JP4525964B2 - 肺高血圧症予防治療剤 - Google Patents

肺高血圧症予防治療剤 Download PDF

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Publication number
JP4525964B2
JP4525964B2 JP2003548846A JP2003548846A JP4525964B2 JP 4525964 B2 JP4525964 B2 JP 4525964B2 JP 2003548846 A JP2003548846 A JP 2003548846A JP 2003548846 A JP2003548846 A JP 2003548846A JP 4525964 B2 JP4525964 B2 JP 4525964B2
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Japan
Prior art keywords
pulmonary hypertension
general formula
administration
therapeutic agent
patent document
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JP2003548846A
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English (en)
Japanese (ja)
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JPWO2003047591A1 (ja
Inventor
真一 佐藤
一郎 生垣
宏明 下川
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Asahi Kasei Pharma Corp
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Asahi Kasei Pharma Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2003548846A 2001-11-30 2002-11-21 肺高血圧症予防治療剤 Expired - Lifetime JP4525964B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001367144 2001-11-30
JP2001367144 2001-11-30
PCT/JP2002/012154 WO2003047591A1 (fr) 2001-11-30 2002-11-21 Medicaments contre l'hypertension arterielle pulmonaire primitive

Publications (2)

Publication Number Publication Date
JPWO2003047591A1 JPWO2003047591A1 (ja) 2005-04-14
JP4525964B2 true JP4525964B2 (ja) 2010-08-18

Family

ID=19176934

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003548846A Expired - Lifetime JP4525964B2 (ja) 2001-11-30 2002-11-21 肺高血圧症予防治療剤

Country Status (3)

Country Link
JP (1) JP4525964B2 (fr)
AU (1) AU2002349411A1 (fr)
WO (1) WO2003047591A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE551059T1 (de) 2005-10-26 2012-04-15 Asahi Kasei Pharma Corp Fasudil in kombination mit bosentan zur behandlung von pulmonaler arterieller hypertonie
US20090036465A1 (en) * 2006-10-18 2009-02-05 United Therapeutics Corporation Combination therapy for pulmonary arterial hypertension
CN106461677B (zh) 2014-04-22 2018-09-11 国立大学法人东北大学 肺高血压病的检查方法
CN105085478B (zh) * 2014-04-28 2019-04-12 南京明德新药研发股份有限公司 异喹啉磺胺衍生物及其药物组合物和制药用途

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06141894A (ja) * 1992-11-11 1994-05-24 Asahi Chem Ind Co Ltd ミオシン軽鎖リン酸化酵素の活性測定法
WO1998006433A1 (fr) * 1996-08-12 1998-02-19 Yoshitomi Pharmaceutical Industries, Ltd. MEDICAMENTS COMPRENANT UN INHIBITEUR DE LA Rho KINASE
WO1999047153A2 (fr) * 1998-03-19 1999-09-23 Brigham & Women's Hospital, Inc. REMISE A NIVEAU DE LA SYNTHASE D'OXYDE NITRIQUE DES CELLULES ENDOTHELIALES DE TYPE III AU MOYEN D'INHIBITEURS DE LA FONCTION GTPase DE $i(rho)
WO2000003746A2 (fr) * 1998-07-14 2000-01-27 The Brigham And Women's Hospital, Inc. Remise a niveau de la synthase dl'oxyde nitrique des cellules endotheliales de type iii par des agents venant disloquer l'organisation cytosquelettique de l'actine
US6228843B1 (en) * 1999-04-23 2001-05-08 University Technology Corporation Method of using PKC inhibiting compounds to treat vascular disease
JP2001172182A (ja) * 1999-11-02 2001-06-26 Pfizer Inc 肺高血圧症の治療方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06141894A (ja) * 1992-11-11 1994-05-24 Asahi Chem Ind Co Ltd ミオシン軽鎖リン酸化酵素の活性測定法
WO1998006433A1 (fr) * 1996-08-12 1998-02-19 Yoshitomi Pharmaceutical Industries, Ltd. MEDICAMENTS COMPRENANT UN INHIBITEUR DE LA Rho KINASE
WO1999047153A2 (fr) * 1998-03-19 1999-09-23 Brigham & Women's Hospital, Inc. REMISE A NIVEAU DE LA SYNTHASE D'OXYDE NITRIQUE DES CELLULES ENDOTHELIALES DE TYPE III AU MOYEN D'INHIBITEURS DE LA FONCTION GTPase DE $i(rho)
WO2000003746A2 (fr) * 1998-07-14 2000-01-27 The Brigham And Women's Hospital, Inc. Remise a niveau de la synthase dl'oxyde nitrique des cellules endotheliales de type iii par des agents venant disloquer l'organisation cytosquelettique de l'actine
US6228843B1 (en) * 1999-04-23 2001-05-08 University Technology Corporation Method of using PKC inhibiting compounds to treat vascular disease
JP2001172182A (ja) * 1999-11-02 2001-06-26 Pfizer Inc 肺高血圧症の治療方法

Also Published As

Publication number Publication date
AU2002349411A1 (en) 2003-06-17
JPWO2003047591A1 (ja) 2005-04-14
WO2003047591A1 (fr) 2003-06-12

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