JP4550947B2 - ガングリオシドgm2に対するヒト型相補性決定領域(cdr)移植抗体 - Google Patents

ガングリオシドgm2に対するヒト型相補性決定領域(cdr)移植抗体 Download PDF

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JP4550947B2
JP4550947B2 JP06698197A JP6698197A JP4550947B2 JP 4550947 B2 JP4550947 B2 JP 4550947B2 JP 06698197 A JP06698197 A JP 06698197A JP 6698197 A JP6698197 A JP 6698197A JP 4550947 B2 JP4550947 B2 JP 4550947B2
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antibody
ser
chain
region
human
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Japanese (ja)
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JPH10257893A (ja
JPH10257893A5 (enExample
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和靖 中村
陳雄 花井
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Kyowa Kirin Co Ltd
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Kyowa Hakko Kirin Co Ltd
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Priority to JP06698197A priority Critical patent/JP4550947B2/ja
Application filed by Kyowa Hakko Kirin Co Ltd filed Critical Kyowa Hakko Kirin Co Ltd
Priority to DE69824234T priority patent/DE69824234T2/de
Priority to AT98105047T priority patent/ATE268382T1/de
Priority to AU59420/98A priority patent/AU751948B2/en
Priority to EP98105047A priority patent/EP0882794B1/en
Priority to CA002226400A priority patent/CA2226400C/en
Priority to ES98105047T priority patent/ES2219802T3/es
Publication of JPH10257893A publication Critical patent/JPH10257893A/ja
Publication of JPH10257893A5 publication Critical patent/JPH10257893A5/ja
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734Complement-dependent cytotoxicity [CDC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP06698197A 1997-03-19 1997-03-19 ガングリオシドgm2に対するヒト型相補性決定領域(cdr)移植抗体 Expired - Lifetime JP4550947B2 (ja)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP06698197A JP4550947B2 (ja) 1997-03-19 1997-03-19 ガングリオシドgm2に対するヒト型相補性決定領域(cdr)移植抗体
AT98105047T ATE268382T1 (de) 1997-03-19 1998-03-19 MENSCHLICHE-ßCDR-GRAFTEDß-ANTIKÖRPER GEGEN GANGLIOSID GM2
AU59420/98A AU751948B2 (en) 1997-03-19 1998-03-19 Human complementarity determining region (CDR)-grafted antibody to ganglioside GM2
EP98105047A EP0882794B1 (en) 1997-03-19 1998-03-19 Human complementarity determining region (CDR)-grafted antibody to ganglioside gm2
DE69824234T DE69824234T2 (de) 1997-03-19 1998-03-19 Menschliche"CDR-grafted"-Antikörper gegen Gangliosid GM2
CA002226400A CA2226400C (en) 1997-03-19 1998-03-19 Human complementarity determining region (cdr) - grafted antibody to ganglioside gm2
ES98105047T ES2219802T3 (es) 1997-03-19 1998-03-19 Anticuerpo contra el glangliosido gm2, injertado en la zona de determinacion de complementariedad humana (cdr).

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP06698197A JP4550947B2 (ja) 1997-03-19 1997-03-19 ガングリオシドgm2に対するヒト型相補性決定領域(cdr)移植抗体

Publications (3)

Publication Number Publication Date
JPH10257893A JPH10257893A (ja) 1998-09-29
JPH10257893A5 JPH10257893A5 (enExample) 2005-02-24
JP4550947B2 true JP4550947B2 (ja) 2010-09-22

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP06698197A Expired - Lifetime JP4550947B2 (ja) 1997-03-19 1997-03-19 ガングリオシドgm2に対するヒト型相補性決定領域(cdr)移植抗体

Country Status (7)

Country Link
EP (1) EP0882794B1 (enExample)
JP (1) JP4550947B2 (enExample)
AT (1) ATE268382T1 (enExample)
AU (1) AU751948B2 (enExample)
CA (1) CA2226400C (enExample)
DE (1) DE69824234T2 (enExample)
ES (1) ES2219802T3 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014088040A1 (ja) 2012-12-06 2014-06-12 国立大学法人 金沢大学 中皮腫の治療方法

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6407734B1 (en) 1994-10-31 2002-06-18 Nec-Mitsubishi Electric Visual Systems Corporation Power supply system capable of reducing power consumption during interruption of an external input signal given to an operating circuit
US7241568B2 (en) 1996-04-03 2007-07-10 Kyowa Hakko Kogyo Co., Ltd. Anti-fibroblast growth factor-8 monoclonal antibody
PT1914244E (pt) 1999-04-09 2013-07-26 Kyowa Hakko Kirin Co Ltd Processo para regular a actividade de moléculas funcionais sob o ponto de vista imunológico
US6693176B1 (en) 1999-07-23 2004-02-17 University Of Massachusetts Antitumor antibodies, proteins, and uses thereof
AU7449200A (en) * 1999-09-30 2001-04-30 Kyowa Hakko Kogyo Co. Ltd. Derivatives of antibody against ganglioside gm2
FR2807767B1 (fr) * 2000-04-12 2005-01-14 Lab Francais Du Fractionnement Anticorps monoclonaux anti-d
AU2016204535C1 (en) * 2000-04-12 2017-02-23 Laboratoire Français Du Fractionnement Et Des Biotechnologies Anti-D monoclonal antibodies
JP2001299349A (ja) * 2000-04-19 2001-10-30 Suntory Ltd 新規組換え型抗体とそのcdrのアミノ酸配列およびそれをコードする遺伝子
WO2002031140A1 (en) * 2000-10-06 2002-04-18 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
ES2303859T3 (es) 2001-06-28 2008-09-01 Kyowa Hakko Kogyo Co., Ltd Anticuerpo humanizado contra el factor de crecimiento fibroblastico 8 y fragmento del anticuerpo.
US7935338B2 (en) 2001-12-11 2011-05-03 University Of Massachusetts Antibodies to treat cancer
WO2003057251A1 (fr) * 2001-12-28 2003-07-17 Kyowa Hakko Kogyo Co., Ltd. Remedes contre l'arthrite
JPWO2003084569A1 (ja) 2002-04-09 2005-08-11 協和醗酵工業株式会社 抗体組成物含有医薬
US20040115204A1 (en) 2002-12-11 2004-06-17 Fanger Gary R. Antibodies to treat cancer
US7691810B2 (en) 2003-10-09 2010-04-06 Kyowa Hakko Kirin Co., Ltd Method of producing recombinant antithrombin III composition
JPWO2005035578A1 (ja) * 2003-10-09 2007-11-22 協和醗酵工業株式会社 ガングリオシドgm2に特異的に結合する抗体組成物
EP2107115A1 (en) 2007-01-24 2009-10-07 Kyowa Hakko Kirin Co., Ltd. Genetically recombinant antibody composition capable of binding specifically to ganglioside gm2
FR2953841B1 (fr) * 2009-12-16 2011-12-30 Centre Nat Rech Scient Anticorps diriges contre le recepteur de la transferrine et leurs utilisations pour l'immunotherapie des tumeurs qui dependent du fer
KR101913440B1 (ko) 2010-03-02 2018-10-30 교와 핫꼬 기린 가부시키가이샤 개변 항체 조성물

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69333524T2 (de) * 1992-09-07 2005-06-16 Kyowa Hakko Kogyo Co., Ltd. Humanisierte Antikörper, die mit dem GM2-Gangliosid reagieren

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014088040A1 (ja) 2012-12-06 2014-06-12 国立大学法人 金沢大学 中皮腫の治療方法

Also Published As

Publication number Publication date
ATE268382T1 (de) 2004-06-15
ES2219802T3 (es) 2004-12-01
JPH10257893A (ja) 1998-09-29
EP0882794A3 (en) 1999-06-16
DE69824234D1 (de) 2004-07-08
EP0882794B1 (en) 2004-06-02
AU5942098A (en) 1998-10-01
CA2226400A1 (en) 1998-09-19
CA2226400C (en) 2008-12-02
EP0882794A2 (en) 1998-12-09
DE69824234T2 (de) 2005-06-23
AU751948B2 (en) 2002-09-05

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