JP4566128B2 - イリノテカン塩酸塩の結晶多形の製造方法 - Google Patents
イリノテカン塩酸塩の結晶多形の製造方法 Download PDFInfo
- Publication number
- JP4566128B2 JP4566128B2 JP2005502882A JP2005502882A JP4566128B2 JP 4566128 B2 JP4566128 B2 JP 4566128B2 JP 2005502882 A JP2005502882 A JP 2005502882A JP 2005502882 A JP2005502882 A JP 2005502882A JP 4566128 B2 JP4566128 B2 JP 4566128B2
- Authority
- JP
- Japan
- Prior art keywords
- irinotecan hydrochloride
- crystals
- irinotecan
- type crystal
- type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003046908 | 2003-02-25 | ||
| JP2003046908 | 2003-02-25 | ||
| PCT/JP2004/002126 WO2004076460A1 (ja) | 2003-02-25 | 2004-02-24 | イリノテカン塩酸塩の結晶多形の製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2004076460A1 JPWO2004076460A1 (ja) | 2006-06-01 |
| JP4566128B2 true JP4566128B2 (ja) | 2010-10-20 |
Family
ID=32923248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005502882A Expired - Fee Related JP4566128B2 (ja) | 2003-02-25 | 2004-02-24 | イリノテカン塩酸塩の結晶多形の製造方法 |
Country Status (12)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060046993A1 (en) * | 2004-09-01 | 2006-03-02 | Pharmacia Italia S.P.A. | Crystalline polymorphic form of irinotecan hydrochloride |
| WO2006038526A1 (ja) * | 2004-10-01 | 2006-04-13 | Kabushiki Kaisha Yakult Honsha | イリノテカン酸付加塩 |
| EP1951235B1 (en) | 2005-09-20 | 2010-03-10 | Scinopharm Singapore Pte, Ltd. | Novel crystal forms of irinotecan hydrochloride |
| CN101318964B (zh) * | 2007-06-07 | 2010-12-15 | 上海迪赛诺医药发展有限公司 | 盐酸伊立替康新晶型及其制备方法 |
| US7572803B2 (en) * | 2007-10-25 | 2009-08-11 | The Christus Stehlin Foundation For Cancer Research | Hydrated crystalline esters of camptothecin |
| IT1391757B1 (it) * | 2008-11-11 | 2012-01-27 | Antibioticos Spa | Irinotecan cloridrato cristallino e metodi per la sua preparazione |
| CN102311443B (zh) * | 2011-08-24 | 2014-07-16 | 上海北卡医药技术有限公司 | 盐酸伊立替康的新晶型及其制备方法 |
| CN102617584B (zh) * | 2012-03-14 | 2013-10-16 | 海南锦瑞制药股份有限公司 | 一种盐酸伊立替康化合物及其药物组合物 |
| CN111100135A (zh) * | 2019-10-24 | 2020-05-05 | 连云港杰瑞药业有限公司 | 一种盐酸伊立替康的精制方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005525367A (ja) * | 2002-03-01 | 2005-08-25 | フアルマシア・イタリア・エツセ・ピー・アー | 塩酸イリノテカンの結晶多形 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6247193A (ja) | 1985-08-26 | 1987-02-28 | 内橋エステック株式会社 | 電子部品のはんだ付方法 |
| JPH034077A (ja) | 1989-05-30 | 1991-01-10 | Nissho Corp | 逆止弁 |
| JPH07277981A (ja) | 1994-04-12 | 1995-10-24 | Yakult Honsha Co Ltd | 徐放性抗腫瘍製剤 |
| JPH1017472A (ja) | 1996-07-04 | 1998-01-20 | Yakult Honsha Co Ltd | 徐放性抗腫瘍製剤 |
-
2004
- 2004-02-24 WO PCT/JP2004/002126 patent/WO2004076460A1/ja active Application Filing
- 2004-02-24 NZ NZ541990A patent/NZ541990A/en not_active IP Right Cessation
- 2004-02-24 US US10/546,687 patent/US7488825B2/en not_active Expired - Fee Related
- 2004-02-24 KR KR1020057014560A patent/KR101095382B1/ko not_active IP Right Cessation
- 2004-02-24 BR BRPI0407791-1A patent/BRPI0407791A/pt not_active IP Right Cessation
- 2004-02-24 EP EP04714012A patent/EP1598356A4/en not_active Withdrawn
- 2004-02-24 CN CNB2004800047816A patent/CN100418970C/zh not_active Expired - Fee Related
- 2004-02-24 AU AU2004215560A patent/AU2004215560B2/en not_active Ceased
- 2004-02-24 CA CA2516643A patent/CA2516643C/en not_active Expired - Fee Related
- 2004-02-24 JP JP2005502882A patent/JP4566128B2/ja not_active Expired - Fee Related
- 2004-02-25 TW TW093104774A patent/TW200508239A/zh not_active IP Right Cessation
-
2005
- 2005-08-18 IL IL170350A patent/IL170350A/en not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005525367A (ja) * | 2002-03-01 | 2005-08-25 | フアルマシア・イタリア・エツセ・ピー・アー | 塩酸イリノテカンの結晶多形 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2516643C (en) | 2011-04-19 |
| US20060234904A1 (en) | 2006-10-19 |
| WO2004076460A1 (ja) | 2004-09-10 |
| BRPI0407791A (pt) | 2006-02-14 |
| KR20050100661A (ko) | 2005-10-19 |
| CN1751048A (zh) | 2006-03-22 |
| CN100418970C (zh) | 2008-09-17 |
| AU2004215560B2 (en) | 2009-09-24 |
| JPWO2004076460A1 (ja) | 2006-06-01 |
| TW200508239A (en) | 2005-03-01 |
| EP1598356A4 (en) | 2008-07-02 |
| NZ541990A (en) | 2009-04-30 |
| US7488825B2 (en) | 2009-02-10 |
| IL170350A (en) | 2010-11-30 |
| CA2516643A1 (en) | 2004-09-10 |
| TWI326684B (US07521420-20090421-C00691.png) | 2010-07-01 |
| AU2004215560A1 (en) | 2004-09-10 |
| KR101095382B1 (ko) | 2011-12-16 |
| EP1598356A1 (en) | 2005-11-23 |
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