JP4549440B2 - 基準対照血液および製法 - Google Patents
基準対照血液および製法 Download PDFInfo
- Publication number
- JP4549440B2 JP4549440B2 JP50302998A JP50302998A JP4549440B2 JP 4549440 B2 JP4549440 B2 JP 4549440B2 JP 50302998 A JP50302998 A JP 50302998A JP 50302998 A JP50302998 A JP 50302998A JP 4549440 B2 JP4549440 B2 JP 4549440B2
- Authority
- JP
- Japan
- Prior art keywords
- wbc
- composition
- whole blood
- fixed
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5002—Partitioning blood components
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1402—Data analysis by thresholding or gating operations performed on the acquired signals or stored data
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/101666—Particle count or volume standard or control [e.g., platelet count standards, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/106664—Blood serum or blood plasma standard or control
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/107497—Preparation composition [e.g., lysing or precipitation, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/108331—Preservative, buffer, anticoagulant or diluent
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25125—Digestion or removing interfering materials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2525—Stabilizing or preserving
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dispersion Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Sampling And Sample Adjustment (AREA)
- Extrusion Moulding Of Plastics Or The Like (AREA)
- Holo Graphy (AREA)
- Apparatuses And Processes For Manufacturing Resistors (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/673,672 US5858790A (en) | 1996-06-26 | 1996-06-26 | Hematology reference control and method of preparation |
| US08/673,672 | 1996-06-26 | ||
| PCT/US1997/009567 WO1997049982A1 (en) | 1996-06-26 | 1997-05-29 | Hematology reference control and method of preparation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007182849A Division JP4686506B2 (ja) | 1996-06-26 | 2007-07-12 | 基準対照血液および製法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000513441A JP2000513441A (ja) | 2000-10-10 |
| JP4549440B2 true JP4549440B2 (ja) | 2010-09-22 |
Family
ID=24703633
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50302998A Expired - Fee Related JP4549440B2 (ja) | 1996-06-26 | 1997-05-29 | 基準対照血液および製法 |
| JP2007182849A Expired - Fee Related JP4686506B2 (ja) | 1996-06-26 | 2007-07-12 | 基準対照血液および製法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007182849A Expired - Fee Related JP4686506B2 (ja) | 1996-06-26 | 2007-07-12 | 基準対照血液および製法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US5858790A (enExample) |
| EP (1) | EP1021701B1 (enExample) |
| JP (2) | JP4549440B2 (enExample) |
| AT (1) | ATE441846T1 (enExample) |
| CA (1) | CA2257359C (enExample) |
| DE (1) | DE69739565D1 (enExample) |
| ES (1) | ES2330902T3 (enExample) |
| WO (1) | WO1997049982A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6509192B1 (en) * | 1992-02-24 | 2003-01-21 | Coulter International Corp. | Quality control method |
| US6221668B1 (en) * | 1999-08-20 | 2001-04-24 | Streck Laboratories, Inc. | Hematology control and system for multi-parameter hematology measurements |
| US6200500B1 (en) * | 1999-08-20 | 2001-03-13 | Streck Laboratories, Inc. | Hematology control and system for multi-parameter hematology measurements |
| US6444471B1 (en) | 1999-10-18 | 2002-09-03 | Research & Diagnostic Systems, Inc. | Reticulocyte containing complete blood control |
| US6514763B2 (en) | 2000-04-28 | 2003-02-04 | Hematronix, Inc. | Hematology blood control and method for preparation of same |
| US6653063B2 (en) | 2000-06-12 | 2003-11-25 | Hematronix, Inc. | Hematology composition using preserved white blood cells in combination with source particles to simulate native white blood cells and method of making same |
| DE60125549T2 (de) * | 2000-06-12 | 2007-06-28 | Bio-Rad Laboratories, Inc., Hercules | Hämatologische zusammensetzung mit präservierten weissen blutkörperchen |
| US6448085B1 (en) * | 2001-04-13 | 2002-09-10 | Sysmex Corporation | Quality control material and calibrator for nucleated red blood cell tested on hematology analyzer |
| US6759246B1 (en) * | 2001-11-30 | 2004-07-06 | Research & Diagnostic Systems, Inc. | Hematology control composition including lymphocyte analogs and method for preparation and use |
| US6653137B2 (en) | 2001-12-03 | 2003-11-25 | Streck Laboratories Inc. | Hematology reference control |
| US6723563B2 (en) | 2001-12-03 | 2004-04-20 | Streck Laboratories Inc. | Hematology reference control |
| DE10231308C5 (de) | 2002-07-10 | 2009-10-15 | Cmi Uvk Gmbh | Verfahren und Vorrichtung zum Recyceln von Edelstahl-Beizbädern |
| CA2447586A1 (en) * | 2002-11-01 | 2004-05-01 | Streck Laboratories, Inc. | Improved hematology reagent and methods |
| US6900058B2 (en) * | 2003-03-11 | 2005-05-31 | Bionostics, Inc. | Control solution for photometric analysis |
| EP1668353B1 (en) * | 2003-10-02 | 2015-03-18 | Beckman Coulter, Inc. | Reference control for optical measurement of nucleated red blood cells of a blood sample |
| US7198953B2 (en) * | 2003-10-12 | 2007-04-03 | Beckman Coulter, Inc. | Method of using a reference control composition for measurement of nucleated red blood cells |
| WO2005043113A2 (en) * | 2003-10-12 | 2005-05-12 | Beckman Coulter, Inc. | Method of using a reference control composition for measurement of nucleated red blood cells |
| US7195919B2 (en) * | 2003-12-19 | 2007-03-27 | Beckman Coulter, Inc. | Hematology controls for reticulocytes and nucleated red blood cells |
| US7208319B2 (en) * | 2004-02-10 | 2007-04-24 | Beckman Coulter, Inc. | Method of measurement of nucleated red blood cells |
| US7008792B2 (en) * | 2004-02-10 | 2006-03-07 | Beckman Coulter, Inc. | Method of measurement of nucleated red blood cells |
| EP1738163A4 (en) * | 2004-04-07 | 2008-01-23 | Beckman Coulter Inc | REFERENCE CONTROL COMPOSITION CONTAINING NUCLEIC RED GLOBULE COMPONENT |
| US7354767B2 (en) * | 2006-03-16 | 2008-04-08 | Beckman Coulter, Inc. | Reference control composition containing a nucleated red blood cell component made of non-nucleated blood cells |
| EP2082224B1 (en) | 2006-11-14 | 2015-05-13 | Beckman Coulter, Inc. | Hematology linearity control composition system and method of use |
| US7618821B2 (en) * | 2007-04-13 | 2009-11-17 | Streck, Inc. | Simulated blood components and methods |
| CN101311724B (zh) * | 2007-05-24 | 2014-11-12 | 深圳迈瑞生物医疗电子股份有限公司 | 单群白细胞模拟离子、包含单群白细胞模拟离子的校准物及其制备方法 |
| CN101311725B (zh) * | 2007-05-25 | 2014-03-26 | 深圳迈瑞生物医疗电子股份有限公司 | 一种五分类白细胞质控物及其制备方法 |
| CN101561443B (zh) * | 2008-04-15 | 2013-08-21 | 深圳迈瑞生物医疗电子股份有限公司 | 五分类白细胞模拟物粒子、其制备方法以及含该模拟粒子的质控物和校准物 |
| US20100086962A1 (en) * | 2008-10-08 | 2010-04-08 | Streck, Inc. | Hematology controls and methods |
| CN102109430B (zh) | 2009-12-25 | 2013-11-06 | 深圳迈瑞生物医疗电子股份有限公司 | 有核红细胞模拟粒子,血液质控物及其制备方法和用途 |
| US8546144B2 (en) | 2010-11-17 | 2013-10-01 | Streck, Inc. | Method of preparing controls for glycated hemoglobin S-A1c derived from healthy blood cells |
| US8551784B2 (en) | 2010-11-17 | 2013-10-08 | Streck, Inc. | Cis di-ahl modified controls for glycated hemoglobin S-A1c derived from healthy blood cells |
| CN103492883B (zh) * | 2011-04-28 | 2016-02-17 | 贝克曼考尔特公司 | 稳定性延长的血液学对照组合物 |
| JP6990185B2 (ja) | 2016-01-28 | 2022-01-12 | ベックマン コールター, インコーポレイテッド | 感染検出及び識別システム並びに方法 |
| EP3491381B1 (en) | 2016-07-29 | 2025-09-24 | Streck LLC | Suspension composition for hematology analysis control |
| AU2018227456A1 (en) | 2017-02-28 | 2019-09-12 | Beckman Coulter, Inc. | Cross discipline disease management system |
| US11467318B2 (en) * | 2017-05-08 | 2022-10-11 | Halliburton Energy Services, Inc. | Inversion processing of well log data |
| US11852640B2 (en) * | 2017-10-27 | 2023-12-26 | Beckman Coulter, Inc. | Hematology analyzers and methods of operation |
| US11521706B2 (en) | 2018-04-20 | 2022-12-06 | Beckman Coulter, Inc. | Testing and representing suspicion of sepsis |
| US11538566B2 (en) | 2018-05-23 | 2022-12-27 | Beckman Coulter, Inc. | Sample analysis with test determination based on identified condition |
| WO2019204804A1 (en) | 2018-04-20 | 2019-10-24 | Beckman Coulter, Inc. | Sepsis infection determination systems and methods |
| CN111989032B (zh) | 2018-06-15 | 2024-07-19 | 拜克门寇尔特公司 | 存在母细胞标志时确定败血症的方法 |
| JP7561821B2 (ja) | 2019-07-12 | 2024-10-04 | ベックマン コールター, インコーポレイテッド | 感染に対する免疫応答を評価するためのシステムおよび方法 |
| EP3997713B1 (en) | 2019-07-12 | 2025-06-11 | Beckman Coulter, Inc. | Method of detecting sepsis using vital signs, including systolic blood pressure, hematology parameters, and combinations thereof |
| EP4097599A4 (en) * | 2020-01-31 | 2024-02-28 | Bio-Rad Laboratories, Inc. | STABLE REFERENCE MATERIALS FOR AUTOMATED HEMATOLOGY TESTING PLATFORMS |
| EP4208021A4 (en) * | 2020-09-03 | 2024-10-30 | Bio-Rad Laboratories, Inc. | PREPARATION OF NUCLEATED RBC (NRBC) ANALOGUES FOR USE AS REFERENCE HEMATOLOGY CONTROLS IN AUTOMATED HEMATOLOGY ANALYZERS |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3632735A (en) * | 1970-03-11 | 1972-01-04 | Pfizer & Co C | Method of stabilizing fowl red blood cells for use in hematology control compositions |
| US4219440A (en) * | 1979-06-06 | 1980-08-26 | Coulter Electronics, Inc. | Multiple analysis hematology reference control reagent and method of making the same |
| US4704364A (en) * | 1984-05-18 | 1987-11-03 | Coulter Electronics, Inc. | Hematology control compositions for three populations of leukocytes; and methods for their preparation and use in whole blood control systems |
| US4847204A (en) * | 1984-05-24 | 1989-07-11 | Southeast Vetlab, Inc. | Calibrator composition and method of producing and using same for veterinary applications |
| EP0182874B1 (en) * | 1984-05-31 | 1993-10-20 | Coulter Corporation | A reagent system and method for identification, enumeration and examination of classes and subclasses of blood leukocytes |
| US4698312A (en) * | 1986-07-28 | 1987-10-06 | Fisher Scientific Company | Stabilizing blood cells with aromatic polyaldehyde for use in hematology controls and calibrators |
| US4777139A (en) * | 1987-06-25 | 1988-10-11 | Fisher Scientific Company | Hematology control or calibrator with red cell components of enhanced stability |
| IE76319B1 (en) * | 1990-07-23 | 1997-10-22 | Becton Dickinson Co | Preservation of cells as controls or standards in cellular analysis |
| US5262327A (en) * | 1991-05-09 | 1993-11-16 | Streck Laboratories, Inc. | White blood cell hematology control |
| US5270208A (en) * | 1991-05-09 | 1993-12-14 | Streck Laboratories, Inc. | White blood cell hematology control |
| BR9305952A (pt) * | 1992-02-24 | 1997-10-21 | Coulter Corp | Produto de controle de hematologia processo para utilizar o mesmo e processo para fabricação de análogos de leucócito |
| WO1993017329A1 (en) * | 1992-02-24 | 1993-09-02 | Coulter Corporation | Suspension media for hematological composition and method for its use |
| CA2156752C (en) * | 1993-02-25 | 1999-01-05 | Young Ran Kim | Multipurpose reagent system for rapid lysis of whole blood samples |
| US5559037A (en) * | 1994-12-15 | 1996-09-24 | Abbott Laboratories | Method for rapid and simultaneous analysis of nucleated red blood cells |
-
1996
- 1996-06-26 US US08/673,672 patent/US5858790A/en not_active Expired - Fee Related
-
1997
- 1997-05-29 JP JP50302998A patent/JP4549440B2/ja not_active Expired - Fee Related
- 1997-05-29 ES ES97928807T patent/ES2330902T3/es not_active Expired - Lifetime
- 1997-05-29 DE DE69739565T patent/DE69739565D1/de not_active Expired - Lifetime
- 1997-05-29 WO PCT/US1997/009567 patent/WO1997049982A1/en not_active Ceased
- 1997-05-29 EP EP97928807A patent/EP1021701B1/en not_active Expired - Lifetime
- 1997-05-29 CA CA002257359A patent/CA2257359C/en not_active Expired - Fee Related
- 1997-05-29 AT AT97928807T patent/ATE441846T1/de not_active IP Right Cessation
-
1998
- 1998-10-16 US US09/173,823 patent/US6187590B1/en not_active Expired - Fee Related
-
2007
- 2007-07-12 JP JP2007182849A patent/JP4686506B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2330902T3 (es) | 2009-12-16 |
| JP2008026317A (ja) | 2008-02-07 |
| EP1021701A1 (en) | 2000-07-26 |
| ATE441846T1 (de) | 2009-09-15 |
| WO1997049982A1 (en) | 1997-12-31 |
| CA2257359C (en) | 2006-03-14 |
| DE69739565D1 (de) | 2009-10-15 |
| JP4686506B2 (ja) | 2011-05-25 |
| CA2257359A1 (en) | 1997-12-31 |
| EP1021701B1 (en) | 2009-09-02 |
| US6187590B1 (en) | 2001-02-13 |
| US5858790A (en) | 1999-01-12 |
| JP2000513441A (ja) | 2000-10-10 |
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