JP4570874B2 - 植物から誘導されるか又は誘導し得る食欲抑制活性を有する物質 - Google Patents
植物から誘導されるか又は誘導し得る食欲抑制活性を有する物質 Download PDFInfo
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- JP4570874B2 JP4570874B2 JP2003543614A JP2003543614A JP4570874B2 JP 4570874 B2 JP4570874 B2 JP 4570874B2 JP 2003543614 A JP2003543614 A JP 2003543614A JP 2003543614 A JP2003543614 A JP 2003543614A JP 4570874 B2 JP4570874 B2 JP 4570874B2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Nutrition Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Polymers & Plastics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Description
i)前記の最初のバイオマスを乾燥し、乾燥粉末に粉砕することによって、
ii)植物バイオマスを圧搾し、樹液を回収し、次いで該樹液を乾燥することによって、
iii)適切な溶媒を用いて前記植物バイオマスの抽出液(これは粗抽出液として使用してもよいし又はさらに分別してもよい)を調製することによって、
iv)前記植物バイオマスから純粋物質、特にプレグナングリコシド類を単離することによって、
調製し得る。
(i)前記植物の植物性物質を乾燥して粗粉末に粉砕し;
(ii)前記粉末を溶媒で抽出して抽出液を形成し;
(iii)前記抽出液を多数の画分に分別し;
(iv)前記の多数の画分を濃縮又は乾燥し;次いで
(v)食欲の抑制に効果がある画分を選択する
工程の1つ又はそれ以上によって調製し得る。
(実施例)
分類学的に同定された植物バイオマス(茎)を凍結乾燥し、コーヒー粉砕機又はその均等物を使用して微細粉末に粉砕した。抽出方法:100mlのエタノールを、10gの植物粉末に加え、室温で15時間攪拌した。各試料を濾過し、得られた抽出液を真空下で濃縮して乾固した。試料250mgを、ラット満腹モデルにおける試験に使用した。
動物:これらの試験は、雄性スプラーグ・ドーリーラット〔RA238系OFA/IC;IFFA−CREDO、l’Arbresle産(仏国セデックス所在)〕を用いて行った。前記動物の体重が270gから290gに到達した時点で、実験に先立ち動物をMacrolone type IVケージに5つの群で飼育した。動物は、温度及び湿度を調節した環境(21℃から23℃;湿度47%)中で12:12の明暗サイクル(消灯18:00)の下で飼育した。実験の開始3日前に、動物を秤量し、それぞれをMacrolone type IIIAケージで飼育し、記録装置を備えた部屋に移した。この部屋は、温度及び湿度について上記と同様に調節し、その部屋にはその他の動物を住まわせなかった。標準ラット用チャウペレット(Nafag Ecosan 890、Gossau、スイス国)と水道水を自由に採取できるように存在させ、消費された食物の連続記録を可能にする部分変更した食事桶と飲用吸い込み口により提供した。
Claims (14)
- 食欲の抑制が必要なヒト又はその他の哺乳動物において食欲を抑制するための医薬の製造における、王犀角及びオルベア・ヴァリエガタの植物の少なくとも1種から得た又は得られる植物性物質の0.01mgから200mg/kg体重/日の使用。
- 肥満症の治療及び/又は予防を必要とするヒト又はその他の哺乳動物において肥満症の治療及び/又は予防するための医薬の製造における、王犀角及びオルベア・ヴァリエガタの植物の少なくとも1種から得た又は得られる植物性物質の0.01mgから200mg/kg体重/日の使用。
- 体重減少又は所望の体重維持を必要とするヒト又はその他の哺乳動物において体重減少又は所望の体重維持を促進するための医薬の製造における、王犀角及びオルベア・ヴァリエガタの植物の少なくとも1種から得た又は得られる植物性物質の0.01mgから200mg/kg体重/日の使用。
- 前記の植物性物質が、王犀角及びオルベア・ヴァリエガタの植物の少なくとも1種の植物から得たか又は得られる樹液、濃縮物、抽出物、画分又は活性化合物である、請求項1から3のいずれか1項に記載の使用。
- 前記の植物性物質が有効量の1種又はそれ以上のサポニンを含有するものである、請求項1から3のいずれか1項に記載の使用。
- 前記の植物性物質が有効量のスタバロシドA、B及びCのうちの少なくとも1種を含有する、請求項1から3のいずれか1項に記載の使用。
- 有効量のスタバロシドCが含有される、請求項6に記載の使用。
- 前記の濃縮物、抽出物、画分又は活性化合物が前記の植物性物質をアルコール系溶媒で処理する工程を含む方法によって得られたものである、請求項4に記載の使用。
- 王犀角及びオルベア・ヴァリエガタの植物の少なくとも1種の植物から得られたか又は得られる植物性物質を含有してなる食欲抑制薬組成物。
- 王犀角及びオルベア・ヴァリエガタの植物の少なくとも1種の植物から得られたか又は得られる植物性物質の0.01mgから200mg/kg体重/日と、製薬学的に有効な担体とを含有してなる肥満症の治療及び/又は予防用の医薬品。
- 王犀角及びオルベア・ヴァリエガタの植物の少なくとも1種の植物から得られたか又は得られる植物性物質を含有する組成物の使用であって、食欲を抑制又は抑止用の医薬又は医薬組成物の製造における使用。
- 王犀角及びオルベア・ヴァリエガタの植物の少なくとも1種の植物から得られたか又は得られる植物性物質を含有する組成物の使用であって、肥満症の治療及び/又は予防用の医薬又は医薬組成物の製造における使用。
- 王犀角及びオルベア・ヴァリエガタの植物の少なくとも1種の植物から得られたか又は得られる植物性物質を含有する組成物の使用であって、体重減少又は所望の体重維持を促進するための医薬又は医薬組成物の製造における使用。
- (i)前記植物の植物性物質を乾燥して粗粉末に粉砕し;
(ii)前記粉末を溶媒で抽出して抽出液を形成し;
(iii)前記抽出液を多数の画分に分別し;
(iv)前記の多数の画分を濃縮又は乾燥し;次いで
(v)食欲の抑制に効果がある画分を選択する
ことからなる王犀角及びオルベア・ヴァリエガタの植物の少なくとも1種の植物の食欲抑制画分の調製方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33240101P | 2001-11-16 | 2001-11-16 | |
PCT/EP2002/012301 WO2003041727A2 (en) | 2001-11-16 | 2002-11-04 | Plant derived or derivable material with appetite suppressing activity |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2005519029A JP2005519029A (ja) | 2005-06-30 |
JP2005519029A5 JP2005519029A5 (ja) | 2006-01-05 |
JP4570874B2 true JP4570874B2 (ja) | 2010-10-27 |
Family
ID=23298062
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003543614A Expired - Fee Related JP4570874B2 (ja) | 2001-11-16 | 2002-11-04 | 植物から誘導されるか又は誘導し得る食欲抑制活性を有する物質 |
Country Status (5)
Country | Link |
---|---|
US (3) | US7008648B2 (ja) |
EP (2) | EP1448213A2 (ja) |
JP (1) | JP4570874B2 (ja) |
BR (1) | BR0214216A (ja) |
WO (1) | WO2003041727A2 (ja) |
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US7976880B2 (en) * | 2003-06-04 | 2011-07-12 | Ramaswamy Rajendran | Pregnane glycoside compositions and Caralluma extract products and uses thereof |
US7060308B2 (en) * | 2003-06-04 | 2006-06-13 | Ramaswamy Rajendran | Caralluma extract products and processes for making the same |
US8877178B2 (en) | 2003-12-19 | 2014-11-04 | The Iams Company | Methods of use of probiotic bifidobacteria for companion animals |
US20050158294A1 (en) | 2003-12-19 | 2005-07-21 | The Procter & Gamble Company | Canine probiotic Bifidobacteria pseudolongum |
JP4881294B2 (ja) * | 2004-04-07 | 2012-02-22 | ラトガーズ, ザ ステイト ユニバーシティ オブ ニュー ジャージー | 食欲抑制性組成物及び方法 |
GB0411703D0 (en) * | 2004-05-25 | 2004-06-30 | Phytopharm Plc | Selective separation or extraction of steroidal glycosides |
US7500679B2 (en) * | 2004-10-08 | 2009-03-10 | Wade James T | Board for supporting front of snow vehicle |
US20060083795A1 (en) * | 2004-10-19 | 2006-04-20 | Lima Shatkina | Meal replacement products having appetite suppressing qualities |
JP4938006B2 (ja) | 2005-05-31 | 2012-05-23 | ザ・アイムス・カンパニー | ネコ科動物プロバイオティク・ビフィドバクテリア |
AU2006253006B8 (en) | 2005-05-31 | 2011-09-15 | Alimentary Health Ltd | Feline probiotic Lactobacilli |
US20070082114A1 (en) * | 2005-10-07 | 2007-04-12 | Catani Steven J | Methods for reducing weight |
US20070082030A1 (en) * | 2005-10-07 | 2007-04-12 | Aimutis William R | Fiber satiety compositions |
US20070082025A1 (en) * | 2005-10-07 | 2007-04-12 | Catani Steven J | Methods for achieving and maintaining weight loss |
US20070082026A1 (en) * | 2005-10-07 | 2007-04-12 | Aimutis William R Jr | Compositions and methods for reducing food intake and controlling weight |
US20070082084A1 (en) * | 2005-10-07 | 2007-04-12 | Catani Steven J | Methods for weight management |
US20070082107A1 (en) * | 2005-10-07 | 2007-04-12 | Aimutis William R Jr | Compositions and methods for reducing food intake and controlling weight |
US20070082029A1 (en) * | 2005-10-07 | 2007-04-12 | Aimutis William R | Fiber satiety compositions |
US20070082028A1 (en) * | 2005-10-07 | 2007-04-12 | Aimutis William R Jr | Compositions and methods for inducing satiety and reducing caloric intake |
US20070082108A1 (en) * | 2005-10-07 | 2007-04-12 | Aimutis William R Jr | Methods for reducing calorie intake |
US20070082115A1 (en) * | 2005-10-07 | 2007-04-12 | Aimutis William Ronald Jr | Methods for inducing satiety, reducing food intake and reducing weight |
US20070082085A1 (en) * | 2005-10-07 | 2007-04-12 | Catani Steven J | Compositions and methods for reducing food intake and controlling weight |
US8945652B2 (en) | 2005-11-23 | 2015-02-03 | The Coca-Cola Company | High-potency sweetener for weight management and compositions sweetened therewith |
AU2006330112A1 (en) * | 2005-12-24 | 2007-07-05 | Dsm Ip Assets B.V. | Long term weight maintenance |
US20070207227A1 (en) * | 2006-02-23 | 2007-09-06 | Conopco, Inc., D/B/A Unilever, A Corporation Of New York | Appetite suppressant compositions |
BRPI0711240A2 (pt) * | 2006-06-13 | 2011-08-30 | Unilever Nv | produto de proção única e método para a supressão do apetite |
CA2660464A1 (en) * | 2006-08-17 | 2008-02-21 | Unilever Plc | Processes for production of hoodia plant extracts containing steroidal glycosides |
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US20080085354A1 (en) * | 2006-10-06 | 2008-04-10 | Teresa Marie Paeschke | Controlled hydration of hydrocolloids |
EP2120979A1 (en) * | 2006-12-21 | 2009-11-25 | Unilever N.V. | Process for harvesting plants of the apocynaceae family |
EP2124966B1 (en) | 2007-02-01 | 2015-09-09 | IAMS Europe B.V. | Method for decreasing inflammation and stress in a mammal using glucose antimetabolites, avocado or avocado extracts |
US7767248B2 (en) * | 2007-02-02 | 2010-08-03 | Overly Iii Harry J | Soft chew confectionary with high fiber and sugar content and method for making same |
US20080188447A1 (en) * | 2007-02-02 | 2008-08-07 | Svyatoslav Komarnytsky | Glucocorticoid-lowering composition |
US20090011079A1 (en) * | 2007-07-02 | 2009-01-08 | Bestsweet, Inc. | Hard Coated Confectionary Having A Consumable Soft Chewing Core With An Active And Method For Making Same |
US20090041902A1 (en) * | 2007-08-10 | 2009-02-12 | Jadwiga Malgorzata Bialek | Composite food product in a pack comprising fibers and method for preparing such product |
EP2080517A1 (en) | 2008-01-18 | 2009-07-22 | Unilever N.V. | Process for obtaining dried plant material |
US20090324757A1 (en) * | 2008-03-31 | 2009-12-31 | Rutgers, The State University Of New Jersey | Compositions and Methods for Modulating Visceral Sensation and/or Gastrointestinal Reflex Activity |
US20090263510A1 (en) | 2008-04-21 | 2009-10-22 | Conopco, Inc., D/B/A Unilever | Process of making Hoodia plant extract with improved flavor |
US7923435B2 (en) | 2008-04-21 | 2011-04-12 | Phytopharm Plc | Hoodia plant extract with improved flavor |
US9771199B2 (en) | 2008-07-07 | 2017-09-26 | Mars, Incorporated | Probiotic supplement, process for making, and packaging |
US10104903B2 (en) | 2009-07-31 | 2018-10-23 | Mars, Incorporated | Animal food and its appearance |
EP2329836A1 (en) | 2009-12-03 | 2011-06-08 | I.R.B. Istituto Di Ricerche Biotecnologiche S.r.l. | Extracts obtained from hoodia gordonii cells lines, their preparation and use |
TW201242521A (en) * | 2011-04-26 | 2012-11-01 | Sheng-I Lu | Method of producing food from plants and apparatus thereof |
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JP2551012B2 (ja) * | 1987-07-20 | 1996-11-06 | ライオン株式会社 | 口腔用組成物 |
JPH07184548A (ja) * | 1993-12-28 | 1995-07-25 | Meiji Seito Kk | 口腔用組成物 |
GEP20022709B (en) | 1997-04-15 | 2002-06-25 | Csir Za | Pharmaceutical Compositions Having Appetite Suppressant Activity |
JP2000175649A (ja) * | 1998-12-11 | 2000-06-27 | Sanei Gen Ffi Inc | ギムネマ酸を含有する甘味組成物 |
ES2314100T3 (es) * | 2001-05-03 | 2009-03-16 | Monsanto Technology Llc | Derivados de piruvato. |
EP1763359B1 (en) * | 2004-04-27 | 2014-10-08 | Ramaswamy Rajendran | Use of pregnane glycosides in the treatment/management of obesity |
-
2002
- 2002-11-04 EP EP02787555A patent/EP1448213A2/en not_active Withdrawn
- 2002-11-04 BR BR0214216-3A patent/BR0214216A/pt not_active Application Discontinuation
- 2002-11-04 WO PCT/EP2002/012301 patent/WO2003041727A2/en active Application Filing
- 2002-11-04 JP JP2003543614A patent/JP4570874B2/ja not_active Expired - Fee Related
- 2002-11-04 EP EP08013122A patent/EP1994837A3/en not_active Withdrawn
- 2002-11-04 US US10/287,049 patent/US7008648B2/en not_active Expired - Fee Related
-
2005
- 2005-09-19 US US11/230,013 patent/US20060024389A1/en not_active Abandoned
- 2005-09-19 US US11/230,012 patent/US7482028B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1994837A3 (en) | 2009-11-11 |
US7008648B2 (en) | 2006-03-07 |
US7482028B2 (en) | 2009-01-27 |
WO2003041727A2 (en) | 2003-05-22 |
US20060024388A1 (en) | 2006-02-02 |
EP1448213A2 (en) | 2004-08-25 |
WO2003041727A3 (en) | 2003-09-25 |
JP2005519029A (ja) | 2005-06-30 |
EP1994837A2 (en) | 2008-11-26 |
US20030152648A1 (en) | 2003-08-14 |
US20060024389A1 (en) | 2006-02-02 |
BR0214216A (pt) | 2004-09-21 |
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