200260A1 (ru) 2009-08-12 2012-09-28 Новартис Аг Гетероциклические гидразоны и их применение для лечения рака и воспаления
NZ598220A (en) 2009-08-17 2014-02-28 Intellikine Llc Heterocyclic compounds and uses thereof
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US20110098311A1 (en) 2009-10-22 2011-04-28 Vertex Pharmaceuticals Incorported Compositions for treatment of cystic fibrosis and other chronic diseases
US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
UY33597A (es) 2010-09-09 2012-04-30 Irm Llc Compuestos y composiciones como inhibidores de la trk
US8372845B2 (en) 2010-09-17 2013-02-12 Novartis Ag Pyrazine derivatives as enac blockers
EP2673277A1 (en) 2011-02-10 2013-12-18 Novartis AG [1, 2, 4]triazolo [4, 3 -b]pyridazine compounds as inhibitors of the c-met tyrosine kinase
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MA34969B1 (fr) 2011-02-25 2014-03-01 Irm Llc Composes et compositions en tant qu inibiteurs de trk
US8883819B2 (en) 2011-09-01 2014-11-11 Irm Llc Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
CA2848809A1 (en) 2011-09-15 2013-03-21 Novartis Ag 6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyradines as c-met tyrosine kinase
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WO2013038378A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine amide derivatives
WO2013038386A1 (en) 2011-09-16 2013-03-21 Novartis Ag Heterocyclic compounds for the treatment of cystic fibrosis
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JP2005539043A (ja) 2005-12-22
US7632844B2 (en) 2009-12-15
US20080319067A1 (en) 2008-12-25
AU2003255493B8 (en) 2009-03-26
US7329676B2 (en) 2008-02-12
CA2495827A1 (en) 2004-03-11
ATE348616T1 (de) 2007-01-15

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