JP4520620B2 - 毛管状血球成分分離構造物および方法 - Google Patents

毛管状血球成分分離構造物および方法 Download PDF

Info

Publication number
JP4520620B2
JP4520620B2 JP2000328528A JP2000328528A JP4520620B2 JP 4520620 B2 JP4520620 B2 JP 4520620B2 JP 2000328528 A JP2000328528 A JP 2000328528A JP 2000328528 A JP2000328528 A JP 2000328528A JP 4520620 B2 JP4520620 B2 JP 4520620B2
Authority
JP
Japan
Prior art keywords
plasma
capillary
reaction
reaction region
pathway
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2000328528A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001183363A5 (https=
JP2001183363A (ja
Inventor
エス.ブーラー ラフビール
ディー.ウイルゼイ クリストファー
エヌ.シェルトン ジェフリー
Original Assignee
ロシュ ダイアグノスティックス オペレーションズ インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ロシュ ダイアグノスティックス オペレーションズ インコーポレーテッド filed Critical ロシュ ダイアグノスティックス オペレーションズ インコーポレーテッド
Publication of JP2001183363A publication Critical patent/JP2001183363A/ja
Publication of JP2001183363A5 publication Critical patent/JP2001183363A5/ja
Application granted granted Critical
Publication of JP4520620B2 publication Critical patent/JP4520620B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/49Blood
    • G01N33/491Blood by separating the blood components
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0681Filter
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0825Test strips
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406Moving fluids with specific forces or mechanical means specific forces capillary forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/08Regulating or influencing the flow resistance
    • B01L2400/084Passive control of flow resistance
    • B01L2400/086Passive control of flow resistance using baffles or other fixed flow obstructions
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125Digestion or removing interfering materials
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Ecology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • External Artificial Organs (AREA)
JP2000328528A 1999-10-28 2000-10-27 毛管状血球成分分離構造物および方法 Expired - Fee Related JP4520620B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/428691 1999-10-28
US09/428,691 US6319719B1 (en) 1999-10-28 1999-10-28 Capillary hematocrit separation structure and method

Publications (3)

Publication Number Publication Date
JP2001183363A JP2001183363A (ja) 2001-07-06
JP2001183363A5 JP2001183363A5 (https=) 2007-10-04
JP4520620B2 true JP4520620B2 (ja) 2010-08-11

Family

ID=23699972

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000328528A Expired - Fee Related JP4520620B2 (ja) 1999-10-28 2000-10-27 毛管状血球成分分離構造物および方法

Country Status (6)

Country Link
US (1) US6319719B1 (https=)
EP (1) EP1096254B1 (https=)
JP (1) JP4520620B2 (https=)
AT (1) ATE292799T1 (https=)
CA (1) CA2324131C (https=)
DE (1) DE60019228T2 (https=)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6749814B1 (en) 1999-03-03 2004-06-15 Symyx Technologies, Inc. Chemical processing microsystems comprising parallel flow microreactors and methods for using same
US6406672B1 (en) * 2000-01-28 2002-06-18 Roche Diagnostics Plasma retention structure providing internal flow
US6555387B1 (en) * 2000-09-27 2003-04-29 Becton, Dickinson And Company Method for producing thin liquid samples for microscopic analysis
US6814843B1 (en) * 2000-11-01 2004-11-09 Roche Diagnostics Corporation Biosensor
SE0201738D0 (sv) * 2002-06-07 2002-06-07 Aamic Ab Micro-fluid structures
US20040019300A1 (en) * 2002-07-26 2004-01-29 Leonard Leslie Anne Microfluidic blood sample separations
AU2003267147A1 (en) * 2002-09-10 2004-04-30 Placor, Inc. Method and device for monitoring platelet function
JP4075765B2 (ja) * 2002-10-30 2008-04-16 日本電気株式会社 分離装置およびその製造方法、ならびに分析システム
JP2004354364A (ja) * 2002-12-02 2004-12-16 Nec Corp 微粒子操作ユニット、それを搭載したチップと検出装置、ならびにタンパク質の分離、捕獲、および検出方法
DE10305050A1 (de) * 2003-02-07 2004-08-19 Roche Diagnostics Gmbh Analytisches Testelement und Verfahren für Blutuntersuchungen
JPWO2004097393A1 (ja) * 2003-04-28 2006-07-13 松下電器産業株式会社 フィルタとそれを備えたバイオセンサ
EP1642125B1 (en) * 2003-06-20 2017-09-27 Roche Diabetes Care GmbH Biosensor with multiple electrical functionalities
US8679853B2 (en) 2003-06-20 2014-03-25 Roche Diagnostics Operations, Inc. Biosensor with laser-sealed capillary space and method of making
JP2007524816A (ja) * 2003-06-20 2007-08-30 エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト 細い均一な試薬ストリップの製造方法およびその試薬
US8071030B2 (en) * 2003-06-20 2011-12-06 Roche Diagnostics Operations, Inc. Test strip with flared sample receiving chamber
DE10352535A1 (de) * 2003-11-07 2005-06-16 Steag Microparts Gmbh Mikrostrukturierte Trennvorrichtung und Verfahren zum Abtrennen von flüssigen Bestandteilen aus einer Partikel enthaltenden Flüssigkeit
GB0329220D0 (en) * 2003-12-17 2004-01-21 Inverness Medical Switzerland System
DE102004027422A1 (de) * 2004-06-04 2005-12-29 Boehringer Ingelheim Microparts Gmbh Vorrichtung zur Aufnahme von Blut und Abtrennung von Blutbestandteilen
JP2007523355A (ja) * 2004-08-21 2007-08-16 エルジー・ライフ・サイエンシズ・リミテッド 微細流体素子及びそれを備えた診断及び分析装置
WO2006031095A1 (en) * 2004-09-13 2006-03-23 Leja Holding B.V. Capillary-loading slide and method of microscopic research with correction of the serge silberberg effect
EP1875232A2 (en) * 2005-04-25 2008-01-09 PlaCor, Inc. Methods and devices for monitoring platelet function
DE102005048236A1 (de) * 2005-10-07 2007-04-12 Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg Vorrichtung und Verfahren zur Bestimmung der Volumenanteile der Phasen in einer Suspension
JP2007309741A (ja) * 2006-05-17 2007-11-29 Olympus Corp 血液分離方法および血液分離装置
DE102006025477B4 (de) * 2006-05-30 2009-01-15 Ekf - Diagnostic Gmbh Küvette und Verfahren zu ihrer Herstellung
US20100099130A1 (en) * 2006-10-25 2010-04-22 Placor Inc. Methods and devices for monitoring platelet function
KR100897524B1 (ko) 2006-12-04 2009-05-15 한국전자통신연구원 혈장 분리용 마이크로 필터 소자
JP5309312B2 (ja) * 2007-11-01 2013-10-09 Jfeテクノス株式会社 マイクロチップ、マイクロチップデバイス及びマイクロチップを用いた蒸発操作方法
EP2260300B1 (en) 2008-03-07 2013-09-25 Advanced Microdevices Pvt Ltd Method and device for particle removal and droplet preparation for qualitative and quantitative bioanalysis
JP5438351B2 (ja) * 2009-03-30 2014-03-12 Jfeテクノス株式会社 マイクロチップを用いたpet用標識化合物の調剤方法及び装置
SG184592A1 (en) * 2011-03-18 2012-10-30 Univ Singapore Isolating target cells from a biological fluid
JP5490492B2 (ja) * 2009-10-30 2014-05-14 学校法人立命館 血漿分離器及び血液分析装置
EP2375249B1 (en) 2010-04-09 2019-12-25 F. Hoffmann-La Roche AG Devices and process for separating plasma from a blood sample
ES2715828T3 (es) * 2010-04-15 2019-06-06 Cytogen Co Ltd Dispositivo microfluídico y métodos para aislar dianas
US20110301049A1 (en) * 2010-06-04 2011-12-08 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Fluid Flow Contour Control Using Flow Resistance
TWI439689B (zh) 2010-09-23 2014-06-01 華廣生技股份有限公司 Electrochemical test specimen
RU2477645C1 (ru) * 2011-08-24 2013-03-20 Российская Федерация, от имени которой выступает Министерство промышленности и торговли Российской Федерации (Минпромторг России) Устройство для отделения частиц от жидкости
EP2587248A1 (en) * 2011-10-25 2013-05-01 Koninklijke Philips Electronics N.V. Filtering particles from blood or other media
WO2013082273A1 (en) 2011-11-30 2013-06-06 Wellstat Diagnostics, Llc. Filtration module
JP6073072B2 (ja) * 2012-04-27 2017-02-01 株式会社キコーコーポレーション ナノファイバー不織布を用いたろ過装置
US9081001B2 (en) 2012-05-15 2015-07-14 Wellstat Diagnostics, Llc Diagnostic systems and instruments
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
WO2014024154A1 (en) * 2012-08-08 2014-02-13 Koninklijke Philips N.V. Centrifugal microfluidic device and methods of use
US10058866B2 (en) 2013-03-13 2018-08-28 Abbott Laboratories Methods and apparatus to mitigate bubble formation in a liquid
US9535082B2 (en) 2013-03-13 2017-01-03 Abbott Laboratories Methods and apparatus to agitate a liquid
USD962471S1 (en) 2013-03-13 2022-08-30 Abbott Laboratories Reagent container
USD978375S1 (en) 2013-03-13 2023-02-14 Abbott Laboratories Reagent container
PL2972268T3 (pl) 2013-03-15 2017-10-31 Hoffmann La Roche Sposoby zabezpieczenia przed błędem w elektrochemicznym pomiarze analitu, przyrządy i urządzenia oraz układy je zawierające
JP6352954B2 (ja) 2013-03-15 2018-07-04 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 電気化学的な分析物測定において回復パルスからの情報を使用する方法およびデバイス、装置とそれらを組み込むシステム
KR101743382B1 (ko) 2013-03-15 2017-06-02 에프. 호프만-라 로슈 아게 전기화학적 측정 중 높은 항산화제 레벨들을 검출하고 그로부터 분석물질 농도를 페일세이프하는 방법들 뿐만 아니라 상기 방법들을 통합한 기기들, 장치들 및 시스템들
WO2014140170A1 (en) 2013-03-15 2014-09-18 Roche Diagnostics Gmbh Methods of scaling data used to construct biosensor algorithms as well as devices, apparatuses and systems incorporating the same
WO2014172247A1 (en) 2013-04-15 2014-10-23 Becton, Dickinson And Company Blood sampling transfer device
MX2015014472A (es) 2013-04-15 2016-02-05 Becton Dickinson Co Dispositivo medico para la recogida de una muestra biologica.
MX368995B (es) 2013-04-15 2019-10-23 Becton Dickinson Co Dispositivo de separación de fluidos biológicos y sistema de separación y análisis de fluidos biológicos.
EP2986383B1 (en) 2013-04-15 2020-08-26 Becton, Dickinson and Company Biological fluid separation device and biological fluid separation and testing system
WO2014172233A1 (en) * 2013-04-15 2014-10-23 Becton, Dickinson And Company Biological fluid transfer device and biological fluid sampling system
BR112015026252B1 (pt) 2013-04-15 2022-03-22 Becton, Dickinson And Company Dispositivo de coleta de fluido biológico e sistema de coleta e teste de fluido biológico
CA3005826C (en) 2013-04-15 2021-11-23 Becton, Dickinson And Company Biological fluid collection device and biological fluid separation and testing system
EP3135377A1 (en) 2013-04-15 2017-03-01 Becton, Dickinson and Company Biological fluid collection device and biological fluid separation and testing system
MX369605B (es) 2013-04-15 2019-11-13 Becton Dickinson Co Dispositivo de transferencia de muestreo de fluidos biologicos y sistema de separacion y analisis de fluidos biologicos.
US9597028B2 (en) 2013-04-15 2017-03-21 Becton, Dickinson And Company Biological fluid collection device and biological fluid separation and testing system
US9380973B2 (en) 2013-04-15 2016-07-05 Becton, Dickinson And Company Biological fluid sampling transfer device and biological fluid separation and testing system
US10080516B2 (en) 2013-04-15 2018-09-25 Becton, Dickinson And Company Biological fluid collection device and biological fluid separation and testing system
US10194851B2 (en) 2013-04-15 2019-02-05 Becton, Dickinson And Company Blood sampling transfer device and blood separation and testing system
US9408568B2 (en) 2013-04-15 2016-08-09 Becton, Dickinson And Company Biological fluid sampling device
ES2903175T3 (es) 2015-03-31 2022-03-31 Hoffmann La Roche Tarjeta de separación de plasma
MX2018001352A (es) 2015-08-06 2018-05-22 Becton Dickinson Co Dispositivo de recoleccion de fluido biologico y sistema de recoleccion de fluido biologico.
KR102372113B1 (ko) 2016-10-05 2022-03-07 에프. 호프만-라 로슈 아게 다중 분석물 진단 테스트 엘리먼트들을 위한 검출 시약들 및 전극 배열들, 그리고 그것을 사용하는 방법들
EP3529612B1 (en) 2016-10-24 2024-12-11 F. Hoffmann-La Roche AG Methods of correcting for uncompensated resistances in the conductive elements of biosensors, as well as devices and systems
KR101872780B1 (ko) * 2017-01-24 2018-06-29 광주과학기술원 헤링본 타입 유체유도유닛 및 이를 이용한 세포 농축 장치
GB2583106A (en) * 2019-04-16 2020-10-21 Univ Warwick Motile cell sorting device

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5113428B1 (https=) * 1970-05-09 1976-04-28
DE2757384A1 (de) * 1976-12-29 1978-07-06 Rosemount Inc Nach dem prinzip der wirbelabloesung arbeitender durchflussmesser
US4233029A (en) 1978-10-25 1980-11-11 Eastman Kodak Company Liquid transport device and method
US4310399A (en) 1979-07-23 1982-01-12 Eastman Kodak Company Liquid transport device containing means for delaying capillary flow
US4302313A (en) 1979-07-23 1981-11-24 Eastman Kodak Company Electrode-containing device with capillary transport between electrodes
US4271119A (en) 1979-07-23 1981-06-02 Eastman Kodak Company Capillary transport device having connected transport zones
US4426451A (en) 1981-01-28 1984-01-17 Eastman Kodak Company Multi-zoned reaction vessel having pressure-actuatable control means between zones
US4473457A (en) 1982-03-29 1984-09-25 Eastman Kodak Company Liquid transport device providing diversion of capillary flow into a non-vented second zone
US4439526A (en) 1982-07-26 1984-03-27 Eastman Kodak Company Clustered ingress apertures for capillary transport devices and method of use
US4549952A (en) 1982-11-22 1985-10-29 Eastman Kodak Company Capillary transport device having means for increasing the viscosity of the transported liquid
US4618476A (en) 1984-02-10 1986-10-21 Eastman Kodak Company Capillary transport device having speed and meniscus control means
US5164598A (en) 1985-08-05 1992-11-17 Biotrack Capillary flow device
US5144139A (en) 1985-08-05 1992-09-01 Biotrack, Inc. Capillary flow device
US5140161A (en) 1985-08-05 1992-08-18 Biotrack Capillary flow device
US4963498A (en) 1985-08-05 1990-10-16 Biotrack Capillary flow device
US4948961A (en) 1985-08-05 1990-08-14 Biotrack, Inc. Capillary flow device
US4756884A (en) 1985-08-05 1988-07-12 Biotrack, Inc. Capillary flow device
US5004923A (en) 1985-08-05 1991-04-02 Biotrack, Inc. Capillary flow device
US5204525A (en) 1985-08-05 1993-04-20 Biotrack Capillary flow device
US5135719A (en) 1986-10-29 1992-08-04 Biotrack, Inc. Blood separation device comprising a filter and a capillary flow pathway exiting the filter
US4753776A (en) * 1986-10-29 1988-06-28 Biotrack, Inc. Blood separation device comprising a filter and a capillary flow pathway exiting the filter
US4849340A (en) 1987-04-03 1989-07-18 Cardiovascular Diagnostics, Inc. Reaction system element and method for performing prothrombin time assay
EP0286088B1 (en) * 1987-04-08 1994-09-14 Hitachi, Ltd. A sheath flow type flow-cell device
GB8709882D0 (en) 1987-04-27 1987-06-03 Genetics Int Inc Membrane configurations
US5051237A (en) * 1988-06-23 1991-09-24 P B Diagnostic Systems, Inc. Liquid transport system
US5208147A (en) * 1988-07-21 1993-05-04 Radiometer A/S Means for measuring a characteristic in a sample fluid
US4957582A (en) 1989-03-16 1990-09-18 Eastman Kodak Company Capillary transport zone coated with adhesive
EP0388782A1 (en) 1989-03-20 1990-09-26 Quantai Biotronics Inc. Method for determination of analytes
US5039617A (en) 1989-04-20 1991-08-13 Biotrack, Inc. Capillary flow device and method for measuring activated partial thromboplastin time
CA2019865A1 (en) 1989-07-12 1991-01-12 Yatin B. Thakore Device and method for separation of fluid components for component testing
CA2020029A1 (en) 1989-07-12 1991-01-13 Yatin B. Thakore Device and method for separation of plasma from blood and determination of blood analytes
US5135716A (en) 1989-07-12 1992-08-04 Kingston Diagnostics, L.P. Direct measurement of HDL cholesterol via dry chemistry strips
US5620863A (en) 1989-08-28 1997-04-15 Lifescan, Inc. Blood glucose strip having reduced side reactions
AU640162B2 (en) 1989-08-28 1993-08-19 Lifescan, Inc. Blood separation and analyte detection techniques
US5230866A (en) 1991-03-01 1993-07-27 Biotrack, Inc. Capillary stop-flow junction having improved stability against accidental fluid flow
US5540888A (en) 1991-11-11 1996-07-30 British Technology Group Limited Liquid transfer assay devices
AU677780B2 (en) * 1992-05-01 1997-05-08 Trustees Of The University Of Pennsylvania, The Microfabricated detection structures
US6156270A (en) * 1992-05-21 2000-12-05 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US5458852A (en) * 1992-05-21 1995-10-17 Biosite Diagnostics, Inc. Diagnostic devices for the controlled movement of reagents without membranes
US5885527A (en) 1992-05-21 1999-03-23 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membrances
GB9309797D0 (en) 1993-05-12 1993-06-23 Medisense Inc Electrochemical sensors
US6113855A (en) * 1996-11-15 2000-09-05 Biosite Diagnostics, Inc. Devices comprising multiple capillarity inducing surfaces
US5976336A (en) 1997-04-25 1999-11-02 Caliper Technologies Corp. Microfluidic devices incorporating improved channel geometries
US5798031A (en) 1997-05-12 1998-08-25 Bayer Corporation Electrochemical biosensor
DE19753849A1 (de) 1997-12-04 1999-06-10 Roche Diagnostics Gmbh Analytisches Testelement mit sich verjüngendem Kapillarkanal
GB9907665D0 (en) 1999-04-01 1999-05-26 Cambridge Molecular Tech Fluidic devices

Also Published As

Publication number Publication date
EP1096254B1 (en) 2005-04-06
CA2324131C (en) 2007-07-31
JP2001183363A (ja) 2001-07-06
US6319719B1 (en) 2001-11-20
CA2324131A1 (en) 2001-04-28
EP1096254A3 (en) 2001-06-13
DE60019228T2 (de) 2006-05-11
DE60019228D1 (de) 2005-05-12
ATE292799T1 (de) 2005-04-15
EP1096254A2 (en) 2001-05-02

Similar Documents

Publication Publication Date Title
JP4520620B2 (ja) 毛管状血球成分分離構造物および方法
JP4587298B2 (ja) マイクロ流体デバイス内での粒子分離方法及び装置
US7736907B2 (en) Device for collecting blood and separating blood constituents, method for separating blood constituents and use of said device
EP1120164B1 (en) Fluid flow control in curved capillary channels
CA2331855C (en) Plasma retention structure providing internal flow
CN103890590B (zh) 生物流体样品分析盒
KR100876064B1 (ko) 유체가 제어식으로 운반되는 유체 분석 장치
EP2167955B1 (en) Chip for analyzing fluids
CA2024891C (en) Blood collection device
US20050249641A1 (en) Microstructured platform and method for manipulating a liquid
EP2962104B1 (en) Lateral flow assay device with test strip retainer
US20080290048A1 (en) Plasma separation device and method thereof
JP2004283828A (ja) 粒子を含む液体から液体成分を分離するための微細構造型分離装置およびマイクロ流体方法
JP2005177749A (ja) サンプルを処理するためのマイクロタイタ・プレート、システム及び方法
EP3171151A1 (en) Device for constant-volume collection using centrifugation or for further storage
CN102695561A (zh) 样品处理盒以及在离心力下处理和/或分析样品的方法
EP2986386B1 (en) Biological fluid separation device and biological fluid separation and testing system
JPH0473747B2 (https=)
JPH09318630A (ja) 赤血球反応を実施するための装置
WO2009014380A2 (en) Module for detecting analytes in fluids and chip having the same
JP4752546B2 (ja) 遠心分離デバイス及び遠心分離方法
CA2324129A1 (en) Moisture-curable compositions containing isocyanate and succinyl urea groups
EP2454018B1 (en) Tube for separating portions of a sample
US20060204403A1 (en) Micro-fluidic fluid separation device and method
JPWO2004097393A1 (ja) フィルタとそれを備えたバイオセンサ

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070821

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070821

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20080902

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100209

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100416

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20100511

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20100521

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130528

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees